LOCUS       NM_054102               3513 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus influenza virus NS1A binding protein (Ivns1abp),
            transcript variant 2, mRNA.
ACCESSION   NM_054102
VERSION     NM_054102.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3513)
  AUTHORS   Donatova,K., Mlada,M., Lopusna,K., Baran,F. and Betakova,T.
  TITLE     Changes in the Expression of Proteins Associated with
            Neurodegeneration in the Brains of Mice after Infection with
            Influenza A Virus with Wild Type and Truncated NS1
  JOURNAL   Int J Mol Sci 25 (5), 2460 (2024)
   PUBMED   38473707
  REMARK    GeneRIF: Changes in the Expression of Proteins Associated with
            Neurodegeneration in the Brains of Mice after Infection with
            Influenza A Virus with Wild Type and Truncated NS1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3513)
  AUTHORS   Lin,Y., Luo,Y., Hu,F., Wang,T., Dong,Y., Yang,D., He,X., Chen,X.,
            Wang,J., Du,J. and Zhang,X.
  TITLE     Overexpression of Short Variant Form of New Kelch Family Protein
            Leads to Erythroid and Megakaryocyte Dysplasia by Targeting
            Megakaryocyte-Erythroid Progenitors
  JOURNAL   DNA Cell Biol 37 (10), 831-838 (2018)
   PUBMED   30124330
  REMARK    GeneRIF: Overexpression of short variant form of new Kelch family
            protein ND1 leads to erythroid and megakaryocyte dysplasia by
            targeting megakaryocyte-erythroid progenitors.
REFERENCE   3  (bases 1 to 3513)
  AUTHORS   Xing,J., Weng,L., Yuan,B., Wang,Z., Jia,L., Jin,R., Lu,H., Li,X.C.,
            Liu,Y.J. and Zhang,Z.
  TITLE     Identification of a role for TRIM29 in the control of innate
            immunity in the respiratory tract
  JOURNAL   Nat Immunol 17 (12), 1373-1380 (2016)
   PUBMED   27695001
  REMARK    Erratum:[Nat Immunol. 2016 Nov 16;17(12):1479. doi:
            10.1038/ni1216-1479a.. PMID: 27849197]
REFERENCE   4  (bases 1 to 3513)
  AUTHORS   Guazzi,P., Goitre,L., Ferro,E., Cutano,V., Martino,C.,
            Trabalzini,L. and Retta,S.F.
  TITLE     Identification of the Kelch family protein Nd1-L as a novel
            molecular interactor of KRIT1
  JOURNAL   PLoS One 7 (9), e44705 (2012)
   PUBMED   22970292
REFERENCE   5  (bases 1 to 3513)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 3513)
  AUTHORS   Fujimura,L., Matsudo,Y., Kang,M., Takamori,Y., Tokuhisa,T. and
            Hatano,M.
  TITLE     Protective role of Nd1 in doxorubicin-induced cardiotoxicity
  JOURNAL   Cardiovasc Res 64 (2), 315-321 (2004)
   PUBMED   15485691
REFERENCE   7  (bases 1 to 3513)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 3513)
  AUTHORS   Sasagawa,K., Matsudo,Y., Kang,M., Fujimura,L., Iitsuka,Y.,
            Okada,S., Ochiai,T., Tokuhisa,T. and Hatano,M.
  TITLE     Identification of Nd1, a novel murine kelch family protein,
            involved in stabilization of actin filaments
  JOURNAL   J Biol Chem 277 (46), 44140-44146 (2002)
   PUBMED   12213805
  REMARK    GeneRIF: Nd1-L functions as a stabilizer of actin filaments as an
            actin-binding protein and may play a role in the dynamic
            organization of the actin cytoskeleton
REFERENCE   9  (bases 1 to 3513)
  AUTHORS   Kang,M., Matsudo,Y., Sasagawa,K., Tokuhisa,T. and Hatano,M.
  TITLE     Nd1, a novel murine Kelch family protein, may play the role of a
            housekeeping gene
  JOURNAL   Biochim Biophys Acta 1519 (3), 167-174 (2001)
   PUBMED   11418182
REFERENCE   10 (bases 1 to 3513)
  AUTHORS   Shoji,H., Tsuchida,K., Kishi,H., Yamakawa,N., Matsuzaki,T., Liu,Z.,
            Nakamura,T. and Sugino,H.
  TITLE     Identification and characterization of a PDZ protein that interacts
            with activin type II receptors
  JOURNAL   J Biol Chem 275 (8), 5485-5492 (2000)
   PUBMED   10681527
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355706.1, AK146494.1 and AC115060.9.
