LOCUS       NM_023844               4822 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus junction adhesion molecule 2 (Jam2), mRNA.
ACCESSION   NM_023844
VERSION     NM_023844.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4822)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4822)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   3  (bases 1 to 4822)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4822)
  AUTHORS   Wang,Q., Ding,S.L., Li,Y., Royall,J., Feng,D., Lesnar,P.,
            Graddis,N., Naeemi,M., Facer,B., Ho,A., Dolbeare,T., Blanchard,B.,
            Dee,N., Wakeman,W., Hirokawa,K.E., Szafer,A., Sunkin,S.M., Oh,S.W.,
            Bernard,A., Phillips,J.W., Hawrylycz,M., Koch,C., Zeng,H.,
            Harris,J.A. and Ng,L.
  TITLE     The Allen Mouse Brain Common Coordinate Framework: A 3D Reference
            Atlas
  JOURNAL   Cell 181 (4), 936-953 (2020)
   PUBMED   32386544
REFERENCE   5  (bases 1 to 4822)
  AUTHORS   Schottlaender,L.V., Abeti,R., Jaunmuktane,Z., Macmillan,C.,
            Chelban,V., O'Callaghan,B., McKinley,J., Maroofian,R.,
            Efthymiou,S., Athanasiou-Fragkouli,A., Forbes,R., Soutar,M.P.M.,
            Livingston,J.H., Kalmar,B., Swayne,O., Hotton,G., Pittman,A.,
            Mendes de Oliveira,J.R., de Grandis,M., Richard-Loendt,A.,
            Launchbury,F., Althonayan,J., McDonnell,G., Carr,A., Khan,S.,
            Beetz,C., Bisgin,A., Tug Bozdogan,S., Begtrup,A., Torti,E.,
            Greensmith,L., Giunti,P., Morrison,P.J., Brandner,S.,
            Aurrand-Lions,M. and Houlden,H.
  CONSRTM   SYNAPS Study Group
  TITLE     Bi-allelic JAM2 Variants Lead to Early-Onset Recessive Primary
            Familial Brain Calcification
  JOURNAL   Am J Hum Genet 106 (3), 412-421 (2020)
   PUBMED   32142645
REFERENCE   6  (bases 1 to 4822)
  AUTHORS   Johnson-Leger,C.A., Aurrand-Lions,M., Beltraminelli,N., Fasel,N.
            and Imhof,B.A.
  TITLE     Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte
            transendothelial migration
  JOURNAL   Blood 100 (7), 2479-2486 (2002)
   PUBMED   12239159
  REMARK    GeneRIF: promotes lymphocyte transendothelial migration
REFERENCE   7  (bases 1 to 4822)
  AUTHORS   Luscinskas,F.W., Ma,S., Nusrat,A., Parkos,C.A. and Shaw,S.K.
  TITLE     Leukocyte transendothelial migration: a junctional affair
  JOURNAL   Semin Immunol 14 (2), 105-113 (2002)
   PUBMED   11978082
  REMARK    Review article
REFERENCE   8  (bases 1 to 4822)
  AUTHORS   Aurrand-Lions,M., Johnson-Leger,C., Lamagna,C., Ozaki,H., Kita,T.
            and Imhof,B.A.
  TITLE     Junctional adhesion molecules and interendothelial junctions
  JOURNAL   Cells Tissues Organs 172 (3), 152-160 (2002)
   PUBMED   12476045
  REMARK    GeneRIF: Results suggest a role for junctional adhesion molecule-2
            (JAM-2) in facilitating transmigration in endothelial cells.
REFERENCE   9  (bases 1 to 4822)
  AUTHORS   Palmeri,D., van Zante,A., Huang,C.C., Hemmerich,S. and Rosen,S.D.
  TITLE     Vascular endothelial junction-associated molecule, a novel member
            of the immunoglobulin superfamily, is localized to intercellular
            boundaries of endothelial cells
  JOURNAL   J Biol Chem 275 (25), 19139-19145 (2000)
   PUBMED   10779521
REFERENCE   10 (bases 1 to 4822)
  AUTHORS   Aurrand-Lions,M.A., Duncan,L., Du Pasquier,L. and Imhof,B.A.
  TITLE     Cloning of JAM-2 and JAM-3: an emerging junctional adhesion
            molecular family?
  JOURNAL   Curr Top Microbiol Immunol 251, 91-98 (2000)
   PUBMED   11036763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC028778.1 and AC164162.2.
