LOCUS       NM_001357588            6360 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus jade family PHD finger 2 (Jade2), transcript variant
            1, mRNA.
ACCESSION   NM_001357588 XM_006534466
VERSION     NM_001357588.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6360)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6360)
  AUTHORS   Fan,M., Liu,Y., Shang,Y., Xue,Y., Liang,J. and Huang,Z.
  TITLE     JADE2 Is Essential for Hippocampal Synaptic Plasticity and
            Cognitive Functions in Mice
  JOURNAL   Biol Psychiatry 92 (10), 800-814 (2022)
   PUBMED   36008159
  REMARK    GeneRIF: JADE2 Is Essential for Hippocampal Synaptic Plasticity and
            Cognitive Functions in Mice.
REFERENCE   3  (bases 1 to 6360)
  AUTHORS   Han,X., Gui,B., Xiong,C., Zhao,L., Liang,J., Sun,L., Yang,X.,
            Yu,W., Si,W., Yan,R., Yi,X., Zhang,D., Li,W., Li,L., Yang,J.,
            Wang,Y., Sun,Y.E., Zhang,D., Meng,A. and Shang,Y.
  TITLE     Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking
            system in neural development
  JOURNAL   Mol Cell 55 (3), 482-494 (2014)
   PUBMED   25018020
  REMARK    GeneRIF: Results show that Jade-2 is a major LSD1 negative
            regulator during neurogenesis in vitro and in vivo in both mouse
            developing cerebral cortices and zebra fish embryos.
REFERENCE   4  (bases 1 to 6360)
  AUTHORS   Redshaw,N., Camps,C., Sharma,V., Motallebipour,M., Guzman-Ayala,M.,
            Oikonomopoulos,S., Thymiakou,E., Ragoussis,J. and Episkopou,V.
  TITLE     TGF-beta/Smad2/3 signaling directly regulates several miRNAs in
            mouse ES cells and early embryos
  JOURNAL   PLoS One 8 (1), e55186 (2013)
   PUBMED   23390484
REFERENCE   5  (bases 1 to 6360)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6360)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   7  (bases 1 to 6360)
  AUTHORS   Tzouanacou,E., Tweedie,S. and Wilson,V.
  TITLE     Identification of Jade1, a gene encoding a PHD zinc finger protein,
            in a gene trap mutagenesis screen for genes involved in
            anteroposterior axis development
  JOURNAL   Mol Cell Biol 23 (23), 8553-8552 (2003)
   PUBMED   14612400
REFERENCE   8  (bases 1 to 6360)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669920.15 and AL645602.14.
            
            On Nov 18, 2022 this sequence version replaced NM_001357588.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147453.1, SRR13422590.401753.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               AL669920.15        23023-23365         c
            344-431             AL669920.15        20592-20679         c
            432-489             AL669920.15        14706-14763         c
            490-584             AL669920.15        12318-12412         c
            585-742             AL645602.14        239768-239925       c
            743-903             AL645602.14        235448-235608       c
            904-1115            AL645602.14        234611-234822       c
            1116-1283           AL645602.14        232461-232628       c
            1284-1400           AL645602.14        230754-230870       c
            1401-1865           AL645602.14        229138-229602       c
