LOCUS       NM_181593               3280 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus inositol 1,4,5-trisphosphate 3-kinase C (Itpkc), mRNA.
ACCESSION   NM_181593
VERSION     NM_181593.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3280)
  AUTHORS   Scoumanne,A., Molina-Ortiz,P., Monteyne,D., Perez-Morga,D.,
            Erneux,C. and Schurmans,S.
  TITLE     Specific expression and function of inositol 1,4,5-trisphosphate
            3-kinase C (ITPKC) in wild type and knock-out mice
  JOURNAL   Adv Biol Regul 62, 1-10 (2016)
   PUBMED   27036498
  REMARK    GeneRIF: The expression of ITPKC in various ciliated tissues
            suggest a role for the enzyme either in the development or in the
            function of these specialized cellular structures.
REFERENCE   2  (bases 1 to 3280)
  AUTHORS   Dietrich,J.E., Panavaite,L., Gunther,S., Wennekamp,S., Groner,A.C.,
            Pigge,A., Salvenmoser,S., Trono,D., Hufnagel,L. and Hiiragi,T.
  TITLE     Venus trap in the mouse embryo reveals distinct molecular dynamics
            underlying specification of first embryonic lineages
  JOURNAL   EMBO Rep 16 (8), 1005-1021 (2015)
   PUBMED   26142281
REFERENCE   3  (bases 1 to 3280)
  AUTHORS   Leyman,A., Pouillon,V., Bostan,A., Schurmans,S., Erneux,C. and
            Pesesse,X.
  TITLE     The absence of expression of the three isoenzymes of the inositol
            1,4,5-trisphosphate 3-kinase does not prevent the formation of
            inositol pentakisphosphate and hexakisphosphate in mouse embryonic
            fibroblasts
  JOURNAL   Cell Signal 19 (7), 1497-1504 (2007)
   PUBMED   17355905
  REMARK    GeneRIF: These data show that the absence of expression of the
            three isoenzymes of Itpk does not prevent the formation of IP5 and
            IP6, at least in mouse embryonic fibroblasts.[Itpka, Itpkb, Itpkc]
REFERENCE   4  (bases 1 to 3280)
  AUTHORS   Pouillon,V., Hascakova-Bartova,R., Pajak,B., Adam,E., Bex,F.,
            Dewaste,V., Van Lint,C., Leo,O., Erneux,C. and Schurmans,S.
  TITLE     Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte
            development
  JOURNAL   Nat Immunol 4 (11), 1136-1143 (2003)
   PUBMED   14517551
REFERENCE   5  (bases 1 to 3280)
  AUTHORS   Dewaste,V., Pouillon,V., Moreau,C., Shears,S., Takazawa,K. and
            Erneux,C.
  TITLE     Cloning and expression of a cDNA encoding human inositol
            1,4,5-trisphosphate 3-kinase C
  JOURNAL   Biochem J 352 Pt 2 (Pt 2), 343-351 (2000)
   PUBMED   11085927
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY275976.1 and BC053450.1.
