LOCUS       NM_019826               3623 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus isovaleryl coenzyme A dehydrogenase (Ivd), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_019826
VERSION     NM_019826.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3623)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3623)
  AUTHORS   Peng,M.Z., Shao,Y.X., Li,X.Z., Zhang,K.D., Cai,Y.N., Lin,Y.T.,
            Jiang,M.Y., Liu,Z.C., Su,X.Y., Zhang,W., Jiang,X.L. and Liu,L.
  TITLE     Mitochondrial FAD shortage in SLC25A32 deficiency affects
            folate-mediated one-carbon metabolism
  JOURNAL   Cell Mol Life Sci 79 (7), 375 (2022)
   PUBMED   35727412
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3623)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3623)
  AUTHORS   Suzuki,T., Kikuguchi,C., Nishijima,S., Nagashima,T., Takahashi,A.,
            Okada,M. and Yamamoto,T.
  TITLE     Postnatal liver functional maturation requires Cnot
            complex-mediated decay of mRNAs encoding cell cycle and immature
            liver genes
  JOURNAL   Development 146 (4) (2019)
   PUBMED   30733279
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3623)
  AUTHORS   Willard,J.M., Reinard,T., Mohsen,A. and Vockley,J.
  TITLE     Cloning of genomic and cDNA for mouse isovaleryl-CoA dehydrogenase
            (IVD) and evolutionary comparison to other known IVDs
  JOURNAL   Gene 270 (1-2), 253-257 (2001)
   PUBMED   11404023
REFERENCE   6  (bases 1 to 3623)
  AUTHORS   Frerman,F.E., Sabran,J.L., Taylor,J.L. and Grossberg,S.E.
  TITLE     Leucine catabolism during the differentiation of 3T3-L1 cells.
            Expression of a mitochondrial enzyme system
  JOURNAL   J Biol Chem 258 (11), 7087-7093 (1983)
   PUBMED   6304077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772255.12.
            
            On Jan 23, 2023 this sequence version replaced NM_019826.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077416.1, SRR17253011.5912205.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AL772255.12        157238-157411
            175-264             AL772255.12        164679-164768
            265-316             AL772255.12        164975-165026
            317-486             AL772255.12        166622-166791
            487-580             AL772255.12        168129-168222
            581-717             AL772255.12        168412-168548
            718-814             AL772255.12        169909-170005
            815-908             AL772255.12        171560-171653
            909-990             AL772255.12        172132-172213
            991-1095            AL772255.12        172905-173009
            1096-1168           AL772255.12        173119-173191
            1169-3623           AL772255.12        175697-178151
FEATURES             Location/Qualifiers
     source          1..3623
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.64 cM"
     gene            1..3623
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /note="isovaleryl coenzyme A dehydrogenase"
                     /db_xref="GeneID:56357"
                     /db_xref="MGI:MGI:1929242"
     exon            1..174
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1302
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /EC_number="1.3.8.4"
                     /EC_number="1.3.8.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; isovaleryl-CoA dehydrogenase, mitochondrial;
                     butyryl-CoA dehydrogenase"
                     /codon_start=1