            
            On Mar 22, 2011 this sequence version replaced NM_023844.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028757.1, BC028778.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1326              BC028778.1         1-1326
            1327-4822           AC164162.2         47511-51006         c
FEATURES             Location/Qualifiers
     source          1..4822
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 46.92 cM"
     gene            1..4822
                     /gene="Jam2"
                     /gene_synonym="1110002N23Rik; 2410030G21Rik;
                     2410167M24Rik; JAM-2; JAM-B; Jcam2; VE-JAM"
                     /note="junction adhesion molecule 2"
                     /db_xref="GeneID:67374"
                     /db_xref="MGI:MGI:1933820"
     exon            1..431
                     /gene="Jam2"
                     /gene_synonym="1110002N23Rik; 2410030G21Rik;
                     2410167M24Rik; JAM-2; JAM-B; Jcam2; VE-JAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..1261
                     /gene="Jam2"
                     /gene_synonym="1110002N23Rik; 2410030G21Rik;
                     2410167M24Rik; JAM-2; JAM-B; Jcam2; VE-JAM"
                     /note="junction cell adhesion molecule 2; junction
                     adhesion molecule B; junctional adhesion molecule 2;
                     vascular endothelial junction-associated molecule;
                     junctional adhesion molecule B"
                     /codon_start=1
                     /product="junctional adhesion molecule B precursor"
                     /protein_id="NP_076333.3"
                     /db_xref="CCDS:CCDS37381.1"
                     /db_xref="GeneID:67374"
                     /db_xref="MGI:MGI:1933820"
                     /translation="MARSPQGLLMLLLLHYLIVALDYHKANGFSASKDHRQEVTVIEF
                     QEAILACKTPKKTTSSRLEWKKVGQGVSLVYYQQALQGDFKDRAEMIDFNIRIKNVTR
                     SDAGEYRCEVSAPTEQGQNLQEDKVMLEVLVAPAVPACEVPTSVMTGSVVELRCQDKE
                     GNPAPEYIWFKDGTSLLGNPKGGTHNNSSYTMNTKSGILQFNMISKMDSGEYYCEARN
                     SVGHRRCPGKRMQVDVLNISGIIATVVVVAFVISVCGLGTCYAQRKGYFSKETSFQKG
                     SPASKVTTMSENDFKHTKSFII"
     exon            432..500
                     /gene="Jam2"
                     /gene_synonym="1110002N23Rik; 2410030G21Rik;
                     2410167M24Rik; JAM-2; JAM-B; Jcam2; VE-JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            501..608
                     /gene="Jam2"
                     /gene_synonym="1110002N23Rik; 2410030G21Rik;
                     2410167M24Rik; JAM-2; JAM-B; Jcam2; VE-JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            609..761
                     /gene="Jam2"
                     /gene_synonym="1110002N23Rik; 2410030G21Rik;
                     2410167M24Rik; JAM-2; JAM-B; Jcam2; VE-JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            762..961
                     /gene="Jam2"
                     /gene_synonym="1110002N23Rik; 2410030G21Rik;
                     2410167M24Rik; JAM-2; JAM-B; Jcam2; VE-JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1061
                     /gene="Jam2"
                     /gene_synonym="1110002N23Rik; 2410030G21Rik;
                     2410167M24Rik; JAM-2; JAM-B; Jcam2; VE-JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1169
                     /gene="Jam2"
                     /gene_synonym="1110002N23Rik; 2410030G21Rik;
                     2410167M24Rik; JAM-2; JAM-B; Jcam2; VE-JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1185
