LOCUS       NM_008413               5070 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus Janus kinase 2 (Jak2), transcript variant 1, mRNA.
ACCESSION   NM_008413
VERSION     NM_008413.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5070)
  AUTHORS   Strobl,K., Klufa,J., Jin,R., Artner-Gent,L., Krauss,D.,
            Novoszel,P., Strobl,J., Stary,G., Vujic,I., Griss,J., Holcmann,M.,
            Farlik,M., Homey,B., Sibilia,M. and Bauer,T.
  TITLE     JAK-STAT1 as therapeutic target for EGFR deficiency-associated
            inflammation and scarring alopecia
  JOURNAL   EMBO Mol Med 16 (12), 3142-3168 (2024)
   PUBMED   39521937
REFERENCE   2  (bases 1 to 5070)
  AUTHORS   Usart,M., Stetka,J., Luque Paz,D., Hansen,N., Kimmerlin,Q., Almeida
            Fonseca,T., Lock,M., Kubovcakova,L., Karjalainen,R., Hao-Shen,H.,
            Borsch,A., El Taher,A., Schulz,J., Leroux,J.C., Dirnhofer,S. and
            Skoda,R.C.
  TITLE     Loss of Dnmt3a increases self-renewal and resistance to
            pegIFN-alpha in JAK2-V617F-positive myeloproliferative neoplasms
  JOURNAL   Blood 143 (24), 2490-2503 (2024)
   PUBMED   38493481
  REMARK    GeneRIF: Loss of Dnmt3a increases self-renewal and resistance to
            pegIFN-alpha in JAK2-V617F-positive myeloproliferative neoplasms.
REFERENCE   3  (bases 1 to 5070)
  AUTHORS   Haage,T.R., Charakopoulos,E., Bhuria,V., Baldauf,C.K., Korthals,M.,
            Handschuh,J., Muller,P., Li,J., Harit,K., Nishanth,G., Frey,S.,
            Bottcher,M., Fischer,K.D., Dudeck,J., Dudeck,A., Lipka,D.B.,
            Schraven,B., Green,A.R., Muller,A.J., Mougiakakos,D. and Fischer,T.
  TITLE     Neutrophil-specific expression of JAK2-V617F or CALRmut induces
            distinct inflammatory profiles in myeloproliferative neoplasia
  JOURNAL   J Hematol Oncol 17 (1), 43 (2024)
   PUBMED   38853260
  REMARK    GeneRIF: Neutrophil-specific expression of JAK2-V617F or CALRmut
            induces distinct inflammatory profiles in myeloproliferative
            neoplasia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5070)
  AUTHORS   Shrestha,H., Radler,P.D., Dennaoui,R., Wicker,M.N., Rajbhandari,N.,
            Sun,Y., Peck,A.R., Vistisen,K., Triplett,A.A., Beydoun,R.,
            Sterneck,E., Saur,D., Rui,H. and Wagner,K.U.
  TITLE     The Janus kinase 1 is critical for pancreatic cancer initiation and
            progression
  JOURNAL   Cell Rep 43 (5), 114202 (2024)
   PUBMED   38733583
REFERENCE   5  (bases 1 to 5070)
  AUTHORS   Ma,J.K., Su,L.D., Feng,L.L., Li,J.L., Pan,L., Danzeng,Q., Li,Y.,
            Shang,T., Zhan,X.L., Chen,S.Y., Ying,S., Hu,J.R., Chen,X.Q.,
            Zhang,Q., Liang,T. and Lu,X.J.
  TITLE     TFPI from erythroblasts drives heme production in central
            macrophages promoting erythropoiesis in polycythemia
  JOURNAL   Nat Commun 15 (1), 3976 (2024)
   PUBMED   38729948
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5070)
  AUTHORS   Gilardi-Hebenstreit,P., Nieto,M.A., Frain,M., Mattei,M.G.,
            Chestier,A., Wilkinson,D.G. and Charnay,P.