                     /product="isovaleryl-CoA dehydrogenase, mitochondrial
                     isoform 1 precursor"
                     /protein_id="NP_062800.1"
                     /db_xref="CCDS:CCDS16586.1"
                     /db_xref="GeneID:56357"
                     /db_xref="MGI:MGI:1929242"
                     /translation="MATAIRLLGRRVSSWRLRPSPSPLAVPRRAHSILPVDDDINGLN
                     EEQKQLRHTISKFLQENLAPKAQEIDQTNDFKNLREFWKQLGSLGVLGITAPVQYGGS
                     GLGYLEHVLVMEEISRASGAVGLSYGAHSNLCVNQIVRNGNEAQKEKYLPKLISGEFI
                     GALAMSEPNAGSDVVSMKLKAEKKGDHYVLNGNKFWITNGPDADILVVYAKTDLTAVP
                     ASRGITAFIVEKGMPGFSTSKKLDKLGMRGSNTCELVFEDCKVPAANVLSQESKGVYV
                     LMSGLDLERLVLAGGPLGIMQAVLDHTIPYLHVREAFGQKIGQFQLMQGKMADMYTRL
                     MASRQYVYNVAKACDEGHIIPKDCAGVILYAAECATQVALDGIQCLGGNGYINDFPMG
                     RFLRDAKLYEIGAGTSEVRRLVIGRAFNADFR"
     exon            175..264
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            265..316
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            317..486
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            487..580
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            581..717
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            718..814
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            815..908
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            909..990
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1095
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1168
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..3623
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2051..2056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /note="hexamer: AATATA"
     polyA_site      2068
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /note="major polyA site"
     regulatory      2610..2615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /note="hexamer: ATTATA"
     polyA_site      2629
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
     regulatory      2725..2730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2753
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
     regulatory      3601..3606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3623
                     /gene="Ivd"
                     /gene_synonym="1300016K07Rik; 6720455E18Rik"
ORIGIN      
        1 agtccaagct cctggtgcac cgcagagatg gcgactgcaa tccggctgct gggacggcga
       61 gtttccagtt ggagactgcg gccatcaccg tcgcccctcg ctgtcccgcg gcgggcccac
      121 tcgatattgc ctgtggacga tgatatcaac gggctaaacg aggagcagaa gcagcttcgt
      181 catactatat ctaagtttct tcaagagaac ctggccccca aggcccaaga gattgatcaa
      241 accaatgact tcaagaacct gagagagttc tggaaacagc tggggagcct gggcgtactg
      301 ggcatcacag cccccgttca gtatggtggc tctggcctgg gctacctaga acatgtgttg
      361 gtaatggaag agatatcccg ggcttcggga gcagtggggc tcagctacgg tgctcactcc
      421 aacctctgcg tcaaccagat tgttcgaaat gggaatgagg cacagaaaga gaaatacctt
      481 cccaagctca tcagtggtga gttcatcgga gccttggcca tgagtgaacc caatgctggc
      541 tctgacgttg tctccatgaa gctaaaagca gaaaagaaag gagatcacta tgttctgaat
      601 ggcaacaagt tctggatcac caatggccct gatgctgata tcctagtcgt gtatgccaag
      661 acagatttga ccgctgtgcc agcttctcgg ggcatcacag ccttcattgt ggagaagggt
      721 atgcctggtt ttagtacctc caagaagctt gacaagctgg gtatgagggg ctccaacacc
      781 tgcgagctgg tctttgaaga ctgcaaggtt cctgccgcta acgtcctgag ccaggagagt
