LOCUS       NM_008412               1924 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus involucrin (Ivl), mRNA.
ACCESSION   NM_008412
VERSION     NM_008412.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1924)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1924)
  AUTHORS   Schmidt,A.D., Miciano,C., Zheng,Q., Mathyer,M.E., Grice,E.A. and de
            Guzman Strong,C.
  TITLE     Involucrin Modulates Vitamin D Receptor Activity in the Epidermis
  JOURNAL   J Invest Dermatol 143 (6), 1052-1061 (2023)
   PUBMED   36642403
  REMARK    GeneRIF: Involucrin Modulates Vitamin D Receptor Activity in the
            Epidermis.
REFERENCE   3  (bases 1 to 1924)
  AUTHORS   Deng,Z., Butt,T., Arhatari,B.D., Darido,C., Auden,A., Swaroop,D.,
            Partridge,D.D., Haigh,K., Nguyen,T., Haigh,J.J., Carpinelli,M.R.
            and Jane,S.M.
  TITLE     Dysregulation of Grainyhead-like 3 expression causes widespread
            developmental defects
  JOURNAL   Dev Dyn 252 (5), 647-667 (2023)
   PUBMED   36606449
REFERENCE   4  (bases 1 to 1924)
  AUTHORS   Butera,A., Agostini,M., Cassandri,M., De Nicola,F., Fanciulli,M.,
            D'Ambrosio,L., Falasca,L., Nardacci,R., Wang,L., Piacentini,M.,
            Knight,R.A., Jia,W., Sun,Q., Shi,Y., Wang,Y., Candi,E. and
            Melino,G.
  TITLE     ZFP750 affects the cutaneous barrier through regulating lipid
            metabolism
  JOURNAL   Sci Adv 9 (17), eadg5423 (2023)
   PUBMED   37115925
REFERENCE   5  (bases 1 to 1924)
  AUTHORS   Godsel,L.M., Roth-Carter,Q.R., Koetsier,J.L., Tsoi,L.C.,
            Huffine,A.L., Broussard,J.A., Fitz,G.N., Lloyd,S.M., Kweon,J.,
            Burks,H.E., Hegazy,M., Amagai,S., Harms,P.W., Xing,X., Kirma,J.,
            Johnson,J.L., Urciuoli,G., Doglio,L.T., Swindell,W.R.,
            Awatramani,R., Sprecher,E., Bao,X., Cohen-Barak,E., Missero,C.,
            Gudjonsson,J.E. and Green,K.J.
  TITLE     Translational implications of Th17-skewed inflammation due to
            genetic deficiency of a cadherin stress sensor
  JOURNAL   J Clin Invest 132 (3) (2022)
   PUBMED   34905516
REFERENCE   6  (bases 1 to 1924)
  AUTHORS   Song,H.J., Poy,G., Darwiche,N., Lichti,U., Kuroki,T., Steinert,P.M.
            and Kartasova,T.
  TITLE     Mouse Sprr2 genes: a clustered family of genes showing differential
            expression in epithelial tissues
  JOURNAL   Genomics 55 (1), 28-42 (1999)
   PUBMED   9888996
REFERENCE   7  (bases 1 to 1924)
  AUTHORS   Hanley,K., Feingold,K.R., Komuves,L.G., Elias,P.M., Muglia,L.J.,
            Majzoub,J.A. and Williams,M.L.
  TITLE     Glucocorticoid deficiency delays stratum corneum maturation in the
            fetal mouse
  JOURNAL   J Invest Dermatol 111 (3), 440-444 (1998)
   PUBMED   9740238
REFERENCE   8  (bases 1 to 1924)
  AUTHORS   Murgia,C., Blaikie,P., Kim,N., Dans,M., Petrie,H.T. and
            Giancotti,F.G.
  TITLE     Cell cycle and adhesion defects in mice carrying a targeted
            deletion of the integrin beta4 cytoplasmic domain
  JOURNAL   EMBO J 17 (14), 3940-3951 (1998)
   PUBMED   9670011
REFERENCE   9  (bases 1 to 1924)
  AUTHORS   Gandarillas,A. and Watt,F.M.
  TITLE     The 5' noncoding region of the mouse involucrin gene: comparison
            with the human gene and genes encoding other cornified envelope
            precursors
  JOURNAL   Mamm Genome 6 (9), 680-682 (1995)
   PUBMED   8535084
REFERENCE   10 (bases 1 to 1924)
  AUTHORS   Djian,P., Phillips,M., Easley,K., Huang,E., Simon,M., Rice,R.H. and
            Green,H.
  TITLE     The involucrin genes of the mouse and the rat: study of their
            shared repeats
  JOURNAL   Mol Biol Evol 10 (6), 1136-1149 (1993)
   PUBMED   8277848
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY142984.1, AA789977.1 and AC125089.4.
