LOCUS       NM_010589               3950 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus Janus kinase 3 (Jak3), transcript variant 1, mRNA.
ACCESSION   NM_010589
VERSION     NM_010589.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3950)
  AUTHORS   Seyed-Razavi,Y., Lee,S.R., Fan,J., Shen,W., Cornish,E.E. and
            Gillies,M.C.
  TITLE     JR5558 mice are a reliable model to investigate subretinal fibrosis
  JOURNAL   Sci Rep 14 (1), 18752 (2024)
   PUBMED   39138242
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3950)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3950)
  AUTHORS   Banerjee,A., Li,D., Guo,Y., Mei,Z., Lau,C., Chen,K., Westwick,J.,
            Klauda,J.B., Schrum,A., Lazear,E.R. and Krupnick,A.S.
  TITLE     A reengineered common chain cytokine augments CD8+ T cell-dependent
            immunotherapy
  JOURNAL   JCI Insight 7 (10), e158889 (2022)
   PUBMED   35603788
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3950)
  AUTHORS   Lei,Z., Liu,W., Nie,Y., Yang,Y., Chen,G., Huang,L., Wu,H., Lei,Y.,
            Chen,L., Hu,Q., Rong,H., Yu,S., Song,Q., Tong,F. and Guo,J.
  TITLE     EpCAM Is Essential to Maintaining the Immune Homeostasis of
            Intestines via Keeping the Expression of pIgR in the Intestinal
            Epithelium of Mice
  JOURNAL   Front Immunol 13, 843378 (2022)
   PUBMED   35493520
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3950)
  AUTHORS   Palko,S.I., Saba,N.J., Mullane,E., Nicholas,B.D., Nagasaka,Y.,
            Ambati,J., Gelfand,B.D., Ishigami,A., Bargagna-Mohan,P. and
            Mohan,R.
  TITLE     Compartmentalized citrullination in Muller glial endfeet during
            retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 119 (9) (2022)
   PUBMED   35197297
REFERENCE   6  (bases 1 to 3950)
  AUTHORS   Tortolani,P.J., Lal,B.K., Riva,A., Johnston,J.A., Chen,Y.Q.,
            Reaman,G.H., Beckwith,M., Longo,D., Ortaldo,J.R., Bhatia,K.,
            McGrath,I., Kehrl,J., Tuscano,J., McVicar,D.W. and O'Shea,J.J.
  TITLE     Regulation of JAK3 expression and activation in human B cells and B
            cell malignancies
  JOURNAL   J Immunol 155 (11), 5220-5226 (1995)
   PUBMED   7594533
REFERENCE   7  (bases 1 to 3950)
  AUTHORS   Nosaka,T., van Deursen,J.M., Tripp,R.A., Thierfelder,W.E.,
            Witthuhn,B.A., McMickle,A.P., Doherty,P.C., Grosveld,G.C. and
            Ihle,J.N.
  TITLE     Defective lymphoid development in mice lacking Jak3
  JOURNAL   Science 270 (5237), 800-802 (1995)
   PUBMED   7481769
  REMARK    Erratum:[Science 1996 Jan 5;271(5245):17]
REFERENCE   8  (bases 1 to 3950)
  AUTHORS   Thomis,D.C., Gurniak,C.B., Tivol,E., Sharpe,A.H. and Berg,L.J.
  TITLE     Defects in B lymphocyte maturation and T lymphocyte activation in
            mice lacking Jak3
  JOURNAL   Science 270 (5237), 794-797 (1995)
   PUBMED   7481767
REFERENCE   9  (bases 1 to 3950)
  AUTHORS   Yin,T., Keller,S.R., Quelle,F.W., Witthuhn,B.A., Tsang,M.L.,
            Lienhard,G.E., Ihle,J.N. and Yang,Y.C.
