LOCUS       NM_022888               1126 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus IZUMO1 receptor, JUNO (Izumo1r), transcript variant 1,
            mRNA.
ACCESSION   NM_022888
VERSION     NM_022888.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1126)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1126)
  AUTHORS   Alfar,R., Napoleon,J.V., Shahriar,I., Finnell,R., Walchle,C.,
            Johnson,A. and Low,P.S.
  TITLE     Selective reprogramming of regulatory T cells in solid tumors can
            strongly enhance or inhibit tumor growth
  JOURNAL   Front Immunol 14, 1274199 (2023)
   PUBMED   37928524
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1126)
  AUTHORS   Zarin,P., Shwartz,Y., Ortiz-Lopez,A., Hanna,B.S., Sassone-Corsi,M.,
            Hsu,Y.C., Mathis,D. and Benoist,C.
  TITLE     Treg cells require Izumo1R to regulate gammadeltaT cell-driven
            inflammation in the skin
  JOURNAL   Proc Natl Acad Sci U S A 120 (14), e2221255120 (2023)
   PUBMED   36972453
  REMARK    GeneRIF: Treg cells require Izumo1R to regulate gammadeltaT
            cell-driven inflammation in the skin.
REFERENCE   4  (bases 1 to 1126)
  AUTHORS   Brukman,N.G., Nakajima,K.P., Valansi,C., Flyak,K., Li,X.,
            Higashiyama,T. and Podbilewicz,B.
  TITLE     A novel function for the sperm adhesion protein IZUMO1 in cell-cell
            fusion
  JOURNAL   J Cell Biol 222 (2) (2023)
   PUBMED   36394541
REFERENCE   5  (bases 1 to 1126)
  AUTHORS   Wang,H., Hong,X. and Kinsey,W.H.
  TITLE     Sperm-oocyte signaling: the role of IZUMO1R and CD9 in PTK2B
            activation and actin remodeling at the sperm binding sitedagger
  JOURNAL   Biol Reprod 104 (6), 1292-1301 (2021)
   PUBMED   33724343
  REMARK    GeneRIF: Sperm-oocyte signaling: the role of IZUMO1R and CD9 in
            PTK2B activation and actin remodeling at the sperm binding
            sitedagger.
REFERENCE   6  (bases 1 to 1126)
  AUTHORS   Tian,Y., Wu,G., Xing,J.C., Tang,J., Zhang,Y., Huang,Z.M., Jia,Z.C.,
            Zhao,R., Tian,Z.Q., Wang,S.F., Chen,X.L., Wang,L., Wu,Y.Z. and
            Ni,B.
  TITLE     A novel splice variant of folate receptor 4 predominantly expressed
            in regulatory T cells
  JOURNAL   BMC Immunol 13, 30 (2012)
   PUBMED   22694797
  REMARK    GeneRIF: This study describes a novel FR4 transcript variant,
            FR4D3, in which exon 3 is deleted. The mRNA of FR4D3 encodes a FR4
            variant truncated by 189 bp. FR4D3 was found to be predominantly
            expressed in CD4(+)CD25(+) Treg cells.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1126)
  AUTHORS   Cherukad,J., Wainwright,V. and Watson,E.D.
  TITLE     Spatial and temporal expression of folate-related transporters and
            metabolic enzymes during mouse placental development
  JOURNAL   Placenta 33 (5), 440-448 (2012)
   PUBMED   22365888
REFERENCE   8  (bases 1 to 1126)
  AUTHORS   Jia,Z., Zhao,R., Tian,Y., Huang,Z., Tian,Z., Shen,Z., Wang,Q.,
            Wang,J., Fu,X. and Wu,Y.
  TITLE     A novel splice variant of FR4 predominantly expressed in CD4+CD25+
            regulatory T cells
  JOURNAL   Immunol Invest 38 (8), 718-729 (2009)
   PUBMED   19860584
  REMARK    GeneRIF: novel splice variant of FR4 predominantly expressed in
            CD4+CD25+ regulatory T cells
REFERENCE   9  (bases 1 to 1126)
  AUTHORS   Yamaguchi,T., Hirota,K., Nagahama,K., Ohkawa,K., Takahashi,T.,
            Nomura,T. and Sakaguchi,S.
  TITLE     Control of immune responses by antigen-specific regulatory T cells
            expressing the folate receptor
  JOURNAL   Immunity 27 (1), 145-159 (2007)
   PUBMED   17613255
  REMARK    GeneRIF: Regulatory T cells (Treg) express high amounts of folate
            receptor 4, which distinguishes Treg from other naive or activated
            T cells.
REFERENCE   10 (bases 1 to 1126)
  AUTHORS   Spiegelstein,O., Eudy,J.D. and Finnell,R.H.
  TITLE     Identification of two putative novel folate receptor genes in
            humans and mouse
  JOURNAL   Gene 258 (1-2), 117-125 (2000)
   PUBMED   11111049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC136743.5.