  TITLE     An Eph-related receptor protein tyrosine kinase gene segmentally
            expressed in the developing mouse hindbrain
  JOURNAL   Oncogene 7 (12), 2499-2506 (1992)
   PUBMED   1281307
  REMARK    Erratum:[Oncogene. 1993 Apr;8(4):1103.. PMID: 8455939]
REFERENCE   7  (bases 1 to 5070)
  AUTHORS   Harpur,A.G., Andres,A.C., Ziemiecki,A., Aston,R.R. and Wilks,A.F.
  TITLE     JAK2, a third member of the JAK family of protein tyrosine kinases
  JOURNAL   Oncogene 7 (7), 1347-1353 (1992)
   PUBMED   1620548
REFERENCE   8  (bases 1 to 5070)
  AUTHORS   Pritchard,M.A., Baker,E., Callen,D.F., Sutherland,G.R. and
            Wilks,A.F.
  TITLE     Two members of the JAK family of protein tyrosine kinases map to
            chromosomes 1p31.3 and 9p24
  JOURNAL   Mamm Genome 3 (1), 36-38 (1992)
   PUBMED   1581631
REFERENCE   9  (bases 1 to 5070)
  AUTHORS   Wilks,A.F., Harpur,A.G., Kurban,R.R., Ralph,S.J., Zurcher,G. and
            Ziemiecki,A.
  TITLE     Two novel protein-tyrosine kinases, each with a second
            phosphotransferase-related catalytic domain, define a new class of
            protein kinase
  JOURNAL   Mol Cell Biol 11 (4), 2057-2065 (1991)
   PUBMED   1848670
REFERENCE   10 (bases 1 to 5070)
  AUTHORS   Wilks,A.F.
  TITLE     Two putative protein-tyrosine kinases identified by application of
            the polymerase chain reaction
  JOURNAL   Proc Natl Acad Sci U S A 86 (5), 1603-1607 (1989)
   PUBMED   2466296
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162456.3 and AC119228.10.
            
            On Apr 5, 2019 this sequence version replaced NM_008413.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.1423578.1,
                                           SRR7652917.170775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-316               AC162456.3         32956-33271         c
            317-399             AC162456.3         32555-32637         c
            400-650             AC162456.3         22641-22891         c
            651-774             AC162456.3         13600-13723         c
            775-892             AC162456.3         9955-10072          c
            893-1038            AC162456.3         8179-8324           c
            1039-1360           AC162456.3         2436-2757           c
            1361-1480           AC162456.3         1413-1532           c
            1481-1638           AC162456.3         80-237              c
            1639-1750           AC119228.10        54317-54428
            1751-1937           AC119228.10        55917-56103
            1938-2065           AC119228.10        56690-56817
            2066-2200           AC119228.10        59183-59317
            2201-2288           AC119228.10        62872-62959
            2289-2416           AC119228.10        63658-63785
            2417-2555           AC119228.10        64526-64664
            2556-2707           AC119228.10        66309-66460
            2708-2858           AC119228.10        66604-66754
            2859-2995           AC119228.10        67495-67631
            2996-3185           AC119228.10        68925-69114
            3186-3310           AC119228.10        69628-69752
            3311-3483           AC119228.10        69915-70087
            3484-3601           AC119228.10        77611-77728
            3602-3715           AC119228.10        78944-79057
            3716-5070           AC119228.10        79757-81111
FEATURES             Location/Qualifiers
     source          1..5070
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 23.73 cM"
     gene            1..5070
