LOCUS       NM_008409               1632 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus integral membrane protein 2A (Itm2a), mRNA.
ACCESSION   NM_008409
VERSION     NM_008409.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1632)
  AUTHORS   Morales-Alcala,C.C., Georgiou,I.C., Timmis,A.J. and Riobo-Del
            Galdo,N.A.
  TITLE     Integral Membrane Protein 2A Is a Negative Regulator of Canonical
            and Non-Canonical Hedgehog Signalling
  JOURNAL   Cells 10 (8), 2003 (2021)
   PUBMED   34440772
  REMARK    GeneRIF: Integral Membrane Protein 2A Is a Negative Regulator of
            Canonical and Non-Canonical Hedgehog Signalling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1632)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1632)
  AUTHORS   Sah,R.K., Ma,J., Bah,F.B., Xing,Z., Adlat,S., Oo,Z.M., Wang,Y.,
            Bahadar,N., Bohio,A.A., Nagi,F.H., Feng,X., Zhang,L. and Zheng,Y.
  TITLE     Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung
            Development and Prenatal Lethality
  JOURNAL   Int J Mol Sci 21 (21), 8223 (2020)
   PUBMED   33153107
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1632)
  AUTHORS   Chen,G., Yao,Y., Xu,G. and Zhang,X.
  TITLE     Regional difference in microRNA regulation in the skull vault
  JOURNAL   Dev Dyn 248 (10), 1009-1019 (2019)
   PUBMED   31397024
REFERENCE   5  (bases 1 to 1632)
  AUTHORS   Davies,S.J., Ryan,J., O'Connor,P.B.F., Kenny,E., Morris,D.,
            Baranov,P.V., O'Connor,R. and McCarthy,T.V.
  TITLE     Itm2a silencing rescues lamin A mediated inhibition of 3T3-L1
            adipocyte differentiation
  JOURNAL   Adipocyte 6 (4), 259-276 (2017)
   PUBMED   28872940
  REMARK    GeneRIF: Itm2a knockdown is sufficient to rescue the inhibitory
            effects of lamin A WT and R482W mutant overexpression on 3T3-L1
            differentiation.
REFERENCE   6  (bases 1 to 1632)
  AUTHORS   Barber,T.D., Barber,M.C., Tomescu,O., Barr,F.G., Ruben,S. and
            Friedman,T.B.
  TITLE     Identification of target genes regulated by PAX3 and PAX3-FKHR in
            embryogenesis and alveolar rhabdomyosarcoma
  JOURNAL   Genomics 79 (3), 278-284 (2002)
   PUBMED   11863357
REFERENCE   7  (bases 1 to 1632)
  AUTHORS   Yamaza,H., Matsuo,K., Kiyoshima,T., Shigemura,N., Kobayashi,I.,
            Wada,H., Akamime,A. and Sakai,H.
  TITLE     Detection of differentially expressed genes in the early
            developmental stage of the mouse mandible
  JOURNAL   Int J Dev Biol 45 (4), 675-680 (2001)
   PUBMED   11461004
REFERENCE   8  (bases 1 to 1632)
  AUTHORS   Mahler,M., Bristol,I.J., Sundberg,J.P., Churchill,G.A.,
            Birkenmeier,E.H., Elson,C.O. and Leiter,E.H.
  TITLE     Genetic analysis of susceptibility to dextran sulfate
            sodium-induced colitis in mice
  JOURNAL   Genomics 55 (2), 147-156 (1999)
   PUBMED   9933561
REFERENCE   9  (bases 1 to 1632)
  AUTHORS   Pittois,K., Wauters,J., Bossuyt,P., Deleersnijder,W. and
            Merregaert,J.
  TITLE     Genomic organization and chromosomal localization of the Itm2a gene
  JOURNAL   Mamm Genome 10 (1), 54-56 (1999)
   PUBMED   9892734
REFERENCE   10 (bases 1 to 1632)
  AUTHORS   Deleersnijder,W., Hong,G., Cortvrindt,R., Poirier,C.,
            Tylzanowski,P., Pittois,K., Van Marck,E. and Merregaert,J.
  TITLE     Isolation of markers for chondro-osteogenic differentiation using
            cDNA library subtraction. Molecular cloning and characterization of
            a gene belonging to a novel multigene family of integral membrane
            proteins
  JOURNAL   J Biol Chem 271 (32), 19475-19482 (1996)
   PUBMED   8702637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L38971.1 and BQ568915.1.