            
            On Feb 14, 2006 this sequence version replaced NM_054102.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.68831.1, SRR1660813.633.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AL355706.1         1-47
            48-3321             AK146494.1         1-3274
            3322-3513           AC115060.9         150489-150680       c
FEATURES             Location/Qualifiers
     source          1..3513
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 64.06 cM"
     gene            1..3513
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /note="influenza virus NS1A binding protein"
                     /db_xref="GeneID:117198"
                     /db_xref="MGI:MGI:2152389"
     exon            1..258
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            259..486
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            487..615
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             505..2433
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /note="isoform 2 is encoded by transcript variant 2;
                     influenza virus NS1A-binding protein homolog; kelch family
                     protein Nd1; ND1-L2; kelch family protein Nd1-L;
                     NS1-binding protein homolog"
                     /codon_start=1
                     /product="influenza virus NS1A-binding protein homolog
                     isoform 2"
                     /protein_id="NP_473443.2"
                     /db_xref="CCDS:CCDS15359.1"
                     /db_xref="GeneID:117198"
                     /db_xref="MGI:MGI:2152389"
                     /translation="MIPNGYLMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEML
                     AHRAVLACCSPYLFEIFNSDSDPHGVSHVKLDDLNPEAVEVLLNYAYTAQLKADKELV
                     KDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEH
                     LLQISEEEEFLKLPRLKLEVMLEDNVCLPSNGKLYTKVINWVQRSIWENGDSLEELME
                     EVQTLYYSADHKLLDGNPLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISGSSTGCLS
                     SPNASMQSPKHEWKIVASEKTSNNTYLCLAVLDSTFCVIFLHGRNSPQSSPTSTPKLS
                     KSLSFEMQPDELLEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYDPHT
                     DHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDPNIDDWTPVPELR
                     TNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKSWTSCAPLNIRRHQSAVC
                     ELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLDGKLFVGGG
                     FDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGITTVGNTIYAVGGFDGNEFLNTVE
                     VYNPQSNEWSPYTKIFQF"
     exon            616..785
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            786..861
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1035
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1161
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1269
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1399
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1624
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1746
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1873
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2005
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2179
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..3513
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3300..3305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /note="hexamer: ATTAAA"
     polyA_site      3327
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /note="major polyA site"
     regulatory      3465..3470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /note="hexamer: ATTAAA"
     polyA_site      3486
                     /gene="Ivns1abp"
                     /gene_synonym="1190004M08Rik; 1700126I16Rik; HSPC068;
                     mKIAA0850; ND1; Nd1-L; Nd1-S; NS-1; NS1-BP"
                     /note="major polyA site"
ORIGIN      
        1 gacgtgcgag ggagtgcggc gcgagcgcgc gcggcggcgg cggcggtggc agtgtgttcg
       61 ggacgcgcgt ggaggtcggt cagtcgctcg gaggtgctgg gcgcgtcgtg gcggcgagcg
      121 agttcccgcg agtacccact ggtcttcctc agcccgcagc ctcccgcccg gtcgccccga
