LOCUS       NM_146125               1808 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus inositol 1,4,5-trisphosphate 3-kinase A (Itpka), mRNA.
ACCESSION   NM_146125 XM_917505
VERSION     NM_146125.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1808)
  AUTHORS   Blechner,C., Becker,L., Fuchs,H., Rathkolb,B., Prehn,C., Adler,T.,
            Calzada-Wack,J., Garrett,L., Gailus-Durner,V., Morellini,F.,
            Conrad,S., Holter,S.M., Wolf,E., Klopstock,T., Adamski,J.,
            Busch,D., de Angelis,M.H., Schmeisser,M.J. and Windhorst,S.
  TITLE     Physiological relevance of the neuronal isoform of
            inositol-1,4,5-trisphosphate 3-kinases in mice
  JOURNAL   Neurosci Lett 735, 135206 (2020)
   PUBMED   32593773
REFERENCE   2  (bases 1 to 1808)
  AUTHORS   Yli-Karjanmaa,M., Larsen,K.S., Fenger,C.D., Kristensen,L.K.,
            Martin,N.A., Jensen,P.T., Breton,A., Nathanson,L., Nielsen,P.V.,
            Lund,M.C., Carlsen,S.L., Gramsbergen,J.B., Finsen,B., Stubbe,J.,
            Frich,L.H., Stolp,H., Brambilla,R., Anthony,D.C., Meyer,M. and
            Lambertsen,K.L.
  TITLE     TNF deficiency causes alterations in the spatial organization of
            neurogenic zones and alters the number of microglia and neurons in
            the cerebral cortex
  JOURNAL   Brain Behav Immun 82, 279-297 (2019)
   PUBMED   31505254
REFERENCE   3  (bases 1 to 1808)
  AUTHORS   Choi,B., Lee,H.W., Mo,S., Kim,J.Y., Kim,H.W., Rhyu,I.J., Hong,E.,
            Lee,Y.K., Choi,J.S., Kim,C.H. and Kim,H.
  TITLE     Inositol 1,4,5-trisphosphate 3-kinase A overexpressed in mouse
            forebrain modulates synaptic transmission and mGluR-LTD of CA1
            pyramidal neurons
  JOURNAL   PLoS One 13 (4), e0193859 (2018)
   PUBMED   29617377
  REMARK    GeneRIF: Thisstudy shows that overexpressed IP3-kinase A plays a
            role in some forms of hippocampus-dependent learning and memory
            tasks as well as in synaptic transmission and plasticity by
            regulating both presynaptic and postsynaptic functions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1808)
  AUTHORS   Chung,S., Kim,I.H., Lee,D., Park,K., Kim,J.Y., Lee,Y.K., Kim,E.J.,
            Lee,H.W., Choi,J.S., Son,G.H., Sun,W., Shin,K.S. and Kim,H.
  TITLE     The role of inositol 1,4,5-trisphosphate 3-kinase A in regulating
            emotional behavior and amygdala function
  JOURNAL   Sci Rep 6, 23757 (2016)
   PUBMED   27053114
  REMARK    GeneRIF: Findings demonstrate that IP3K-A plays an important role
            in regulating affective states by modulating metabotropic receptor
            signaling pathways and neural activity in the amygdala.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1808)
  AUTHORS   Windhorst,S., Minge,D., Bahring,R., Huser,S., Schob,C.,
            Blechner,C., Lin,H.Y., Mayr,G.W. and Kindler,S.
  TITLE     Inositol-1,4,5-trisphosphate 3-kinase A regulates dendritic
            morphology and shapes synaptic Ca2+ transients
  JOURNAL   Cell Signal 24 (3), 750-757 (2012)
   PUBMED   22120525
  REMARK    GeneRIF: At synapses of Inositol-1,4,5-trisphosphate 3-kinase-A
            deficient neurons the levels of Ins(1,4,5)P3-5-phosphatase (inpp5a)
            and sarcoplasmic/endoplasmic reticulum calcium ATPase pump-2b
            (serca2b) were increased.
REFERENCE   6  (bases 1 to 1808)
  AUTHORS   Windhorst,S., Fliegert,R., Blechner,C., Mollmann,K., Hosseini,Z.,
            Gunther,T., Eiben,M., Chang,L., Lin,H.Y., Fanick,W., Schumacher,U.,
            Brandt,B. and Mayr,G.W.
