LOCUS       NM_146145               5299 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus Janus kinase 1 (Jak1), transcript variant 1, mRNA.
ACCESSION   NM_146145
VERSION     NM_146145.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5299)
  AUTHORS   Strobl,K., Klufa,J., Jin,R., Artner-Gent,L., Krauss,D.,
            Novoszel,P., Strobl,J., Stary,G., Vujic,I., Griss,J., Holcmann,M.,
            Farlik,M., Homey,B., Sibilia,M. and Bauer,T.
  TITLE     JAK-STAT1 as therapeutic target for EGFR deficiency-associated
            inflammation and scarring alopecia
  JOURNAL   EMBO Mol Med 16 (12), 3142-3168 (2024)
   PUBMED   39521937
REFERENCE   2  (bases 1 to 5299)
  AUTHORS   Shrestha,H., Radler,P.D., Dennaoui,R., Wicker,M.N., Rajbhandari,N.,
            Sun,Y., Peck,A.R., Vistisen,K., Triplett,A.A., Beydoun,R.,
            Sterneck,E., Saur,D., Rui,H. and Wagner,K.U.
  TITLE     The Janus kinase 1 is critical for pancreatic cancer initiation and
            progression
  JOURNAL   Cell Rep 43 (5), 114202 (2024)
   PUBMED   38733583
REFERENCE   3  (bases 1 to 5299)
  AUTHORS   Zhang,J., Xu,Y., Wei,C., Yin,Z., Pan,W., Zhao,M., Ding,W., Xu,S.,
            Liu,J., Yu,J., Ye,J., Ye,D., Qin,J.J., Wan,J. and Wang,M.
  TITLE     Macrophage neogenin deficiency exacerbates myocardial remodeling
            and inflammation after acute myocardial infarction through
            JAK1-STAT1 signaling
  JOURNAL   Cell Mol Life Sci 80 (11), 324 (2023)
   PUBMED   37824022
  REMARK    GeneRIF: Macrophage neogenin deficiency exacerbates myocardial
            remodeling and inflammation after acute myocardial infarction
            through JAK1-STAT1 signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5299)
  AUTHORS   Liu,H., Zhou,Z., Deng,H., Tian,Z., Wu,Z., Liu,X., Ren,Z. and
            Jiang,Z.
  TITLE     Trim65 attenuates isoproterenol-induced cardiac hypertrophy by
            promoting autophagy and ameliorating mitochondrial dysfunction via
            the Jak1/Stat1 signaling pathway
  JOURNAL   Eur J Pharmacol 949, 175735 (2023)
   PUBMED   37080331
  REMARK    GeneRIF: Trim65 attenuates isoproterenol-induced cardiac
            hypertrophy by promoting autophagy and ameliorating mitochondrial
            dysfunction via the Jak1/Stat1 signaling pathway.
REFERENCE   5  (bases 1 to 5299)
  AUTHORS   Iino,Y., Naganuma,T. and Arita,M.
  TITLE     Dysregulated ceramide metabolism in mouse progressive dermatitis
            resulting from constitutive activation of Jak1
  JOURNAL   J Lipid Res 64 (2), 100329 (2023)
   PUBMED   36639058
  REMARK    GeneRIF: Dysregulated ceramide metabolism in mouse progressive
            dermatitis resulting from constitutive activation of Jak1.
REFERENCE   6  (bases 1 to 5299)
  AUTHORS   Finidori,J. and Kelly,P.A.
  TITLE     Cytokine receptor signalling through two novel families of
            transducer molecules: Janus kinases, and signal transducers and
            activators of transcription
  JOURNAL   J Endocrinol 147 (1), 11-23 (1995)
   PUBMED   7490523
  REMARK    Review article
REFERENCE   7  (bases 1 to 5299)
  AUTHORS   Pritchard,M.A., Baker,E., Callen,D.F., Sutherland,G.R. and
            Wilks,A.F.
  TITLE     Two members of the JAK family of protein tyrosine kinases map to
            chromosomes 1p31.3 and 9p24
  JOURNAL   Mamm Genome 3 (1), 36-38 (1992)
   PUBMED   1581631
REFERENCE   8  (bases 1 to 5299)
  AUTHORS   Wilks,A.F., Harpur,A.G., Kurban,R.R., Ralph,S.J., Zurcher,G. and
            Ziemiecki,A.
