LOCUS       NM_028708               5987 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus janus kinase and microtubule interacting protein 3
            (Jakmip3), transcript variant 1, mRNA.
ACCESSION   NM_028708 XM_355952
VERSION     NM_028708.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5987)
  AUTHORS   Mu,X., Liu,S.J., Zheng,L.Y., Ouyang,C., Abdalla,A.M.E., Wang,X.X.,
            Chen,K., Yang,F.F. and Meng,N.
  TITLE     The long coiled-coil protein NECC2 regulates oxLDL-induced
            endothelial oxidative damage and exacerbates atherosclerosis
            development in apolipoprotein E -/- mice
  JOURNAL   Free Radic Biol Med 216, 106-117 (2024)
   PUBMED   38461872
  REMARK    GeneRIF: The long coiled-coil protein NECC2 regulates oxLDL-induced
            endothelial oxidative damage and exacerbates atherosclerosis
            development in apolipoprotein E [-/-] mice.
REFERENCE   2  (bases 1 to 5987)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK018189.2 and AK220482.1.
            
            On May 3, 2013 this sequence version replaced NM_028708.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AK018189.2         3-22
            21-5987             AK220482.1         1-5967
FEATURES             Location/Qualifiers
     source          1..5987
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 83.0 cM"
     gene            1..5987
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /note="janus kinase and microtubule interacting protein 3"
                     /db_xref="GeneID:74004"
                     /db_xref="MGI:MGI:1921254"
     exon            1..71
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            72..314
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..2714
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neuroendocrine long coiled-coil protein 2"
                     /codon_start=1
                     /product="janus kinase and microtubule-interacting protein
                     3 isoform 1"
                     /protein_id="NP_082984.1"
                     /db_xref="GeneID:74004"
                     /db_xref="MGI:MGI:1921254"
                     /translation="MSKKGAGSRAKGDKAETLAALQAANEELRAKLTDIQIELQQEKS
                     KVSKVEREKSQELKQVREHEQRKHAVLVTELKTKLHEEKMKELQAVREALLRQHEAEL
                     LRVIKIKDNENQRLQALLNTLRDGAPDKVKTVLLCEAKEEAKKGFEVEKVKMQQEISE
                     LKGAKKQVEEALTMVIQADKIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIRFK
                     DRAVFVLERELGVQAGHAQRLQLQKEALDEQLSQAKEAERHPGSPRRELPYASGAGDA
                     SDHSGSPEQQLDEKDARRFQLKIAELSAIIRKLEDRNALLSEERNELLKRLREAESQY
                     KPLLDKNKRLTRKNEDLSHTLRRIESKLKFVTQENIEMRQRAGIIRRPSSLNDLDQSQ
                     DEREIDFLKLQIVEQQNLIDELSKTLETAGYVKSVLERDKLLRYRKQRKKMAKLPKPV
                     VVETFFGYDEEASLESDGSSISYQTDRTDQTPCTPEDDLEEGMAKEETELRFRQLTME
                     YQALQRAYALLQEQVGGTLDAEREVKTREQLQAEIQRAQTRVEDLEKALAEQGQDMKW
                     IEEKQALYRRNQELVEKIKQMETEEARLKHEVQDAKDQNELLEFRILELEERERKSPA
                     INFHHTPFVDGKSPLQVYCEAEGVTDILVTELMKKLDILGDNANLTNEEQVVVIQART
                     VLTLAEKWLQRIEETESALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQAHKHI
                     LELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERM
                     ELLQIAQQRIKELEERIETQKRQIKELEEKFLFLFLFFSLAFILWS"
     exon            315..812
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1028
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1148
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1295
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1427
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1463
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1523
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1652
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1781
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1865
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1928
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2027
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2126
