LOCUS       NM_001368390             739 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus IZUMO family member 2 (Izumo2), transcript variant 2,
            mRNA.
ACCESSION   NM_001368390 XM_006541238
VERSION     NM_001368390.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 739)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC150895.2.
            
            On Feb 9, 2019 this sequence version replaced XM_006541238.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA463022.1, SRR5189685.313216.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               AC150895.2         61572-61816         c
            246-320             AC150895.2         61416-61490         c
            321-407             AC150895.2         60205-60291         c
            408-428             AC150895.2         60015-60035         c
            429-509             AC150895.2         57468-57548         c
            510-633             AC150895.2         55095-55218         c
            634-739             AC150895.2         50698-50803         c
FEATURES             Location/Qualifiers
     source          1..739
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.89 cM"
     gene            1..739
                     /gene="Izumo2"
                     /gene_synonym="1700023D19Rik"
                     /note="IZUMO family member 2"
                     /db_xref="GeneID:75510"
                     /db_xref="MGI:MGI:1922760"
     exon            1..245
                     /gene="Izumo2"
                     /gene_synonym="1700023D19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..676
                     /gene="Izumo2"
                     /gene_synonym="1700023D19Rik"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; izumo sperm-egg fusion protein 2"
                     /codon_start=1
                     /product="izumo sperm-egg fusion protein 2 isoform 2
                     precursor"
                     /protein_id="NP_001355319.1"
                     /db_xref="GeneID:75510"
                     /db_xref="MGI:MGI:1922760"
                     /translation="MPLALALVLLCGLGGPGAWGCLQCDQSVLLELRQLRDAIVTKRF
                     HLEGLQARAQALLLSMEGPFFRDYAMNAFVGKVVVDQLEKVATSFKNQAQYIKANSKT
                     DVPLLEELVSFREHAIKELKGALRDYEMKACDHKTCHSFKAEVLDCLYCKKTMPKCVK
                     KKYCFEDGQFRMTLKFQDDNKPRNMVLVGDLVTVGLAILTFLVILIAACTYRQNRKLL
                     LK"
     exon            246..320
                     /gene="Izumo2"
                     /gene_synonym="1700023D19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            321..407
                     /gene="Izumo2"
                     /gene_synonym="1700023D19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            408..428
                     /gene="Izumo2"
                     /gene_synonym="1700023D19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            429..509
                     /gene="Izumo2"
                     /gene_synonym="1700023D19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            510..633
                     /gene="Izumo2"
                     /gene_synonym="1700023D19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            634..739
                     /gene="Izumo2"
                     /gene_synonym="1700023D19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      706..711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Izumo2"
                     /gene_synonym="1700023D19Rik"
                     /note="hexamer: AATAAA"
     regulatory      715..720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Izumo2"
                     /gene_synonym="1700023D19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      725
                     /gene="Izumo2"
                     /gene_synonym="1700023D19Rik"
                     /note="major polyA site"
     polyA_site      739
                     /gene="Izumo2"
                     /gene_synonym="1700023D19Rik"
                     /note="major polyA site"
ORIGIN      
        1 caaagtcccc accatgcctt tggccttggc cctggtgctt ttgtgtggcc tgggcggccc
       61 cggggcatgg ggctgcctgc agtgcgacca gtcagtgcta ctggagctca ggcagttgcg
      121 tgatgccatc gtcaccaagc gcttccatct ggaagggctg caggcgcgcg cgcaggccct
      181 gctgttgagc atggaggggc ctttcttcag ggactatgca atgaacgctt tcgtggggaa
      241 agtggtcgtg gatcaactgg aaaaagtggc gacatccttc aagaaccaag cccagtatat
      301 aaaggctaac tctaagacag acgttcctct gctggaagag ctggtgagct tcagggaaca
      361 tgccatcaag gaactaaagg gagcattaag agactatgaa atgaaagcct gtgaccacaa
      421 aacttgtcac tcgttcaaag cggaggtcct ggactgttta tattgcaaga aaaccatgcc
      481 caagtgcgtc aagaaaaagt actgctttga ggatgggcag ttccgcatga ctctgaagtt
      541 ccaggacgac aacaaaccaa ggaacatggt attggtggga gacttggtga ctgtaggatt
      601 ggccatccta accttcttgg tcatcctgat tgcggcttgt acctacaggc aaaaccggaa
      661 actcctgctg aagtaggcca gagactttgg tgtttgtaaa aggaaaataa atttaataaa
      721 atctgtgtga attctttaa
//
