LOCUS       NM_001163527            3689 bp    mRNA    linear   ROD 28-MAY-2024
DEFINITION  Mus musculus inositol 1,4,5-triphosphate receptor interacting
            protein-like 1 (Itpripl1), transcript variant 1, mRNA.
ACCESSION   NM_001163527 XM_485065 XM_918079
VERSION     NM_001163527.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3689)
  AUTHORS   Deng,S., Zhang,Y., Wang,H., Liang,W., Xie,L., Li,N., Fang,Y.,
            Wang,Y., Liu,J., Chi,H., Sun,Y., Ye,R., Shan,L., Shi,J., Shen,Z.,
            Wang,Y., Wang,S., Brosseau,J.P., Wang,F., Liu,G., Quan,Y. and Xu,J.
  TITLE     ITPRIPL1 binds CD3epsilon to impede T cell activation and enable
            tumor immune evasion
  JOURNAL   Cell 187 (9), 2305-2323 (2024)
   PUBMED   38614099
REFERENCE   2  (bases 1 to 3689)
  AUTHORS   Deng,S., Shi,J., Sun,Y., Quan,Y., Shen,Z., Wang,Y., Li,H. and Xu,J.
  TITLE     Development of a monoclonal antibody to ITPRIPL1 for
            immunohistochemical diagnosis of non-small cell lung cancers:
            accuracy and correlation with CD8+ T cell infiltration
  JOURNAL   Front Cell Dev Biol 11, 1297211 (2023)
   PUBMED   38188019
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3689)
  AUTHORS   Thomas,J.W. and Green,E.D.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Comparative sequence analysis of a single-gene conserved segment in
            mouse and human
  JOURNAL   Mamm Genome 14 (10), 673-678 (2003)
   PUBMED   14694903
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928590.10.
            
            On or before Jul 24, 2009 this sequence version replaced
            XM_918079.2, XM_485065.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC130218.1, SRR11927932.3491565.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               AL928590.10        117322-117564       c
            244-3689            AL928590.10        112876-116321       c
FEATURES             Location/Qualifiers
     source          1..3689
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.79 cM"
     gene            1..3689
                     /gene="Itpripl1"
                     /gene_synonym="1700041B20Rik"
                     /note="inositol 1,4,5-triphosphate receptor interacting
                     protein-like 1"
                     /db_xref="GeneID:73338"
                     /db_xref="MGI:MGI:1920588"
     exon            1..243
                     /gene="Itpripl1"
                     /gene_synonym="1700041B20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            244..3689
                     /gene="Itpripl1"
                     /gene_synonym="1700041B20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1901
                     /gene="Itpripl1"
                     /gene_synonym="1700041B20Rik"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; inositol 1,4,5-trisphosphate
                     receptor-interacting protein-like 1"
                     /codon_start=1
                     /product="inositol 1,4,5-trisphosphate