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2180
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2246
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2315
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2393
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2597
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2663
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2736
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..3689
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
     exon            3690..5987
                     /gene="Jakmip3"
                     /gene_synonym="6330417G02Rik; mKIAA4091"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcgccac tgcgatggct gagcccgacc gtcggacgcc gccgcccgaa gcctgatcga
       61 ggggaacctt ggtgactgag aaaatgtaac ggaggacacc tgccaagagt ttggcgtgga
      121 taccctggcc cagacggagc agctgcccct gggtgtcttt ctggccatcc agcctcacca
      181 tgtcaaagaa gggtgcaggc agccgggcca agggggacaa agcagagaca ctcgctgcat
      241 tgcaggctgc caacgaggag ctgcgagcca agctcacaga catccagatc gagctgcagc
      301 aggagaagag caaggttagc aaagttgagc gggagaagag ccaggagctg aagcaggtgc
      361 gggagcacga acagcgcaag cacgcggtcc tggtcacgga gctcaagacc aagctgcacg
      421 aggagaagat gaaggagctg caggccgtgc gcgaggcact gttgcgacag cacgaggccg
      481 agctcctgag ggtcatcaag attaaggaca acgagaacca gcggctgcag gccttgctca
      541 acaccctgcg ggatggcgcg cccgacaagg tgaagacggt gctcctgtgt gaagcgaagg
      601 aggaggccaa gaaggggttt gaggtggaga aggtcaagat gcaacaagag atctcagagc
      661 tcaaaggggc caagaaacag gtcgaggagg cactgactat ggtcatccag gcagacaaga
      721 tcaaggctgc ggagatcagg agtgtctacc atctgcatca ggaagaaatc acccggatca
      781 agaaggagtg tgagcgtgag atccgcaggc tgatggagga gataagattt aaagacagag
      841 cagtcttcgt gctggaaaga gagttagggg ttcaagccgg gcatgcccag agactgcagc
      901 tccagaaaga ggctctagat gagcagcttt cccaggccaa agaggctgag cggcacccgg
      961 gcagccccag acgggaactt ccttatgcaa gcggtgcagg agacgcctca gaccactcag
     1021 gaagccctga acagcagttg gacgagaagg atgctaggcg cttccaactt aaaattgcgg
     1081 agttaagtgc catcatccgt aagctagaag accgcaacgc cttgctgtct gaagaaagaa
     1141 atgagctgct aaagcggctg agagaagctg aaagtcagta caagccattg ctggataaga
     1201 acaagcgcct tactcggaaa aacgaagacc tgtctcacac tctgcggcgc atagaaagca
     1261 agttgaaatt tgtcactcag gagaacatag aaatgaggca gagagcgggg atcatccgga
     1321 gacccagctc cttaaatgac ctcgatcaaa gtcaagatga gagagagatc gacttcctaa
     1381 agctccagat cgtggagcag cagaacctca ttgatgagct ttctaaaacc ctggagacag
     1441 caggctatgt gaagagtgtg ttggagcgtg ataagctgtt gaggtatcgg aaacaaagaa
     1501 agaaaatggc gaaactcccc aagccggttg tcgtggagac cttctttggc tatgatgaag
     1561 aagcttccct ggagtccgat ggatcttcca tttcttatca aactgacagg acggatcaga
     1621 ccccatgcac ccccgaagat gacctggagg agggcatggc caaggaagag acggagctga
     1681 ggttccggca gctgaccatg gagtaccagg cactacagcg agcctatgcc ttgctgcagg
     1741 aacaagtcgg agggaccctg gatgcagaac gagaagttaa gactcgtgag cagctgcaag
     1801 cagagataca gagagctcag acacgggtgg aggacctgga aaaggctctg gctgagcaag
     1861 ggcaggatat gaagtggatt gaagagaagc aagcactgta tcgacgaaat caagagctcg
     1921 tagaaaagat aaaacaaatg gagacggagg aggcacggct gaagcacgag gtccaggatg
     1981 caaaggacca gaatgagctg ctggaattcc ggatcctgga gctcgaggag agggagagaa
     2041 agtccccggc catcaacttc caccatacac cttttgtgga cgggaagagc cccctgcagg
     2101 tgtattgtga ggccgaaggt gtaacggaca tcctggtcac ggagctgatg aagaagctgg
     2161 atatcctggg ggataacgcc aatctgacca atgaggagca agtggttgtc attcaagcca
     2221 ggacagtcct gaccttggct gaaaagtggc tccagaggat tgaagagaca gagtcagcgc
     2281 tgcagcggaa aatggtagat ctggagagcg agaaggagct gttcagtaag cagaaaggct
     2341 acctggatga ggagctggac tacaggaagc aggccttgga ccaagcccac aagcacatcc
     2401 tggagctgga agccatgttg tatgatgccc tgcagcagga ggccggggcc aaggtggccg
     2461 agctgctgtc agaagaagaa cgtgagaagc tcaaggtggc cgtggagcag tggaagcgcc
     2521 aggtcatgag cgagctgaga gaacgggatg cacagatcct gagagagcgc atggaactgc
     2581 tgcagattgc acagcagaga attaaggagc tagaagaaag aatagaaacc cagaagaggc
     2641 aaataaagga gctggaagaa aagtttttat ttttgttctt gtttttctcc ctagctttca
     2701 ttctctggtc atagctgttc ttggcacact gaactgccct ctgcaaaggc agacctttgt