            
            On Jan 3, 2020 this sequence version replaced NM_022888.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028431.1, AF250145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC136743.5         193737-193791       c
            56-196              AC136743.5         192407-192547       c
            197-385             AC136743.5         191672-191860       c
            386-524             AC136743.5         190757-190895       c
            525-1126            AC136743.5         190047-190648       c
FEATURES             Location/Qualifiers
     source          1..1126
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 4.42 cM"
     gene            1..1126
                     /gene="Izumo1r"
                     /gene_synonym="0910001L11Rik; Folbp3; Folr4; Juno"
                     /note="IZUMO1 receptor, JUNO"
                     /db_xref="GeneID:64931"
                     /db_xref="MGI:MGI:1929185"
     exon            1..55
                     /gene="Izumo1r"
                     /gene_synonym="0910001L11Rik; Folbp3; Folr4; Juno"
                     /inference="alignment:Splign:2.1.0"
     exon            56..196
                     /gene="Izumo1r"
                     /gene_synonym="0910001L11Rik; Folbp3; Folr4; Juno"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..793
                     /gene="Izumo1r"
                     /gene_synonym="0910001L11Rik; Folbp3; Folr4; Juno"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; probable folate receptor delta; FR-delta;
                     folate-binding protein 3; sperm-egg fusion protein Juno;
                     folate receptor 4 (delta); IZUMO1 receptor protein JUNO"
                     /codon_start=1
                     /product="sperm-egg fusion protein Juno isoform 1
                     precursor"
                     /protein_id="NP_075026.1"
                     /db_xref="CCDS:CCDS22831.1"
                     /db_xref="GeneID:64931"
                     /db_xref="MGI:MGI:1929185"
                     /translation="MAQWWQILLGLWAVLPTLAGDKLLSVCMNSKRHKQEPGPEDELY
                     QECRPWEDNACCTRSTSWEAHLEEPLLFNFSMMHCGLLTPACRKHFIQAICFHECSPN
                     LGPWIQPVVPNGQEEQRVWGVPLCQEDCEDWWRACHSSLTCKSNWLHGWDWSEEKKHC
                     PAHEPCLPFSYHFPTPDDLCEKIWNNTFKASPERRNSGRCLQKWFEPTLSNPNVEVAL
                     HFAGSALAPQLSYTLPAFSLCLLFHP"
     exon            197..385
                     /gene="Izumo1r"
                     /gene_synonym="0910001L11Rik; Folbp3; Folr4; Juno"
                     /inference="alignment:Splign:2.1.0"
     exon            386..524
                     /gene="Izumo1r"
                     /gene_synonym="0910001L11Rik; Folbp3; Folr4; Juno"
                     /inference="alignment:Splign:2.1.0"
     exon            525..1126
                     /gene="Izumo1r"
                     /gene_synonym="0910001L11Rik; Folbp3; Folr4; Juno"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1105..1110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Izumo1r"
                     /gene_synonym="0910001L11Rik; Folbp3; Folr4; Juno"
                     /note="hexamer: AATAAA"
     polyA_site      1126
                     /gene="Izumo1r"
                     /gene_synonym="0910001L11Rik; Folbp3; Folr4; Juno"
                     /note="major polyA site"
ORIGIN      
        1 agcccgctca cctctttggc atcaggagga gcaacaggag ggccctgcct tgaaggtcat
       61 ggcacagtgg tggcagatcc tcttggggtt gtgggcagtc ctacccacct tggcagggga
      121 caaactgctc agcgtctgca tgaattccaa gcgccacaag caagaacctg gcccagaaga
      181 cgaactctac caggagtgca ggccttggga ggacaatgcc tgctgcacac gttccacaag
      241 ttgggaagcc caccttgagg agcccttgct ctttaacttc agcatgatgc actgtggact
      301 gctgaccccg gcctgtcgca agcacttcat ccaggccatc tgcttccatg agtgttcccc
      361 caacctgggg ccttggatcc agccggtggt cccaaacggg caggaagagc agcgggtttg
      421 gggcgtgccg ctgtgccagg aggattgtga ggactggtgg cgagcctgcc actcatcttt
      481 gacttgtaaa tccaactggc tccatggctg ggactggagt gaggagaaga aacactgccc
      541 cgcacatgag ccctgcctcc ctttttcgta tcacttcccc accccggatg acctgtgtga
      601 gaagatctgg aacaacacat tcaaggccag tcccgagcgc aggaacagtg ggcggtgtct
      661 gcagaagtgg tttgagccca cccttagcaa ccccaacgtg gaagtggccc tccactttgc
      721 cggctctgcc ttagccccac agctctctta caccctccca gccttctctc tgtgcctgtt
      781 gttccatccc tgatccctgc ttccctctcc aacccacatt tcctgatcct tctgggccat
      841 ggccatctcc atcctcaggc tattcatgtt gggggcaggc tggcacctga atttctcatg
      901 cctcccaggg tcccctccat gcttggctcc atctccactg gtctggatgg cagctggtac
      961 ccagcagtct acggtgcctc atttctcctg cctttacaaa tgggcactac tataggactc
     1021 cggcgcttct tctgtccaca gccatctctt ttgtgacaga gacaatgctg acagccaagc
     1081 gacatgtcct atcatggtac cttcaataaa aggctaggaa actcta
//
