LOCUS       NM_026365               1218 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus jagunal homolog 1 (Jagn1), transcript variant 1, mRNA.
ACCESSION   NM_026365
VERSION     NM_026365.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1218)
  AUTHORS   Hagelkruys,A., Wirnsberger,G., Stadlmann,J., Wohner,M., Horrer,M.,
            Vilagos,B., Jonsson,G., Kogler,M., Tortola,L., Novatchkova,M.,
            Bonelt,P., Hoffmann,D., Koglgruber,R., Steffen,U., Schett,G.,
            Busslinger,M., Bergthaler,A., Klein,C. and Penninger,J.M.
  TITLE     A crucial role for Jagunal homolog 1 in humoral immunity and
            antibody glycosylation in mice and humans
  JOURNAL   J Exp Med 218 (1) (2021)
   PUBMED   32930709
  REMARK    GeneRIF: A crucial role for Jagunal homolog 1 in humoral immunity
            and antibody glycosylation in mice and humans.
REFERENCE   2  (bases 1 to 1218)
  AUTHORS   Nosak,C., Silva,P.N., Sollazzo,P., Moon,K.M., Odisho,T.,
            Foster,L.J., Rocheleau,J.V. and Volchuk,A.
  TITLE     Jagn1 Is Induced in Response to ER Stress and Regulates Proinsulin
            Biosynthesis
  JOURNAL   PLoS One 11 (2), e0149177 (2016)
   PUBMED   26882284
  REMARK    GeneRIF: These results identify a novel role for Jagn1 in
            regulating proinsulin biosynthesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1218)
  AUTHORS   Wirnsberger,G., Zwolanek,F., Stadlmann,J., Tortola,L., Liu,S.W.,
            Perlot,T., Jarvinen,P., Durnberger,G., Kozieradzki,I., Sarao,R., De
            Martino,A., Boztug,K., Mechtler,K., Kuchler,K., Klein,C., Elling,U.
            and Penninger,J.M.
  TITLE     Jagunal homolog 1 is a critical regulator of neutrophil function in
            fungal host defense
  JOURNAL   Nat Genet 46 (9), 1028-1033 (2014)
   PUBMED   25129145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU609459.1, AK141417.1 and AI842017.1.
            
            On Mar 19, 2011 this sequence version replaced NM_026365.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU609459.1, AK141417.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BU609459.1         1-21
            22-1194             AK141417.1         2-1174
            1195-1218           AI842017.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..1218
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.76 cM"
     gene            1..1218
                     /gene="Jagn1"
                     /gene_synonym="5830427H10Rik"
                     /note="jagunal homolog 1"
                     /db_xref="GeneID:67767"
                     /db_xref="MGI:MGI:1915017"
     exon            1..229
                     /gene="Jagn1"
                     /gene_synonym="5830427H10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            230..1201
                     /gene="Jagn1"
                     /gene_synonym="5830427H10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1179..1184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jagn1"
                     /gene_synonym="5830427H10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1184
                     /gene="Jagn1"
                     /gene_synonym="5830427H10Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggatagaga ggccggaagt tctcccggag ctccacgccg tgtagtgaaa gccgggccga
       61 ggtagcaggg aaggggttcg cagggtgctt ggctgggtgt gtgagcagag ggtcggcgtt
      121 aggggcctta gttctgtaca atggcgtctc gggcaggccc gcgagcggcc ggcaccgacg
      181 gcagcgactt tcagcaccgg gagcgcgtcg ccatgcacta ccagatgagt gtgaccctca
      241 agtacgaaat caagaagctg atctacgtgc atctcgtcat atggctgctg ttggtggcca
      301 agatgagcgt gggacacctg aggctcttgt cacatgatca ggtggccatg ccctatcagt
      361 gggaatatcc gtatttgttg agcattgtgc cctctgtctt gggcctgctc tccttccctc
      421 ggaacaacat tagctacctg gtgctctcca tgatcagcat ggggctcttc tccatcgctc
      481 ccctcattta tggcagcatg gagatgttcc ctgcggcaca gcaactctac cgccatggca
      541 aggcctatcg cttcctgttt ggtttttctg ctgtctctgt catgtacctg gtgttggtac
      601 tggcagtcca agttcatgcc tggcaactgt actacagcaa aaaactctta gactcttggt
      661 tcaccagcac acaggagaag aaacggaaat gaagcctgct tgataaactg ctctgagggg
      721 taaaacctag gtctcccatt gagcagcgtg aagggagctg tccagactct ccatcgattg
      781 tggcatctgt gatgttggca cctagtgcac actaggctca gattttggcc tagagttctg
      841 ttaccatctg ctgaggtggc aaagctgttg tatttaattt atgcttgact agctgcagct
      901 gggtgaccaa tggctgtgac acactttacc tggttgaact tgaggccctt tagagtttgg
      961 gttttccaga ctgagcctta tccttgcctt ctcttggccg tactccctcc ttccattcgt
     1021 cacctcttca ccaccagtac tagaagaaat atggaataaa tcagtacatg aaagcagact
     1081 tcagtctgtg ggtcatgggc aagcaacatt tgggaagttg ctcccctatg ggctgttctg
     1141 tttactgcaa accattttaa ataaaaagaa cctcaataaa taaagttaag actgtcctgt
     1201 gaaaaaaaaa aaaaaaaa
//