     2761 cctctaatgg gaccagagag cagcaggtgc cagagaaagt gtggagaatt gcacttcaac
     2821 actgaagact tgcgagtgtt tgggctctgt gccccgccct gtggaggatg agggcaaaag
     2881 cactgtgacc tgcagctact gtccacttgg ggtgagccag gactggaact ggtcttgctg
     2941 actagtgctt ctccaggaga ggtctagctt tgactgctgg tgactttcag cccagagagt
     3001 aggccccacc ccaatcacac caatgtgtaa tgttccctgc cgtgcagggg taagaattgc
     3061 tcccgtgctg gagcccacac tggacaccca cctcgttccc atagtgacca tcagtactct
     3121 tggaagaaga tctcagaact gcccagactt gcccctagtg gcaagatgaa ggctgtggtc
     3181 tcagtggtga ccctgggtgt cacactgtgg ttactcactg tggccctgag cacttgatgc
     3241 tgaacagacc ccaagcccaa ccttgttctg tcacactggt gtctctgtga ggacagctga
     3301 gtcatgacct cccaccggcc tcctaccctg tactcccaga cacaaaggct agaatcctat
     3361 ccccggctgc tggtcaggaa cacagtggaa agatcagaga agaggccagg gagcatatgg
     3421 gatgagtctg cagaggcctg gccctgaaga gtgtggatca aagcacagcc aaagtatggt
     3481 ggagttgtgg ccctcctagc ctggaagacc cccagcaggt gggcctagcc tgagaacctc
     3541 aggtggcaag ggcaggtgac gaaggtagct gaagatggcc tcgtccacag cctgtgcaca
     3601 taagaaatgg tccagaagag aaggtgaaga caagatgctc ctaagggacc atcagcctca
     3661 gaaggtagcc acagtgcagt ggcctacaga gagaaaacag agcagccatg aggacggtca
     3721 aatgaggttt ccattgtgct agatggtaca tccagcgtcc aggaaagtct tcccttgtat
     3781 ggaccagctg catcctggtt ggaggagact cttctgtcct catcgcatcc ctgctaggct
     3841 aagattgtca ccctctgtgc tgaagtcagg agggcatgcg tgtgcatgtg tgttcatgtg
     3901 tgtgcttctc aatgagaagc cagtgcccgg attagagccc tttcaaagca cctagaagct
     3961 ggcacactgg atagggagat atgcagtcag gtgtgaccat tacattcaac attgtatact
     4021 aggaagctca gtagccaggg ggaaggaatg agggtactgt ctgaaagtat taggttcatc
     4081 ttatatttgt gtcaggaaaa atgttctgct gtggtgccga tgaccaagta gttacaggcc
     4141 cctaggtcaa aatcagagaa aagcttacag gattggacac atgggccctt ttttcagcga
     4201 ctccaggatt tctgctggga aatgcactag gtgctcttgg tccttcctgt tggctaccca
     4261 tgcccagtca tcatttctct agctgagcct gactttgggt ttggtctttg aatctgaaat
     4321 ttttagtcct tagtgcatgg tcttgtctta tttaaatgac ttccttccct tgacccattt
     4381 gctgtactca gcactgaatg gcagcaatag ggctgtatca gcggtgctgc cacagatctg
     4441 aaggtgacag aaaccactgt gttagtgacc gatggaccgt gtaatgcagg catctccaag
     4501 ctgtctcagg tccatgctgc tccctgccca ccagcgctcc tggcccagct ctaggtgaac
     4561 ttgcaagaga tcagtaactc agtaggaaca aaaagttgca ctggaaactc accccgcctc
     4621 acaccccttc ggttcagtgg gaacgtgggt ctgcatgttg tgtgtgtgtc cggaatactt
     4681 catcatactc cccacccacc cacccaacac tctaaattac agaactttgt tgtttttaag
     4741 aaaggctgta taagaaagag aagcatgtaa ataagtccca gtgctcatta agtcgttact
     4801 gtttatgtgt aaagtatatg tacatagaaa gaaaaatggc tcaatgaatg ttaggtaaaa
     4861 tccccaaacc aaactgcatt tttacccagc tctgttcctg aaagcacatg cttagctgga
     4921 aggctgtccc tcccttgtca cctgatccca aagtcagatc tgaacttggg gcagggatgg
     4981 gggagtaaat tcgagccttt gttactgatt cttgctgcca atgagcatct gaagagccca
     5041 agcacttcaa aagtaaggtg cattttctaa atcccagact gaatctttta tcccaaatgc
     5101 tgggttggac aggattccct cccacgtttg agctcccgct gctatctcct aaaacagggc
     5161 atccgtgtgc catggcactg ccctggtgaa gcaagaagag ggaccctgac acagcccccc
     5221 aggatctcga actgtgccac ttgaggtgtg ggcctcggct tcacgttgca tgaagttgtc
     5281 agcccgctca ccctgtgtgc agcacatgga acagcataag cgttttcgtt tgtctaaact
     5341 agaaatccac gtaaactgca gagtcctttg tgaacagccg tgtggtgtct actttgtttc
     5401 tctggtctag cgtcctgttg ctgaaggctg tgatggacat ctttgccctt gcagactctg
     5461 tagccttcag gaaacctgag tgccttatgc agcttgtgaa caccgactgg aagtcaggag
     5521 ggagggtgga gagtggctct gaggcacact gatcgatcag ctctggccat cactccacca
     5581 tcgaaccctt taaggtgggt tgtgtgttaa aacacagtca tggatctaag tttaggctca
     5641 ggaaaatcac attgtgagta tatgtatcaa agcatatatt tattgttatc ttttcttaaa
     5701 aaagctttac tgtaaactta tgcaaaaagg agcagaactt ggcttcttgt ggcaaagtgc
     5761 caggcagtat ttgtgttcga tgaagcgatc ctcaacacag cccctctcaa cactcaacct
     5821 ttccgttccg tgctaaacag tattcccagg cttaaactag gtttgtatcg tggtcaatta
     5881 taaattttac acatattttt gtattgtggt tcctataata tataccagag aatttttact
     5941 tatttgtaaa ttattgtaca gttttaataa aacttgtttt aaatcct
//