                     receptor-interacting protein-like 1 isoform a precursor"
                     /protein_id="NP_001156999.1"
                     /db_xref="CCDS:CCDS50701.1"
                     /db_xref="GeneID:73338"
                     /db_xref="MGI:MGI:1920588"
                     /translation="MAVISLMFLAVMYVVHHPLMVSDRMDLDTLARSRQLEKRMSEEM
                     RQLEMEFEERSRAAEQKQKVENFWRGDTSSDQLVLGKKDMGWPFQAGGQDGGPLGWIL
                     GNLWNAGLFCLFLIFELLRQSMQHEPAFESSSEEEEEEIRVVPVSSYTRLSDFPSQEA
                     LEAFYKHYIQNAIRDLPCTCEFVESFVDDLIEACRVLSRREAHPQLEDCLGFGAAFEK
                     WGTLHETQNFDVLVPIVPPQGTMFILEMRDPALGRRCGCVKVDSECMCKHEKLLGDVL
                     CLVHHRDHSAMLSKCTSSIKAALCTSSHLDVCKTVQWFRNMVSNAWALVAHKYDFKLT
                     FPPSTTSCKLRLGYRSGRSLSISLVLGVQREDTLVYLVSQAPEQEQLTSVDWPESFAA
                     CEHLFLKLVGRFAPENTCHLKCLQIVLSLQDHQILPPGASRPILTSYHFKTALMHLLL
                     RLPLTDWQHSMLSLRLQDLLWFLGRGLQQRSLHHFLIGNTYLPLTIPIPKAFRNAEPV
                     NLFQHLVLNPVAHSQAVEEFHNLLAQVKTLPCSPVAGGL"
     regulatory      3660..3665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itpripl1"
                     /gene_synonym="1700041B20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3680
                     /gene="Itpripl1"
                     /gene_synonym="1700041B20Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaggcgggaa ccgctgtgga ttgctggagt ccgccgggac cagcaccgcg tggtagtcgc
       61 tgcagtccgc tgcccgcaga ctttggacct cggagacatg gtctgtaccc agaaagagct
      121 cgtcaggtgg actctctcag tttgtgtgga gtatgaactg ggagcatcgc gtacgcccgg
      181 aagaaggcga gggcggccag gtcgcgctgt ctctttaaga acgctctcct gctaactgag
      241 accatgcaga ggcctccatg gctgtgataa gcctcatgtt cttggcagtg atgtatgttg
      301 ttcaccaccc cctgatggtc agtgaccgca tggacctgga cacgctagct aggagtcggc
      361 agctggagaa gcgaatgagc gaggagatgc ggcagttaga gatggagttt gaagagagga
      421 gccgagccgc tgagcagaag cagaaagtgg agaacttctg gagaggggat acatccagtg
      481 accagttagt gctggggaag aaggacatgg gatggccctt ccaggccggt ggccaagatg
      541 gggggcctct gggctggata ctgggaaacc tgtggaatgc aggcctcttt tgcctttttc
      601 tcatctttga gctcctacga cagagcatgc agcacgagcc agcctttgag tccagcagcg
      661 aggaggaaga ggaagagatc cgtgtcgtgc ccgtctcctc ttacacccgg ctctctgatt
      721 ttccctccca ggaagccctg gaagcctttt acaaacatta tatccaaaat gccatccgtg
      781 acctgccctg cacctgtgag tttgtggaga gctttgtgga tgatctcatt gaggcctgcc
      841 gggtgctcag ccgccgggag gctcacccac agttggagga ctgcctgggc tttggggctg
      901 cctttgagaa gtggggaacc ctccacgaga cccagaattt cgatgtcctg gtgcccattg
      961 tccctcccca gggcactatg tttatcttgg agatgagaga tccggctctg ggccgtcgtt
     1021 gtggctgtgt gaaggtggac tctgagtgca tgtgcaagca tgagaagctc ttgggggatg
     1081 tgttgtgcct ggtgcaccac agggaccact cagccatgtt gagcaagtgt actagctcca
     1141 tcaaggcagc tctctgcacc agctcgcacc tggacgtgtg taagaccgtg cagtggttcc
     1201 gaaacatggt gagcaatgcc tgggcactag tggcccacaa atacgacttt aagctcactt
     1261 tcccaccgtc caccacctcc tgcaagctca ggttgggtta ccgctcaggc cgctctctgt
