LOCUS       NM_013822               5493 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus jagged 1 (Jag1), mRNA.
ACCESSION   NM_013822 XM_990538
VERSION     NM_013822.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5493)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5493)
  AUTHORS   Defamie,V., Aliar,K., Sarkar,S., Vyas,F., Shetty,R., Reddy
            Narala,S., Fang,H., Saw,S., Tharmapalan,P., Sanchez,O., Knox,J.J.,
            Waterhouse,P.D. and Khokha,R.
  TITLE     Metalloproteinase inhibitors regulate biliary progenitor cells
            through sDLK1 in organoid models of liver injury
  JOURNAL   J Clin Invest 135 (3), e164997 (2024)
   PUBMED   39699962
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5493)
  AUTHORS   Gil,Y., Ryu,J., Yang,H., Ma,Y., Nam,K.H., Jang,S.W. and Shim,S.
  TITLE     Molecular Characterization of Subdomain Specification of Cochlear
            Duct Based on Foxg1 and Gata3
  JOURNAL   Int J Mol Sci 25 (23), 12700 (2024)
   PUBMED   39684410
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5493)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
  REMARK    GeneRIF: Jag1 represses Notch activation in lateral supporting
            cells and inhibits an outer hair cell fate in the medial cochlea.
REFERENCE   5  (bases 1 to 5493)
  AUTHORS   Masek,J., Filipovic,I., Van Hul,N., Belicova,L., Jirouskova,M.,
            Oliveira,D.V., Frontino,A.M., Hankeova,S., He,J., Turetti,F.,
            Iqbal,A., Cervenka,I., Sarnova,L., Verboven,E., Brabec,T.,
            Bjorkstrom,N.K., Gregor,M., Dobes,J. and Andersson,E.R.
  TITLE     Jag1 insufficiency alters liver fibrosis via T cell and hepatocyte
            differentiation defects
  JOURNAL   EMBO Mol Med 16 (11), 2946-2975 (2024)
   PUBMED   39358604
REFERENCE   6  (bases 1 to 5493)
  AUTHORS   Oda,T., Elkahloun,A.G., Pike,B.L., Okajima,K., Krantz,I.D.,
            Genin,A., Piccoli,D.A., Meltzer,P.S., Spinner,N.B., Collins,F.S.
            and Chandrasekharappa,S.C.
  TITLE     Mutations in the human Jagged1 gene are responsible for Alagille
            syndrome
  JOURNAL   Nat Genet 16 (3), 235-242 (1997)
   PUBMED   9207787
REFERENCE   7  (bases 1 to 5493)
  AUTHORS   Johnston,S.H., Rauskolb,C., Wilson,R., Prabhakaran,B., Irvine,K.D.
            and Vogt,T.F.
  TITLE     A family of mammalian Fringe genes implicated in boundary
            determination and the Notch pathway
  JOURNAL   Development 124 (11), 2245-2254 (1997)
   PUBMED   9187150
REFERENCE   8  (bases 1 to 5493)
  AUTHORS   Mitsiadis,T.A., Henrique,D., Thesleff,I. and Lendahl,U.
  TITLE     Mouse Serrate-1 (Jagged-1): expression in the developing tooth is
            regulated by epithelial-mesenchymal interactions and fibroblast
            growth factor-4
  JOURNAL   Development 124 (8), 1473-1483 (1997)
   PUBMED   9108364
REFERENCE   9  (bases 1 to 5493)
  AUTHORS   Zimrin,A.B., Pepper,M.S., McMahon,G.A., Nguyen,F., Montesano,R. and
            Maciag,T.
  TITLE     An antisense oligonucleotide to the notch ligand jagged enhances
            fibroblast growth factor-induced angiogenesis in vitro
  JOURNAL   J Biol Chem 271 (51), 32499-32502 (1996)
   PUBMED   8955070
REFERENCE   10 (bases 1 to 5493)
  AUTHORS   Lindsell,C.E., Boulter,J., diSibio,G., Gossler,A. and Weinmaster,G.