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /note="Janus kinase 2"
                     /db_xref="GeneID:16452"
                     /db_xref="MGI:MGI:96629"
     exon            1..316
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            317..399
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            400..650
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..3823
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /EC_number="2.7.10.2"
                     /note="JAK-2"
                     /codon_start=1
                     /product="tyrosine-protein kinase JAK2"
                     /protein_id="NP_032439.2"
                     /db_xref="CCDS:CCDS37950.1"
                     /db_xref="GeneID:16452"
                     /db_xref="MGI:MGI:96629"
                     /translation="MGMACLTMTEMEATSTSPVHQNGDIPGSANSVKQIEPVLQVYLY
                     HSLGQAEGEYLKFPSGEYVAEEICVAASKACGITPVYHNMFALMSETERIWYPPNHVF
                     HIDESTRHDILYRIRFYFPHWYCSGSSRTYRYGVSRGAEAPLLDDFVMSYLFAQWRHD
                     FVHGWIKVPVTHETQEECLGMAVLDMMRIAKEKDQTPLAVYNSVSYKTFLPKCVRAKI
                     QDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEQFEVKESA
                     RGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDVQLYCDFPDIIDVSIKQANQE
                     CSNESRIVTVHKQDGKVLEIELSSLKEALSFVSLIDGYYRLTADAHHYLCKEVAPPAV
                     LENIHSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
                     HCLITKNENGEYNLSGTKRNFSNLKDLLNCYQMETVRSDSIIFQFTKCCPPKPKDKSN
                     LLVFRTNGISDVQISPTLQRHNNVNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRRE
                     VGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCGEENIL
                     VQEFVKFGSLDTYLKKNKNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVCAKNILLI
                     REEDRRTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFG
                     TTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWTELANLINNCMDYEPDFRPAF
                     RAVIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLG
                     KGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK
                     GVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLGTKRY
                     IHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESK
                     FSVASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNGRL
                     PRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRVDQIRDSIAA"
     exon            651..774
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            775..892
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1038
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1360
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1480
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1638
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1750
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1937
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2065
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2200
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2288
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2416
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2555
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2707
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2858
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2995
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3185
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3310
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            3311..3483
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            3484..3601