      841 aagggggtct acgtattgat gagcgggctg gacctagagc gcctggtgct agcaggtggg
      901 ccccttggga tcatgcaggc tgtcctggac cacaccattc cctacttgca tgtgagggag
      961 gcctttggcc agaagatcgg ccaattccag ctgatgcagg gaaagatggc cgacatgtac
     1021 acccgcctca tggcaagtcg acagtacgtc tacaatgtcg ccaaagcctg tgacgagggc
     1081 cacatcattc ccaaggactg tgccggtgtg attctgtatg cagccgagtg tgccacacag
     1141 gtagccctgg acggcattca gtgtctaggt ggaaatggct acatcaatga cttccccatg
     1201 ggccgctttc tacgagatgc caaactgtat gagatcggag ctgggaccag tgaagtgagg
     1261 cggttggtca ttggccgagc tttcaatgca gacttccgct agccctctgc ggcccatcgc
     1321 cccctggtcc cagcaccgag aggcctttct ttggaagcag agatgtggca gccctctgac
     1381 ctgtctaagg aagctctgct gctcagctgc ccttctctgt cagccctctg ccccgtgtga
     1441 agtcggattc tccagccgtt ccgggcagga aagcctaaaa tgactgctaa aatgactttg
     1501 gctttttggg gggtttgggg ggagggtggc agtgtctgtg ccattgcttt ctacatctga
     1561 atgtgatgac ctgaccctcc aggtagcatc tgacaggtac ccgactcctt ttcttgggca
     1621 agcctctggc agggtgccct ttctgttcaa gggtaacaga ggcattaccc ctttcagttg
     1681 tcagatactt gtggtctcat ttcttgagga aaaggcaaaa gccatctcct tcttaactgt
     1741 ttctccaaga gctagacagc tccagaatgc ctatggcaga cccaggaagg acagagtcca
     1801 cagtccaggc aagacaacac agaagatcgg ctccctcgtg tacctgagtc tgtctgcatc
     1861 actctgtcac aggctagcac tgggcctgct catgtgacct tctgcagctg actggccagc
     1921 agacacaggt cctgtggccc agcccaggtt gcctggctcc cctccagcct tgttgcctct
     1981 gtatatttct ctagacaccc tgtggctaat tttattacaa ctgcacaatg tctgttgcca
     2041 ttttgtatta aatatactgc aaggtaaacc cttctgcgcc caaagccgtg ttctgcagga
     2101 gaaacaagcc acttgctatg gtcctgtctg catccagaga atgtccttga agcggcctgc
     2161 ccttcagttt gccctttggg aatgggatag gaggccagaa taggaagtct cagacccaga
     2221 tctcctggtg acttttcttc ttgttgtgtg tgaaattgta cctaggctgt gctaggcagg
     2281 cactgcacca ctgagtcagc tccttgccct accaacttct ccatggtttt attttagtct
     2341 ccctgtagcc gagactagct ttgaactaag accctgaaca gtagatctgc ccctatctct
     2401 tgagtgctgg gattacaggc aacaccctgt gctttttctt aaaggaaagg gggagaaaat
     2461 gggggggggg tgtcaagtgt gggaagacag gaggagagtc ttaagtttct ggaggatttt
     2521 gagagttttt tttttggggg ggggttgctt ttgattcaga gtctaactgt aactcagaat
     2581 cctcctgcct ctgcctcctg actgccaaaa ttatatacat gaaccaccac agctggcata
     2641 tctgagtttt gtttcatttg tctagctata tagcccaggc tggccttgga ctcaaagatc
     2701 ctcctctgcc tccctagttc tgagattaaa ggcacgtgca accaccacac ccagctcaaa
     2761 ctctgcaagg ttgttttgtt cttttaatac ttgacttttt caaggtcaga attggagcta
     2821 ggatcctaat gggctagcaa cagggacatc ccaaccttgg gcctcccaac cttgggccgt
     2881 cacaaatagc gcccaggccg tggattacca cattcatgtg agttcccaaa aataaagact
     2941 gtttttcctg gctcccagcc caacagtctt agcctaggtg gagtgctgag gtctgagaca
     3001 ggtggagtca gcaccttagc aaccccacac ccgtcccatc ttaagagggg gttcatgaat
     3061 gcagtagata cactgaccag ctgaggaaga tccctggaac aacccacaga agatgatcaa
     3121 aatgaggcag aggacctgca cgcctgcaag attgtcacca agccagacaa cctgggttgg
     3181 agtccaagaa cccatatggg ggatggagag ttgccctctg acctccataa gttatcagaa
     3241 ggcaacatgt cacccagtca tgccatagga accctaccaa cgagagtgtg ccccagaagt
     3301 tcacctgtta aaaacctcag tcccagccat ttgttaatgg tttaggtagt aatgacttta
     3361 gtggctttat aaaagggaat cttaaactag tgtgcctgct ctgtcgtgtc aggtctccta
     3421 ccatgttatc aggcaagaga agaacactgg agttgggagc gccatgcttt tgatagtcag
     3481 cctctggaac catgagctat aattacccaa tctgtttgta tccagctata gcaactgaaa
     3541 ggaagaatgt gattgttttt ctgaattttt ttttaatgtg acacacaaga aatgttttta
     3601 aataaaagac aaaataaaaa cta
//
