LOCUS       NM_022417               2024 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus integral membrane protein 2C (Itm2c), mRNA.
ACCESSION   NM_022417
VERSION     NM_022417.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2024)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2024)
  AUTHORS   Trezise,S., Karnowski,A., Fedele,P.L., Mithraprabhu,S., Liao,Y.,
            D'Costa,K., Kueh,A.J., Hardy,M.P., Owczarek,C.M., Herold,M.J.,
            Spencer,A., Shi,W., Willis,S.N., Nutt,S.L. and Corcoran,L.M.
  TITLE     Mining the Plasma Cell Transcriptome for Novel Cell Surface
            Proteins
  JOURNAL   Int J Mol Sci 19 (8), 2161 (2018)
   PUBMED   30042348
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2024)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 2024)
  AUTHORS   Rengaraj,D., Gao,F., Liang,X.H. and Yang,Z.M.
  TITLE     Expression and regulation of type II integral membrane protein
            family members in mouse male reproductive tissues
  JOURNAL   Endocrine 31 (2), 193-201 (2007)
   PUBMED   17873332
  REMARK    GeneRIF: Both Itm2a and Itm2c were not detected in the epididymis
            and vas deferens during sexual maturation.
REFERENCE   5  (bases 1 to 2024)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   6  (bases 1 to 2024)
  AUTHORS   Wu,H., Liu,G., Li,C. and Zhao,S.
  TITLE     bri3, a novel gene, participates in tumor necrosis
            factor-alpha-induced cell death
  JOURNAL   Biochem Biophys Res Commun 311 (2), 518-524 (2003)
   PUBMED   14592447
REFERENCE   7  (bases 1 to 2024)
  AUTHORS   McClive,P.J., Hurley,T.M., Sarraj,M.A., van den Bergen,J.A. and
            Sinclair,A.H.
  TITLE     Subtractive hybridisation screen identifies sexually dimorphic gene
            expression in the embryonic mouse gonad
  JOURNAL   Genesis 37 (2), 84-90 (2003)
   PUBMED   14595844
REFERENCE   8  (bases 1 to 2024)
  AUTHORS   Choi,S.C., Kim,J., Kim,T.H., Cho,S.Y., Park,S.S., Kim,K.D. and
            Lee,S.H.
  TITLE     Cloning and characterization of a type II integral transmembrane
            protein gene, Itm2c, that is highly expressed in the mouse brain
  JOURNAL   Mol Cells 12 (3), 391-397 (2001)
   PUBMED   11804340
REFERENCE   9  (bases 1 to 2024)
  AUTHORS   Vidal,R., Calero,M., Revesz,T., Plant,G., Ghiso,J. and Frangione,B.
  TITLE     Sequence, genomic structure and tissue expression of Human BRI3, a
            member of the BRI gene family
  JOURNAL   Gene 266 (1-2), 95-102 (2001)
   PUBMED   11290423
REFERENCE   10 (bases 1 to 2024)
  AUTHORS   Inoue,S., Sano,H. and Ohta,M.
  TITLE     Growth suppression of Escherichia coli by induction of expression
            of mammalian genes with transmembrane or ATPase domains
  JOURNAL   Biochem Biophys Res Commun 268 (2), 553-561 (2000)
   PUBMED   10679242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY255015.1, AK036377.1 and BE991371.1.
            
            On Nov 15, 2007 this sequence version replaced NM_022417.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF282981.1, AF272044.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                BY255015.1         3-57
            56-2001             AK036377.1         2-1947
            2002-2024           BE991371.1         21-43               c
FEATURES             Location/Qualifiers
     source          1..2024
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 43.94 cM"
     gene            1..2024
                     /gene="Itm2c"
                     /gene_synonym="3110038L02Rik; BRI3; Bricd2c; E25; E25C;
                     ITM3"
                     /note="integral membrane protein 2C"
                     /db_xref="GeneID:64294"
                     /db_xref="MGI:MGI:1927594"
     exon            1..280
                     /gene="Itm2c"
                     /gene_synonym="3110038L02Rik; BRI3; Bricd2c; E25; E25C;
                     ITM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..964
                     /gene="Itm2c"
                     /gene_synonym="3110038L02Rik; BRI3; Bricd2c; E25; E25C;
                     ITM3"
                     /note="transmembrane protein BRI3; integral membrane
                     protein 3"
                     /codon_start=1
                     /product="integral membrane protein 2C"
                     /protein_id="NP_071862.2"
                     /db_xref="CCDS:CCDS35641.1"
                     /db_xref="GeneID:64294"
                     /db_xref="MGI:MGI:1927594"