  TITLE     Two novel protein-tyrosine kinases, each with a second
            phosphotransferase-related catalytic domain, define a new class of
            protein kinase
  JOURNAL   Mol Cell Biol 11 (4), 2057-2065 (1991)
   PUBMED   1848670
REFERENCE   9  (bases 1 to 5299)
  AUTHORS   Wilks,A.F., Kurban,R.R., Hovens,C.M. and Ralph,S.J.
  TITLE     The application of the polymerase chain reaction to cloning members
            of the protein tyrosine kinase family
  JOURNAL   Gene 85 (1), 67-74 (1989)
   PUBMED   2482828
REFERENCE   10 (bases 1 to 5299)
  AUTHORS   Wilks,A.F.
  TITLE     Two putative protein-tyrosine kinases identified by application of
            the polymerase chain reaction
  JOURNAL   Proc Natl Acad Sci U S A 86 (5), 1603-1607 (1989)
   PUBMED   2466296
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645668.15, AK152128.1, AK141210.1 and AL627251.13.
            
            On Aug 10, 2006 this sequence version replaced NM_146145.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.178196.1,
                                           SRR1660821.135411.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AL645668.15        17965-18002         c
            39-1401             AK152128.1         2-1364
            1402-3957           AK141210.1         1344-3899
            3958-5299           AL627251.13        106733-108074       c
FEATURES             Location/Qualifiers
     source          1..5299
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 46.19 cM"
     gene            1..5299
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /note="Janus kinase 1"
                     /db_xref="GeneID:16451"
                     /db_xref="MGI:MGI:96628"
     exon            1..241
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            242..322
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..3778
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tyrosine-protein kinase JAK1; JAK-1"
                     /codon_start=1
                     /product="tyrosine-protein kinase JAK1 isoform 1"
                     /protein_id="NP_666257.2"
                     /db_xref="CCDS:CCDS18393.1"
                     /db_xref="GeneID:16451"
                     /db_xref="MGI:MGI:96628"
                     /translation="MQYLNIKEDCNAMAFCAKMRSFKKTEVKQVVPEPGVEVTFYLLD
                     REPLRLGSGEYTAEELCIRAAQECSISPLCHNLFALYDESTKLWYAPNRIITVDDKTS
                     LRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKRVPEATPLLDASSLEYLFA
                     QGQYDLIKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYK
                     RYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLET
                     LTKHYGAEIFETSMLLISSENELSRCHSNDSGNVLYEVMVTGNLGIQWRQKPNVVPVE
                     KEKNKLKRKKLEYNKHKKDDERNKLREEWNNFSYFPEITHIVIKESVVSINKQDNKNM
                     ELKLSSREEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAI
                     NKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEVLGGQKQFKNFQIEVQKGRYSL
                     HGSMDHFPSLRDLMNHLKKQILRTDNISFVLKRCCQPKPREISNLLVATKKAQEWQPV
                     YSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTLLDYKDEEGIAEEKKIKVILKVLD
                     PSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKS
                     DALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPG
                     IPVSVLTRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTL
                     IEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVS
                     EKQPTTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESG
                     GNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPKNKN
                     KINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETD
                     KEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDFSPMALFL
                     KMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQNLIE
                     GFEALLK"
     exon            323..521
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            522..645