            1866-1983           AL645602.14        225274-225391       c
            1984-2115           AL645602.14        222692-222823       c
            2116-6360           AL645602.14        217651-221895       c
FEATURES             Location/Qualifiers
     source          1..6360
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.5 cM"
     gene            1..6360
                     /gene="Jade2"
                     /gene_synonym="1200017K05Rik; mKIAA0239; Phf15"
                     /note="jade family PHD finger 2"
                     /db_xref="GeneID:76901"
                     /db_xref="MGI:MGI:1924151"
     exon            1..343
                     /gene="Jade2"
                     /gene_synonym="1200017K05Rik; mKIAA0239; Phf15"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..2921
                     /gene="Jade2"
                     /gene_synonym="1200017K05Rik; mKIAA0239; Phf15"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein Jade-2; PHD finger protein 15; jade family PHD
                     finger protein 2; E3 ubiquitin-protein ligase Jade-2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase Jade-2 isoform 1"
                     /protein_id="NP_001344517.1"
                     /db_xref="GeneID:76901"
                     /db_xref="MGI:MGI:1924151"
                     /translation="MRAPRPPAPAPGAPGFGSILPAPAPAAARSRGQRPSGGHRGARA
                     PGEHTSPPGPPVPSSLGGLGLAEQSTKQMEEKRRKYSISSDNSDTTDGHVTSTSASRC
                     SKLPSSTKSGWPRQNEKKPSEVFRTDLITAMKIPDSYQLSPDDYYILADPWRQEWEKG
                     VQVPAGAEAIPEPVVRLLPPLKGPPTQMSPDSPTLGEGAHPDWPGGSRYDLDEIDAYW
                     LELLNSELKEMEKPELDELTLERVLEELETLCHQNMAQAIETQEGLGIEYDEDVVCDV
                     CRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGSWLCRTCALGVQPKCLLCPKRGG
                     ALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKISHIPASRWALSCSLCKECTGT
                     CIQCSMPSCITAFHVTCAFDRGLEMRTILADNDEVKFKSLCQEHSDGGPRSEPTSEPV
                     EPSQAVEDLEKVTLRKQRLQQLEENFYELVEPAEVAERLDLAEALVDFIYQYWKLKRR
                     ANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVRNLCYMVTRRERTKH
                     TICKLQEQIFHLQMKLIEQDLCREPSGRRSKGKKNDSKRKGREGPKGSSPEKKEKVKA
                     GPESVLGQLGLSTSFPIDGTFFNSWLAQSVQITAEDMAMSEWSLNSGHREDPAPGLLS
                     EELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPSPLQDGPSARTTPDKQPK
                     KAWAQDGKGTQGPPMRKPPRRTSSHLPSSPAAGDCPVPATLESPPPLASEILDKTAPM
                     ASDLNVQVPGPTVSPKPLGRLRPPREMKVSRKSPGARSDAGTGLPSAVAERPKVSLHF
                     DTEADGYFSDEEMSDSEVEAEDSGVQRASREAGAEEVVRMGVLAS"
     exon            344..431
                     /gene="Jade2"
                     /gene_synonym="1200017K05Rik; mKIAA0239; Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            432..489
                     /gene="Jade2"
                     /gene_synonym="1200017K05Rik; mKIAA0239; Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            490..584
                     /gene="Jade2"
                     /gene_synonym="1200017K05Rik; mKIAA0239; Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            585..742
                     /gene="Jade2"