     1321 ccatcagttt ggttctaggg gtgcaacggg aagatacctt ggtctacctg gtgagtcagg
     1381 cccccgagca agaacagctc accagtgtgg attggcctga gtcctttgca gcttgtgaac
     1441 acttgtttct gaagctggtg gggcgctttg cccctgagaa cacctgccac ctcaagtgcc
     1501 tgcagatcgt tttgagtctt caggaccatc agatcttacc cccgggagca tctcgcccca
     1561 ttctcacctc ctaccacttc aagacagccc tcatgcactt gttgctacga ctgcctctga
     1621 cagactggca gcacagtatg ctctctctgc gcctccagga cctcctctgg ttcttaggcc
     1681 gaggcctcca gcaaaggtct ctccatcatt tcctcattgg taacacctac ctgcccctga
     1741 ccatacccat tcctaaggca tttcggaatg ctgagcctgt caatcttttc cagcacctgg
     1801 tactaaaccc agtggcacac tcgcaggcag tggaggaatt ccacaacctt ttggcccagg
     1861 tgaaaactct accttgctcc ccagtggctg gaggacttta atggaaagac cattaaaata
     1921 tatacatgta gataggtatt gctgattcct caggctgcaa atgtgactga ccttcgcctt
     1981 gcccgtggga agaaggctgc agccagtgga gcctgatctg ggagagctgg gggtggctga
     2041 gggcttatct cctgacttaa tttcagtcat gacctaaaga aagtaaaagt gcgtgaaaac
     2101 aaatgttatg ggaggggatt gccgctgtgg cactgagatc ctgttgaact gcattttgta
     2161 tcaaccctgg aagccaaagc tccagcgatc cctccgtgct agctcagttc tttctgtgac
     2221 tggctccgtg ttccctgtga aacagcttgt gttgcactgt tagcgtaatt cccacccaaa
     2281 ctgatgcctc ccacctttct cccttgaagc gacagccaca gtttatactt caagatgtaa
     2341 gttttcatga ctggtttgaa agcacaacca agatgtttct tttcttttct ttctttcttt
     2401 ctttcttttt tttttttttt tttttttttt ttttgagaca gggtttctct gtgtagccct
     2461 gactgtccta gaactcactc catagaccag gctggctttg aacttataga gatccacttg
     2521 cctctgcctc ccaagtgctg ggagtgtatg ctgccactgt cagacaaaga tgtatttgta
     2581 gttcatgtgt atgagtgttt tgtctgcatt ctaatctatg catcatacgc atgtaatacc
     2641 tgcagaggac aggagagggc attagttccc ctggacctgg agttaaagat ggttgtgagc
     2701 tgctgtgtgg gtgctaggaa tttagcttgg atcctctgga agagcagcca gtgctcttta
     2761 accactgagc caactttcca gccccattct tttctttttc ttcattggca cacaaattta
     2821 tagctgtttt tgtgtgtctg agtactcaaa tatttgttag ttttgattca ttatgagtta
     2881 gtggtgactc atcccatttt aagaaaatgt gtttcctaga cttagtgaaa ccagcgacac
     2941 ctgatgaccc tcctcgttcc tggaagcgct attagaaagc tcttcctggt gatgattttc
     3001 tgggggctct acgatggaca atctgtttcc tagagagtgg cctgtttgtt acatggaaag
     3061 gctgagctgc cgctcactgt gcgttcctct ggtgatggct ttccattttc ttttcaaaga
     3121 tgacacagag gtttcttgaa ctttgtggtt ttgaaacgag gagtccccac aatccaggcc
     3181 ggttgccagg cctgggcagg aaggcctgtg aagtagatca gttccaagag ccctgattgt
     3241 agtcggtgac tgtcacgttt tcctcttgtt ccaaaacctg catcttgagt attaaaaaaa
     3301 tagttatggg tgtggttgtt tttgaagtat caaagctgtt ctgtacccaa cactgccagg
     3361 aaatctggga aggagaccct ggcccttcgt ttgactttcc ctctgcagtt ggtgaggaag
     3421 gaggtatcag atgctagcct ttggggtttc tgtggaggga tccataccat agccaaaaat
     3481 aaaagaattc tagaaacgta tgtcaatctt tgaaattctt gctacacaga ggtatagtat
     3541 tctccatgtt acctgctttc caggtaaaag gatgcggtga tgcctctgtg ctggtgggaa
     3601 ttctgttttt aagatgtctg tagacttttg agaaaactat ctgcttctat attaactcca
     3661 ataaaaatgt atggaggctg gtctctgta
//
