LOCUS       NM_001081175            6199 bp    mRNA    linear   ROD 17-MAR-2023
DEFINITION  Mus musculus inositol 1,4,5-trisphosphate 3-kinase B (Itpkb),
            transcript variant 1, mRNA.
ACCESSION   NM_001081175 XM_205854
VERSION     NM_001081175.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6199)
  AUTHORS   Marongiu L, Mingozzi F, Cigni C, Marzi R, Di Gioia M, Garre M,
            Parazzoli D, Sironi L, Collini M, Sakaguchi R, Morii T, Crosti M,
            Moro M, Schurmans S, Catelani T, Rotem R, Colombo M, Shears S,
            Prosperi D, Zanoni I and Granucci F.
  TITLE     Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization
            and the inflammatory activity of dendritic cells
  JOURNAL   Sci Signal 14 (676) (2021)
   PUBMED   33785611
  REMARK    GeneRIF: Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca(2+)
            mobilization and the inflammatory activity of dendritic cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6199)
  AUTHORS   Apicco DJ, Shlevkov E, Nezich CL, Tran DT, Guilmette E, Nicholatos
            JW, Bantle CM, Chen Y, Glajch KE, Abraham NA, Dang LT, Kaynor GC,
            Tsai EA, Nguyen KH, Groot J, Liu Y, Weihofen A, Hurt JA, Runz H and
            Hirst WD.
  TITLE     The Parkinson's disease-associated gene ITPKB protects against
            alpha-synuclein aggregation by regulating ER-to-mitochondria
            calcium release
  JOURNAL   Proc Natl Acad Sci U S A 118 (1) (2021)
   PUBMED   33443159
  REMARK    GeneRIF: The Parkinson's disease-associated gene ITPKB protects
            against alpha-synuclein aggregation by regulating
            ER-to-mitochondria calcium release.
REFERENCE   3  (bases 1 to 6199)
  AUTHORS   Thangavelu G, Du J, Paz KG, Loschi M, Zaiken MC, Flynn R, Taylor
            PA, Kirchmeier AK, Panoskaltsis-Mortari A, Luznik L, MacDonald KP,
            Hill GR, Maillard I, Munn DH, Serody JS, Murphy WJ, Miklos D,
            Cutler CS, Koreth J, Antin JH, Soiffer RJ, Ritz J, Dahlberg C,
            Miller AT and Blazar BR.
  TITLE     Inhibition of inositol kinase B controls acute and chronic
            graft-versus-host disease
  JOURNAL   Blood 135 (1), 28-40 (2020)
   PUBMED   31697815
REFERENCE   4  (bases 1 to 6199)
  AUTHORS   Westernberg L, Conche C, Huang YH, Rigaud S, Deng Y, Siegemund S,
            Mukherjee S, Nosaka L, Das J and Sauer K.
  TITLE     Non-canonical antagonism of PI3K by the kinase Itpkb delays
            thymocyte beta-selection and renders it Notch-dependent
  JOURNAL   Elife 5, e10786 (2016)
   PUBMED   26880557
  REMARK    GeneRIF: Thus, non-canonical phosphoinositide 3-kinase-antagonism
            by Itpkb restricts pre-T cell receptor induced metabolic activation
            to enforce coincidence-detection of pre-T cell receptor expression
            and Notch-engagement.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6199)
  AUTHORS   Miller AT, Dahlberg C, Sandberg ML, Wen BG, Beisner DR, Hoerter JA,
            Parker A, Schmedt C, Stinson M, Avis J, Cienfuegos C, McPate M,
            Tranter P, Gosling M, Groot-Kormelink PJ, Dawson J, Pan S, Tian SS,
            Seidel HM and Cooke MP.