            
            On Jun 9, 2018 this sequence version replaced NM_181593.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053450.1, AK154888.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BY275976.1         46-65
            21-3280             BC053450.1         1-3260
FEATURES             Location/Qualifiers
     source          1..3280
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.85 cM"
     gene            1..3280
                     /gene="Itpkc"
                     /gene_synonym="9130023N17Rik; IP3K C"
                     /note="inositol 1,4,5-trisphosphate 3-kinase C"
                     /db_xref="GeneID:233011"
                     /db_xref="MGI:MGI:2442554"
     exon            1..1267
                     /gene="Itpkc"
                     /gene_synonym="9130023N17Rik; IP3K C"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..2167
                     /gene="Itpkc"
                     /gene_synonym="9130023N17Rik; IP3K C"
                     /EC_number="2.7.1.127"
                     /note="IP3 3-kinase C; insP 3-kinase C"
                     /codon_start=1
                     /product="inositol-trisphosphate 3-kinase C"
                     /protein_id="NP_853624.1"
                     /db_xref="CCDS:CCDS21015.1"
                     /db_xref="GeneID:233011"
                     /db_xref="MGI:MGI:2442554"
                     /translation="MRRCPCRGSLSEAEAGALPAEARMGLEALRGGRRRQPGLQRPGP
                     GAGGPTGRPEGGGPRAWIEESSLHSEAERTDLEPAPCPNGPQAESCGDGHAECEAAGL
                     VVASEKPRQNKELDGSNLQTHPRRNSPLVEMEMAGSWTDGFRTDLHRSDLQSRPKRAS
                     LCTQPGFDESWTELDRSDMWQTLPERDNKPRVDNLRTHHGVSKLQTHPVCLSPESSAD
                     NSGKELSADASRTPHDTDGFWIESQTDDSLKGPSTQTACRQPGSDGFSSKDTESALTQ
                     PGTDGLRDDSVLGESNGNDPLDLSEPGELVTNLCSHLECSSLCPVPRLIITPETPEPE
                     AQPVGPQSRIEGGTGGFSSASSFDESEDDLVAGGGGTSDPEDRAGSKPWKKLKTVLKY
                     SPFVVSFHKHYYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLELLMGDPLRPFVPA
                     YYGMVQRDGQAFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPKPRKDMYEK
                     MVAVDPGAPTPEEHAQGAITKPRYMQWRETLSSTSTLGFRIEGIKKADGTCNTNFKKT
                     QALEQVTKVLEDFVNGDLGILRKYVARLEDLRETLENSPFFKTHEVVGSSLLFVHDHT
                     GLAKVWMIDFGKTVALPDHQMLSHRLPWTEGNREDGYLWGLDNLICLLQGLAQS"
     exon            1268..1370
                     /gene="Itpkc"
                     /gene_synonym="9130023N17Rik; IP3K C"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1584
                     /gene="Itpkc"
                     /gene_synonym="9130023N17Rik; IP3K C"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1789
                     /gene="Itpkc"
                     /gene_synonym="9130023N17Rik; IP3K C"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1891
                     /gene="Itpkc"
                     /gene_synonym="9130023N17Rik; IP3K C"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1963
                     /gene="Itpkc"
                     /gene_synonym="9130023N17Rik; IP3K C"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..3238
                     /gene="Itpkc"
                     /gene_synonym="9130023N17Rik; IP3K C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3217..3222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itpkc"
                     /gene_synonym="9130023N17Rik; IP3K C"
                     /note="hexamer: AATAAA"
     polyA_site      3236
                     /gene="Itpkc"
                     /gene_synonym="9130023N17Rik; IP3K C"
                     /note="major polyA site"
ORIGIN      
        1 gcatatccga gcggcctgga gctcggcggg ccggaaccca cgagttgggg ctccccagcc
       61 acacccctcg taggatttta aaggggaagg aggggccgga cgggccaaag cccgggccct
      121 gggagcgggt atgaggcgct gcccgtgccg ggggagcctg agcgaggcgg aggccggcgc
