LOCUS       NM_008410               1796 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus integral membrane protein 2B (Itm2b), mRNA.
ACCESSION   NM_008410 XR_105626 XR_106869
VERSION     NM_008410.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1796)
  AUTHORS   Yin,T., Yesiltepe,M. and D'Adamio,L.
  TITLE     Functional BRI2-TREM2 interactions in microglia: implications for
            Alzheimer's and related dementias
  JOURNAL   EMBO Rep 25 (3), 1326-1360 (2024)
   PUBMED   38347225
  REMARK    GeneRIF: Functional BRI2-TREM2 interactions in microglia:
            implications for Alzheimer's and related dementias.
REFERENCE   2  (bases 1 to 1796)
  AUTHORS   Andrade-Talavera,Y., Chen,G., Pansieri,J., Arroyo-Garcia,L.E.,
            Toleikis,Z., Smirnovas,V., Johansson,J., Morozova-Roche,L. and
            Fisahn,A.
  TITLE     S100A9 amyloid growth and S100A9 fibril-induced impairment of gamma
            oscillations in area CA3 of mouse hippocampus ex vivo is prevented
            by Bri2 BRICHOS
  JOURNAL   Prog Neurobiol 219, 102366 (2022)
   PUBMED   36273719
  REMARK    GeneRIF: S100A9 amyloid growth and S100A9 fibril-induced impairment
            of gamma oscillations in area CA3 of mouse hippocampus ex vivo is
            prevented by Bri2 BRICHOS.
REFERENCE   3  (bases 1 to 1796)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1796)
  AUTHORS   Yao,W., Yin,T., Tambini,M.D. and D'Adamio,L.
  TITLE     The Familial dementia gene ITM2b/BRI2 facilitates glutamate
            transmission via both presynaptic and postsynaptic mechanisms
  JOURNAL   Sci Rep 9 (1), 4862 (2019)
   PUBMED   30890756
  REMARK    GeneRIF: The Familial dementia gene ITM2b/BRI2 facilitates
            glutamate transmission via both presynaptic and postsynaptic
            mechanisms.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1796)
  AUTHORS   Goldsworthy,M., Bai,Y., Li,C.M., Ge,H., Lamas,E., Hilton,H.,
            Esapa,C.T., Baker,D., Baron,W., Juan,T., Veniant,M.M., Lloyd,D.J.
            and Cox,R.D.
  TITLE     Haploinsufficiency of the Insulin Receptor in the Presence of a
            Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse
            Model of Type 2 Diabetes
  JOURNAL   Diabetes 65 (5), 1434-1446 (2016)
   PUBMED   26868295
REFERENCE   6  (bases 1 to 1796)
  AUTHORS   Fleischer,A., Ayllon,V. and Rebollo,A.
  TITLE     ITM2BS regulates apoptosis by inducing loss of mitochondrial
            membrane potential
  JOURNAL   Eur J Immunol 32 (12), 3498-3505 (2002)
   PUBMED   12442332
  REMARK    GeneRIF: ITM2B(S) induces apoptosis via a caspase-dependent
            mitochondrial pathway.
REFERENCE   7  (bases 1 to 1796)
  AUTHORS   Fleischer,A., Ayllon,V., Dumoutier,L., Renauld,J.C. and Rebollo,A.
  TITLE     Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon
            IL-2-deprivation which interacts with Bcl-2
  JOURNAL   Oncogene 21 (20), 3181-3189 (2002)
   PUBMED   12082633
  REMARK    GeneRIF: The shor form of ITM2B induces apoptosis in
            IL-2-stimulated cells. The long form can't induce it. ITM2B(s)
            interacts with Bcl-2, but not with Bad. Mutation of the L and D
            residues in the BH3 domain abolished the ability of ITM2B(s) to
            promote apoptosis.
REFERENCE   8  (bases 1 to 1796)
  AUTHORS   Inoue,S., Sano,H. and Ohta,M.