  TITLE     Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3
            genes identify ligand-receptor pairs that may function in neural
            development
  JOURNAL   Mol Cell Neurosci 8 (1), 14-27 (1996)
   PUBMED   8923452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL713981.17.
            
            On Mar 19, 2011 this sequence version replaced NM_013822.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF171092.1, BC058675.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               AL713981.17        96066-96409         c
            345-650             AL713981.17        95293-95598         c
            651-702             AL713981.17        86756-86807         c
            703-957             AL713981.17        81470-81724         c
            958-1018            AL713981.17        79945-80005         c
            1019-1149           AL713981.17        76082-76212         c
            1150-1269           AL713981.17        75336-75455         c
            1270-1383           AL713981.17        74342-74455         c
            1384-1497           AL713981.17        73096-73209         c
            1498-1611           AL713981.17        72386-72499         c
            1612-1658           AL713981.17        71839-71885         c
            1659-1832           AL713981.17        71325-71498         c
            1833-1983           AL713981.17        70744-70894         c
            1984-2148           AL713981.17        69654-69818         c
            2149-2262           AL713981.17        69101-69214         c
            2263-2376           AL713981.17        68486-68599         c
            2377-2490           AL713981.17        68285-68398         c
            2491-2607           AL713981.17        68001-68117         c
            2608-2635           AL713981.17        67505-67532         c
            2636-2721           AL713981.17        66966-67051         c
            2722-2835           AL713981.17        65807-65920         c
            2836-2945           AL713981.17        65135-65244         c
            2946-3179           AL713981.17        64811-65044         c
            3180-3311           AL713981.17        64464-64595         c
            3312-3462           AL713981.17        64171-64321         c
            3463-5493           AL713981.17        61340-63370         c
FEATURES             Location/Qualifiers
     source          1..5493
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..5493
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /note="jagged 1"
                     /db_xref="GeneID:16449"
                     /db_xref="MGI:MGI:1095416"
     exon            1..344
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..3920
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /note="Serrate-1; protein jagged-1"
                     /codon_start=1
                     /product="protein jagged-1 precursor"
                     /protein_id="NP_038850.1"
                     /db_xref="CCDS:CCDS16797.1"
                     /db_xref="GeneID:16449"
                     /db_xref="MGI:MGI:1095416"
                     /translation="MRSPRTRGRPGRPLSLLLALLCALRAKVCGASGQFELEILSMQN
                     VNGELQNGNCCGGVRNPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVI
                     GGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLLVEAWDSSNDTIQPDSIIEKASHSGM
                     INPSRQWQTLKQNTGIAHFEYQIRVTCDDHYYGFGCNKFCRPRDDFFGHYACDQNGNK
                     TCMEGWMGPDCNKAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGTC
                     NEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNRGTCSNTGPDKYQCSCPEGYSGPNCE
                     IAEHACLSDPCHNRGSCKETSSGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDL
                     VNGFKCVCPPQWTGKTCQLDANECEAKPCVNARSCKNLIASYYCDCLPGWMGQNCDIN
                     INDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINR
                     FQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDH
                     CRTTTCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGT
                     YCHENINDCESNPCKNGGTCIDGVNSYKCICSDGWEGAHCENNINDCSQNPCHYGGTC
                     RDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEVDTFKCMCPGGWEGTTC
                     NIARNSSCLPNPCHNGGTCVVNGDSFTCVCKEGWEGPICTQNTNDCSPHPCYNSGTCV
                     DGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYQCICPPGHSGAKCH
                     EVSGRSCITMGRVILDGAKWDDDCNTCQCLNGRVACSKVWCGPRPCRLHKSHNECPSG
                     QSCIPVLDDQCFVRPCTGVGECRSSSLQPVKTKCTSDSYYQDNCANITFTFNKEMMSP
                     GLTTEHICSELRNLNILKNVSAEYSIYIACEPSLSANNEIHVAISAEDIRDDGNPVKE
                     ITDKIIDLVSKRDGNSSLIAAVAEVRVQRRPLKNRTDFLVPLLSSVLTVAWVCCLVTA
                     FYWCVRKRRKPSSHTHSAPEDNTTNNVREQLNQIKNPIEKHGANTVPIKDYENKNSKM
                     SKIRTHNSEVEEDDMDKHQQKVRFAKQPVYTLVDREEKAPSGTPTKHPNWTNKQDNRD
                     LESAQSLNRMEYIV"
     exon            345..650
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            651..702
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..957
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1018
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1149
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1269
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1383
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1497
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1611
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1658
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1832
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1983
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2148
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2262
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2376
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2490
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2607
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2635
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2721
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2835
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2945
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3179
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3311
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..3462
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..5493
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5440..5445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /note="hexamer: AATAAA"
     polyA_site      5458
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /note="major polyA site"
     regulatory      5464..5469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /note="hexamer: ATTAAA"
     polyA_site      5491
                     /gene="Jag1"
                     /gene_synonym="ABE2; Gena228; Gsfabe2; Htu; Ozz; Ser-1"
                     /note="major polyA site"
ORIGIN      