  TITLE     Interleukin-9 induces tyrosine phosphorylation of insulin receptor
            substrate-1 via JAK tyrosine kinases
  JOURNAL   J Biol Chem 270 (35), 20497-20502 (1995)
   PUBMED   7544789
REFERENCE   10 (bases 1 to 3950)
  AUTHORS   Rane,S.G. and Reddy,E.P.
  TITLE     JAK3: a novel JAK kinase associated with terminal differentiation
            of hematopoietic cells
  JOURNAL   Oncogene 9 (8), 2415-2423 (1994)
   PUBMED   7518579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162033.11, AK038268.1 and AW456897.1.
            
            On Jul 7, 2010 this sequence version replaced NM_010589.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and shares its terminal exon with the insulin-like 3
            gene(GeneID:16336). Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088365.1, SRR7345562.2310614.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AC162033.11        131986-132176
            192-3929            AK038268.1         3-3740
            3930-3950           AW456897.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..3950
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.43 cM"
     gene            1..3950
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /note="Janus kinase 3"
                     /db_xref="GeneID:16453"
                     /db_xref="MGI:MGI:99928"
     exon            1..201
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            202..394
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..3513
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /EC_number="2.7.10.2"
                     /codon_start=1
                     /product="tyrosine-protein kinase JAK3"
                     /protein_id="NP_034719.2"
                     /db_xref="CCDS:CCDS22403.1"
                     /db_xref="GeneID:16453"
                     /db_xref="MGI:MGI:99928"
                     /translation="MAPPSEETPLIPQRSCSLSSSEAGALHVLLPPRGPGPPQRLSFS
                     FGDYLAEDLCVRAAKACGILPVYHSLFALATEDFSCWFPPSHIFCIEDVDTQVLVYRL
                     RFYFPDWFGLETCHRFGLRKDLTSAILDLHVLEHLFAQHRSDLVSGRLPVGLSMKEQG
                     EFLSLAVLDLAQMAREQAQRPGELLKTVSYKACLPPSLRDVIQGQNFVTRRRIRRTVV
                     LALRRVVACQADRYALMAKYILDLERLHPAATTETFRVGLPGAQEEPGLLRVAGDNGI
                     SWSSGDQELFQTFCDFPEIVDVSIKQAPRVGPAGEHRLVTVTRMDGHILEAEFPGLPE
                     ALSFVALVDGYFRLICDSRHYFCKEVAPPRLLEEEAELCHGPITLDFAIHKLKAAGSL
                     PGTYILRRSPQDYDSFLLTACVQTPLGPDYKGCLIRQDPSGAFSLVGLSQPHRSLREL
                     LAACWNSGLRVDGAALNLTSCCAPRPKEKSNLIVVRRGCTPAPAPGCSPSCCALTQLS
                     FHTIPTDSLEWHENLGHGSFTKIFRGRRREVVDGETHDSEVLLKVMDSRHRNCMESFL
                     EAASLMSQVSYPHLVLLHGVCMAGDSIMVQEFVYLGAIDMYLRKRGHLVSASWKLQVT
                     KQLAYALNYLEDKGLPHGNVSARKVLLAREGGDGNPPFIKLSDPGVSPTVLSLEMLTD
                     RIPWVAPECLQEAQTLGLEADKWGFGATTWEVFSGGPAHITSLEPAKKLKFYEDQGQL
                     PALKWTELAGLITQCMAYDPGRRPSFRAILRDLNGLITSDYELLSDPTPGIPSPRDEL
                     CGGAQLYACQDPAIFEERHLKYISLLGKGNFGSVELCRYDPLGDNTGPLVAVKQLQHS
                     GPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHR
                     ARLHTDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVKIADFGLAKLLPL
                     GKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEF
                     LSMMGPEREGPPLCRLLELLAEGRRLPPPPTCPTEVQELMQLCWAPSPHDRPAFGTLS