  TITLE     Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling
            in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune
            Disease
  JOURNAL   PLoS One 10 (6), e0131071 (2015)
   PUBMED   26121493
  REMARK    GeneRIF: These data identify Itpkb as an essential mediator of T
            cell activation and suggest Itpkb inhibition as a novel approach to
            treat autoimmune disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6199)
  AUTHORS   Pouillon V, Hascakova-Bartova R, Pajak B, Adam E, Bex F, Dewaste V,
            Van Lint C, Leo O, Erneux C and Schurmans S.
  TITLE     Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte
            development
  JOURNAL   Nat Immunol 4 (11), 1136-1143 (2003)
   PUBMED   14517551
REFERENCE   7  (bases 1 to 6199)
  AUTHORS   Buck KJ, Rademacher BS, Metten P and Crabbe JC.
  TITLE     Mapping murine loci for physical dependence on ethanol
  JOURNAL   Psychopharmacology (Berl) 160 (4), 398-407 (2002)
   PUBMED   11919667
REFERENCE   8  (bases 1 to 6199)
  AUTHORS   Dragani TA, Peissel B, Zanesi N, Aloisi A, Dai Y, Kato M, Suzuki H
            and Nakashima I.
  TITLE     Mapping of melanoma modifier loci in RET transgenic mice
  JOURNAL   Jpn J Cancer Res 91 (11), 1142-1147 (2000)
   PUBMED   11092979
REFERENCE   9  (bases 1 to 6199)
  AUTHORS   Barrat FJ, Depetris D, Certain S, Mattei MG and de Saint Basile G.
  TITLE     Localization of the Rab escort protein-2 (REP2) and inositol
            1,4,5-trisphosphate 3-kinase (ITPKB) genes to mouse chromosome 1 by
            in situ hybridization and precision of the syntenic regions between
            mouse and human 1q42-q44
  JOURNAL   Genomics 43 (1), 111-113 (1997)
   PUBMED   9226383
REFERENCE   10 (bases 1 to 6199)
  AUTHORS   Perou CM, Perchellet A, Jago T, Pryor R, Kaplan J and Justice MJ.
  TITLE     Comparative mapping in the beige-satin region of mouse chromosome
            13
  JOURNAL   Genomics 39 (2), 136-146 (1997)
   PUBMED   9027500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121838.2.
            
            On Mar 17, 2023 this sequence version replaced NM_001081175.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158000.1, SRR14777535.2658795.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               AC121838.2         118975-119233       c
            260-2378            AC121838.2         115524-117642       c
            2379-2478           AC121838.2         36981-37080         c
            2479-2692           AC121838.2         35754-35967         c
            2693-2897           AC121838.2         31396-31600         c
            2898-2999           AC121838.2         29395-29496         c
            3000-3071           AC121838.2         28408-28479         c
            3072-6199           AC121838.2         24952-28079         c
FEATURES             Location/Qualifiers
     source          1..6199
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.27 cM"
     gene            1..6199
                     /gene="Itpkb"
                     /gene_synonym="1110033J02Rik; E130307H12Rik"