  TITLE     Growth suppression of Escherichia coli by induction of expression
            of mammalian genes with transmembrane or ATPase domains
  JOURNAL   Biochem Biophys Res Commun 268 (2), 553-561 (2000)
   PUBMED   10679242
REFERENCE   9  (bases 1 to 1796)
  AUTHORS   Pittois,K., Deleersnijder,W. and Merregaert,J.
  TITLE     cDNA sequence analysis, chromosomal assignment and expression
            pattern of the gene coding for integral membrane protein 2B
  JOURNAL   Gene 217 (1-2), 141-149 (1998)
   PUBMED   9795190
REFERENCE   10 (bases 1 to 1796)
  AUTHORS   Kerr,S.M., Vambrie,S., McKay,S.J. and Cooke,H.J.
  TITLE     Analysis of cDNA sequences from mouse testis
  JOURNAL   Mamm Genome 5 (9), 557-565 (1994)
   PUBMED   8000140
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154718.2.
            
            On Apr 15, 2018 this sequence version replaced NM_008410.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160725.1, AK152650.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               AC154718.2         171224-171503       c
            281-409             AC154718.2         154513-154641       c
            410-616             AC154718.2         152535-152741       c
            617-727             AC154718.2         151966-152076       c
            728-878             AC154718.2         150756-150906       c
            879-1796            AC154718.2         148440-149357       c
FEATURES             Location/Qualifiers
     source          1..1796
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 38.88 cM"
     gene            1..1796
                     /gene="Itm2b"
                     /gene_synonym="Bri; Bri2; Bricd2b; D14Sel6; E25BMM;
                     imBRI2"
                     /note="integral membrane protein 2B"
                     /db_xref="GeneID:16432"
                     /db_xref="MGI:MGI:1309517"
     exon            1..280
                     /gene="Itm2b"
                     /gene_synonym="Bri; Bri2; Bricd2b; D14Sel6; E25BMM;
                     imBRI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..964
                     /gene="Itm2b"
                     /gene_synonym="Bri; Bri2; Bricd2b; D14Sel6; E25BMM;
                     imBRI2"
                     /note="immature BRI2; transmembrane protein BRI; integral
                     membrane protein 2B (E25B protein)"
                     /codon_start=1
                     /product="integral membrane protein 2B precursor"
                     /protein_id="NP_032436.1"
                     /db_xref="CCDS:CCDS27269.1"
                     /db_xref="GeneID:16432"
                     /db_xref="MGI:MGI:1309517"
                     /translation="MVKVTFNSALAQKEAKKDEPKSSEEALIVPPDAVAVDCKDPGDV
                     VPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGLKYIKDDVILNE
                     PSADAPAARYQTIEENIKIFEEDAVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLN
                     LDKCYVIPLNTSIVMPPKNLLELLINIKAGTYLPQSYLIHEHMVITDRIENVDNLGFF
                     IYRLCHDKETYKLQRRETIRGIQKREASNCFTIRHFENKFAVETLICS"
     exon            281..409
                     /gene="Itm2b"
                     /gene_synonym="Bri; Bri2; Bricd2b; D14Sel6; E25BMM;
                     imBRI2"
                     /inference="alignment:Splign:2.1.0"
     exon            410..616
                     /gene="Itm2b"
                     /gene_synonym="Bri; Bri2; Bricd2b; D14Sel6; E25BMM;
                     imBRI2"
                     /inference="alignment:Splign:2.1.0"
     exon            617..727
                     /gene="Itm2b"
                     /gene_synonym="Bri; Bri2; Bricd2b; D14Sel6; E25BMM;
