LOCUS       NM_080558               5109 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus ITPR interacting domain containing 2 (Itprid2), mRNA.
ACCESSION   NM_080558
VERSION     NM_080558.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5109)
  AUTHORS   Fujimoto,T. and Shirasawa,S.
  TITLE     Identification of KRAP-expressing cells and the functional
            relevance of KRAP to the subcellular localization of IP3R in the
            stomach and kidney
  JOURNAL   Int J Mol Med 30 (6), 1287-1293 (2012)
   PUBMED   22992961
  REMARK    GeneRIF: KRAP physically associates with IP3 receptors and
            regulates their proper localization in the mucous cells and the
            chief cells of the stomach and in the proximal tubular cells of the
            kidneys.
REFERENCE   2  (bases 1 to 5109)
  AUTHORS   Fujimoto,T. and Shirasawa,S.
  TITLE     KRAS-induced actin-interacting protein: a potent target for
            obesity, diabetes and cancer
  JOURNAL   Anticancer Res 31 (7), 2413-2417 (2011)
   PUBMED   21873152
  REMARK    GeneRIF: KRAP-deficient mice show altered whole-body energy
            metabolism & resistance to diet-induced obesity and diabetes.
            Review.
            Review article
REFERENCE   3  (bases 1 to 5109)
  AUTHORS   Fujimoto,T., Machida,T., Tsunoda,T., Doi,K., Ota,T., Kuroki,M. and
            Shirasawa,S.
  TITLE     KRAS-induced actin-interacting protein regulates inositol
            1,4,5-trisphosphate-receptor-mediated calcium release
  JOURNAL   Biochem Biophys Res Commun 408 (2), 214-217 (2011)
   PUBMED   21457704
  REMARK    GeneRIF: KRAP is involved in the proper regulation of IP3R-mediated
            Ca2+ release.
REFERENCE   4  (bases 1 to 5109)
  AUTHORS   Fujimoto,T., Machida,T., Tanaka,Y., Tsunoda,T., Doi,K., Ota,T.,
            Okamura,T., Kuroki,M. and Shirasawa,S.
  TITLE     KRAS-induced actin-interacting protein is required for the proper
            localization of inositol 1,4,5-trisphosphate receptor in the
            epithelial cells
  JOURNAL   Biochem Biophys Res Commun 407 (2), 438-443 (2011)
   PUBMED   21420385
  REMARK    GeneRIF: These findings demonstrate that KRAP physically associates
            with IP(3)R and regulates the proper localization of IP(3)R in the
            epithelial cells in vivo and cultured cells.
REFERENCE   5  (bases 1 to 5109)
  AUTHORS   Miyasaka,K., Fujimoto,T., Kawanami,T., Takiguchi,S., Jimi,A.,
            Funakoshi,A. and Shirasawa,S.
  TITLE     Pancreatic hypertrophy in Ki-ras-induced actin-interacting protein
            gene knockout mice
  JOURNAL   Pancreas 40 (1), 79-83 (2011)
   PUBMED   21160370
  REMARK    GeneRIF: The lack and/or decrease in Ki-ras-induced
            actin-interacting protein level in the pancreas may promote the
            pancreatic growth and hypertrophy.
REFERENCE   6  (bases 1 to 5109)
  AUTHORS   Fujimoto,T., Miyasaka,K., Koyanagi,M., Tsunoda,T., Baba,I., Doi,K.,
            Ohta,M., Kato,N., Sasazuki,T. and Shirasawa,S.
  TITLE     Altered energy homeostasis and resistance to diet-induced obesity
            in KRAP-deficient mice
  JOURNAL   PLoS One 4 (1), e4240 (2009)
   PUBMED   19156225
REFERENCE   7  (bases 1 to 5109)
  AUTHORS   Inokuchi,J., Komiya,M., Baba,I., Naito,S., Sasazuki,T. and
            Shirasawa,S.
  TITLE     Deregulated expression of KRAP, a novel gene encoding
            actin-interacting protein, in human colon cancer cells
  JOURNAL   J Hum Genet 49 (1), 46-52 (2004)
   PUBMED   14673706
REFERENCE   8  (bases 1 to 5109)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 5109)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ129385.1, CF539296.1 and BC079535.1.
