LOCUS       NP_064307               2701 aa            linear   ROD 19-AUG-2024
DEFINITION  inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 isoform 1
            [Mus musculus].
ACCESSION   NP_064307 XP_358368
VERSION     NP_064307.2
DBSOURCE    REFSEQ: accession NM_019923.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2701)
  AUTHORS   Xu,L., Xu,Y., Jiang,Y., Jiang,J., Chen,S., Sun,D., Li,S., Wei,F.
            and Zhu,H.
  TITLE     IP3R2 regulates apoptosis by Ca2+ transfer through mitochondria-ER
            contacts in hypoxic photoreceptor injury
  JOURNAL   Exp Eye Res 245, 109965 (2024)
   PUBMED   38851477
  REMARK    GeneRIF: IP3R2 regulates apoptosis by Ca2+ transfer through
            mitochondria-ER contacts in hypoxic photoreceptor injury.
REFERENCE   2  (residues 1 to 2701)
  AUTHORS   Zhang,M., Zhi,N., Feng,J., Liu,Y., Zhang,M., Liu,D., Yuan,J.,
            Dong,Y., Jiang,S., Ge,J., Wu,S. and Zhao,X.
  TITLE     ITPR2 Mediated Calcium Homeostasis in Oligodendrocytes is Essential
            for Myelination and Involved in Depressive-Like Behavior in
            Adolescent Mice
  JOURNAL   Adv Sci (Weinh) 11 (20), e2306498 (2024)
   PUBMED   38476116
  REMARK    GeneRIF: ITPR2 Mediated Calcium Homeostasis in Oligodendrocytes is
            Essential for Myelination and Involved in Depressive-Like Behavior
            in Adolescent Mice.
REFERENCE   3  (residues 1 to 2701)
  AUTHORS   Ahmadpour,N., Kantroo,M., Stobart,M.J., Meza-Resillas,J.,
            Shabanipour,S., Parra-Nunez,J., Salamovska,T., Muzaleva,A.,
            O'Hara,F., Erickson,D., Di Gaetano,B., Carrion-Falgarona,S.,
            Weber,B., Lamont,A., Lavine,N.E., Kauppinen,T.M., Jackson,M.F. and
            Stobart,J.L.
  TITLE     Cortical astrocyte N-methyl-D-aspartate receptors influence whisker
            barrel activity and sensory discrimination in mice
  JOURNAL   Nat Commun 15 (1), 1571 (2024)
   PUBMED   38383567
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 2701)
  AUTHORS   Gonzalez-Arias,C., Sanchez-Ruiz,A., Esparza,J., Sanchez-Puelles,C.,
            Arancibia,L., Ramirez-Franco,J., Gobbo,D., Kirchhoff,F. and
            Perea,G.
  TITLE     Dysfunctional serotonergic neuron-astrocyte signaling in
            depressive-like states
  JOURNAL   Mol Psychiatry 28 (9), 3856-3873 (2023)
   PUBMED   37773446
REFERENCE   5  (residues 1 to 2701)
  AUTHORS   Miguel-Quesada,C., Zaforas,M., Herrera-Perez,S., Lines,J.,
            Fernandez-Lopez,E., Alonso-Calvino,E., Ardaya,M., Soria,F.N.,
            Araque,A., Aguilar,J. and Rosa,J.M.
  TITLE     Astrocytes adjust the dynamic range of cortical network activity to
            control modality-specific sensory information processing
  JOURNAL   Cell Rep 42 (8), 112950 (2023)
   PUBMED   37543946
REFERENCE   6  (residues 1 to 2701)
  AUTHORS   Parrington,J., Brind,S., De Smedt,H., Gangeswaran,R., Lai,F.A.,
            Wojcikiewicz,R. and Carroll,J.
  TITLE     Expression of inositol 1,4,5-trisphosphate receptors in mouse
            oocytes and early embryos: the type I isoform is upregulated in
            oocytes and downregulated after fertilization
  JOURNAL   Dev Biol 203 (2), 451-461 (1998)
   PUBMED   9808793
REFERENCE   7  (residues 1 to 2701)
  AUTHORS   Kim,J.H., Hui,P., Yue,D., Aycock,J., Leclerc,C., Bjoring,A.R. and
            Perkins,A.S.
  TITLE     Identification of candidate target genes for EVI-1, a zinc finger
            oncoprotein, using a novel selection strategy
  JOURNAL   Oncogene 17 (12), 1527-1538 (1998)
   PUBMED   9794230
REFERENCE   8  (residues 1 to 2701)
  AUTHORS   Futatsugi,A., Kuwajima,G. and Mikoshiba,K.
