LOCUS       NM_010588               5147 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus jagged 2 (Jag2), transcript variant 1, mRNA.
ACCESSION   NM_010588
VERSION     NM_010588.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5147)
  AUTHORS   Defamie,V., Aliar,K., Sarkar,S., Vyas,F., Shetty,R., Reddy
            Narala,S., Fang,H., Saw,S., Tharmapalan,P., Sanchez,O., Knox,J.J.,
            Waterhouse,P.D. and Khokha,R.
  TITLE     Metalloproteinase inhibitors regulate biliary progenitor cells
            through sDLK1 in organoid models of liver injury
  JOURNAL   J Clin Invest 135 (3), e164997 (2024)
   PUBMED   39699962
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5147)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   3  (bases 1 to 5147)
  AUTHORS   Huang,H., Jiang,Y., Liu,J., Luo,D., Yuan,J., Mu,R., Yu,X., Sun,D.,
            Lin,J., Chen,Q., Li,X., Jiang,M., Xu,J., Chu,B., Yin,C., Zhang,L.,
            Ye,Y., Cao,B., Wang,Q. and Zhang,Y.
  TITLE     Jag1/2 maintain esophageal homeostasis and suppress foregut
            tumorigenesis by restricting the basal progenitor cell pool
  JOURNAL   Nat Commun 15 (1), 4124 (2024)
   PUBMED   38750026
  REMARK    GeneRIF: Jag1/2 maintain esophageal homeostasis and suppress
            foregut tumorigenesis by restricting the basal progenitor cell
            pool.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5147)
  AUTHORS   Mandula,J.K., Sierra-Mondragon,R.A., Jimenez,R.V., Chang,D.,
            Mohamed,E., Chang,S., Vazquez-Martinez,J.A., Cao,Y., Anadon,C.M.,
            Lee,S.B., Das,S., Rocha-Munguba,L., Pham,V.M., Li,R., Tarhini,A.A.,
            Furqan,M., Dalton,W., Churchman,M., Moran-Segura,C.M., Nguyen,J.,
            Perez,B., Kojetin,D.J., Obermayer,A., Yu,X., Chen,A., Shaw,T.I.,
            Conejo-Garcia,J.R. and Rodriguez,P.C.
  TITLE     Jagged2 targeting in lung cancer activates anti-tumor immunity via
            Notch-induced functional reprogramming of tumor-associated
            macrophages
  JOURNAL   Immunity 57 (5), 1124-1140 (2024)
   PUBMED   38636522
  REMARK    GeneRIF: Jagged2 targeting in lung cancer activates anti-tumor
            immunity via Notch-induced functional reprogramming of
            tumor-associated macrophages.
REFERENCE   5  (bases 1 to 5147)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 5147)
  AUTHORS   Luo,B., Aster,J.C., Hasserjian,R.P., Kuo,F. and Sklar,J.
  TITLE     Isolation and functional analysis of a cDNA for human Jagged2, a
            gene encoding a ligand for the Notch1 receptor
  JOURNAL   Mol Cell Biol 17 (10), 6057-6067 (1997)
   PUBMED   9315665
REFERENCE   7  (bases 1 to 5147)
  AUTHORS   Nakayama,H., Liu,Y., Stifani,S. and Cross,J.C.
  TITLE     Developmental restriction of Mash-2 expression in trophoblast
            correlates with potential activation of the notch-2 pathway
  JOURNAL   Dev Genet 21 (1), 21-30 (1997)
   PUBMED   9291577
REFERENCE   8  (bases 1 to 5147)
  AUTHORS   Shawber,C., Boulter,J., Lindsell,C.E. and Weinmaster,G.
  TITLE     Jagged2: a serrate-like gene expressed during rat embryogenesis
  JOURNAL   Dev Biol 180 (1), 370-376 (1996)
   PUBMED   8948600
REFERENCE   9  (bases 1 to 5147)
  AUTHORS   Burmeister,M., Novak,J., Liang,M.Y., Basu,S., Ploder,L.,
            Hawes,N.L., Vidgen,D., Hoover,F., Goldman,D., Kalnins,V.I.,
            Roderick,T.H., Taylor,B.A., Hankin,M.H. and McInnes,R.R.