        1 agaggtggaa gaggggggag cgcctcaaag aagcgatcag aataataaaa ggaggccggg
       61 ctctttgcct tctggaacgc gcggctcttg aaagggcttt tgaaaagtag tgttgttttc
      121 cagtcgtgca tgctccaatc cacggagtat attagagccg ggacgcggcg gccgcggggg
      181 cagcgacgac ggcagcctcg gcgggagcac cagcgctagc agcggcggcg gcgtccggag
      241 tgcccgtggc gcgcggcgca gcgatgcggt ccccacggac gcgcggccgg cccgggcgcc
      301 ccctgagtct tctgctcgcc ctgctctgtg ccctgcgagc caaggtgtgc ggggcctcgg
      361 gtcagtttga gctggagatc ctgtccatgc agaacgtgaa tggagagcta cagaatggga
      421 actgttgtgg tggagtccgg aaccctggcg accgcaagtg cacccgcgac gagtgtgata
      481 cgtacttcaa agtgtgcctc aaggagtatc agtcccgcgt cactgccggg ggaccctgca
      541 gcttcggctc agggtctacg cctgtcatcg ggggtaacac cttcaatctc aaggccagcc
      601 gtggcaacga ccgtaatcgc atcgtactgc ctttcagttt cgcctggccg aggtcctaca
      661 ctttgctggt ggaggcctgg gattccagta atgacactat tcaacctgat agcataattg
      721 aaaaggcttc tcactcaggc atgataaacc ctagccggca atggcagaca ctgaaacaaa
      781 acacagggat tgcccacttc gagtatcaga tccgagtgac ctgtgatgac cactactatg
      841 gctttggctg caataagttc tgtcgtccca gagatgactt ctttggacat tatgcctgtg
      901 accagaacgg caacaaaact tgcatggaag gctggatggg tcctgattgc aacaaagcta
      961 tctgccgaca gggctgcagt cccaagcatg ggtcttgtaa acttccaggt gactgcaggt
     1021 gccagtacgg ttggcagggc ctgtactgcg acaagtgcat cccgcaccca ggatgtgtcc
     1081 acggcacctg caatgaaccc tggcagtgcc tctgtgagac caactggggt ggacagctct
     1141 gtgacaaaga tctgaattac tgtgggactc atcagccctg tctcaaccgg ggaacatgta
     1201 gcaacactgg gcctgacaaa taccagtgct cctgcccaga gggctactcg ggccccaact
     1261 gtgaaattgc tgagcatgct tgtctctctg acccctgcca taaccgaggc agctgcaagg
     1321 agacctcctc aggctttgag tgtgagtgtt ctccaggctg gactggcccc acgtgttcca
     1381 caaacatcga tgactgttct ccaaataact gttcccatgg gggcacctgc caggatctgg
     1441 tgaatggatt caagtgtgtg tgcccgcccc agtggactgg caagacttgt cagttagatg
     1501 caaatgagtg cgaggccaaa ccttgtgtaa atgccagatc ctgtaagaat ctgattgcca
     1561 gctactactg tgattgcctt cctggctgga tgggtcagaa ctgtgacata aatatcaatg
     1621 actgccttgg ccagtgtcag aatgacgcct cctgtcggga tttggttaat ggttatcgct
     1681 gtatctgtcc acctggctat gcaggcgatc actgtgagag agacatcgat gagtgtgcta
     1741 gcaacccctg cttgaatggg ggtcactgtc agaatgaaat caacagattc cagtgtctct
     1801 gtcccactgg tttctctgga aacctctgtc agctggacat cgattactgc gagcccaacc
     1861 cttgccagaa tggcgcccag tgctacaatc gtgccagtga ctatttctgc aagtgccccg
     1921 aggactatga gggcaagaac tgctcacacc tgaaagacca ctgccgtacc accacctgcg
     1981 aagtgattga cagctgcact gtggccatgg cctccaacga cacgcctgaa ggggtgcggt
     2041 atatctcttc taacgtctgt ggtccccatg ggaagtgcaa gagccagtcg ggaggcaaat
     2101 tcacctgtga ctgtaacaaa ggcttcaccg gcacctactg ccatgaaaat atcaacgact
     2161 gcgagagcaa cccctgtaaa aacggtggca cctgcatcga tggcgttaac tcctacaagt
     2221 gtatctgtag tgacggctgg gagggagcgc actgtgagaa caacataaat gactgtagcc
     2281 agaacccttg tcactacggg ggtacatgtc gagacctggt caatgacttt tactgtgact
     2341 gcaaaaatgg ctggaaagga aagacttgcc attcccgtga cagccagtgt gacgaagcca
     2401 cgtgtaataa tggtggtacc tgctatgatg aagtggacac gtttaagtgc atgtgtcccg
     2461 gtggctggga aggaacaacc tgtaatatag ctagaaacag tagctgcctg ccgaacccct
     2521 gtcataatgg aggtacctgc gtggtcaatg gagactcctt cacctgtgtc tgcaaagaag
     2581 gctgggaggg gcctatttgt actcaaaata ccaacgactg cagtccccat ccttgttaca
     2641 atagcgggac ctgtgtggac ggagacaact ggtatcggtg cgaatgtgcc ccgggttttg
     2701 ctgggccaga ctgcaggata aacatcaatg agtgccagtc ttccccttgt gcctttgggg