  TITLE     Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell
            motility-promoting protein that increases the metastatic potential
            of tumor cells by two functional activities
  JOURNAL   J Biol Chem 285 (8), 5541-5554 (2010)
   PUBMED   20022963
  REMARK    GeneRIF: Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell
            motility-promoting protein that increases the metastatic potential
            of tumor cells by two functional activities.
REFERENCE   7  (bases 1 to 1808)
  AUTHORS   Kim,I.H., Park,S.K., Hong,S.T., Jo,Y.S., Kim,E.J., Park,E.H.,
            Han,S.B., Shin,H.S., Sun,W., Kim,H.T., Soderling,S.H. and Kim,H.
  TITLE     Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for
            synaptic Rac signaling
  JOURNAL   J Neurosci 29 (44), 14039-14049 (2009)
   PUBMED   19890013
  REMARK    GeneRIF: Inositol 1,4,5-trisphosphate 3-kinase A is critical for
            spatial and temporal regulation of spine actin remodeling, synaptic
            plasticity, and learning and memory via an activity-dependent Rac
            scaffolding mechanism.
REFERENCE   8  (bases 1 to 1808)
  AUTHORS   Leyman,A., Pouillon,V., Bostan,A., Schurmans,S., Erneux,C. and
            Pesesse,X.
  TITLE     The absence of expression of the three isoenzymes of the inositol
            1,4,5-trisphosphate 3-kinase does not prevent the formation of
            inositol pentakisphosphate and hexakisphosphate in mouse embryonic
            fibroblasts
  JOURNAL   Cell Signal 19 (7), 1497-1504 (2007)
   PUBMED   17355905
  REMARK    GeneRIF: These data show that the absence of expression of the
            three isoenzymes of Itpk does not prevent the formation of IP5 and
            IP6, at least in mouse embryonic fibroblasts.[Itpka, Itpkb, Itpkc]
REFERENCE   9  (bases 1 to 1808)
  AUTHORS   Jun,K., Choi,G., Yang,S.G., Choi,K.Y., Kim,H., Chan,G.C.,
            Storm,D.R., Albert,C., Mayr,G.W., Lee,C.J. and Shin,H.S.
  TITLE     Enhanced hippocampal CA1 LTP but normal spatial learning in
            inositol 1,4,5-trisphosphate 3-kinase(A)-deficient mice
  JOURNAL   Learn Mem 5 (4-5), 317-330 (1998)
   PUBMED   10454357
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL844536.13.
            
            On Nov 17, 2006 this sequence version replaced NM_146125.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027291.1, ERR3363657.2727.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-525               AL844536.13        203975-204499
            526-622             AL844536.13        210828-210924
            623-839             AL844536.13        211000-211216
            840-1044            AL844536.13        211311-211515
            1045-1146           AL844536.13        211732-211833
            1147-1218           AL844536.13        212115-212186
            1219-1808           AL844536.13        212302-212891
FEATURES             Location/Qualifiers
     source          1..1808
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.97 cM"
     gene            1..1808
                     /gene="Itpka"
                     /note="inositol 1,4,5-trisphosphate 3-kinase A"
                     /db_xref="GeneID:228550"
                     /db_xref="MGI:MGI:1333822"
     exon            1..525
                     /gene="Itpka"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1422
                     /gene="Itpka"
                     /EC_number="2.7.1.127"
                     /note="IP3K A; IP3 3-kinase A; insP 3-kinase A; IP3-kinase
                     A"
                     /codon_start=1
                     /product="inositol-trisphosphate 3-kinase A"
                     /protein_id="NP_666237.1"