                     /gene="Jam2"
                     /gene_synonym="1110002N23Rik; 2410030G21Rik;
                     2410167M24Rik; JAM-2; JAM-B; Jcam2; VE-JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1228
                     /gene="Jam2"
                     /gene_synonym="1110002N23Rik; 2410030G21Rik;
                     2410167M24Rik; JAM-2; JAM-B; Jcam2; VE-JAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..4822
                     /gene="Jam2"
                     /gene_synonym="1110002N23Rik; 2410030G21Rik;
                     2410167M24Rik; JAM-2; JAM-B; Jcam2; VE-JAM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4346..4351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jam2"
                     /gene_synonym="1110002N23Rik; 2410030G21Rik;
                     2410167M24Rik; JAM-2; JAM-B; Jcam2; VE-JAM"
                     /note="hexamer: AATAAA"
     polyA_site      4374
                     /gene="Jam2"
                     /gene_synonym="1110002N23Rik; 2410030G21Rik;
                     2410167M24Rik; JAM-2; JAM-B; Jcam2; VE-JAM"
                     /note="major polyA site"
ORIGIN      
        1 gtctgggggc ggggggccga cctgcagggt tctccctcaa gaggctagtc ctctgccgcc
       61 actcgcttag gaccctgcgg acaccgcgtc ccgcgtccac gccctcccct caaccctctt
      121 ccacccttca aaagaaggac tgtcccagac accacgtcct agggccagaa gacctgcccc
      181 cacgacagtc gctggagaca ccccagaccg gagagactga catcgggaca ggacccgccc
      241 ctctgcttcc acctctcagg gacctcctct gctccgccgc cgggcgaagt gctgggagac
      301 ccagccgcct gtcgcgctcc tgcaggggga ccctcagcta ggcagccagc tggcgcccgc
      361 gtagatggcg aggagccccc aaggcctcct gatgctgctg ctgctacact acttgatcgt
      421 cgccctggac tatcataagg caaatgggtt ttctgcatca aaagaccacc gtcaagaagt
      481 cacagtaata gagttccaag aggctatttt ggcttgtaaa accccaaaga agactacctc
      541 ctccagactg gagtggaaga aggtgggaca gggggtctcc ttggtctact accaacaggc
      601 tctccaaggt gactttaaag accgtgctga gatgatagat ttcaatatac gaatcaaaaa
      661 tgttacaaga agtgatgctg gagagtatcg ctgtgaagtc agcgctccga ctgagcaagg
      721 ccagaacctg caggaagata aagtcatgct agaagtacta gtggctcctg ctgttcctgc
      781 ctgtgaagtg cccacttctg ttatgactgg aagtgtggtg gagctacgat gccaggataa
      841 agaaggaaac ccagctccgg agtacatctg gtttaaagat ggcacaagtt tgctagggaa
      901 tccaaaaggc ggcacacaca acaacagctc gtacacaatg aacacgaagt ctggaattct
      961 gcaattcaac atgatttcca agatggacag tggagagtat tactgcgaag cccggaactc
     1021 tgtcggacac cgcaggtgcc ctgggaagcg aatgcaagta gatgttctca acataagcgg
     1081 catcatagca acggttgtgg tggtggcctt cgtgatttct gtatgtggcc ttggcacatg
     1141 ctatgctcag aggaaaggct acttttcaaa agaaacttcc ttccagaagg gcagtcctgc
     1201 atctaaagtc actacgatga gcgaaaatga tttcaagcac acaaaatcct ttataattta
     1261 aaagaattcc agttttgagc tgcaccaaaa ccagttgtca catgttatta aaatattgta
     1321 aaactctgtg tcttacactt gcaaagtgat gaagaaatat gaaagtggga gttcatcaga
     1381 agttttatga tctctaactc acaagaaata ttttaagcaa aatgttcttg ccatcactaa
     1441 attacaacct ggcatcttgt gtctgaccta aagtgaaatg tctggtaata ttctgagttt
     1501 ttgaagtgca aatgaatgtc agtttggagt tgactatatc acactgactg taaggctaat
     1561 ccaagaagca agaatatact ccatgtgttc tctccatgca agaatggctt atgtgttcag
     1621 gaaatactct aacgaatgga aaccctgttc acaaaattcc taccagaatc ctcttcttac
     1681 ctctaaataa cttgggttcc attgtcctgt gtctctatat cccagggctg ggtcttacgt
     1741 ctaaggattt gcactttata ttttctttca cttctcagaa ccaaaagcag catgaaggga
     1801 gctgctactg ccatttcctt ggaggctttt ggagaggctc agcgacctgg acattagaat
     1861 gcattactag agcctacaca actccacaga cacccttttt gtgcttgagt ggtgacctgt
     1921 tatctgtctc taaaagcaat tctgaactgg gctagttcct ccccggtgaa gatgaagggt