  TITLE     Ocular retardation mouse caused by Chx10 homeobox null allele:
            impaired retinal progenitor proliferation and bipolar cell
            differentiation
  JOURNAL   Nat Genet 12 (4), 376-384 (1996)
   PUBMED   8630490
REFERENCE   10 (bases 1 to 5147)
  AUTHORS   Milaire,J.
  TITLE     Histochemical observations on the developing foot of normal,
            oligosyndactylous (Os-plus) and syndactylous (sm-sm) mouse embryos
  JOURNAL   Arch Biol (Liege) 78 (2), 223-288 (1967)
   PUBMED   4305644
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160929.2.
            
            On Jul 21, 2022 this sequence version replaced NM_010588.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF038572.1, SRR9219383.58398.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-399               AC160929.2         125712-126110       c
            400-750             AC160929.2         125175-125525       c
            751-808             AC160929.2         118293-118350       c
            809-1060            AC160929.2         116524-116775       c
            1061-1121           AC160929.2         116365-116425       c
            1122-1252           AC160929.2         113102-113232       c
            1253-1372           AC160929.2         112897-113016       c
            1373-1486           AC160929.2         112627-112740       c
            1487-1600           AC160929.2         112173-112286       c
            1601-1714           AC160929.2         111898-112011       c
            1715-1761           AC160929.2         111764-111810       c
            1762-1935           AC160929.2         111491-111664       c
            1936-2086           AC160929.2         110650-110800       c
            2087-2239           AC160929.2         110419-110571       c
            2240-2353           AC160929.2         110229-110342       c
            2354-2467           AC160929.2         109909-110022       c
            2468-2581           AC160929.2         109683-109796       c
            2582-2698           AC160929.2         109458-109574       c
            2699-2726           AC160929.2         108986-109013       c
            2727-2812           AC160929.2         108822-108907       c
            2813-2926           AC160929.2         108202-108315       c
            2927-3042           AC160929.2         107996-108111       c
            3043-3291           AC160929.2         107352-107600       c
            3292-3423           AC160929.2         106737-106868       c
            3424-3580           AC160929.2         105846-106002       c
            3581-5147           AC160929.2         104112-105678       c
FEATURES             Location/Qualifiers
     source          1..5147
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.37 cM"
     gene            1..5147
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /note="jagged 2"
                     /db_xref="GeneID:16450"
                     /db_xref="MGI:MGI:1098270"
     exon            1..399
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..4077
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein jagged-2; syndactylism"
                     /codon_start=1
                     /product="protein jagged-2 isoform 1 precursor"
                     /protein_id="NP_034718.2"
                     /db_xref="CCDS:CCDS26200.1"
                     /db_xref="GeneID:16450"
                     /db_xref="MGI:MGI:1098270"