                     /db_xref="CCDS:CCDS16607.1"
                     /db_xref="GeneID:228550"
                     /db_xref="MGI:MGI:1333822"
                     /translation="MTLPGRPTGMARPRGAGPCSPGLERAPRRSVGELRLLFEARCAA
                     VAAAAAAGEPRARGAKRRGGQVPNGLPRAAPAPVIPQLTVTSEEDVTPASPGPPDQEG
                     NWLPAAGSHLQQPRRLSTSSLSSTGSSSLLEDSEDDLLSDSESRSRGNVQLETSEDVG
                     QKSHWQKIRTMVNLPVMSPFRKRYSWVQLAGHTGSFKAAGTSGLILKRSSEPEHYCLV
                     RLMADVLRGCVPAFHGIVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKA
                     RERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIK
                     KADGSCSTDFKTTRSREQVTRVFEEFMQGDAEVLRRYLNRLQQIRDTLEISDFFRRHE
                     VIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLI
                     GILASLAER"
     exon            526..622
                     /gene="Itpka"
                     /inference="alignment:Splign:2.1.0"
     exon            623..839
                     /gene="Itpka"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1044
                     /gene="Itpka"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1146
                     /gene="Itpka"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1218
                     /gene="Itpka"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1808
                     /gene="Itpka"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcgggct ggtgggctcg gctgcggctc cggtgccggg agatgaccct gcccgggcgc
       61 ccgacgggca tggcgcggcc acggggcgcg gggccctgca gccccgggct ggagagggct
      121 ccgcgccgga gcgtcgggga gctgcgcctg ctcttcgaag cgcgctgcgc cgcagtcgcc
      181 gctgcagcag ccgcagggga gccccgggcc cgcggggcca agcggcgtgg gggacaagtg
      241 cccaacgggc tcccgcgtgc tgcccctgcc ccggtgatcc ctcagctcac tgtgacaagc
      301 gaggaggatg tgaccccggc cagcccaggg ccgccagacc aggaggggaa ctggctccca
      361 gctgcggggt cgcacctgca gcagccacgc cgcctctcca cctcgtccct ctcctccacc
      421 ggctcctcgt cgctgctcga ggactcggag gacgatctgc tgagcgacag tgagagcagg
      481 agccgcggca acgtgcagct ggaaaccagc gaggacgtgg ggcagaaaag ccactggcag
      541 aagatccgta ccatggtcaa tctgcctgtc atgagtcctt tcagaaagcg ctactcctgg
      601 gtgcagttag cagggcacac agggagtttc aaagctgccg gcaccagtgg cctgatcctg
      661 aaacgcagct cggagcctga acactactgc ctggtgcggc tgatggctga cgtgctgcgt
      721 gggtgtgtgc cggccttcca tggcatagtc gagcgggatg gtgaaagcta cttgcagtta
      781 caggacctgc tcgatggctt cgatgggcct tgtgtgcttg actgcaagat gggtgtcaga
      841 acttacctgg aagaggagct gaccaaagcc cgagaacgac ccaagctgcg gaaggacatg
      901 tataagaaga tgctggcagt ggaccctgag gcacctactg aggaggagca tgcgcagcgc
      961 gccgtcacca aaccacgcta catgcaatgg cgcgaaggca tcagctccag cactacactc
     1021 ggctttcgca ttgagggcat caagaaagcc gatggatctt gcagtactga tttcaaaact
     1081 acacgaagcc gagagcaagt gacccgtgtc tttgaggagt tcatgcaagg agatgcagaa
     1141 gtgctgagga ggtatctgaa ccgcctacag cagatccggg ataccctgga gatctctgat
     1201 ttctttagac ggcacgaggt gattggcagc tcactcctct tcgtgcatga ccattgccat
     1261 cgtgctggtg tgtggctcat cgattttggc aagaccacgc ctctccccga tggccagatc
     1321 ctggatcatc ggaggccctg ggaggagggc aaccgtgagg acggctattt gctggggctg
     1381 gacaatctca ttggcatctt ggccagcctg gctgagagat gaggctgagc ccttttccct
     1441 caacgtgggc cggctggtca gacagatgtg cacctgtggc tgcatcccca ccatgcatgc
     1501 cggcaagaga ctggaacccc gctgggcggg cagttcacat ggtcctgcag gaccgggtgc
     1561 catccactaa gggggtgtag tacatcagga gttgcctacc acacaagcct gtttcccaga
     1621 gctgaatgac actaatttat agggaggggg agaaacaatg ggcttctccc ccagcccagc
     1681 tcttctcaag tggctttgca cctctccaga gggtcccgat ccataattgt acttcacagg
     1741 tatatagact tcctggtcta actcctgcac tacagtggac acccttccta ataaaactca
     1801 aagattca
//