                     /gene_synonym="1200017K05Rik; mKIAA0239; Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            743..903
                     /gene="Jade2"
                     /gene_synonym="1200017K05Rik; mKIAA0239; Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1115
                     /gene="Jade2"
                     /gene_synonym="1200017K05Rik; mKIAA0239; Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1283
                     /gene="Jade2"
                     /gene_synonym="1200017K05Rik; mKIAA0239; Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1400
                     /gene="Jade2"
                     /gene_synonym="1200017K05Rik; mKIAA0239; Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1865
                     /gene="Jade2"
                     /gene_synonym="1200017K05Rik; mKIAA0239; Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1983
                     /gene="Jade2"
                     /gene_synonym="1200017K05Rik; mKIAA0239; Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2115
                     /gene="Jade2"
                     /gene_synonym="1200017K05Rik; mKIAA0239; Phf15"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..6360
                     /gene="Jade2"
                     /gene_synonym="1200017K05Rik; mKIAA0239; Phf15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6340..6345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jade2"
                     /gene_synonym="1200017K05Rik; mKIAA0239; Phf15"
                     /note="hexamer: AATAAA"
     polyA_site      6360
                     /gene="Jade2"
                     /gene_synonym="1200017K05Rik; mKIAA0239; Phf15"
                     /note="major polyA site"
ORIGIN      
        1 agaaacatac acagggggtt ggtgaatggt gccgaccgcg gccatcgcag ttggaggcta
       61 tttttttggg gggtgagtag cgtccatgga gttactttgc gcccactcct agtggcacca
      121 gctctgagct ggagggctga ccatcttccc agcaggggtg cggggcttgg ggggcgccgc
      181 ggcccggtcg cctccctcgc cacgaccccg gatggatgcg cgccccccgc cctcccgcgc
      241 cggccccagg agctcctggc ttcgggagca tccttcccgc gccggccccc gccgccgcgc
      301 gtagccgagg gcagcgcccc tcgggagggc accgcggagc aagggcccca ggcgaacaca
      361 ccagccctcc aggccctccg gtcccatctt ccttgggcgg gttaggactc gcagagcaat
      421 ctactaagca gatggaagag aagaggcgaa aatattccat cagcagcgac aactctgata
      481 ccactgacgg tcacgtgaca tccacatcag catcaagatg ttccaaactg cccagcagca
      541 ccaagtcggg ctggccccgg cagaacgaga agaagccctc agaggttttc cggacagact
      601 tgatcacagc catgaagatc ccagattcat accagctcag cccggatgac tactacatcc
      661 tggcggaccc gtggcgacaa gaatgggaga aaggggtgca ggtacctgct ggagcggagg
      721 ccattccaga gcctgtggtg aggctcctcc caccactgaa aggccccccc acgcagatgt
      781 ccccagatag ccccacactt ggtgagggtg cccatcctga ctggccagga ggcagccgct
      841 acgacctgga tgagatcgat gcgtactggt tggaacttct caactcggag ctcaaggaga
      901 tggagaagcc cgagctggat gagctaacgt tagagcgtgt tctagaggag ctagagacat
      961 tgtgccacca gaatatggca caggccattg agacacagga ggggctgggc atcgagtacg
     1021 acgaggacgt tgtctgcgac gtgtgccgtt cccctgaagg cgaggatggc aacgagatgg
     1081 tcttctgtga caaatgcaat gtctgtgtgc accaggcatg ctacgggatc ctcaaggtgc
     1141 ctacgggcag ctggctgtgc cggacctgtg ccctgggagt ccagcctaag tgcctgctct