                     /note="inositol 1,4,5-trisphosphate 3-kinase B"
                     /db_xref="GeneID:320404"
                     /db_xref="MGI:MGI:109235"
     exon            1..259
                     /gene="Itpkb"
                     /gene_synonym="1110033J02Rik; E130307H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            260..2378
                     /gene="Itpkb"
                     /gene_synonym="1110033J02Rik; E130307H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2478
                     /gene="Itpkb"
                     /gene_synonym="1110033J02Rik; E130307H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2692
                     /gene="Itpkb"
                     /gene_synonym="1110033J02Rik; E130307H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2897
                     /gene="Itpkb"
                     /gene_synonym="1110033J02Rik; E130307H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..2999
                     /gene="Itpkb"
                     /gene_synonym="1110033J02Rik; E130307H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3071
                     /gene="Itpkb"
                     /gene_synonym="1110033J02Rik; E130307H12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..6199
                     /gene="Itpkb"
                     /gene_synonym="1110033J02Rik; E130307H12Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacagcggta gtgtctccaa ccaagcacag agcaacgcag ggtcggcctg gcggtgtccc
       61 ctccgggatc gcctagtccc tgcgccggta cattcagctt cgttgcaccc cactttttcc
      121 gtcttccata agttgttgcg gaaacccttt gggagctttt ttattttttt aaaaaaactt
      181 taagccactt ggtctgtacg agcccggagt ccccggggca tgtcgcctgc acgggacctg
      241 gaagtctgag caattgcagc cgcgaaatcg tttatggagc ttggggcggg ggccgagccc
      301 gcgattttgc cctgtgcccg ccgcctaggc catgctgctc catcagcgcg cagagctacg
      361 gccgccgggc ctccgggact aagccgagag ccgcgggagg aggaggcgcc ggcggtggag
      421 cgggacggag agccgcggcg gcgggcggac cctgtactat ggctgtgtac tgctatgccc
      481 tcaatagcct ggtgatcatg aacagcacca acgagctcaa gagtggcggc ccccggccca
      541 gcggcagcga gacgccccag ccctccggga gggccgcgct gagtcccggc agcgtcttca
      601 gccctgggag aggcgcttcc tttctcttcc ccccagcaga gtcgctgtcc ctggaggagc
      661 ccgggagtcc tgggggctgg cgcagcggcc ggcgcaggct gaatagtagc agcggtagcg
      721 gaggtggcag cagcagcagc aacagcagca gcagcagtgg cgtgggcagt cccagttggg
      781 ctggccgcct gcgaggggac gcgcagcagg tggtggcggc ccgcatcctc tccccacctg
      841 ggccagagga ggcccagagg aagctgcgga ttctgcagcg cgagttgcaa aatgtgcagg
      901 tgaaccagaa agtgggcatg ttcgaggcgc aaatccaggc acagagctct gccattcaag
      961 cgccccgaag cccgcgtttg ggtagggctc gttcgccctc cccgtgtccc ttccgaagta
     1021 gcagccagcc ccccgaaagg gtcttggctc cgtgttctcc aagtgaggaa cgcagaacaa
     1081 agtcctgggg agaacaatgt acagaaaccc cagataccaa ctctggaagg agaagcagac
     1141 tcagcacaca cccctcgaag gacaaggagg gagtggcccc tcttttaggc ccagccagcc
     1201 cgaccaggtt agggactcag agtccatcta cttccgtgag aatggaaaga ggtaccccgg
     1261 ccagtccccg ctgtggctca cccacaccca tggaaactga caagagggtt gctccctcac