                     /translation="MRARGWGRLPRRLLLLLVLCVQATRPMGYFELQLSALRNVNGEL
                     LSGACCDGDGRTTRAGGCGRDECDTYVRVCLKEYQAKVTPTGPCSYGYGATPVLGGNS
                     FYLPPAGAAGDRARARSRTGGHQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPDEE
                     LLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFF
                     GHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGKFCDEC
                     VPYPGCVHGSCVEPWHCDCETNWGGLLCDKDLNYCGSHHPCVNGGTCINAEPDQYLCA
                     CPDGYLGKNCERAEHACASNPCANGGSCHEVPSGFECHCPSGWNGPTCALDIDECASN
                     PCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCL
                     PGWKGINCQININDCHGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELEYDKCASSPCR
                     RGGICEDLVDGFRCHCPRGLSGLHCEVDMDLCEPSPCLNGARCYNLEGDYYCACPEDF
                     GGKNCSVPRDTCPGGACRVIDGCGFEAGSRARGVAPSGICGPHGHCVSLPGGNFSCIC
                     DSGFTGTYCHENIDDCMGQPCRNGGTCIDEVDSFRCFCPSGWEGELCDINPNDCLPDP
                     CHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPP
                     GWKGSTCTIAKNSSCVPNPCVNGGTCVGSGDSFSCICRDGWEGRTCTHNTNDCNPLPC
                     YNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPG
                     RSGPRCQEVVIFTRPCWSRGMSFPHGSSWMEDCNSCRCLDGHRDCSKVWCGWKPCLLS
                     GQPSDPSAQCPPGQQCQEKAVGQCLQPPCENWGECTAEEPLPPSTPCQPRSSHLDNNC
                     ARLTLRFNRDQVPQGTTVGAICSGIRALPATRAAAHDRLLLLLCDRASSGASAVEVAV
                     SFSPARDLPDSSLIQSTAHAIVAAITQRGNSSLLLAVTEVKVETVVMGGSSTGLLVPV
                     LCSVFSVLWLACVVICVWWTRKRRKERERSRLPRDESANNQWAPLNPIRNPIERPGGS
                     GLGTGGHKDILYQCKNFTPPPRRAGEALPGPAGHGAGGEDEEDEELSRGDGDSPEAEK
                     FISHKFTKDPSCSLGRPARWAPGPKVDNRAVRSTKDVRRAGRE"
     exon            400..750
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            751..808
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1060
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1121
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1252
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1372
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1486
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1600
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1714
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1761
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1935
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2086
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2239
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2353
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2467
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2581
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2698
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2726
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2812
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2926
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..3042
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3291
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            3292..3423
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            3424..3580
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     exon            3581..5147
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4234..4239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /note="hexamer: TATAAA"