     1201 gccccaagcg aggaggagcc ctgaagccca ctagaagtgg gaccaagtgg gtacacgtca
     1261 gctgtgccct gtggattcct gaggtcagca ttggctgtcc agagaagatg gagcccatta
     1321 ccaagatctc gcatattccg gccagccgct gggccctgtc ctgcagcctc tgcaaggagt
     1381 gcacaggtac ctgcatccag tgttccatgc cttcctgcat cacagcattc cacgttacgt
     1441 gcgcctttga ccgaggcctg gaaatgcgga ctatattagc tgacaatgac gaggtcaagt
     1501 tcaagtcact ttgccaggag cacagtgacg ggggccctcg gagtgagcct acttctgagc
     1561 ctgtggagcc cagccaggcc gttgaggatc tggaaaaggt gaccttacgc aagcagcggc
     1621 tgcagcagct ggaagaaaac ttctatgagc tagtggagcc agctgaggtg gctgaacggc
     1681 tagacctggc tgaggcactg gtggacttca tctaccagta ctggaagttg aagcggagag
     1741 ctaatgccaa ccagccgctg ttgacgccca agactgacga ggtggacaac ctggcccaac
     1801 aggaacagga tgtcctctat cgacgcctga agcttttcac ccacctgcgg caggacctgg
     1861 agagggtaag gaacctgtgc tacatggtga caagacggga gagaacgaaa cacaccatct
     1921 gtaaacttca ggagcagata ttccatctac agatgaaact tattgagcaa gacctttgca
     1981 gagagccttc tgggaggagg tcaaagggca agaagaatga ttcaaaaagg aaaggccgag
     2041 agggtcccaa gggcagcagc cctgagaaga aagagaaagt gaaggctggg cccgagtctg
     2101 tgctggggca gctgggtcta tccacctcgt tccccatcga cggcactttc ttcaacagct
     2161 ggttggcaca gtcggttcag atcacagcag aggacatggc catgagcgag tggtctttga
     2221 acagtgggca ccgggaggat cctgctccag gtctgctgtc agaggaattg ctacaagatg
     2281 aggagacgct gctcagcttc atgagggacc cctcgctacg acctggtgac cctgccagaa
     2341 aggcccgagg ccgcactcgc ctgcctgcca agaagaaacc atccccgctg caggatgggc
     2401 ccagtgcacg gaccactcca gacaagcaac ccaagaaggc ctgggcccag gatggcaagg
     2461 ggacgcaagg accacccatg aggaagccac cacggaggac gtcttctcat ttgccgtcca
     2521 gccctgcagc tggggactgt ccagtcccag caacactgga aagccctcca ccactggcct
     2581 ccgagatact agacaagaca gcccccatgg cttccgactt aaatgtccaa gtgcctggcc
     2641 ctacagtgag ccccaaaccc ttgggcaggc tccggccacc ccgagagatg aaggtcagtc
     2701 ggaaatctcc gggtgctaga tccgatgctg ggacaggact accgtctgct gtggccgaga
     2761 ggccaaaggt cagcctgcat tttgacaccg aggctgacgg ctacttctct gatgaggaga
     2821 tgagcgattc tgaggtagag gcagaggaca gtggggtaca acgagcttcc agggaggcag
     2881 gggcagagga ggtggttcgc atgggggtgc tggcctccta attcacccag gccctgccct
     2941 ggtcccccta caaggcctca gcccaatcac aactgccatt tccaactgct gagtgtctca
     3001 gacccaccac tctgtcgtgg ttttattttt aatatagaga gagttctgaa ttccaccccg
     3061 ttgtctttcc tctgtgctgg cctaggacat taggattcct cccgtggccc cggccacggg
     3121 ggactatacc aggttctatg tgccaccccg gtcccagccc atgccacatc gctgggcttc
     3181 tggcttgatg tagacaaggt gagggagaga gctcagggct cctgcccact gccattgggt
     3241 gacacagact gtcgtttggg cattatttca tggcagatgg gccatcccag ggcctgcccc
     3301 gccttgtccc cccaggttgc actggggtcc attttgggtg gggaggtgtc ctgctgcact
     3361 ccgctgatcc gtaaggaagt atataacaag tgatacccag ccagtctatt cactgtcaca
     3421 agcacaacga gtctctatga gaaagcactg agggggcgca gggggcccac tggctcctga
     3481 gtagcccaca ccatctgagg cccgccctcc cgcccgcccg caacccctcc tcccttgctg
     3541 ctctgtccct gccagtgccc agcccaagca gctctgagaa agggttccct ggatccttcc
     3601 tgagctgtgt tctttactca ggggactccc caaacggtcc tccccgtgta caggtggagg
     3661 gctccaaggg agggccagtg cccagcccgg gacttggggc tcagatcagc ccactgcaga
     3721 gaatcactct ggggctctaa cttccttctt tcttcctttg gggccagtct cggccacagt