      181 gccccttcca gcgccttccg cctgcagccc gtcgaagctc tggagatgaa tttcgccatc
      241 tcttcagaga tgacccagat tatgatgcat gattatcaca gaagaaattc atgtctatag
      301 cttttaagga cttgattaca tcattttcaa gcctgctagt tttggaacca ccattaaagc
      361 ctaagacatc tcccttcagt cagccacctt tcttcacact gtaacgaagt gctttgtttc
      421 aacactcctt ctttgtcttt ggatcatttg cgttctcagt gacacatttc tcttcagtaa
      481 ttgttgccaa atttataagg aaaaatgatt cccaatggat atttgatgtt tgaagatgaa
      541 aattttattg aatcatctgt tgccaaatta aatgccttga ggaagagtgg gcagttctgt
      601 gatgttcgac ttcaggtctg tggccatgag atgctagcac acagggcagt cctggcttgc
      661 tgtagcccct atctatttga aatcttcaat agtgacagtg accctcatgg agtttctcat
      721 gtgaagttgg atgatctcaa tccagaagct gttgaagtct tgctgaatta tgcatacacg
      781 gctcagttga aagctgataa ggaattagta aaagatgttt attctgcagc caagaagctg
      841 aagatggacc gagtcaagca ggtctgcgga gattatttac tatctagaat ggatgttact
      901 agctgcatct cttaccgaaa ttttgcaagt tgtatgggag actcccgttt gttgaataaa
      961 gttgacgctt atattcagga gcatttgtta caaatttcag aagaggagga atttcttaag
     1021 cttccgagac taaagttgga ggtaatgctt gaagataatg tgtgcttgcc cagcaatggc
     1081 aagttgtata caaaggtaat caactgggtg cagcgtagca tctgggagaa tggagacagc
     1141 ctggaggagc tcatggaaga ggttcaaacc ttgtactact cagctgatca caagctgctt
     1201 gatgggaacc cactagatgg acaggctgag gtgtttggca gtgatgatga ccacattcag
     1261 tttgtgcaga aaaagccacc ccgtgagaat ggccataagc agataagtgg cagttccact
     1321 ggatgtctct cttctccaaa tgcttcaatg caaagcccta agcatgagtg gaaaatcgtt
     1381 gcttcagaaa agacttcaaa taacacttac ttgtgcctgg ctgtgctgga cagtacattc
     1441 tgtgtcattt tccttcatgg gcggaacagt ccacagagct caccaacaag tactccaaaa
     1501 ctgagcaaga gtttaagctt cgagatgcaa ccagatgagc ttctagaaaa gcccatgtct
     1561 cccatgcagt acgcacggtc tggactaggg acagcagaga tgaatggcaa actcatagct
     1621 gcaggtggtt ataacagaga ggaatgtctt cgaacagttg aatgctatga tccacataca
     1681 gatcactggt ccttccttgc tcccatgaga acaccaagag cccgctttca aatggctgtg
     1741 ctgatgggac agctctatgt ggtgggtgga tcaaatggac actcagatga cctgagttgt
     1801 ggagaaatgt atgatccaaa cattgatgac tggacccctg ttccagagct gagaaccaac
     1861 cgttgtaatg caggagtgtg tgctctgaat gggaaattgt acattgttgg tggctctgat
     1921 ccatatggtc aaaagggcct gaaaaattgt gatgtatttg atcctgtaac gaagtcatgg
     1981 acaagctgtg ctcctcttaa cattcgtcga caccagtctg cagtttgtga acttggtggt
     2041 tatttgtata taattggagg tgcagaatct tggaattgtc tgaacacagt agaacgatac
     2101 aatcctgaaa acaacacctg gactttaatt gcacccatga atgtggcgag gcgaggggct
     2161 ggagtcgctg tgcttgatgg aaaactgttt gtaggtggtg gctttgatgg ttctcacgcc
     2221 atcagttgtg tggagatgta tgatccaact agaaatgaat ggaagatgat gggaaatatg
     2281 acttcaccaa ggagcaatgc tgggatcaca actgtaggga ataccattta tgcagtggga
     2341 ggattcgatg gcaatgagtt tctgaatact gtggaagtct acaaccctca gtcaaatgag
     2401 tggagccctt acacaaagat tttccagttt taacaaattt aagaacccca aactaacagg
     2461 cttagtgatg taattgtgtt tagtagaggt acacttgtga ataaggaggg tgggtggggt
     2521 agatgttgct aactgcaaca caaagctttt gcatattgca tattattaaa catgctgtac
     2581 atactttttg tgtttggaac ggaatgcaaa gatgaaggtc tgtttctgta ttcttaagac
     2641 atctttggtt attttacttt ttgaaggttg atactgtaaa agaataaacc acaaattgat
     2701 tgggaacatc atttcaagaa gtccctgctc ctccacattt gttttgccga tttgcacatt
     2761 aaatgactct tccctcaatt ctgtcttaag aggcaagagg ggtagggttt acacgtaggc
     2821 agttgggttt tttaagggcc ccttttcaat aactggaaca ctctataaca agatacttat
     2881 ttaaatagat aacaatgact atttttgttt ttattaaaag aaagttgaca tgcctaccaa
     2941 tatttagtct tttatgatta catttttata actttttata ttctcagcag agtgctttat
     3001 ctgttgaagt aaaatgtgac agattcacat tatcaaagca gagtggcaga ggaaaggatg
     3061 cagagtggct gtttctttta aaaaatgctc agaacgcaga cttcaccatt tgccgcagct
     3121 gtaccttttt ttctttccta tctgagagtg cagtatcgat gttatttgga tggagttgct
     3181 gaatggtaac agtaattcaa acccaggttt gatgagttac ttgacttact gaagcattta
     3241 aactgtcttt atttatcatt aaccaaacaa atgtaagtgg aagcctttga ttgaaaacaa
     3301 ttaaactgta ttgggtttgt gaatgcaccc cttttcagaa gtgttttgtt cagctttctt
     3361 acctggatta atactggttg gggtggctcg gtgtctgtgt agtgctacac ctaatttatg
     3421 gtgcccaaat gagcaaatct aatgcttgct gcagatacaa acacattaaa ggtactttgc
     3481 agtaaatcct tgcactgtgg gatttaatgt cca
//