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            646..799
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            800..963
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1303
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1492
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1650
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1774
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1961
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2068
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2212
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2300
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2428
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2564
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2716
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2867
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..2962
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3155
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3280
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3453
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3454..3571
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3572..3682
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3683..5299
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4885..4890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4906
                     /gene="Jak1"
                     /gene_synonym="BAP004; C130039L05Rik"
                     /note="major polyA site"
ORIGIN      
        1 agagttggag gggcggggcg ccggtgcgtt tttagagcgc aggccgccgc agccgcggag
       61 tagccggcag ccgctgacgc gccgcggggt ccgcgcccag cctcgctcgt cctttcggtg
      121 cctctcctta gccgcgggtg tccacgccgg accctgcacg gcaggctgag ttgcctgcca
      181 gactcctgac ccagatcgac cctgcgccaa ggagccgcgc ggcccggcgc acacggaagt
      241 gatcagctct gaatgggctt tggaaggtaa agaagaaaat ccagtctgct ttcagggaca
      301 ctggacaacc gaataaatgc agtatctaaa tataaaagag gactgcaatg ccatggcgtt
      361 ctgtgctaaa atgaggagct tcaagaagac tgaggtgaag caggtggtcc ctgagcctgg
      421 agtggaggtg actttctatc tgttggacag ggagcccctc cgcctgggca gcggagagta
      481 tacagccgag gagctgtgca tcagggccgc ccaggagtgc agtatctctc ctctctgtca
      541 caacctcttc gccctgtacg atgagagcac caagctctgg tacgctccga accgaatcat
      601 cactgtggat gacaaaacgt ctctccggct ccactaccgc atgaggttct actttaccaa
      661 ctggcacgga accaatgaca acgaacagtc tgtatggcga cattctccaa agaagcagaa
      721 aaacggctat gagaagaaaa gggttccaga agcaacccca ctccttgatg ccagttcact
      781 ggagtatctg tttgcacagg gacagtatga tttgatcaaa tgcctggctc ccattcggga
      841 ccccaagacg gagcaagacg gacatgatat tgaaaatgag tgcctgggca tggcggtcct
      901 ggccatctcc cactatgcca tgatgaagaa gatgcagttg ccggaacttc ccaaagacat
      961 cagctacaag cgatatattc cagaaacatt gaataaatcc atcagacaga ggaaccttct
     1021 taccaggatg cgaataaata atgttttcaa ggatttcttg aaggaattta acaacaagac
     1081 catctgtgac agcagtgtgt ctacacatga cctgaaggtg aaatacctgg ctaccttgga
     1141 aactttgaca aaacattatg gagctgaaat atttgagact tctatgctac tgatttcatc
     1201 agaaaatgaa ttgagtcgat gccattcgaa tgacagtggc aatgttctct atgaggtcat
     1261 ggtgactgga aatctcggga tccagtggcg gcagaaacca aatgttgttc ctgttgaaaa
     1321 ggaaaaaaat aaactgaagc ggaaaaaact ggaatataat aaacacaaga aggatgatga
     1381 gagaaacaaa ctccgggaag agtggaacaa tttttcctat ttccctgaaa tcacccacat
     1441 tgtaataaag gagtctgtgg tcagcattaa caaacaggac aacaaaaaca tggaactcaa
     1501 gctctcttct cgagaggaag ccttgtcctt tgtgtccctg gtggatggct acttccggct
     1561 cactgcagat gcccaccatt acctctgtac tgatgtggct cccccactga ttgtccacaa
     1621 tatacagaac ggctgccacg gtccaatctg cacagaatat gccatcaata agctgcggca
     1681 ggaagggagt gaagagggga tgtacgtgct gaggtggagc tgcaccgact ttgacaacat
     1741 tcttatgact gtcacctgct ttgaaaagtc tgaggtattg ggtggccaga agcagttcaa
     1801 gaactttcag attgaggtac agaagggccg ctacagcctg catggctcta tggaccactt
     1861 tcccagcctg cgagacctca tgaaccacct caagaagcag atcctgcgca cggacaacat
     1921 aagctttgtg ctgaaacgat gctgtcagcc taagcctcga gaaatctcca atctgctcgt
     1981 agccactaag aaagcccagg agtggcagcc tgtctactcc atgagccagc tgagctttga
