LOCUS       NM_027391               1548 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus iodotyrosine deiodinase (Iyd), mRNA.
ACCESSION   NM_027391
VERSION     NM_027391.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1548)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1548)
  AUTHORS   Phatarphekar,A., Buss,J.M. and Rokita,S.E.
  TITLE     Iodotyrosine deiodinase: a unique flavoprotein present in organisms
            of diverse phyla
  JOURNAL   Mol Biosyst 10 (1), 86-92 (2014)
   PUBMED   24153409
  REMARK    GeneRIF: At least for Metazoa, IYD should provide a new marker for
            tracing the evolutionary development of iodinated amino acids as
            regulatory signals through the tree of life.
REFERENCE   3  (bases 1 to 1548)
  AUTHORS   Afink,G.B., Veenboer,G., de Randamie,J., Keijser,R., Meischl,C.,
            Niessen,H. and Ris-Stalpers,C.
  TITLE     Initial characterization of C16orf89, a novel thyroid-specific gene
  JOURNAL   Thyroid 20 (7), 811-821 (2010)
   PUBMED   20578903
REFERENCE   4  (bases 1 to 1548)
  AUTHORS   McTamney,P.M. and Rokita,S.E.
  TITLE     A mammalian reductive deiodinase has broad power to dehalogenate
            chlorinated and brominated substrates
  JOURNAL   J Am Chem Soc 131 (40), 14212-14213 (2009)
   PUBMED   19777994
REFERENCE   5  (bases 1 to 1548)
  AUTHORS   Thomas,S.R., McTamney,P.M., Adler,J.M., Laronde-Leblanc,N. and
            Rokita,S.E.
  TITLE     Crystal structure of iodotyrosine deiodinase, a novel flavoprotein
            responsible for iodide salvage in thyroid glands
  JOURNAL   J Biol Chem 284 (29), 19659-19667 (2009)
   PUBMED   19436071
  REMARK    GeneRIF: Data show that the structures provide a molecular basis
            for understanding thyroid disease based on mutations of IYD.
REFERENCE   6  (bases 1 to 1548)
  AUTHORS   Friedman,J.E., Watson,J.A. Jr., Lam,D.W. and Rokita,S.E.
  TITLE     Iodotyrosine deiodinase is the first mammalian member of the NADH
            oxidase/flavin reductase superfamily
  JOURNAL   J Biol Chem 281 (5), 2812-2819 (2006)
   PUBMED   16316988
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155833.10 and AC153571.14.
            
            On Jun 28, 2018 this sequence version replaced NM_027391.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023358.1, AK002363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AC155833.10        169531-169718
            189-284             AC155833.10        174767-174862
            285-380             AC153571.14        1-96
            381-540             AC153571.14        1400-1559
            541-697             AC153571.14        6269-6425
            698-1548            AC153571.14        8425-9275
FEATURES             Location/Qualifiers
     source          1..1548
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 2.06 cM"
     gene            1..1548
                     /gene="Iyd"
                     /gene_synonym="0610009A07Rik; Dehal1; IYD-1"
                     /note="iodotyrosine deiodinase"
                     /db_xref="GeneID:70337"
                     /db_xref="MGI:MGI:1917587"
     exon            1..188
                     /gene="Iyd"
                     /gene_synonym="0610009A07Rik; Dehal1; IYD-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..880
                     /gene="Iyd"
                     /gene_synonym="0610009A07Rik; Dehal1; IYD-1"
                     /EC_number="1.21.1.1"
                     /note="iodotyrosine dehalogenase 1 protein"
                     /codon_start=1
                     /product="iodotyrosine deiodinase 1"