  TITLE     Muscle-specific mRNA isoform encodes a protein composed mainly of
            the N-terminal 175 residues of type 2 Ins(1,4,5)P3 receptor
  JOURNAL   Biochem J 334 (Pt 3) (Pt 3), 559-563 (1998)
   PUBMED   9729462
REFERENCE   9  (residues 1 to 2701)
  AUTHORS   De Smedt,H., Missiaen,L., Parys,J.B., Henning,R.H., Sienaert,I.,
            Vanlingen,S., Gijsens,A., Himpens,B. and Casteels,R.
  TITLE     Isoform diversity of the inositol trisphosphate receptor in cell
            types of mouse origin
  JOURNAL   Biochem J 322 (Pt 2) (Pt 2), 575-583 (1997)
   PUBMED   9065779
REFERENCE   10 (residues 1 to 2701)
  AUTHORS   De Smedt,H., Missiaen,L., Parys,J.B., Bootman,M.D., Mertens,L., Van
            Den Bosch,L. and Casteels,R.
  TITLE     Determination of relative amounts of inositol trisphosphate
            receptor mRNA isoforms by ratio polymerase chain reaction
  JOURNAL   J Biol Chem 269 (34), 21691-21698 (1994)
   PUBMED   8063813
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143206.1, AB182288.1, AK028484.1, AK046210.1 and AW049374.1.
            
            On Mar 8, 2005 this sequence version replaced NP_064307.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB182288.1, GU980658.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2701
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.7 cM"
     Protein         1..2701
                     /product="inositol 1,4,5-trisphosphate-gated calcium
                     channel ITPR2 isoform 1"
                     /note="inositol 1,4,5-triphosphate receptor 5; inositol
                     1,4,5-trisphosphate-gated calcium channel ITPR2; inositol
                     1,4,5-trisphosphate receptor type 2; IP3R 2; inositol
                     trisphosphate receptor type 2; type 2 InsP3 receptor; IP3
                     receptor; inositol 1,4,5-trisphosphate type V receptor;
                     type 2 inositol 1,4,5-trisphosphate receptor"
                     /calculated_mol_wt=307345
     Region          5..228
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:462572"
     Region          218..439
                     /region_name="beta-trefoil_MIR_ITPR2"
                     /note="MIR domain, beta-trefoil fold, found in inositol
                     1,4,5-trisphosphate receptor type 2 (ITPR2) and similar
                     proteins; cd23288"
                     /db_xref="CDD:467759"
     Site            order(245..246,386)
                     /site_type="other"
                     /note="putative homotetramer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467759"
     Site            order(265,267..269,275)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:467759"
     Region          475..670
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Site            937
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA.
                     /evidence=ECO:0000269|PubMed:19608738,
                     ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (Q9Z329.4)"
     Region          1135..1174
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z329.4)"
     Site            1160
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14571; propagated from
                     UniProtKB/Swiss-Prot (Q9Z329.4)"
     Region          1202..1344
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Site            1709
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9Z329.4)"
     Site            1711
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9Z329.4)"
     Region          1915..2022
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:462482"
     Site            2228..2248
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z329.4)"
     Site            2261..2281
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z329.4)"
     Region          2306..2552
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Site            2308..2328
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z329.4)"
     Site            2352..2372
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z329.4)"
     Site            2395..2415
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z329.4)"