     polyA_site      4283
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /note="major polyA site"
     regulatory      5111..5116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /note="hexamer: AATGAA"
     polyA_site      5147
                     /gene="Jag2"
                     /gene_synonym="D12Ggc2e; mJagged2-1; Serh; sm"
                     /note="major polyA site"
ORIGIN      
        1 agtctcgtcc cgaacttgtt ggctgcggtg ccgggagcgc gggcgcgcag agccgaggcc
       61 aggacccgcc gccgccgtcg ccgccgccgc cgggtgggag ccgggccggc cgccggagag
      121 cggctgcagt aagccggagc cgccgcctcc cctgcacgcc cgccgcgcag cccgcgcgca
      181 ctgctcgacc ccgcccgcgc cgcctgtgcg gccgccgccg cctgtgcgcc gccgggctcg
      241 gagggcgggc gggcgttgga ggccggcgcg gcggctatag cgggcgcggg cggcggcggc
      301 ggcggcgggg ccgcgggcgg ggtcgaggcg gcgatgcggg cacgcggctg gggacgcctg
      361 cctcggcggc tgctgctgct actggttctg tgcgtgcagg cgacgcggcc catgggctat
      421 ttcgagctgc agctgagcgc gctgcggaac gtgaacgggg agctgctgag cggcgcctgc
      481 tgtgacggcg acggccggac gacgcgcgcg gggggctgcg gccgcgacga gtgcgacacg
      541 tacgtgcgcg tgtgccttaa ggagtaccag gccaaggtga cgcccacggg gccctgcagc
      601 tacggctacg gcgccacgcc cgtgctgggt ggcaactcct tctacctgcc gccggcgggc
      661 gctgcggggg accgagcgcg cgcgcggtct cggaccggcg gccaccagga cccgggcctc
      721 gtcgtcattc cctttcagtt cgcctggccg cgttctttca ccctcatcgt ggaggcctgg
      781 gactgggaca atgacaccac tccagatgag gagctgctga ttgagcgggt gtcgcacgct
      841 ggcatgatca accccgagga ccgctggaag agcctgcact tcagcggcca cgtggcacac
      901 ctggagctgc agatccgagt acgctgtgat gagaactact acagtgccac ctgcaacaag
      961 ttctgccggc cccgcaacga cttctttggc cactatacct gcgaccagta cggcaacaag
     1021 gcctgcatgg atggctggat gggcaaagaa tgcaaagaag ccgtgtgtaa acaaggatgt
     1081 aatttgctcc acgggggatg cactgtgcct ggggagtgca ggtgcagcta cggctggcag
     1141 ggcaagttct gtgacgagtg tgtcccctac cctggctgcg tgcatggcag ctgtgtggag
     1201 ccctggcact gtgactgtga gaccaactgg ggtggcctgc tctgtgacaa agacctgaac
     1261 tactgtggca gccaccaccc ctgtgtcaac gggggtacct gcatcaatgc tgagcctgac
     1321 caatacctct gcgcctgccc agatggctac ttgggcaaga actgcgagcg ggctgagcac
     1381 gcctgtgcct ccaacccgtg tgccaatggg ggctcttgcc acgaagtgcc atctggcttt
     1441 gaatgccact gtccgtcagg atggaacgga cccacctgtg cgctcgacat tgatgagtgt
     1501 gcctctaacc catgtgcagc gggtggtacc tgcgtggatc aggtggacgg cttcgagtgc
     1561 atctgcccgg agcagtgggt gggggctact tgccagctgg acgccaatga gtgtgaaggg
     1621 aagccgtgcc ttaatgcttt ttcttgcaaa aacctgattg gcggctatta ctgtgattgc
     1681 ctcccgggct ggaagggcat caactgccaa atcaacatca acgattgcca tgggcagtgt
     1741 cagcatgggg gcacctgcaa ggacctggtc aatgggtacc agtgtgtgtg cccgcggggc
     1801 tttggaggtc gccattgcga actagagtac gacaagtgtg ccagcagccc ctgccgccgg
     1861 ggtggcatct gtgaggacct ggtggatggc ttccgctgcc actgcccacg gggcctctct
     1921 gggctgcact gtgaggtgga catggatctc tgtgaaccaa gcccctgcct caacggtgct
     1981 cgctgctaca accttgaggg tgactactac tgcgcctgcc cagaagactt tggtggcaag
     2041 aactgctcag tgcccaggga cacatgccct ggcggggcat gtagagtgat cgatggctgc
     2101 gggttcgagg cagggtccag ggcacgcggt gtcgcaccct ctggtatatg tggccctcac
     2161 gggcactgcg ttagcctgcc tgggggaaac ttctcctgca tctgtgacag cggcttcaca
     2221 ggcacctact gccatgaaaa cattgacgac tgcatgggcc agccctgccg caacgggggc
     2281 acgtgcattg acgaagtgga ctccttccgc tgcttctgcc ccagtggctg ggaaggagaa
     2341 ctctgtgaca tcaatcccaa cgactgcctc cccgacccct gccacagccg cggccgctgc