            
            On Aug 26, 2004 this sequence version replaced NM_008409.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167351.1, AK051956.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               L38971.1           4-207
            205-612             BQ568915.1         173-580
            613-1632            L38971.1           616-1635
FEATURES             Location/Qualifiers
     source          1..1632
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 47.52 cM"
     gene            1..1632
                     /gene="Itm2a"
                     /gene_synonym="Bricd2a; E25; Itm2"
                     /note="integral membrane protein 2A"
                     /db_xref="GeneID:16431"
                     /db_xref="MGI:MGI:107706"
     exon            1..255
                     /gene="Itm2a"
                     /gene_synonym="Bricd2a; E25; Itm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..936
                     /gene="Itm2a"
                     /gene_synonym="Bricd2a; E25; Itm2"
                     /codon_start=1
                     /product="integral membrane protein 2A"
                     /protein_id="NP_032435.2"
                     /db_xref="CCDS:CCDS30349.1"
                     /db_xref="GeneID:16431"
                     /db_xref="MGI:MGI:107706"
                     /translation="MVKIAFNTPTAVQKEEARQDVEALVSRTVRAQILTGKELRVVPQ
                     EKDGSSGRCMLTLLGLSFILAGLIVGGACIYKYFMPKSTIYHGEMCFFDSEDPVNSIP
                     GGEPYFLPVTEEADIREDDNIAIIDVPVPSFSDSDPAAIIHDFEKGMTAYLDLLLGNC
                     YLMPLNTSIVMTPKNLVELFGKLASGKYLPHTYVVREDLVAVEEIRDVSNLGIFIYQL
                     CNNRKSFRLRRRDLLLGFNKRAIDKCWKIRHFPNEFIVETKICQE"
     exon            256..387
                     /gene="Itm2a"
                     /gene_synonym="Bricd2a; E25; Itm2"
                     /inference="alignment:Splign:2.1.0"
     exon            388..585
                     /gene="Itm2a"
                     /gene_synonym="Bricd2a; E25; Itm2"
                     /inference="alignment:Splign:2.1.0"
     exon            586..696
                     /gene="Itm2a"
                     /gene_synonym="Bricd2a; E25; Itm2"
                     /inference="alignment:Splign:2.1.0"
     exon            697..847
                     /gene="Itm2a"
                     /gene_synonym="Bricd2a; E25; Itm2"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1632
                     /gene="Itm2a"
                     /gene_synonym="Bricd2a; E25; Itm2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1609..1614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itm2a"
                     /gene_synonym="Bricd2a; E25; Itm2"
                     /note="hexamer: AATAAA"
     polyA_site      1629
                     /gene="Itm2a"
                     /gene_synonym="Bricd2a; E25; Itm2"
                     /note="major polyA site"
ORIGIN      
        1 agacctgagc tcgctgctgc ctgtggaaga ctgggagagg agacactaag tgctgctcaa
       61 gcaagcgcga tcctctcctc tttcaacctg cagcccaaga tactgattcg agccgcgcct
      121 taccgcgcag cccgaagatt caccatggtg aagatcgcct tcaacacccc tacggcggtg
      181 caaaaggagg aggcgcggca agatgtagag gcgctcgtca gtcgcactgt ccgagctcaa
      241 atcctgactg gcaaggagct cagagttgtc ccgcaggaga aagatggctc atctgggaga
      301 tgcatgctta ctctcctagg cctctcattc atcttggcag gactgattgt tggtggagcc
      361 tgcatttaca agtacttcat gcccaagagc accatttacc atggtgagat gtgcttcttt
      421 gattctgagg atcctgtcaa ttccattcct ggaggagagc catactttct gcctgtgact
      481 gaggaggctg atatccgtga ggatgacaac attgccatca ttgatgtgcc tgtgcccagt
      541 ttctctgata gcgatccggc ggcaattatt cacgactttg agaagggaat gactgcttac
      601 ctggacttgc ttttgggaaa ctgttatctg atgcccctca atacttccat tgttatgact
      661 ccaaagaatc tggtggaact ttttggaaaa ctggcaagtg gcaagtattt gcctcatact
      721 tatgtggttc gtgaagacct ggttgctgtg gaagaaattc gtgatgttag taaccttggt
      781 atttttattt accaactttg caacaaccga aaatccttcc gccttagacg cagagacctt
      841 ctgctgggtt tcaacaagcg tgccattgac aaatgctgga agattagaca cttccccaat
      901 gaatttatcg ttgaaaccaa gatctgtcag gagtgaaatg tgacagataa agagtatcct
      961 tgataataag aagtcaggaa cttaccgtct gacttggaaa attgaaattg atgggatact
     1021 catgctattt actcatacat ttactctatt gcttatactg gaaaaggaaa gggaaagggg
     1081 ggagaaaact actaaccact gcaagcgatt gtccaattct actttaattg acattgcttg
     1141 ctgttttcaa caagtcaaat gattatcttt tctcttgaat ttatagggtt tagatttctg
     1201 aaagcagcat gaatgtgtca tcttaccatc ctgacaataa agcccatcct ctggttttat
     1261 ttaaagcaag ctctttccaa catcacttgg ctagagcatg ctttaaattt aaaatatttg
     1321 aaatttgttt ttgacatttt tttgtgtgaa acatgtcaaa tctcttacca ttctttggtt
     1381 ttcttcttta ttatgttcaa ctctcctgat ttcagaagtt acatttttgc atttctatca
     1441 ggtgctgtgt aacgaatctg actgatatgt gaacaatctt catgaggaag caatttttta
     1501 ctcatgtaat gattctttct cactgatatc tgtattgtga aatccacaga actgtacagg
     1561 tgctgaatgc tgtaaggagt tctggttgta tgaattctac aaccctataa taaagtttac
     1621 cgtattcaat ca
//