                     /translation="MVKISFQPAVAGIKADKADKAAASGPASASAPAAEILLTPAREE
                     RPPRHRSRKGGSVGGVCYLSMGMVVLLMGLVFASVYIYRYFFLAQLARDNFFHCGVLY
                     EDSLSSQIRTRLELEEDVKIYLEENYERINVPVPQFGGGDPADIIHDFQRGLTAYHDI
                     SLDKCYVIELNTTIVLPPRNFWELLMNVKRGTYLPQTYIIQEEMVVTEHVRDKEALGS
                     FIYHLCNGKDTYRLRRRSTRRRINKRGGKNCNAIRHFENTFVVETLICGVV"
     exon            281..421
                     /gene="Itm2c"
                     /gene_synonym="3110038L02Rik; BRI3; Bricd2c; E25; E25C;
                     ITM3"
                     /inference="alignment:Splign:2.1.0"
     exon            422..610
                     /gene="Itm2c"
                     /gene_synonym="3110038L02Rik; BRI3; Bricd2c; E25; E25C;
                     ITM3"
                     /inference="alignment:Splign:2.1.0"
     exon            611..721
                     /gene="Itm2c"
                     /gene_synonym="3110038L02Rik; BRI3; Bricd2c; E25; E25C;
                     ITM3"
                     /inference="alignment:Splign:2.1.0"
     exon            722..872
                     /gene="Itm2c"
                     /gene_synonym="3110038L02Rik; BRI3; Bricd2c; E25; E25C;
                     ITM3"
                     /inference="alignment:Splign:2.1.0"
     exon            873..2024
                     /gene="Itm2c"
                     /gene_synonym="3110038L02Rik; BRI3; Bricd2c; E25; E25C;
                     ITM3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2001..2006
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itm2c"
                     /gene_synonym="3110038L02Rik; BRI3; Bricd2c; E25; E25C;
                     ITM3"
                     /note="hexamer: AACAAA"
     polyA_site      2018
                     /gene="Itm2c"
                     /gene_synonym="3110038L02Rik; BRI3; Bricd2c; E25; E25C;
                     ITM3"
                     /note="major polyA site"
ORIGIN      
        1 ggaaggcggg gcgggacgcg ttcggggcgg ggacagaggc gaggactccg gagccatcca
       61 aacttccggt gcctgcggcg cagcaagaag caggcattgc gatcgaggtt gcactggcag
      121 gggctgcagg gagcaggcgc aggtcaacgc agccatggtg aagatcagtt tccagcccgc
      181 ggtagcgggc atcaaggctg ataaagcgga caaagcagcg gcgtctggtc cggcctcggc
      241 atctgccccg gccgcggaga tcctgctgac gccggcgagg gaggaacgcc cccctcgcca
      301 ccgctcccgg aaaggaggct ccgtgggcgg cgtgtgctac ctgtccatgg gcatggttgt
      361 attgctcatg ggccttgtgt ttgcctcggt ctacatctac aggtacttct tccttgctca
      421 gctggcccga gataacttct tccactgtgg tgtgctctac gaagactccc tgtcctccca
      481 gatccggact cgcctggagc tggaagagga tgtgaagatc tatcttgagg agaactatga
      541 acgtattaat gtccctgtgc cccagtttgg tggtggggac cctgcagaca tcatccatga
      601 cttccagcgg ggtctcactg cctaccacga catctcccta gacaagtgct acgtcatcga
      661 gctcaacacc accatcgtgc tacccccacg aaacttctgg gagctcctca tgaacgtgaa
      721 gagagggacc tacctcccac agacgtacat catccaggag gagatggtgg tgacagagca
      781 tgtccgcgac aaggaggctc tgggttcctt catctaccac ctgtgcaacg ggaaggacac
      841 ctaccggctg cggcgccggt ctacccggag gcggatcaac aaacgtgggg gcaagaactg
      901 caacgccatc cgccacttcg agaatacatt tgtggtggag acgctcatct gtggggtggt
      961 gtgaggcctt ccctccaggc tcacccctgc cctgttcttt ctccttctgg cctctctctg
     1021 gccctcctcc tccctttgct tagcttgtac cttgggcact tttccataga tgtgacatgt
     1081 ctcacctatc cttcccagac cgccctcctc cctgtaccag ggctgtgatc tctcggggcc
     1141 tctgcctctg ctgatctttc aggtgggagg tgggagggga cagtcgccca agatggtttc
     1201 tctaactcat tattttaagt catctcccca gtggctgggc caaggggaag gactaaaggg
     1261 aggggctgga catatggaag cctggggcag gggcaggggc gtggtgggat ttggcatgag
     1321 gctcacaaac agcccccaca cttggggaag ccctgaaaga cttttttcct tgcatagcac
     1381 acttcccctg tcctcctggt tcttaggcct gggtgtggac taaggatagg gaaatgtgtc
     1441 ctgggttgga cccatcagag cacaagagaa ggtggctatc ctggggtctt cccaggactc
     1501 ctgtcagtgc cttcagccca ccagcaggag cctggagtta gagggtggga tgagtctgcc
     1561 aagcacaatt gtcctctgag tggaaccaaa gaaatgaaga gccgggccgc cctggcctgg
     1621 cgcctgggaa cacaggggca ggtgggtata gaagtcaccg gctgtgagct gcaggccctg
     1681 ggcagtggat agaacccatg ccttcctaca catctgggct actgtgaatg atggaagcgg
     1741 gagggagagc cacctggtac tttcgtccct gcctcctctt ccgttctgga tctttcccct
     1801 ctgtccaggg gcgtgtgatg ttttttcctg catgttttta ctgatgttcg tgctggctgc
     1861 cctcagccct gagtctggga gaggctttgg tgcctcgggt cagacttggg tgctccatgg
     1921 tagtggagcc cttaaatgct ttgtatattt tctctattag atctcttttc agaagtgtct
     1981 gtagaaaatt aaaaaaaaac aacaaaaaaa acccaaaacc tctt
//
