LOCUS       NM_172584               2856 bp    mRNA    linear   ROD 06-APR-2024
DEFINITION  Mus musculus inositol 1,3,4-triphosphate 5/6 kinase (Itpk1), mRNA.
ACCESSION   NM_172584
VERSION     NM_172584.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2856)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2856)
  AUTHORS   Nakahara,M., Tateyama,H., Araki,M., Nakagata,N., Yamamura,K. and
            Araki,K.
  TITLE     Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from
            MSM/Ms mice
  JOURNAL   Mamm Genome 24 (5-6), 228-239 (2013)
   PUBMED   23604909
REFERENCE   3  (bases 1 to 2856)
  AUTHORS   Majerus,P.W., Wilson,D.B., Zhang,C., Nicholas,P.J. and Wilson,M.P.
  TITLE     Expression of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) and
            its role in neural tube defects
  JOURNAL   Adv Enzyme Regul 50 (1), 365-372 (2010)
   PUBMED   19914276
  REMARK    GeneRIF: Data suggest that relative deficiency of one or more
            inositol phosphates accounts for neural tube defects in inositol
            1,3,4-trisphosphate 5/6-kinase knockout mice.
REFERENCE   4  (bases 1 to 2856)
  AUTHORS   Wilson,M.P., Hugge,C., Bielinska,M., Nicholas,P., Majerus,P.W. and
            Wilson,D.B.
  TITLE     Neural tube defects in mice with reduced levels of inositol
            1,3,4-trisphosphate 5/6-kinase
  JOURNAL   Proc Natl Acad Sci U S A 106 (24), 9831-9835 (2009)
   PUBMED   19482943
REFERENCE   5  (bases 1 to 2856)
  AUTHORS   Yang,L., Reece,J., Gabriel,S.E. and Shears,S.B.
  TITLE     Apical localization of ITPK1 enhances its ability to be a modifier
            gene product in a murine tracheal cell model of cystic fibrosis
  JOURNAL   J Cell Sci 119 (Pt 7), 1320-1328 (2006)
   PUBMED   16537650
  REMARK    GeneRIF: Apical localization of Itpk1 enhances its ability to be a
            modifier gene product in a murine tracheal cell model of cystic
            fibrosis.
REFERENCE   6  (bases 1 to 2856)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 2856)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2856)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC132315.4 and
            AC156033.6.
            
            On May 2, 2007 this sequence version replaced NM_172584.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK038913.1, BC056464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC132315.4         63603-63750         c
            149-173             AC156033.6         7096-7120
            174-299             AC156033.6         59138-59263
            300-417             AC156033.6         76357-76474
            418-516             AC156033.6         94001-94099
            517-557             AC156033.6         94627-94667
            558-723             AC156033.6         98111-98276
            724-791             AC156033.6         103391-103458
            792-954             AC156033.6         108479-108641
            955-2856            AC156033.6         112079-113980
FEATURES             Location/Qualifiers
     source          1..2856
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 51.69 cM"
     gene            1..2856
                     /gene="Itpk1"
                     /note="inositol 1,3,4-triphosphate 5/6 kinase"
                     /db_xref="GeneID:217837"
                     /db_xref="MGI:MGI:2446159"
     exon            1..148
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1313
                     /gene="Itpk1"
                     /EC_number="2.7.1.134"
                     /EC_number="2.7.1.159"
                     /note="ins(1,3,4)P(3) 5/6-kinase; inositol-triphosphate
                     5/6-kinase; inositol 1,3,4-trisphosphate 5/6-kinase"
                     /codon_start=1
                     /product="inositol-tetrakisphosphate 1-kinase"
                     /protein_id="NP_766172.1"
                     /db_xref="CCDS:CCDS26121.1"
                     /db_xref="GeneID:217837"
                     /db_xref="MGI:MGI:2446159"
                     /translation="MQTFLKGKRVGYWLSEKKVKKLNFQAFAELCRKRGIEVVQLNLS
                     RPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRT
                     LLDRSKSYELIRKIEAYMKDDRICSPPFMELTSLCGEDTMRLLEQNGLAFPFICKTRV
                     AHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNF
                     SAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVS
                     LFGIDIIINNQTGQHAVIDVNAFPGYEGVSEFFTDLLNHIATVLQGQSTGGAATEEVA
                     PLRHNRLLAEPAGSLAGERTCSASPGCCGSMKGQDTPWKTETEAGNMGAGASAKLPHQ
                     RLGCTTGVSPSFQQHCVASLATKASSQ"
     exon            149..173
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            174..299
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..417
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..516
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..557
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..723
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..791
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..954
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
     exon            955..2856
                     /gene="Itpk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcctgtggg caatttcctc cggacccagg ctcccgggcc gaggaggaag aagatgcaga
       61 ccttcctgaa agggaagaga gttggctact ggctgagcga gaagaaagtc aagaagctca
      121 atttccaggc cttcgcggag ctgtgcagga agcgagggat agaagtcgtg cagctgaacc
      181 tcagcagacc gattgaggag cagggccccc tggacgtcat catccacaag ctgaccgatg
      241 tcatcctcga ggcagaccag aatgacagcc agtccctgga attggtgcac aggttccaag
      301 agtacatcga tgctcaccct gagaccatcg tcttggatcc cctccccgcc atcaggaccc
      361 tgttagaccg ttccaagtcc tacgaactta tccgaaagat cgaggcctac atgaaagatg
      421 acagaatctg ctcgccgcct ttcatggagc tcacgagcct gtgtggggag gacaccatga
      481 ggctgctgga gcagaacggc ctggccttcc ccttcatttg caaaaccaga gtggctcatg
      541 gaaccaactc tcatgagatg gctattgtgt tcaaccaaga gggcctgaat gccatccagc
      601 ctccctgtgt ggtccagaac ttcatcaacc acaatgctgt cctgtacaag gtgtttgtgg
      661 tgggcgagtc ctacacagtg gtccagagac cctcactcaa gaacttctct gcgggcacat
      721 cagatcgtga gtccatcttc ttcaacagcc acaatgtgtc aaagccggag tcttcatcag
      781 tcctcactga gctggacaag atcgagggtg tgttcgaacg gccaagcgat gaggttatcc
      841 gggagctgtc ccgggctctg cggcaggcgc tgggagtgtc actgtttgga attgacatca
      901 tcattaacaa ccagaccggg cagcatgcag tcatcgatgt caatgccttc ccaggctatg
      961 aaggagtgag tgagttcttt accgacctcc tgaaccacat tgccacagtt ctgcaaggcc
     1021 agagcacggg aggagctgcc acggaggaag tggccccgct aaggcacaac aggctcctgg
     1081 cggaaccggc aggcagcctg gctggggagc ggacgtgcag tgccagccct ggctgctgtg
     1141 gcagcatgaa gggccaggac acaccctgga agactgagac cgaagcaggc aacatgggcg
     1201 ctggtgcttc cgccaagctg ccgcaccaga gacttggctg caccactggc gtatcaccca
     1261 gcttccagca gcactgtgtg gcctctctgg ccaccaaggc ttcctcacag tagccacaga
     1321 gcccaggacc cagaggggca gagcgtggaa aatgcccact gggccagcag ctccacatgg
     1381 gaacactact aagaattcct ggtgatctga ggcttctctg ttttaatttt ttacctgatt
     1441 ttctgatgtt atgatcggaa tgaagggggg gagacagagc agaacatcaa gtggcccagc
     1501 ctcgaggacg ccgcctgact cctgctgtgc agaggtcctc actgagttta cacacgcttg
     1561 tgttctcaac actaggtctg aatgtgaggg gggggggtgc gtgtgtgtgt gtgtgtgtgt
     1621 gtgtgtgtgt gtgtgtgtgt ttgtcatggc aagggtgagt gtgcatgtct gtcttcatgg
     1681 ctgttgtggg ccaggctctg ggcaccgagg aaggaagccc atatctggcc aggctgttgc
     1741 agctaagcag gcgaaggacg aacggttttc ccagttcccc tcctcttcac acctgcccac
     1801 acccagacct caccctccct cttgtcccag atgtgctctc ctccaaggct aacccttgcc
     1861 cccccacctc gctctccaaa gccagggaag cagtagacgc cccctcggga gctctgcatg
     1921 gaggatctgg gttgtaggaa gggaaaggag cttcctgtgg gtgtagccga agcccactgg
     1981 ctattgctag tcttcactgg ctcgtggaat acagcaggcc actatccacc ctaccctgac
     2041 cctattgctc actgagatcc aggaaggagc catctgacta ggagtccagg agtctgccag
     2101 gacccaggat ttaccctggg acttccaaca gatcattccg tgagtcttca ggcctccacc
     2161 acctcatctc ttcagggtgg ctcctgaaac agagaactga aggcctggtc tagtggtcta
     2221 gcccacgagg atctctgctt cctcatgtca tcatccggtc cctcttttca ggtgagagga
     2281 gaccacccac agggctgctc ctgttcacac gcgacagccc ctcctggaac agcaaggccc
     2341 agctccttcc tgctgtgttc atagcgagtc ccttgcactg agcaccaggc aagcccccaa
     2401 gggagttgtg ccccatttca gactcactct gaccccacag cagctggcag accacccact
     2461 ggccccaaag cccacaggaa aggacccctg tggagcccca ggtcagcagc ccaggacccc
     2521 caagggtgat cttgtgtctt aagacatcag ctcactatgt aaagagaatg aggcctctgg
     2581 gttgtcctta ggtctaataa gatagagtac actagaagca gcagccctgg gaaggccact
     2641 aagggccatg caggggcatc ctttgggcaa ggagaagccg attggcttcc tcggaagcag
     2701 agccccagga ctaaccacgt ttacaggacc tgagtgttga actgattgat gtctgtaagt
     2761 caccttccca ggcctgaccc tgaaaacagg gggtgggaag cgtggccgcc tcttgcactg
     2821 ctttgtctcc ggaataaact actgagatca aaccgc
//