            
            On Nov 7, 2012 this sequence version replaced NM_008412.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY142984.1, AA789977.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BY142984.1         3-22
            21-406              AA789977.1         1-386
            407-1924            AC125089.4         44533-46050
FEATURES             Location/Qualifiers
     source          1..1924
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.14 cM"
     gene            1..1924
                     /gene="Ivl"
                     /gene_synonym="1110019C06Rik"
                     /note="involucrin"
                     /db_xref="GeneID:16447"
                     /db_xref="MGI:MGI:96626"
     exon            1..44
                     /gene="Ivl"
                     /gene_synonym="1110019C06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            45..1924
                     /gene="Ivl"
                     /gene_synonym="1110019C06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1474
                     /gene="Ivl"
                     /gene_synonym="1110019C06Rik"
                     /codon_start=1
                     /product="involucrin"
                     /protein_id="NP_032438.2"
                     /db_xref="CCDS:CCDS17561.1"
                     /db_xref="GeneID:16447"
                     /db_xref="MGI:MGI:96626"
                     /translation="MSHQHTLPVTVPAVVQGPLKTVCSPDHIQQEQAKQPTPHPTQCQ
                     VFTEIQEKGFPKHEEKRPNPVKDLPDQKCEHQQQPGPQKQQLQVKKSQQELQEQELHL
                     EKQQLPQEPQGLLCLEQQQQQEPQMQEQHLRQQQQQQQQQQQQQQQQQQQETQEQGLC
                     LGQQKQQQQQQDMLVPQELHLRQHQEKLQDPELHLGQQQKTPEEQKLIPGEKQQELHL
                     GQRHQEPQEQELHLGQKQKQKLHEPELQLGKQQHQKPSEPELPLGKQQQESPEPELPL
                     GKQQQQESPEPELQLGKQQQSHEPDMAGDQKEKQKLHKPELYLRKQQYQESPDPELSL
                     GKQQHQECQEPELQLEEKQHQKPPEPELHLGKQQESHEPDMAEDLEEKQKLGEPELHL
                     GKQQQQQIEREGYQGPKSLGQSLKQEKASRKQQLDYSHLEQEKELSDQPLDQALVKKG
                     KQLERKKHELENRTQQEK"
ORIGIN      
        1 aggactctgc tggaagcctc tgccttctcc ctcctgtgag tttgtttggt ctacagaagc
       61 ttccaagatg tcccatcaac acacactgcc agtgactgtt ccagctgtgg ttcagggacc
      121 tctcaagact gtgtgttctc cagatcatat ccagcaggaa caagcaaagc aaccaactcc
      181 acatcctaca caatgccagg tcttcactga gattcaagag aagggctttc ccaaacatga
      241 ggagaagcgg ccaaaccctg tgaaggatct gcctgatcaa aagtgtgagc accagcagca
      301 gccaggacca caaaagcagc agctgcaggt gaaaaagtca cagcaggagc tgcaggaaca
      361 ggaactgcat ctggagaagc agcagctacc acaagagccc caggggctcc tgtgcctgga
      421 acaacaacag cagcaagagc cacaaatgca agaacagcac ctcagacagc agcagcagca
      481 gcagcagcag cagcagcagc agcagcagca gcagcagcag caagagacac aggagcaggg
      541 tctgtgcctg gggcagcaga agcagcagca gcagcagcaa gacatgctag taccacagga
      601 gctacatctg agacagcacc aggagaagct gcaggatcca gaactgcatc tgggtcagca
      661 gcagaaaact ccagaggagc agaaactgat tccaggagaa aagcagcagg agctgcacct
      721 gggacagagg caccaggagc cacaggagca ggagctacac ctgggacaga aacagaagca
      781 gaagctacat gaaccagaac tgcaactggg aaaacagcag caccagaagc catctgagcc
      841 agaactgcct ctgggaaagc agcagcagga gtcacctgaa ccagaactgc ctctgggaaa
      901 gcagcagcag caggagtcac ctgagccaga actgcaactg ggaaagcagc agcagtcaca
      961 tgagccggat atggcagggg atcagaaaga gaagcagaaa cttcataagc cagaactgta
     1021 cctgagaaag cagcagtacc aggagtcacc tgacccagag ttgtccctgg gaaaacagca
     1081 gcaccaggag tgtcaggaac cagaactgca attggaagag aagcagcatc agaagccacc
     1141 tgaaccagaa ctgcacctgg gaaagcagca ggagtcacat gagccagata tggcagagga
     1201 tctggaagag aagcagaaac ttggtgagcc agaattacac ctaggaaagc agcagcagca
     1261 acagatagag cgtgaaggtt atcaaggacc aaaaagcctg ggtcagtcac ttaagcaaga
     1321 gaaagcttca aggaaacagc agctagatta ctcacatcta gaacaggaga aggagctctc
     1381 agaccagcca ctggatcaag cactagtaaa gaagggtaaa caactggaaa ggaagaaaca
     1441 cgaattggag aaccggacac agcaggagaa gtagatagag caattagtac caagcactga
     1501 ctaagccagt ccaaccagtg aaaggagacg tgctcactac agagaagcag cagcagaacc
     1561 atgaagtgca gtgaagccaa aactaaagca accacaccag tgtcccagag actctccaac
     1621 catcccacat aagggaagag agccatccac acttccttaa ggtcctcagc tggcctactc
     1681 acccataaat ctatctggcc ctgaccatcc tcttgtctat gacaggctgg atacaggatg
     1741 ctatatggtc cggtatcttc cccaagaagc tcaatcccaa ccttaaatat cacaacttct
     1801 tcctgaggca gggggtgggg gaaaaaggga ggcctgtcag tagttagcaa ctctgatgtc
     1861 actcctaatg ttgtggcaga attgtgaata ggtgtaatgt ctaataaatc ctaaaaaccc
     1921 tgtg
//