            
            On Jul 26, 2008 this sequence version replaced NM_080558.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB093303.1, SRR1660821.191001.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               CJ129385.1         50-295
            247-803             CF539296.1         63-619
            804-5109            BC079535.1         183-4488
FEATURES             Location/Qualifiers
     source          1..5109
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 47.58 cM"
     gene            1..5109
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /note="ITPR interacting domain containing 2"
                     /db_xref="GeneID:70599"
                     /db_xref="MGI:MGI:1917849"
     exon            1..320
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            321..366
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            367..416
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            417..473
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            474..513
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            514..612
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            613..821
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1525
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1598
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1687
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..2890
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..2968
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3096
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3247
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..3313
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            3314..3769
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            3770..3887
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..5095
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5071..5076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /note="hexamer: AATAAA"
     polyA_site      5095
                     /gene="Itprid2"
                     /gene_synonym="5730488C15Rik; CS-1; CS1; KRAP; mKIAA1927;
                     SPAG13; Ssfa2"
                     /note="major polyA site"
ORIGIN      
        1 ggctcccccg ggccccctgc ccggctgggc gctgacagca gcggcggggg tccccgcagc
       61 cgccgctgtg tcccgcgcag gctcgggctg ggcccgcgga gcccccggcg cggccatgaa
      121 ccgacccctg tcggcggagg cggaggagga actggagtgg caagtggcga gtcgcaggag
      181 gaaggcctgg gccaagtgcc gcagctcctg gcaggcgtcg gagaccgagg atctgtccac
      241 agagacgacg acgcaggacg aggacgagga cgacgaggag gacctcccag gcacgaagct
      301 gccggcaccc gcggggcgag gaaacgtgcc caacgagaag atcgcgatat ggctcaaaga
      361 ctgccgcacc cctctgggag cctcactgga tgagcaaagc agtggtacgc cgaagggtgt
      421 gcttgtgaga aatggaggaa gctttgaaga tgacctgtca ctgggagctg aagccaatca
      481 cctacatgaa cctgatgctc aagttgaaaa ctgcaacaat atcttggcca aggagagaag
      541 actacagttt catcagaaag ggagaagtat gaattccact gggtctggga aaagcagtgg
      601 taccgtgtca agtgtctcag aactgctgga gctttacgag gaagatcctg aagaaattct
      661 atataatctt ggatttggac gagatgaacc agatattgct tctaaaattc cttccagatt
      721 ttttaattca tcatcctttg ccagaggcat agacattaaa gtatttctga gtgcacagat
      781 gcaacggatg gaagtagaga acccaaacta tgctctgaca agccgatttc gccaaattga
      841 agtcctgact actgtggcca atgcattttc ttctctatat tcccaagtct ctggaactcc
      901 actgcagagg attggaagta tgtcctcggt gacctccacc aaggaggtgg cagactcccc
      961 gccccctcta actcgaagca acactgcaaa ccgtctgatg aaaacactat caaaactgaa
     1021 cttatgtgtt gataaaacag agaaaggaga agggggctct tcccccgcca ctgagaaagg
     1081 aaggactcta agcatctcac tgtctgaaga tggcggcggc ggcaagagtg accctaagct
     1141 tcagaaagtt gtaaagaaga aggagtcgtc ttcgatgctg gctacggtta cagaagaagt
     1201 ctcaggtagt tcatcaaccg tcacagacag cgttgatgca gacagacttt ccgaggaagc
     1261 agacagtacc attagccacc aggaggaaag tgaagaaagc agagaggctc acagtcagga
     1321 gaaggacccg ctccgcaagt ctgctgtgac agatcctgac ttgggtcatg atggccgcgt
     1381 gtccagccac tgcgagctgg agagcagcag tgagctgaaa agtgcccagg cgtcttcgag
     1441 cgagaaagag ccttgtgcac ccctgacaat cccatccata cggaacataa tgacgcagca
     1501 gaaagactcc tttgagatgg aagaggtcca gagcacagag ggagaagccc ctcacgtgcc
     1561 agccacttgc cagctaagtc ttgccaagtc aaaaagagat catctgttga gaactgcaag
     1621 tcagcattcc gatagcagcg gctttgctga ggactccaca gactgtgtct ccctcaacca