     1321 tggagcgctt tggaactagc ttaacgttgg ctactaaagt ggcagcttca gccgcatccg
     1381 ctggaccaca ccctggacat gattctgccc tcatggagac aggctgtgag ctcgggggca
     1441 tgcgcccctg ggaggcccag atggagagac gggggcagtt tctgggcaag gagaccggct
     1501 caaccccaga gcctgtccgg acccacatga gagaaccccc tggaagggtg ggaagaggaa
     1561 ttcattctgt tggtgggcag ggctcctgga cacctgaagt catcaaaaga ccagaagaga
     1621 gggctgtgac tgcccaaagc tcagagccct cagaggaccc cagatggtct agactgcctg
     1681 tagacctgga ttccgtagga cctgagaagg gaggaaatag gatcccaggg atgcgagggc
     1741 cccagcagac cctggacagt gagagagaag gctctccagc actgggcttg cttgggggca
     1801 gccaggcagc acagccaggg gctaggggtg tggaggaaga cgttcattat ggccgaatgc
     1861 tggaaccttt accacctggg gaagtaacaa caaaattgaa agaaccccag tgcctccctg
     1921 gggacaggat gggaatgcag cctgagagtt ccatagtttg gcccagtgcc ttggaggaag
     1981 ctcccctgat ctggacacgt gacacggggg tacagtcgaa ggggacttgg ggaagccagc
     2041 tgccagacgg agatgctcac cctagctgcc aagagatgcc cccagaccag aaggacaagg
     2101 cctccttaaa agaggcctgc agccccagca acatcccagc catccctgca gtcatcatta
     2161 cagatatggg tgctcaggag gatggagggc tagaggagat ccaaggaagc cctcggggtc
     2221 ccctgcctct gaggaagctg tcctcctcct cagcctcctc cactggcttc tcctcttctt
     2281 acgatgactc ggaggaggac atctccagtg accctgagcg cacgctggac cccaactcag
     2341 cctttttgca taccctggac cagcagaagc ccagagtgag caagtcatgg agaaagataa
     2401 agaacatggt gcagtggtcc ccctttgtca tgtccttcaa gaagaagtac ccctggatcc
     2461 agctggcagg acatgcaggg agcttcaagg cagctgcaaa tggccgcatc cttaagaagc
     2521 actgtgagtc tgagcagcgc tgcctggacc ggttaatggc ggatgtgctg agacccttcg
     2581 tgccagccta ccatggggac gtggtgaagg atggggaacg ctacaaccag atggacgacc
     2641 tgctggctga cttcgattcg ccctgcgtga tggactgcaa gatgggtgtc aggacatacc
     2701 tggaggaaga actcaccaag gcccggaaga agcctagctt gcggaaggac atgtaccaga
     2761 agatggtcga ggtggaccct gaggccccca ctgaagagga gaaagcccag cgagctgtga
     2821 ccaagccacg ttacatgcag tggcgggaaa ccatcagttc gacagccacc ctaggcttca
     2881 ggatcgaagg catcaagaag gaagatggct ctgtgaaccg tgacttcaag aagaccaaaa
     2941 caagggagca ggtcaccgag gctttcagag aattcactaa gggaaaccag aacatcttga
     3001 tcgcctaccg ggaccggctg aaggccattc gagcgaccct ggaaatctct cccttcttca
     3061 agtgccacga ggtcattggc agctctctcc tcttcatcca tgacaagaag gagcaagcca
     3121 aggtgtggat gattgacttt gggaaaacca cgccccttcc ggaaggccag accctacaac
     3181 acgacgtccc ctggcaggag gggaaccggg aggatggcta cctctcaggg ctggacaacc
     3241 tcatcgacat cctgacggaa atgtcccagg gcagcccact cacctgaggc caccgccacc
     3301 gtgcatagcc gtgccacttt gcccgccacc tctgcctgtc gcctctctcc tcccctaatt
     3361 cttccttttc ctgtctgagc gcctacctag aacagagcct cccatctgca ctacaggaca
     3421 ctttggagaa aaaaaagaga tttttttttt ctagatcttt acttccccgg cctcctacat
     3481 aggggcttgg aggtggcgtt tctcatgctc tctaaataga accaccttct cgaagagaat
     3541 tacacaaagc taggccccac atcctgttac actcagagtc ggcacgggtc cagaaggccg
     3601 tgtgatccct ggttgcctaa agtcttgaga gattaagcct ccctctggga gacactgccc
     3661 ccctcccaga aaattctggc ccacactggc taccagtagg gaccttgctg ccccctagtg
     3721 gctaatgcca tcagtaagca cagtcccatt tgtgcctctc accacgggcc ctgaagccag