     1981 tcccagtcag cttatgatgg aacaggggca caggggagag aagcatttgc cccataaggc
     2041 aaaggtagat gaacaagctc attttgactc ttgatccagc aaaggcacag gagaaaccat
     2101 agctgaaatg agatgggtct aatgtcttct gaactggtta tccacaaagg ccaccaacca
     2161 gctagtgtca gaattggaaa ttcccagggc tcagcaggaa acccagtcct gttggggact
     2221 actttaccca tattaaaaca aacaaacaaa caaacaaaca aacataaacg caacctggga
     2281 tgtctagttc tgggtaaata agcatgaaag gtcatttact ccctctatca gctttgaaca
     2341 tggtcaagtt ggctttgcac ccaaaaggca aggcagattc tcaggatttg caaacagggc
     2401 aagtggtcag agagtgcctg gtattgatct ggtcacaggg gcgatgccca ctgccataat
     2461 cttccccttt aactttgtgg ccttgagtcc ttcctaacca gtagacacct ttccaaaggg
     2521 ctgacttgtg taaaatggct cagccctcaa gctcagattc acacttgagc tagcaagcta
     2581 caaggaacga gacagtacat aattcaaccc acatggttct tgttacaacc acttaatgta
     2641 gagtacaggt aagtgtgccc acagatccaa gctccttgcc cctggtagcc aacaaacacc
     2701 tgtggtgtat aagaaatcag ggtaaatgtt gcctaggctg ggactatgag ctctgctttg
     2761 ataggaggac tgctatcctt ctgcagtgcc aagcagacag ctctcaagga tgcctcttca
     2821 ggcccacatg cctcttcagg cccacatagc atcacaaggc ccctgcatca atttaaacga
     2881 cacaatccac cccatgagag gacagttacg tagtgcctta ccttcactaa cacatgagaa
     2941 gcttccttgt aagacactga agcctaaagg ttcactttat gcggtgcgaa catctaacaa
     3001 agtctgtgcc aaacacctat tatacattct tagctaagct actgtataca gccatgcaga
     3061 aatcattgta ttaagaatgc tttcttctac acaaaggacc taactgcaca ctaatcttct
     3121 agttattaag tctatccggg agtcactgcc atgaagacct gtctgtctgc tgttttctgt
     3181 gacttgaact ctaacaatgt gtcaaaatct aattgtagtg tctagatgtt gattttattt
     3241 ttcccgcagt caaagtgcag taagggtcta gaaactatgt gagcgagttt tgttttggta
     3301 ctgttgctgt tgtaactaga tccagctcat ttttggtcgg gataggggtt aactcactca
     3361 agcactaagg ctgcatgttt gttttccaat acaactttac aaagaacttc cttcactcta
     3421 caactcactt tgtttgatta aagttcacgc tacaaaaata gctatgcaca gctcaacgtt
     3481 ttagtctcat tcaccggagg gggaagtcac tcacctattg ttcaataacc caggaaactc
     3541 ctccctccct tccacctgct gctgtgaggc agctctagca gtttaaaatc aagtttcact
     3601 tgtctctacg cttggatccc ggccaacttc taaagtcaga gaacacagag ggtaaactac
     3661 ttactggctg ttttgtgtat ggcagaggtg gggttgaggg agtgccaaat ctccctcctc
     3721 ttccaagacc ttgtgaagaa gagcctgcgg tgaccgcttg ctttgcagtg ctgtgttact
     3781 ggaggagctg aacacagcca ccagatccac agctcacact ttcttcaccc acccccatcc
     3841 accatggtcc ccaaacctat ctttgtcaaa ctttagcatt taaaaagaaa gatgcaacag
     3901 aattttatac acaaccaacc caggacccac tttttgtttg ttgccttatt cagcaaactg
     3961 aactatgttt gtctttacaa tttattctgc ccttttgtat acatttgtac tacttcccca
     4021 tccattagtc ctcatcacaa gctatggaaa ttctatttac tcctgaaaga gcaaattcaa
     4081 ctctctgtgg gacttctccc attttccagc tgtgagtttt gtctctgaat tctgatggca
     4141 tctgattctt ttgtgatatt tattgacttc tgtgttacag taccggtagg tatgtatatg
     4201 tctgacatct ctaccaacct gaaaccctga gaaaagaccc atgttgtaca ggtcttcata
     4261 aaccctaagg tatttaagag tatctgaaaa tggtcaatac ctgtgaaaca caaagatatt
     4321 aaatataaac atctacttag gaattaataa aacattgtat tctgatacaa ctcatttatg
     4381 gtctatgaat tattactaca tgaactaagg atagacaaaa attattttcc cttttagcaa
     4441 ttagttgtcc atttccacac aattcatttt tatgcatggg tggtttacct ccatgtgttt
     4501 gtactacatg cgaacctggt acccctagac atcaggagag gaactcagac tccctggaaa
     4561 tggagcccca gatggttgta agctgccgtc taagtgctgg aagcaaactc aagtcctctg
     4621 gaagagcaga ttgctaacca tgaaggcatc tctccagcct tatccacaca attcttaaat
     4681 atttttcatc tcttgtttct tgttcagtta agatttggaa cattttagct gtaataactg
     4741 gtaaagaaat ttatggtgaa ctatcattgg ttggttttat tttacttcct caaatttgaa
     4801 gaaataaaaa caaacaaaaa aa
//