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            3602..3715
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..5070
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4293..4298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /note="hexamer: ATTAAA"
     polyA_site      4315
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /note="major polyA site"
     regulatory      5006..5011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /note="hexamer: AATAAA"
     regulatory      5011..5016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /note="hexamer: AACAAG"
     polyA_site      5034
                     /gene="Jak2"
                     /gene_synonym="Fd17"
                     /note="major polyA site"
     polyA_site      5041
                     /gene="Jak2"
                     /gene_synonym="Fd17"
ORIGIN      
        1 ctcccgccgc gctgacaggc tgggcgggcc cccgctctgg gcgagctcgc gcggcgtcgg
       61 cgcctcggcc gcggccccgg ctccggaggc gcccgtccgt cccggcgagg gctgcaggcg
      121 gctgccgggt ccgccgctgc gggatgtgag tgcgggccaa gcccgcgcgg gagggccccc
      181 gagggcccag cctggcggcc gctcgaccct gcgcccggcc cgggggctcc ctagacctcg
      241 gcccgcccga cgcgtctcgg aggagcggat cctgcgcgcc tcggggcgct cctgtgtggc
      301 ccgacccgtg tcgccggttc ctgaagcagg cgacgggaac aagatgtgaa ctgttttccc
      361 tccccagaag aagaggccct ttttttccct cccgcgaagg ccaatgttct gaaaaaagct
      421 ctagatggga atggcctgcc ttacaatgac agaaatggag gcaacctcca catctcctgt
      481 acatcagaat ggtgatattc ctggaagtgc taattctgtg aagcagatag agccagtcct
      541 tcaagtgtat ctgtaccatt ctcttgggca agctgaagga gagtatctga agtttccaag
      601 tggagagtat gttgcagaag aaatttgtgt ggctgcttct aaagcttgtg gtattacgcc
      661 tgtgtatcat aatatgtttg cgttaatgag tgaaaccgaa aggatctggt acccacccaa
      721 tcatgtcttc cacatagacg agtcaaccag gcatgacata ctctacagga taaggttcta
      781 cttccctcat tggtactgta gtggcagcag cagaacctac agatacggag tgtcccgtgg
      841 ggctgaagct cctctgcttg atgactttgt catgtcttac ctttttgctc agtggcggca
      901 tgattttgtt cacggatgga taaaagtacc tgtgactcat gaaactcagg aagagtgtct
      961 tgggatggcg gtgttagaca tgatgagaat agctaaggag aaagaccaga ctccactggc
     1021 tgtctataac tctgtcagct acaagacatt cttaccaaag tgcgttcgag cgaagatcca
     1081 agactatcac attttaaccc ggaagcgaat caggtacaga tttcgcagat tcattcagca
     1141 attcagtcaa tgtaaagcca ctgccaggaa cctaaaactt aagtatctta taaacctgga
     1201 aaccctgcag tctgccttct acacagaaca gtttgaagta aaagaatctg caagaggtcc
     1261 ttcaggtgag gagatttttg caaccattat aataactgga aacggtggaa ttcagtggtc
     1321 aagagggaaa cataaggaaa gtgagacact gacagaacag gacgtacagt tatattgtga
     1381 tttccctgat attattgatg tcagtattaa gcaagcaaac caggaatgct caaatgaaag
     1441 tagaattgta actgtccata aacaagatgg taaagttttg gagatagaac ttagctcatt
     1501 aaaagaagcc ttgtcattcg tgtcattaat tgacgggtat tacagactaa ctgcggatgc
     1561 gcaccattac ctctgcaaag aggtggctcc cccagctgtg ctcgagaaca tacacagcaa
     1621 ctgccacggc ccaatatcaa tggattttgc cattagcaaa ctaaagaagg cgggtaacca
     1681 gactggacta tatgtgctac gatgcagccc taaggacttc aacaaatact ttctgacctt
     1741 tgctgttgag cgagaaaatg tcattgaata taaacactgt ttgattacga agaatgagaa
     1801 tggagaatac aacctcagcg ggactaagag gaacttcagt aaccttaagg accttttgaa
     1861 ttgctaccag atggaaactg tgcgctcaga cagtatcatc ttccagttta ccaaatgctg
     1921 ccccccaaag ccaaaagata aatcaaacct tctcgtcttc agaacaaatg gtatttctga
     1981 tgttcagatc tcaccaacat tacagaggca taataatgtg aatcaaatgg tgtttcacaa
     2041 aatcaggaat gaagatttaa tatttaatga aagtcttggc caaggtactt ttacaaaaat
     2101 ttttaaaggt gtaagaagag aagttggaga ttatggtcaa ctgcacaaaa cggaagttct
     2161 tttgaaagtc ctagataaag cacataggaa ctattcagag tctttcttcg aagcagcaag