     2041 tcggatcctt aagaaagata ttatacaagg tgagcacctt ggcagaggca caagaacaca
     2101 tatctattct gggaccctgc tggactacaa ggatgaggaa ggaattgctg aagagaagaa
     2161 gataaaagtg atcctcaaag tcctagaccc cagccaccgg gacatctctc tggccttctt
     2221 tgaggctgct agcatgatga gacaggtttc ccacaaacat atagtgtacc tctacggcgt
     2281 gtgtgtccga gatgtggaaa atatcatggt ggaagagttt gtggaggggg ggccgttgga
     2341 tctcttcatg caccggaaaa gtgatgcgct tactaccccc tggaagttca aggttgccaa
     2401 acagctggcc agtgccctga gttacttgga agataaagac ctggttcatg gaaatgtgtg
     2461 cactaaaaac ctccttctgg cccgtgaggg cattgacagt gacattggcc cgttcatcaa
     2521 gcttagtgac cctggcatcc cagtctctgt gctgaccagg caagagtgca tagagcgaat
     2581 cccctggatc gctcctgagt gtgttgaaga ctccaagaac ctgagtgtgg ctgctgacaa
     2641 gtggagcttt ggaaccacgc tctgggaaat ctgctacaac ggagagattc ctctcaaaga
     2701 caagaccctc attgagaaag agaggtttta tgaaagccgc tgcaggcctg tgactccatc
     2761 ttgcaaggag ctagctgacc tcatgactcg ctgcatgaac tatgacccca accagagacc
     2821 cttcttccga gccatcatga gggacattaa caagctggag gagcagaatc cagacattgt
     2881 ttcagaaaag cagccaacaa cagaggtgga ccccactcac tttgaaaagc ggttcctgaa
     2941 gaggattcgt gacttgggag agggtcactt tgggaaggtt gagctctgca gatatgatcc
     3001 tgagggagac aacacagggg agcaggtagc tgtcaagtcc ctgaagcctg agagtggagg
     3061 taaccacata gctgatctga agaaggagat agagatctta cggaacctct accatgagaa
     3121 cattgtgaag tacaaaggaa tctgcatgga agacggaggc aatggtatca agctcatcat
     3181 ggagtttctg ccttcgggaa gcctaaagga gtatctgcca aagaataaga acaaaatcaa
     3241 cctcaaacag cagctaaaat atgccatcca gatttgtaag gggatggact acttgggttc
     3301 tcggcaatac gttcaccggg acttagcagc aagaaatgtc cttgttgaga gtgagcatca
     3361 agtgaagatc ggagactttg gtttaaccaa agcaattgaa accgataagg agtactacac
     3421 agtcaaggac gaccgggaca gcccagtgtt ctggtacgct ccggaatgtt taatccagtg
     3481 taaattttat atcgcctctg atgtctggtc ttttggagtg acactgcacg agctgctcac
     3541 ttactgtgac tcagatttta gtcccatggc cttgttcctg aaaatgatag gcccaactca
     3601 tggccagatg acagtgacac ggcttgtgaa tactctgaaa gaaggaaagc gtctgccatg
     3661 tccacccaac tgtcctgatg aggtttatca gcttatgaga aaatgctggg aattccaacc
     3721 atctaaccgg acaacttttc agaaccttat tgaaggattt gaagcacttt taaaataaga
     3781 agcatgaaca acatttaaat tcccatttat caaatccttc tctcccaagc catttaaaaa
     3841 cgttttttaa gtgaaaagtt tgtattctgc ctctaaagtt cctcaacaaa tactcgagtt
     3901 acacatatgc atatgtcaca ctgtcactca gtgtgtggat atgcctatgt cacactgtca
     3961 ctcagtgtgt ggaactttct ctttaaaggt gtaacatctt aaatttggtg atgaatagtg
     4021 acaaccaaaa gactagattg tgcctaagca ctccttctgg aacaaccgaa tgatcagctg
     4081 catagcaaag gactgtgccg ctggcatatt gatctcagat aaaaacttgt ggacttggct
     4141 gacactctcc cttgccctga aatctcaatg tctattcagt gatagtacaa gcacgtagat
     4201 accacttagt atactattgt ttctattaaa aaaaaaaaaa aaaaggtctg ttcctgctac
     4261 cttttaggac tgaagtttta agcactggta cccactgtgg ggcaaacctg tgctgcagga
     4321 gggagcctgg catacacact ctgcatgtta cttcttgaga actagacctg tgtgcctgtg
     4381 ttttcctgaa cagctgcttt ctgtcaggca gactcctctg acctggatgc ggtcacatcc
     4441 acctttaaga ttgtcagtgc atactccttc ctgacgatcc cctggggcaa gctgccgaca
     4501 gtggcgtaaa caggagacat caccctatac tgcgaaacta cagaaaggaa gacagcttgg
     4561 cccagcgggc tgaagttcag aattcactag gtagttgttg ttggttgact tggaggtagc
     4621 tgggtaatca acagctttca ctttagattc aatgtgaacc gcagagttac tcatgaccaa
     4681 gagtctggca aactcattaa tgctgtttaa tacttgtttg atattttttc accttttgag
     4741 cccttttccc aaagaattca atatcagttt agtagcaaca gtacagttgc catttaaatt
     4801 ggtttagttg ctgtatatca ccatagcccc tgtttacgtc aaacctgtgt ctcgctctat
     4861 atgcactttg tttactcttt atacaataaa catactaaag acttcacatg catatgcctt
     4921 ttaatattaa gcttgcatct tgaaaagcat ttcaaaccat tagctgacac agaaaactaa
     4981 cagcgtagac tttggggggt tggttgtaat gaccttgtac taacatcact tgatttgcat
     5041 ttctgtcttg taataacggg cacaggctgg catagtggag gacccacatg gaatgtgaag
     5101 tgtctctaag ttccctccac tgcttcctcc tcacactgca gctcccagat agcagtctct
     5161 agcctccact attctgtgac ttagagctgc agccagaggc aggaggtgca gggtcagagc
     5221 acaccattag tcatctgctg ggacctcgtg ctggtcatca cctataggaa gcgtgtctag
     5281 gacggtcttc ctttcattt
//