                     /protein_id="NP_081667.1"
                     /db_xref="CCDS:CCDS56670.1"
                     /db_xref="GeneID:70337"
                     /db_xref="MGI:MGI:1917587"
                     /translation="MFLLTPVLVAVVCILVVWVFKNADRNLEKKKEEAQVQPWVDEDL
                     KDSTEDLQVEEDAEEWQEAEESVEHIPFSHTRYPEQEMRMRSQEFYELLNKRRSVRFI
                     SSEHVPMEVIENVIKAAGTAPSGAHTEPWTFVVVKDPDMKHKIREIIEEEEEINYMKR
                     MGKRWVTDLKKLRTNWIKEYLDTAPVLILIFKQVHGFAANGKKKVHYYNEISVSIACG
                     LLLAALQNAGLVTVTTTPLNCGPRLRVLLGRPSHEKLLVLLPVGYPSRDATVPDLKRK
                     ALDQIMVTV"
     exon            189..380
                     /gene="Iyd"
                     /gene_synonym="0610009A07Rik; Dehal1; IYD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..540
                     /gene="Iyd"
                     /gene_synonym="0610009A07Rik; Dehal1; IYD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            541..697
                     /gene="Iyd"
                     /gene_synonym="0610009A07Rik; Dehal1; IYD-1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..1548
                     /gene="Iyd"
                     /gene_synonym="0610009A07Rik; Dehal1; IYD-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1526..1531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Iyd"
                     /gene_synonym="0610009A07Rik; Dehal1; IYD-1"
                     /note="hexamer: ATTAAA"
     polyA_site      1548
                     /gene="Iyd"
                     /gene_synonym="0610009A07Rik; Dehal1; IYD-1"
                     /note="major polyA site"
ORIGIN      
        1 attccaggtc ggacttcaga ccatgtttct cctcacccca gtcttggtag cagttgtctg
       61 tatcttggtt gtatgggtct ttaaaaatgc cgacaggaac ctagagaaaa agaaggagga
      121 ggctcaagtt cagccctggg tggatgaaga cttgaaagac agcacagaag accttcaagt
      181 ggaagaagat gctgaggagt ggcaagaggc agaggagagt gtggagcaca tcccgttctc
      241 tcacacccga tacccagaac aggaaatgag gatgaggtcc caggaattct atgagctcct
      301 caataagaga cgctccgtca ggtttatcag cagcgagcac gtcccaatgg aagtcattga
      361 aaatgtcatc aaagcagcag gaacagctcc aagtggggcc catacagagc cctggacctt
      421 tgtggtggtg aaggacccag acatgaagca taagatcaga gagattatcg aagaggagga
      481 agaaataaat tacatgaaaa ggatgggaaa gcgatgggtc acagacctga agaaactgag
      541 aaccaactgg attaaggagt acttggacac cgccccagtt ctgatcctca ttttcaaaca
      601 agtccatggt tttgctgcga atggaaagaa gaaggtccac tactacaacg agatcagtgt
      661 gtccatcgcc tgtggcctcc tgctggctgc actgcagaat gcagggctag tgacggtcac
      721 taccactccc ctcaactgtg gtcctcgtct gagggtgctc ctgggccgcc cctcacatga
      781 gaagctgttg gtgctacttc ctgtggggta ccccagcaga gatgccacag tgcctgacct
      841 caagcggaaa gctctggacc agatcatggt gacagtatag ccagccaacc taaggagatg
      901 ctggaatgct gggatgaccc ccacttcttt cctcccgggg ctgctggcac ctcttactct
      961 ctgagtcagg tcttctgaaa ccagtgtaca gggaaggcca ctttccttgt agtgattttt
     1021 ttcatacttt ctagaacttt cagtccagta agttattttt aatggactgt tttagtgaat
     1081 atatggggca agaggccaaa aagcaggcat aacttaattt ctctacaaaa ttataaatga
     1141 ttttttattt acatataaaa gtcataaaga agtcacatta gaagatttgc tatagttcct
     1201 aaagctacct atgtaatact ttttaattta aatattgact aatcaagtgg tccttctgct
     1261 ctctgctttc tggtggcatt gagtctaaga atttactact gagatctatt ctgtcactaa
     1321 gcctcatagg gattctgcca atcttgaatg agtgaccttt aacataagca aaatatgaca
     1381 ctcacagaac cagagaggca tgtctaacct gccatggatg tagctggcaa ttatctgaac
     1441 atgagttgca tggagtgtgc cggagctggc ttgtgctagc acatggaaga tggtggttaa
     1501 atattctgaa attatacaac aaattattaa accatttgta ctttgaaa
//