     3781 cttgccgtct ccattatgga gctggccaga ccagaccgtt tgccttttga cgtttcctag
     3841 tcctgctaag agatgagctt cctcttcggt ttcctggtgg aaacatcctt ccaacaagtg
     3901 tagtgggatc ccggggccca gggcaggccg aggctggcct gctgtggctg gttgaatgtt
     3961 gctggatctt cctggattac tctgtccctt agcgccttaa cccctttcct tccctactgt
     4021 acgccccccc ttcctactcc ttcccaaatc cttcctcctc caagccccca ggtagtactg
     4081 aagagttttg atggagtggc cccagggtga tagatagctc agggaacaaa ggaattccgt
     4141 gaaaacattt ttttttttct tttatgaatt actcttgggt cacttctgcc actgggaaag
     4201 ccagaacttc tccaaccaga accttgcaaa agtccagtga accagtcgaa tcattctgag
     4261 aatgccaaag aatcttttga ccataataca cagcacagcc cggacctgac aactgtcgac
     4321 ttgaacttcc tcttcaaagg aattggttag caacaaagtt cagagactcg gttattgcac
     4381 acacctacag agaaagggcc caaggcctca gaggaggccg ccgctgctgc tgctgctgtt
     4441 ggtttacggt ccctgggctg agccgctgtg agtgtggtcc taaactttga ggactccctc
     4501 ccccttttga gggggggaga accctgactg tgaatccagc gtggttcccc cattgccacc
     4561 acttagatac acaaagagca aaacacacgg gaccttcacc cacctcgact ccaaaactat
     4621 caaggtacga cagtgagttt gagcaaaatc agaagcaaag attaatgact tcagtttggg
     4681 gattggacac acgtgtctta tccaaatgga ctccgagggc gtggggtggg ctccaaggat
     4741 cctgggcatc cggatggcat cggctaccac atagacttag tctgcctgcc cgtctcggta
     4801 gtagtgacaa ctcagtcgac gtcggcatcc cccgccccgt ctcttgttta ctgcctctga
     4861 acagaccttc ctctcacctg tgctttgagt cacttcgggt cgcaatttca tctgctgaac
     4921 tgcctggtgg tctgacctgt gggacacgaa gggcatgggg gcttaaagaa caatcaaacg
     4981 ctgcaggggg agggagggaa gcccagttgt tgtctgtgac cccttcagta gaccgagccc
     5041 acggcagtct tcatccagca gctgtctcca ctcctaagat gtccatcagg ctgcagggag
     5101 gatgcggatg tcccataacc tctccctagt tcctcccagg ccacactgtc tcgggtgtag
     5161 atggttttgc cacactatga ccaaggcacc ttttccaggc ctgaggcaat gcccactctt
     5221 gccctcaccc acaacccctc tctagagagg gagaaaggac tctgtgactc gttctggcta
     5281 acgtacccct tccacctcat ttcctcatca caggatacag gctaatgtgc aaggaaagta
     5341 tttttctgta tcataagtgt attttgaaac aagtaaaaga aagatagaat gctcgtttac
     5401 tttattaaat gggctctgat tttgtgaaag gcgagagagt gagttaaggg cctcaggttt
     5461 gttggagaag ccaaccaccc aggttcccgg gcatgggtgt cggactgtgt gcgtgcgtgt
     5521 agcagagtgc tgtgcaggtg tatgtgcaat gcatgggtac cctatgaaac ttgttggggt
     5581 ttctagagat tcaactgcct gattctacag gaatatggca gcaggttaga ctttgggttt
     5641 cctcaccgtt gtcatgtaag gtcacccttt gcccatacct gaagctctgc ataacaatcc
     5701 gtgatctctg tagtaagacc cttgaggcca ctctcccgtg cccttggccc agctggccac
     5761 attggccaaa gagccagaag tgttggagtc ggggaccttt ggttgttctt taagccgctt
     5821 cctgctgcct tctcccaagg atgcacgctt gtgctccatc caaatcattt ggggatggtg
     5881 gtggggaagg tgatatgaat gtcacaggag gagacacctt ctgtctttgt ttcaaagaaa
     5941 gtgatgtgcc atttgttaat atacaagaga aatattgaaa aaatatattg aaaagagcaa
     6001 ttttaaatta tttttggctt atgttgcaat atttattttc ttgtattaga gaagatttct
     6061 ttgtagagaa aaatgtattt ttcattaccg caaagaccta tttctccttt ttgtacattg
     6121 tccttgttcg cgacccttaa cgagcaatag aatgttcggt cacccctgcg tggccagtgc
     6181 ccactgtgcc ctgcatgatt gtgttgctgc tgctgctgct gcatagtttc tggccccgtc
     6241 ccgtcctgct cactcactgg ggcatccgga ttgccggccc ccaccagggt ctgtgtctaa
     6301 ggagcccaca gcactcctca tgtgttggca aactcggtta ataaagcaat gttctctgtg
//