                     PQLDALWRGRPG"
     exon            395..518
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            519..630
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            631..776
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            777..1062
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1185
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1343
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1455
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1642
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1767
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1899
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..1984
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2112
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2245
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2397
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2548
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2688
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2878
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..3003
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3176
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3294
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3405
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3528
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     exon            3529..3934
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3915..3920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /note="hexamer: AATAAA"
     polyA_site      3932
                     /gene="Jak3"
                     /gene_synonym="fae; wil"
                     /note="major polyA site"
ORIGIN      
        1 gtctctgcac agctcccacc ccagaagggt ggcctgcggc acaggtttct agtctccccc
       61 gggcttcccg ccccgccccg cccccagggc gccctgactt tccgtaaatg acggcggcca
      121 ggaagctcag gggccgcaca ggaaggagca gggactttcc tgtcgcagcc tcggctgtcc
      181 tttgcctcgg cacagctgca ggttatactc atggcacctc caagtgagga gacacctctg
      241 atccctcagc gctcttgcag cctctcatcc tcagaggcag gagccctgca tgtgctcctt
      301 cctccccggg gacctgggcc tccccagcga ttgtcattct cttttgggga ctacttggct
      361 gaggatttat gtgtgcgagc tgccaaggcc tgtggcatcc tgcctgttta tcattcgctt
      421 ttcgctctgg ccactgagga cttctcttgc tggtttcccc caagccacat cttctgcata
      481 gaggacgtgg acactcaagt cttggtctac aggctacgct tttatttccc tgactggttt
      541 gggctggaga catgtcaccg ctttgggctg cgcaaagatt tgaccagtgc catccttgac
      601 ttacacgttt tagaacatct ctttgctcag caccgcagtg acctggtgag tgggcgcctc
      661 ccggtgggcc ttagcatgaa ggagcaggga gagttcctga gcctggccgt gctggacttg
      721 gcccagatgg ctcgtgagca ggcccagcgc ccaggagagc tgctgaagac ggtcagttac
      781 aaagcctgtc tgccgcccag cctgcgcgat gtgatccagg gccagaactt cgtgacacgc
      841 aggcgcatcc gcaggaccgt ggtcttggcg ctgcgccgtg tggtcgcctg ccaggccgac
      901 cgctacgcgc tcatggccaa gtatattttg gacctggagc ggctacatcc agcggccacc
      961 accgagacct tccgtgtggg gctcccgggc gcccaggagg agccggggct tctgcgtgtg
     1021 gcgggggaca acggcatctc ctggagctcc ggggaccagg agcttttcca gaccttctgt
     1081 gactttccgg aaatcgtgga tgtcagcatc aagcaggccc cacgtgtggg tccggcaggg
     1141 gaacaccggc tggtcaccgt caccaggatg gacggccaca tcctggaagc ggagtttccg
     1201 gggctgcctg aggcgctgtc cttcgtggcc cttgtggatg ggtacttccg cctgatctgc