                     imBRI2"
                     /inference="alignment:Splign:2.1.0"
     exon            728..878
                     /gene="Itm2b"
                     /gene_synonym="Bri; Bri2; Bricd2b; D14Sel6; E25BMM;
                     imBRI2"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1796
                     /gene="Itm2b"
                     /gene_synonym="Bri; Bri2; Bricd2b; D14Sel6; E25BMM;
                     imBRI2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1593..1598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itm2b"
                     /gene_synonym="Bri; Bri2; Bricd2b; D14Sel6; E25BMM;
                     imBRI2"
                     /note="hexamer: TATAAA"
     polyA_site      1611
                     /gene="Itm2b"
                     /gene_synonym="Bri; Bri2; Bricd2b; D14Sel6; E25BMM;
                     imBRI2"
                     /note="major polyA site"
     regulatory      1771..1776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itm2b"
                     /gene_synonym="Bri; Bri2; Bricd2b; D14Sel6; E25BMM;
                     imBRI2"
                     /note="hexamer: AATAAG"
     polyA_site      1791
                     /gene="Itm2b"
                     /gene_synonym="Bri; Bri2; Bricd2b; D14Sel6; E25BMM;
                     imBRI2"
ORIGIN      
        1 ggaaaccgcg ctgcactgag ccgctgctgc tgtcgcgcag tccgctcctc cgctgcagag
       61 tcgtgccctg agctcggccg acaaggctgc cttcgcagcc gggatcctgc cagccgcgac
      121 cccagccttc gccgtcgccg cctagggcgc cccaggccgc accatggtga aggtgacgtt
      181 caactcggcg ctggcccaga aggaggccaa gaaggacgag cccaagagca gcgaggaggc
      241 gctcatcgtc cctccggatg ccgtggcggt ggattgcaag gacccgggtg acgtggttcc
      301 ggttggacag aggagagcgt ggtgttggtg catgtgtttc ggactggcct tcatgcttgc
      361 tggcgtcatc ctcggagggg cgtacctgta caagtatttt gctcttcagc cagatgatgt
      421 gtactactgt ggactaaagt acatcaaaga tgacgtcatc ctgaacgagc cttctgcgga
      481 tgccccagct gctcgctacc agacaattga agagaacatt aagatctttg aggaagacgc
      541 agtggaattc atcagtgtgc ctgtaccaga gtttgcggac agcgatcctg ccaacattgt
      601 gcacgacttc aacaagaaac tcactgctta tttggacctt aacctggaca agtgctacgt
      661 gattcctctg aacacttcca tcgttatgcc gcccaaaaac ctgctggagc tccttattaa
      721 cattaaggcc gggacctacc tgcctcagtc ctaccttatc catgagcaca tggtgatcac
      781 cgaccgcatc gagaacgtgg acaacctggg cttcttcatc taccgactgt gtcacgacaa
      841 ggagacctac aaactgcagc gccgggaaac aattagaggt attcagaagc gggaagccag
      901 taactgtttc accattcggc attttgagaa caaatttgct gtggagactt taatttgttc
      961 ttgagaagtc aagaaaaaac gtggggagga attcaatgcc acagcatacc ctgccccttt
     1021 gtattttgtg cagtgattgt tttttaaaat cttcttttca tgtaagtagc aaacagggct
     1081 tcactgtctc ttcatctcaa taactcaatt aaaaaccatt atcttaaaaa aagaaaacaa
     1141 aacctttctt ttttctaagt gtggtgtctt tgatgtttga attagcaaat gtgcaggttc
     1201 ctagataaga ttcgcttctc cttagagctt acctactagg aagaatctaa attgcttgga
     1261 aatcactaat ctggattttt gtgttaattc tgcacttcca tgagggaaag atgcctaaag
     1321 aatagtcatt cgcatatgtt aaagggacca cagtgacttg cttgtagatg ctagccctgc
     1381 tacctagtct gttagcattt gaagtcacct tctcatacta ctttaattaa aatgtgccgt
     1441 atcttcaatg ttgctttaac tactttagag gatttcagcc ttgatgtttt aatatcctag
     1501 gcctctgctg taataagatt ttagacaaat gtttggaatt taagaagcaa ctcatgttac
     1561 taatttgtat agcccatatc tgtggaatgg aatataaata tcacaaagcc atgtgatgag
     1621 actgtgcgtt gtttttccca taggataaaa ccaaagaagt aatttggttc ttcatacttt
     1681 aaggtaatcc acatacataa aaaatgaaac tattttataa agtctagttc tctacatgca
     1741 gttataaaaa tcagcttttt aaaaaaataa aataagccat taattactaa atcaga
//