     Site            2521..2541
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z329.4)"
     Site            2607
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (Q9Z329.4)"
     Site            2633
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9Z329.4)"
     Site            2636
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9Z329.4)"
     CDS             1..2701
                     /gene="Itpr2"
                     /gene_synonym="InsP3R-2; InsP3R-5; insP3R2; Ip3r2; Itpr5"
                     /coded_by="NM_019923.4:346..8451"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39709.1"
                     /db_xref="GeneID:16439"
                     /db_xref="MGI:MGI:99418"
ORIGIN      
        1 msdkmssfly igdivslyae gsvngfistl glvddrcvvh peagdlanpp kkfrdclfkv
       61 cpmnrysaqk qywkakqakq gnhteaallk klqhaaeleq kqnesenrkl lgeivkysnv
      121 iqllhiksnk yltvnkrlpa lleknamrvs ldaagnegsw fyihpfwklr segdnivvgd
      181 kvvlmpvnag qplhasnvel ldnpgckevn avncntswki tlfmkfssyr edvlkggdvv
      241 rlfhaeqekf ltcddyekkq hiflrttlrq satsatsska lweievvhhd pcrggagqwn
      301 slfrfkhlat gnylaaelnp dyrdaqnegk nvkdgeiptp kkkrqageki mytlvsvphg
      361 ndiaslfeld attlqradcl vprnsyvrlr hlctntwvts ttipidteee rpvmlkigtc
      421 qtkedkeafa ivcvplsevr dldfandank vlattvkkle ngsitqnerr fvtklledli
      481 ffvadvtnng qdvldvvitk pnrerqklmr eqnilaqvfg ilkapfkeka gegsmlrled
      541 lgdqryapyk yvlrlcyrvl rhsqqdyrkn qeyiaknfcv mqsqigydil aedtitallh
      601 nnrkllekhi takeietfvs llrrnreprf ldylsdlcvs nstaipvtqe lickfmlspg
      661 nadiliqtkl vsmqvenpme ssilpddidd eevwlywids nkephgkair hlaqearegt
      721 kadlevltyy ryqlnlfarm cldrqylain qistqlsvdl ilrcvsdesl pfdlrasfcr
      781 lmlhmhvdrd pqesvvpvry arlwteiptk itiheydsit dssrndmkrk faltmefvee
      841 ylkevvnqpf pfgdkeknkl tfevvhlarn liyfgfysfs ellrltrtll aildivqapm
      901 ssyferlskf qdgsnnvmrt ihgvgemmtq mvlsrgsifp vsvpdaqpiv hpskqaspge
      961 qedvtvmdtk lkvieilqfi lsvrldyris ymlsiykkef gdnndngdps asgtpdtllp
     1021 salvpdidei aaqaetmfag rkektpvqld deggrtflrv lihlimhdya pllsgalqll
     1081 fkhfsqraev lqafkqvqll vsnqdvdnyk qikadldqlr ltvekselwv eksgsyengd
     1141 vgegqakgge eaneesnlls pvqdgaktpq idsnkgnnyr ivkeilirls klcvqnkkcr
     1201 nqhqrllknm gahsvvldll qipyektdek mnevmdlaht flqnfcrgnp qnqvllhkhl
     1261 nlfltpglle aetmrhifmn nyhlcneise rvvqhfvhci ethgrhveyl rflqtivkad
     1321 gkyvkkcqdm vmtelingge dvlifyndra sfpillnmmc serargdesg playhitlve
     1381 llaactegkn vyteikcnsl lplddivrvv thddcipevk iayvnfvnhc yvdtevemke
     1441 iytsnhiwkl fenflvdmar vcntttdrkh adtflercvt esvmnivsgf fnspfsdnst
     1501 slqthqpvfi qllqsafriy nctwpnpaqk asvesciral aevaknrgia ipvdldsqvn
     1561 tlfmknhsst vqraamgwrl sarsgprfke alggpawdyr niieklqdvv asleqqfspm
     1621 mqaefsvlvd vlyspellfp egsdarircg afmsklinht kklmekeekl cikilqtlre
     1681 mlekkdsfme egstlrrill nryfkgdhsi svngplsgay aktaqvggsf sgqdsdkkgi
     1741 smsdiqclld kegaselvid vivntkndri fsegillgia lleggntqtq ysfyqqlheq
     1801 kksekffkvl ydrmkaaqke irstvtvnti dlgskkreed sdvmalgprm rvrdsslhlr
     1861 egmkgqltea ssatskaycv yrremdpeid tmcpgqeags aeeksaeevt mspaitimrp
     1921 ilrflqllce nhnrelqnfl rnqnnktnyn lvcetlqfld cicgsttggl gllglyiner
     1981 nvalvnqtle slteycqgpc henqtciath esngidiiia lilndinplg kyrmdlvlql
     2041 knnaskllla imesrhdsen aerilfnmrp relvdvmkna ynqglecdhg deeggddgvs
     2101 pkdvghniyi lahqlarhnk llqqmlkpgs dpeegdealk yyanhtaqie ivrhdrtmeq
     2161 ivfpvpnice fltreskyrv fntterdeqg skvndffqqt edlynemkwq kkirnnpalf
     2221 wfsrhislwg sisfnlavfi nlavalfypf gddgdegtls pmfsvllwva vaictsmlff
     2281 fskpvgirpf lvsvmlrsiy tiglgptlil lgaanlcnki vflvsfvgnr gtftrgyrav
     2341 ildmaflyhv ayvlvcmlgl fvheffysfl lfdlvyreet llnviksvtr ngrsiiltav
     2401 lalilvylfs iigflflkdd ftmevdrlkn rtpvtgnhgv ptmtlssmme tcqkencspt
     2461 ipssntagee gedgiertcd tllmcivtvl nqglrngggv gdvlrrpskd eplfaarvvy
     2521 dllfffivii ivlnlifgvi idtfadlrse kqkkeeilkt tcficglerd kfdnktvsfe
     2581 ehiksehnmw hylyfivlvk vkdpteytgp esyvaqmite knldwfprmr amslvsnegd
     2641 seqneirnlq eklestmslv kqlsgqlael keqmteqrkn kqrlgflgsn tphvnhhmpp
     2701 h
//