      181 actgccagcc gaggcccgca tggggctgga ggcgctgcga ggtgggcggc ggcgacagcc
      241 tggactacaa cgacctggac cgggagcagg tggcccgacg ggacggccgg aggggggcgg
      301 tccccgggcc tggatcgagg agtccagcct ccactccgag gcggagagga ccgacctcga
      361 gcctgcgccg tgtccgaacg gtccacaggc agaatcctgt ggagatggac acgcggagtg
      421 cgaagcagct ggcctagtag ttgcgtcgga gaagcccagg caaaataagg agctagacgg
      481 gtccaacctc cagacacatc caagaaggaa cagccccctg gttgagatgg agatggccgg
      541 ttcctggaca gatggctttc gaactgatct tcacagatct gacctccagt ctcggccaaa
      601 gagagccagc ctctgtaccc aaccagggtt tgatgagtcc tggaccgaac tggacagatc
      661 cgatatgtgg cagactctgc cagagaggga caacaagccc agggttgata accttaggac
      721 ccaccatggc gtgtccaaac tccaaactca cccagtctgc ctctcaccag aatcaagtgc
      781 tgataactcc ggcaaagaat tgtccgcgga tgcttccagg actccacatg acaccgacgg
      841 cttctggata gagtcccaaa ctgatgactc tctcaaagga cctagtactc agacagcctg
      901 cagacaacct gggagtgatg gtttttcctc aaaagacact gagagtgcct tgactcaacc
      961 tggcactgat ggcctccggg atgacagcgt tttgggggag tccaatggaa atgatccatt
     1021 agatttatca gagcctggag agttggtgac taacctgtgc tcccacctgg agtgcagctc
     1081 cctgtgtcct gtgccccgcc ttatcatcac cccagagact cctgaacctg aggcccagcc
     1141 ggtgggaccc caatcccgga ttgagggggg cactggcggc ttctcttctg cctcctcttt
     1201 tgatgaatct gaggatgact tggtagccgg gggcggaggt accagcgatc ctgaggacag
     1261 agctggaagc aagccctgga agaagctgaa gacagttctg aagtactcgc ccttcgtggt
     1321 ctccttccat aagcactact atccctgggt ccagctttcc ggacacgctg ggaacttcca
     1381 ggccggtgag gatggtcgga ttctgaaacg tttctgtcag tgtgagcagc gcagcctgga
     1441 gctgctgatg ggagaccccc tgcggccttt tgtgcctgct tattatggca tggtgcagcg
     1501 ggatggccag gccttcaacc agatggaaga tctcctggca gactttgagg gcccctctat
     1561 catggactgc aagatgggca gcaggaccta cctggaagag gagctggtga aggccaggga
     1621 acgacccaag ccccggaagg atatgtatga gaagatggtg gcagtggacc ccggggctcc
     1681 caccccagaa gagcatgctc agggtgccat cacgaagccc cgatacatgc agtggaggga
     1741 gaccctgagt tcaacttcca cgctgggctt ccggattgaa ggcatcaaga aggctgatgg
     1801 gacctgcaac accaacttca agaagacaca ggctctggag caggtgacaa aggtgttaga
     1861 agactttgtg aatggggacc ttggaatcct aagaaagtac gtggcgcgac tggaagacct
     1921 ccgagagact ctggaaaatt ctcccttctt caagacccac gaggtagtgg gcagttccct
     1981 tctctttgtg catgaccaca ctggcctggc caaggtctgg atgattgact tcggcaagac
     2041 agtggccctg cctgaccacc agatgctcag tcacaggctg ccttggacag agggcaaccg
     2101 tgaggacggc tacctctggg gtctggacaa tttgatctgc ctccttcagg ggctggccca
     2161 gagctgacgt catctgccac tgctaggctc acttgcagga tagcatgtgt ctggctagaa
     2221 gagtcctaag atgttgtctg ggggaagatg aggtgcttca aagtgtcacc agatcagtga
     2281 ggcttgaggg gcttgagggt ccctggcagc acggggcatc ctgaccagct aggaaagcct
     2341 ctaagggagt accagaggcc acagctgaag aatcaactct tccctgagtc agctctttga
     2401 gcctagagcc aaagggttgg cttttgcttc ccagaggacc aggcatcatt tgtgaagacc
     2461 tgcaggagct acttgtccac ctgggccagt aagatcccca tcctggtgct gagaggagga
     2521 tgtcttcctg ggacgcttgc tgatgctacc tgaggcctag tgcttctgca cagggccagc
     2581 ttgccctcct ccctgccagg gcggggaagg atcccttctg ttccttgtgg actccgagct
     2641 actgcagacc caggccacag ccatacccat ctgtaccagc actgtgacca tccatcttcc
     2701 ttccttggtg caccagctcc agcctcagga cttcctcctc ctggccctga cagcccagct
     2761 cttgtcccag cagaatccag tgacaggaag gagtttctga ggcaggggag gaggcttctc
     2821 catgggaacc agacagcctt gcttcactgt ataagtgccc tgatcacacg cagaatgaag
     2881 tgccaggttg ctcagaagca caaagggtgt ggctactggc cctaaccatg gactacgtgg
     2941 ttctaaccaa agactctaga actctggggt gggggagaaa caatgtgttc tgtgctccag
     3001 aacctcggct tcctggccca tatggatggg cttggcaagg aacctacctc ttctctaagg
     3061 tgaagcccta aggtctgcca aggctgacac gtcttccttt tctactgaca gactttatat
     3121 atatatattt atatacgtgg tagttacctg gggtggtggt gtcagggaat tgaggcaaaa
     3181 tgactttact gtacctccgg cctacagtgg caccccaata aacaggacaa aatcaacaaa
     3241 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