     2761 ccacctgtgt ggatgagatc aatggctacc agtgtatctg ccctccagga catagtggtg
     2821 ccaagtgcca tgaagtttca gggcgatctt gcatcaccat ggggagagtg atacttgatg
     2881 gggccaagtg ggatgatgac tgtaacacct gccagtgcct gaatggacgg gtggcctgct
     2941 ccaaggtctg gtgtggcccg agaccttgca ggctccacaa aagccacaat gagtgcccca
     3001 gtgggcagag ctgcatcccg gtcctggatg accagtgttt cgtgcgcccc tgcactggtg
     3061 ttggcgagtg tcggtcctcc agcctccagc cagtgaagac caagtgcaca tctgactcct
     3121 attaccagga taactgtgca aacatcactt tcacctttaa caaagagatg atgtctccag
     3181 gtcttaccac cgaacacatt tgcagcgaat tgaggaattt gaatatcctg aagaatgttt
     3241 ctgctgaata ttcgatctac atagcctgtg agccttccct gtcagcaaac aatgaaatac
     3301 acgtggccat ctctgcagaa gacatccggg atgatgggaa ccctgtcaag gaaattaccg
     3361 ataaaataat agatctcgtt agtaaacggg atggaaacag ctcacttatt gctgcggttg
     3421 cagaagtcag agttcagagg cgtcctctga aaaacagaac agatttcctg gttcctctgc
     3481 tgagctctgt cttaacagtg gcttgggtct gttgcttggt gacagccttc tactggtgtg
     3541 taaggaagcg gcggaagccc agcagccaca ctcactccgc ccccgaggac aacaccacca
     3601 acaatgtgcg ggagcagctg aaccaaatca aaaaccccat cgagaaacac ggagccaaca
     3661 cggtccccat taaggattac gagaacaaaa actcgaaaat gtcaaaaatc aggacacaca
     3721 actcggaagt ggaggaggat gacatggata aacaccagca gaaagtccgc tttgccaaac
     3781 agccagtgta tacgctggta gacagagagg agaaggcccc cagcggcacg ccgacaaaac
     3841 acccgaactg gacaaataaa caggacaaca gagacttgga aagtgcccag agcttgaacc
     3901 ggatggaata catcgtatag cagacagtgg gctgccgcca taggtagagt ttgagggcac
     3961 cgcggggctt gtagtttctt taaactgttg tcctattcca gtctgaggct gttgttgact
     4021 tagaatcctg tgttaattta agtttcgaca agctggcttc cactggcact ggtagtttct
     4081 gtggttggct gggaaattga gtgcagcgct ctcacagcta tgcaaaaact agtgaatgtg
     4141 ccctggtgtc cattcccctg ccgcagacac atcgggctcc caggagctgc ccagccctag
     4201 gcctggagct tccacatctg ccagcggtcc taatggtgat ggcagcctta ggatcatagt
     4261 tttatttata tttattgact cttgagttgt ttttgtatat tggttttatg atgacgttcg
     4321 agtagttctg tatttgaaag tgcctttgca gctcagaacc acagcaacta tcacaaatga
     4381 ctttattatt tatttttttt tattgtattt ttgttgttgg gggagggggg atttgatgtc
     4441 agcagttgct ggtaaaatga agaatttaaa gaggaaaaat gtgtcaaagt agaatttttg
     4501 tatagttatg taaataattc tttttttatt aatcactgtg tatatttgat ttattaactt
     4561 aataatcaag agccttaaaa catcattcct ttttatttat atgtatgtgt ttagaattga
     4621 aggtttttga tagtgttgta agcatatgac tctttttttt gtgaactttt ctcataacgt
     4681 gttgcctgta agccaaaatt aaggtgtttg gaaatagttt ctcttgaaag gatgggatag
     4741 gctttttccc ctgggaatac tgatggaatt tttttttttt tttttttttt tgtacgacgt
     4801 caggtgttga aacacttcct tgatagcatc actttaagtt taagacacat tttaaggact
     4861 gactgaggca gattaagaat tgctctagaa caggtttctt tctttctttt tttttttttt
     4921 ttcctctttc tttcctgctt tagacttgaa aagagacagg caggcgatct gctacagagc
     4981 agtcagtttt aagggaacag actgagctat atgacttatg tagccagaaa gtgactggtt
     5041 gaatctcatt acaaatatca aattaattgt gtgaagttgg aagcatccca atcttacttt
     5101 gtaaattctg atttattttc accattcgtt atgtaatgct gaaccacttg tagacttgat
     5161 ttcgttgttg ttgtctactg catttaggga gtattctcat aagctagttg aatacttgaa
     5221 ccgtaaaatg tccagttaga tcactgttta gatttgccgt agagtacact gcctgcctta
     5281 agtgaggaaa tcaaagtgct attaccaagc tcaagatcaa aaaaaaggct tataaaacag
     5341 agtgatccag gttcaccacc gggactgggg agatacttgg tgtttgttct attagtgtta
     5401 tatgaacaga aaatacatct ttgatgtgtt gttcctggca ataaattttg aaaagtaata
     5461 tttattaaat tttttgtatg aaaacatgga aca
//