     1261 gactccaggc attatttctg caaggaggtg gcgccgccgc ggctgctgga ggaggaggcg
     1321 gagctgtgcc atggacccat cacgttagac tttgccatcc acaagctgaa ggccgctggc
     1381 tccctcccag gcacctacat tctccgccgc agcccgcagg actatgacag ctttcttctt
     1441 accgcctgcg tccagactcc tcttggcccc gactacaagg gctgcctcat ccgccaggac
     1501 cccagcgggg ctttctccct ggttggcctc agccagcccc acagaagcct gcgggagctg
     1561 cttgcagcct gctggaattc tgggctgcga gtagacggtg ctgccctgaa cctaacatcc
     1621 tgctgcgctc ccagacccaa ggaaaagtcc aatttgatcg tggtgcgaag gggctgcacc
     1681 cccgcgcctg cccctggctg ctccccgtcc tgctgtgcgc tgacacagct gagcttccac
     1741 acaattccaa cggacagcct ggagtggcac gagaacctgg gtcacggttc ttttaccaag
     1801 atcttccgtg gccgcaggcg ggaggtcgtg gatggtgaga cacatgactc ggaagtcctc
     1861 ctgaaggtca tggactccag acatcggaac tgcatggagt cttttctgga agccgcaagc
     1921 ttgatgagcc aagtatccta cccgcacctg gtgttactgc acggcgtctg catggctgga
     1981 gacagcatca tggtgcagga atttgtgtat ctaggagcaa ttgacatgta cctgcgcaag
     2041 cgtggccacc tggtgtcagc cagctggaaa ctgcaggtga ccaagcagct ggcatatgcc
     2101 cttaactact tggaggacaa aggccttcct cacggcaacg tctcagcacg gaaggtgctc
     2161 ctggctcgtg aggggggtga tgggaatcca cctttcatta agctgagtga tcctggtgtc
     2221 agtcccactg tgctgagcct ggaaatgctc accgacagaa taccctgggt ggcccccgaa
     2281 tgtctccagg aggctcagac actcggcttg gaggctgaca agtggggctt tggagccacc
     2341 acgtgggagg tgttcagcgg gggacccgcc cacatcacct cgctggagcc cgccaaaaag
     2401 ctgaagttct atgaggacca gggacagctg cccgctctca aatggacaga actggcggga
     2461 cttatcacac agtgcatggc ctatgatcct ggccggcgcc cctccttccg agctatcctc
     2521 agagacctca acggcctcat tacatcagat tacgagctcc tctcagaccc cacacctggc
     2581 atcccgagtc ctcgagatga gctgtgcggt ggcgcccagc tctatgcctg ccaggacccc
     2641 gccatattcg aggagagaca ccttaagtac atctctttgc tgggcaaggg caactttggc
     2701 agcgtggagc tgtgccgcta tgaccccctg ggggacaata cgggacccct ggtggcagtg
     2761 aaacagctac agcacagcgg gccagaccag cagagggact tccagcggga gattcagatc
     2821 cttaaggctc tgcacagcga cttcatcgtc aagtaccggg gagtcagcta tgggccaggt
     2881 cgccagagcc tgcggttggt gatggagtac ctgcccagcg gctgcctgcg agacttcctg
     2941 cagcgccatc gcgcgcgcct gcacaccgac cgcctactgc tgttcgcttg gcagatctgc
     3001 aagggcatgg agtacctggg tgcgcgccgc tgcgtacacc gtgacctggc tgcgcgcaac
     3061 atcttggtgg agagcgaggc tcatgtgaag atcgcggact tcggcctcgc taagctgctg
     3121 cccctgggaa aggactacta cgtggtccgc gagcctggcc aaagccccat cttttggtat
     3181 gccccggagt ccctatctga caacatcttc tcccgccaat ctgacgtgtg gagcttcgga
     3241 gtggtgttgt acgagctctt cacctactgc gacaagagct gcagcccatc cgctgagttc
     3301 ctgagcatga tggggcctga gcgtgaagga cccccgctct gccgcctcct ggagctgctg
     3361 gcagagggcc gacgcctccc accacctccc acctgcccca ccgaggttca ggagctcatg
     3421 cagctgtgct gggcgcccag cccgcacgac cggccagcct tcggcaccct gagcccccag
     3481 ctggacgcgc tgtggcgtgg aagacccgga tagcagccag gggcgagagg gagctgctgc
     3541 agtggctaga gcagagacat ctcctgcacg cgctggtggc cgacgtggac ccagcgctag
     3601 acccgcagct tcctctccag gcttctcagc gccagcgccg cagtgccgcc accaacgctg
     3661 tgcaccgctg ctgtcttact ggctgcaccc agcaagacct gttgggtctg tgtccccact
     3721 gaaggggcac agggctcagg cggtgcgtcc ttaattgctc cccacctcct ggctatgtca
     3781 ttgcaacaat ccagtttgcc ttggaggatc cctagtttat tcatagatcg cagtaagcaa
     3841 ggaccacagg ccctgtcccc aagaagcccc atcatgacct gtgcccacct cctccctgtg
     3901 tcccaaaaag tctaaataaa aaagcaactt cataaaaaaa aaaaaaaaaa
//