     2221 catgatgagt cagctttctc acaagcattt ggttttgaat tatggtgtct gtgtctgtgg
     2281 agaggagaac attctggttc aagaatttgt aaaatttgga tcactggata catacctgaa
     2341 gaagaacaaa aattccataa atatattatg gaaacttgga gtggctaagc agttggcatg
     2401 ggccatgcat tttctagaag aaaaatccct tattcatggg aatgtgtgtg ctaaaaatat
     2461 cctgcttatc agagaagaag acaggagaac ggggaaccca cctttcatca aacttagtga
     2521 tcctggcatt agcattacag ttctaccgaa ggacattctt caggagagaa taccatgggt
     2581 acctcctgaa tgcattgaga atcctaaaaa tctcaatctg gcaacagaca agtggagctt
     2641 cgggaccact ctgtgggaga tctgcagtgg aggagataag cccctgagtg ctctggattc
     2701 tcaaagaaag ctgcagttct atgaagataa gcatcagctt cctgcaccca agtggacaga
     2761 gttagcaaac cttataaata attgcatgga ctatgagcca gatttcaggc ctgctttcag
     2821 agctgtcatc cgtgatctta acagcctgtt tactccagat tatgaactac taacagaaaa
     2881 tgacatgcta ccaaacatga gaataggtgc cctagggttt tctggtgctt ttgaagacag
     2941 ggaccctaca cagtttgaag agagacactt gaagtttcta cagcagcttg gcaaaggtaa
     3001 cttcgggagt gtggagatgt gccgctatga cccgctgcag gacaacactg gcgaggtggt
     3061 cgctgtgaag aaactccagc acagcactga agagcacctc cgagactttg agagggagat
     3121 cgagatcctg aaatccttgc agcatgacaa catcgtcaag tacaagggag tgtgctacag
     3181 tgcgggtcgg cgcaacctaa gattaattat ggaatattta ccatatggaa gtttacgaga
     3241 ctatctccaa aaacataaag aacggataga tcacaaaaaa cttcttcaat acacatctca
     3301 gatatgcaag ggcatggaat atcttggtac aaaaaggtat atccacaggg acctggcaac
     3361 aaggaacata ttggtggaaa atgagaacag ggttaaaata ggagacttcg gattaaccaa
     3421 agtcttgccg caggacaaag aatactacaa agtaaaggag ccaggggaaa gccccatatt
     3481 ctggtacgca cctgaatcct tgacggagag caagttttct gtggcctcag atgtgtggag
     3541 ctttggagtg gttctatacg aacttttcac atacatcgag aagagtaaaa gtccacccgt
     3601 ggaatttatg cgaatgattg gcaatgataa acaagggcaa atgattgtgt tccatttgat
     3661 agagctactg aagagcaacg gaagattgcc aaggccagaa ggatgcccag atgagattta
     3721 tgtgatcatg acagagtgct ggaacaacaa tgtgagccag cgtccctcct tcagggacct
     3781 ttcccttcgg gtggatcaaa tccgggacag tatagctgcg tgaaagagat ggccttcact
     3841 cagagaccaa gcagacttcc agaaccagaa caaagctctg tagccttgtg tctacacatc
     3901 cttatcatga tgctagctag gcagaagaaa ctgtgacgcc gtctgctcaa agctttggaa
     3961 acgccgtgcg tttgtttcta caccatctgt aaaaaccact gctcaagtct ggcagcatgc
     4021 ttgtgggctg atgcatggag ctcaccacag agtctctgca tctcctctgg cagaagaaga
     4081 aaatagacag ttttcaactc agcttttttg agaaatggaa aaaattataa tgtaaatttt
     4141 gcagtgtagg aaatacacag aacatacatg tacagttttt accacgtgga gtgtataata
     4201 ctttggcctc ttgtgtgatt tacatgaggg ctgatgtttg ttaatgtttt ctaatttttc
     4261 cataggtgat ctataataac ttcatgatac aaattaaaat gctcagaaaa ttaaatacct
     4321 tttctttctt gctcatcttt gctgctctgt tagggcctgt agttccatgc cactgtaaat
     4381 atttttcaaa gcaaaaggaa caaaggtcta gttttacttg tataggaaat cttcctgacc
     4441 ctaaagaatt ttgaaatggg acaatcttac aaagacacag cacaatctat tttcttattt
     4501 gttttccttg tgtttatggt aaatgtgttt ttaaatagaa ctgtctccaa ctttttctat
     4561 gactataatg aatataatga atccttttat aattttgaga ttaagaatgc cagaaatact
     4621 tccctccctt gaactgttaa ctgccaatga gatgtttcaa tccctaagac ttgtcattat
     4681 acattaaatt gaagcataag ccatacataa tttgtaaaat gtacaagctc tttaagatgc
     4741 tttctgggtt ggaacatggc caaagactgt gtgagaggcc tccaggtttg ccattacagc
     4801 tgtgagagaa acgtcctttc ctcagcgtct cccagacaga tgggaaggga agggtgtggg
     4861 gcacatgctg ttcatcccat tcaagaatac cagcaggcgt gtgacgcaca tctcgagatg
     4921 agaagagaga gcgtacatct tttcaaagta taaataattg ttatcatcct tcgtgctgct
     4981 ccctcttaga caatgtcatg tcaaaaataa aacaagattt ttgtgtgtta tttatacaag
     5041 attttaaata tttggtaatt tgtttaaaaa
//