     3781 gacagggacc tgatttctgg gagttggaaa tacaatctct ggggttctgc atctggatta
     3841 tgagcaaagt ctcctccagt gggaagtccc agctcccagg gacactgagt ggcttctcta
     3901 gagatgctaa atcagggccc caccttgcca gcctaggagg agtatggaga gcagctccat
     3961 ttttaaagaa cgtcaccctt ccatctggga gcattgcccg tgaattcaga gaggacattc
     4021 tgcaagcgga gtttcagggg atgacgtcac ctcctagagc tactgattac tgcccttaat
     4081 ctgcttgctg tgggaaggtc cagagctggg cacaatactc aaggctcaca ccaacctcca
     4141 gggagcaatc actaggcagc agttctgaga gccagccaca cccgggagag caatcactag
     4201 gccttaggga accaggattc tggcttcctg gaatgatccc tgagtttccc ttgaaatcac
     4261 tcactctccc agcttgaagg acttagaccg gtgtttctcc atgtaattcg gtagttgcca
     4321 gagttgttca gagggctgcc caagccttcc tcttgctcga gttctgagct tcttgaaggg
     4381 ctatgggaag atagatcatt gttattcgcc acttcagctc tgaagcaagt agcctctctg
     4441 attgaaaaga gtgtacaact tgtatgactt tttaaaagac aaaactccta gctctgttgc
     4501 tgtttggagc tatcctcttc acctctgggc ttatcacctc ctcttttact gagagactct
     4561 ggatggcatg tacagaggct cctctgggat ccacgccagc aggcactgat tagggaccaa
     4621 ggggaatggg gtagaccaac gtgtacacac ctggcgacat agctttgggc agggttggcc
     4681 gtcttgactg tctgccccag ctccctgggg tttctagagc tattggccca cgtggcatat
     4741 gtgcttcccc ttcatgctgg gtgggtgagt gacagttggt gggggcggga ggagggaccc
     4801 acgacgatgt ataagtacag atgtttaaaa aggaactcgt ttaaacttcc tggctcctat
     4861 tcagatgggc ggtgagctcc tgtgcgggct gacttgctaa aggtcacgcc ccacgccccc
     4921 ccccatcctc ggagcccaga ccttgtgaca gcacatgatt gggaagatgg gcagccaggc
     4981 gtggggggag ggcagtagca accaggcatc cagctctgag cctctccagc tgtagttgct
     5041 agagggcttg aggtgacctc gtggtctgta cattggccat ttgctgggaa ggggtatcat
     5101 taattccaag agtctacagc tatgatctgg ccaaaagttc cctcctgctg tctcagagaa
     5161 atgtttgcta aagcaaacca cactataaac aacaacaaca acaaaaatgc tagggaccag
     5221 tttaatgtat gtaaagaaca aaacatgccg agacctttag ggaggtgcca cctgtcacaa
     5281 taatgtgcta agataccata actgggggcc ggttagcaag agcctccaga cagtgctagg
     5341 cagtgctttg tgctgggtgt gttgtgagtg ggaaagcggt gtggagaggc atctttctag
     5401 ggttagtctg ttgccaaggg tgtcttcctt agttggggtt tgtatttgta tgctagtacc
     5461 cactctctgc ctcaaaccat tctcacttct atcctgccag aggcccctcc ttccttctgt
     5521 ggggatgggc agagctcaga tggaatttcc cagaacctcc aacagtctga taaaccgagt
     5581 tctgggaggc ctgctgggga ttcccaaggt cccggccaca caggtgctgg gacatggggc
     5641 aggctccatg tacctaccta tgtgcagggt ccctggggcc ctcctgctct tgggccacca
     5701 gatgtcttgg tggtcagctc tgctttacac acgctgaaga ttgcttcaat tgctttcccc
     5761 agactagact ttagtgccct ttaagaagtg tttaagttat atttattttg tttttttgtt
     5821 ttaattgcac aaaacactaa gatgaaaggc tgggctgttc ttcctaagct ctggggcctg
     5881 ccttctgggg ccattccttc gtggccagag gaaccctgag caggtatagc ctcaagacag
     5941 atgctgttca cctttggctg gctgtattta gcttcgagag cgcctgtctt ctgacaaccc
     6001 tctgtgtata ggccccaccc cttgatccag gccgcttgcc catcagtgcc ttttgggagg
     6061 agaggaccct ccctgcaccc tgacaggcag gctctcctct gaactccttt cctcttggga
     6121 ctgttacatc ccctgccctg tgcccctcag tcgactatag atgctatctc ccttcccaat
     6181 aaagctttgg agaccatta
//