     2401 tatgacctgg tcaatgactt ctactgtgcc tgtgacgatg gctggaaggg caagacctgc
     2461 cactcacgcg agttccagtg tgacgcctac acctgcagca acggtggcac atgctatgac
     2521 agcggcgaca ccttccgctg cgcgtgccct ccgggctgga agggcagcac ctgcaccatc
     2581 gccaagaaca gcagctgtgt gcccaatccc tgtgtgaatg gaggcacctg cgtgggcagc
     2641 ggagactctt tctcctgcat ctgccgggat ggctgggagg gccgcacctg cacacataac
     2701 accaatgact gcaaccctct gccctgctat aacggaggca tctgtgttga tggcgtcaac
     2761 tggttccgct gcgagtgtgc gcctggcttt gcgggtcctg actgccgtat caacattgat
     2821 gagtgccagt cctcgccctg tgcctacgga gccacgtgtg tggatgagat caacgggtac
     2881 cgctgcagct gcccaccagg tcgttctggc cccaggtgcc aggaagtggt catattcacg
     2941 aggccctgct ggtcccgggg aatgtccttc ccgcatggga gttcctggat ggaagactgc
     3001 aacagctgcc gctgcctgga tggccaccgg gattgtagca aggtatggtg cggatggaag
     3061 ccttgcctgc tctctggtca gcccagcgat ccgagtgccc agtgcccccc agggcagcaa
     3121 tgtcaggaga aggccgtggg tcagtgcttg cagccaccct gtgagaactg gggggagtgt
     3181 acagcggagg agcctctgcc acccagcacc ccctgtcagc cacggagcag tcatttggac
     3241 aacaactgtg cccgactcac actgcgcttc aaccgtgatc aagtgcctca gggcaccacc
     3301 gtgggcgcta tctgctctgg aatccgagcc ttgcctgcca cgagggcggc ggcacacgac
     3361 cgcctcctcc tgctgctttg tgatcgagca tcctcggggg ccagtgctgt ggaggtggct
     3421 gtgtctttca gccctgcaag ggacctgcct gacagcagcc tgatccagag cacagcccac
     3481 gccatcgtgg ctgctatcac tcagagagga aatagctcac tgctgctggc tgtcaccgag
     3541 gtcaaggtgg aaacagttgt tatgggtggc tcttccacag gtctgttggt gcccgtgctg
     3601 tgcagcgtgt tcagtgtgct gtggctcgcc tgtgtggtta tctgcgtatg gtggacacga
     3661 aagcgcagga aagaacgtga gaggagccgg ctaccacggg atgagagcgc caacaaccag
     3721 tgggccccgc tcaatcccat ccgcaacccc attgagcggc caggcggcag cggtctggga
     3781 actgggggcc acaaggacat actctaccag tgcaaaaact tcacaccgcc gccccgcagg
     3841 gcaggcgagg cactgcccgg gccagctggc catggggctg gtggggagga cgaggaggat
     3901 gaagagctga gccgtggaga tggggactcc ccagaggcag agaagttcat ctcacacaag
     3961 ttcaccaaag accccagctg ctccctcgga aggccagccc gctgggctcc agggcccaaa
     4021 gtggacaacc gcgccgtcag aagtaccaag gacgtgcgcc gtgctggcag ggaatagcca
     4081 gccaccaggc tggcacccag aacccttgct ggcaccacgc tgcctgccgg accataggag
     4141 gccaaggccg tgtgcatagt ttctttattt tgtgtaaaaa acaaaaccaa aaccaaaaaa
     4201 caaatgttta ttttttacgt ttctttaacc ttgtataaat tattcaacgg ctgtcaggcg
     4261 gaaaacaacg gagtattctc ggatcattgc tatttttgta aagtttccgc gtccgcacgc
     4321 actgtggcag gagagcaggg cgtgtgtatg tgtgtgtgtg tgtgtgtgtc ctcaccaaat
     4381 cgtataatgt ttgttaccac aggccgtcgc tgtttacaga atcttctttt ttattcctca
     4441 tttgggtttc tctctagctc gaggcccaaa agcccacgag acctgtgggc tgggctgtgg
     4501 ctctcagtga gatctgtggc tttcagtgtg gcccgtggct ctcagtggga cctgtggctg
     4561 acagcatggc ccgaggctgt cagtgggact gtggctgttg tcttagctgt agctctcagt
     4621 gggacctgtg gctgtccatg gtacccatgg caattggccc agcctgtgga tgtcagtggg
     4681 acctgtggct gtcagtggca ctggctgctg ggctggcgta ctgtcagtgg gacccgtggt
     4741 ggcccgtgtg atgccggtta catagctgtt ggtggcgcct gtggttgtca gtggggttgg
     4801 aggtcactgg tgtggcctaa ggctggcacg taaacctggc ccatgccttg gctagcccct
     4861 ccagcctgct gtccttgctt cctcctgccc agaactctcc agagatctcc aactgtgctt
     4921 tcagaagtgc ccttcccaac tgctcggttt ccctcccggg acggcggcag tattgaagct
     4981 tgtgacaagt gccttcacac agaccccctc ccagctgtca gcgtttgccg tgggcaccag
     5041 gccgctgccc acctgccggc cccggccacc ctccttgtga aagtgcattt ctgtaaatat
     5101 gtacatatta aatgaatcac tctgtatatt tgatttaata acttaaa
//