     1681 cctcctggtg aacgagtccc tgcaagccat ggggagcagt gctgacagct gtgacagtga
     1741 aaccaccgtc acatcgcttg gtgaggacca cgtgactcct acagcgcaag accagcctta
     1801 cttcaatgag tcagaggagg agtccctggc tcctctgcag aaaggaagag caaaggtgga
     1861 aatagtggct gagaaaagga aagccgacaa ccaagatttc cctcagtgtg tgaccgcaga
     1921 gaatgctgga aacaatgagt ccacaaaggg cccgtgtgag cctggtcatc agatcacaga
     1981 aacaggggag catccacctc tggcagccac tggagagctc cccagggaag agagtgtcga
     2041 gagtgatgta gagaaaggca gtgaatgtga atttgcccag tacaccacac accatattct
     2101 cagatccttg gcttcctttg aagcgcaggg cagcggtatg agctctgaaa agaaaactgg
     2161 gtttccctct tctgtggaca gagtgaacac tgccctgcag agagctcaaa tgaaggtctg
     2221 cagtatgtct gggcagagag tagggcgtag cctaataaaa tcaaaggatc tgttgaaaca
     2281 aaggtacttg ctcgcaaaag ctggctatcc tctgagaagg tctcagtctt tgcccaccac
     2341 tttactgagc ccagtacggg tggtgtcttc tgtcaatgtg cgattatctc caggaaaaga
     2401 gaccaggtgc agcccaccgt ccttcaccta caagtacaca cccgaagagg aacaagacct
     2461 ggaaaagcaa ggaactgaac acgatggtca gtctctggtt aaatctacca tcttcatccc
     2521 gccaccctct gtgaagaaag aagaagcccc tcagagtgag gggacacgac tggaggaatg
     2581 ccaccatgga aggcttgccc cctgcccaca gttcgctcca atatcccagt ccacctgctc
     2641 ccttcactct gtccactctg agtggcagga cagacccctg tgtgaacaca tgaggactct
     2701 gagtgcccac agtgtcccca acatatcggg tgccgcatgt agtgccttct ctcctttcgg
     2761 gtgtccctat tcacacagac atgctgccca cccatacagg gcatgctctg tgaatcctcc
     2821 ttctgccatt gagatgcagt tgcggagagt gttgcatgat attagaagct cactacagaa
     2881 tctttcacag tatcctatga cgagaggacc tgaccttgct gctgctccat acagtactca
     2941 gaactcgtct gtcctacctc tttatgaaaa taccttccag gagcttcaag tcgtgaggcg
     3001 gagcctgaat ctgttcagaa cgcagatgat ggacttggag ctggccatgc tgcggcagca
     3061 aaccgtggtg taccctcata tgacagagga ggacaggtat gaagttgatc agctgcaggg
     3121 tttgcggaac tctgtccgaa tggaactgca ggacctggag atgcagctgg aggagcgctt
     3181 gctgggcctg gatgagcagc tccgtgcagt gcgggtgcca tcacctttcc gcccctctgc
     3241 actcccgggg atgtgtggca gcaggagcgt agataactta tcatgcccgt ctccactgaa
     3301 cgtcatggag cccgtcacag agctaattcg ggagcaatca tacctgaagt ctgagctggg
     3361 cctgggcctt ggagacatgg cgtatgaaat tcctcctgga gagagctcgg agtccgtttt
     3421 ctctcaagcc acatcagagt catcttccgt ctgctccagc ccctcccaca ccaacagaag
     3481 atctagaggg ctacctggga gcaaacccag agcccgctta gtggcgagaa agaagatatt
     3541 ccgagcctct gtggccctga caccaactgc cccctctaga acaggctctg tgcaaacacc
     3601 tccagatctg gagagttccg aagaagctgg aggagctgag gaagcatccc cggtagtggg
     3661 gcttgcatct cacgtggagg aagagccaga ggatctctca ctgatgccag cagccgagga
     3721 gatgcacagg aatgtggagc aagatgaact gcagcaagtc atccgagaga ttaaagagtc
     3781 tattgttggg gaaattcgac gagaaattgt aagtggactt ttggcagcag tgtcttcaag
     3841 taaagcacct ggtcctaagc aggacagcca ctgagcggac gccttcgggt tgagatggat
     3901 cccattaact aatataggca ttgtcagtga tttatgctgg tggaggtgtt gtttgtccta
     3961 tggaagatat tttctactga gctgggctac tgtacacaat ggacagtgtg catttctgta
     4021 caggttacgg ttctatgcat aaacatttta gaaaacaaac atagaaactt aggcactttg
     4081 ctgactcctt tctgaactat cagactggcc atttgaaagc ctagtattta tttgtatgtc
     4141 aatatttgcc cagttgatgt cctatgtaga gttaattgta aaacttgaag aatttcagac
     4201 ataaccaact tataaatgac ctatttcttc aggctagctt ctacaacact gacctccatg
     4261 aggtatttac tgtgcaataa cagattcgtc ttctgagagc ttgaagcaac ccatgatttg
     4321 tccctccact gctcttcact gggttcactt ccaaggagac taatggctct attgtaaaaa
     4381 ttgctcttaa ttcttgaaga ggctactgag aagcagtggg gtagatctca tgaggttacc
     4441 tacagctact tcatgttctt acactgtaag ccttgttgct ttgccccaac aattgtaatt
     4501 tgattatagc tatgagcctt atggtagaca ctatgtaccc tctgcggtgt aattgcatta
     4561 tagctatgtg ccttgtggta agcactatgt actctctgca ttgtccaaat gtcttacttt
     4621 aaggtgtttc ttctgtcttt tcgactaagt agtattgtca agataatggg gcctgtgact
     4681 tgaatggata gaatagaaat gaataagctg gtttttgttt ttccaaatga gatttagatt
     4741 tgtttttctc atgcataaat gattttaatt cagttttaac cagtgaaaac tcgtggtttt
     4801 tctgaaagaa aaaagaaaag ggtttcctat ctggtattat atatgtcaaa taaatgtata
     4861 aagtaacacc caaatgttat tagaaactag tcttttagta tttgtaattt tcaactctta
     4921 ttgtgttact ttgtgtgaaa atttttagtc aaaagtgctt ggaataatgg aatggttagc
     4981 attctttgaa agagtatcta aaaagtttat aaatatttga actatcacac aaaggttgat
     5041 ctctaaaaaa acaaaaaacc ccattaaaac aataaagaat ttattttgcc taaaaaaaaa
     5101 aaaaaaaaa
//
