LOCUS       NP_032435                263 aa            linear   ROD 30-APR-2024
DEFINITION  integral membrane protein 2A [Mus musculus].
ACCESSION   NP_032435
VERSION     NP_032435.2
DBSOURCE    REFSEQ: accession NM_008409.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 263)
  AUTHORS   Morales-Alcala,C.C., Georgiou,I.C., Timmis,A.J. and Riobo-Del
            Galdo,N.A.
  TITLE     Integral Membrane Protein 2A Is a Negative Regulator of Canonical
            and Non-Canonical Hedgehog Signalling
  JOURNAL   Cells 10 (8), 2003 (2021)
   PUBMED   34440772
  REMARK    GeneRIF: Integral Membrane Protein 2A Is a Negative Regulator of
            Canonical and Non-Canonical Hedgehog Signalling.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 263)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 263)
  AUTHORS   Sah,R.K., Ma,J., Bah,F.B., Xing,Z., Adlat,S., Oo,Z.M., Wang,Y.,
            Bahadar,N., Bohio,A.A., Nagi,F.H., Feng,X., Zhang,L. and Zheng,Y.
  TITLE     Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung
            Development and Prenatal Lethality
  JOURNAL   Int J Mol Sci 21 (21), 8223 (2020)
   PUBMED   33153107
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 263)
  AUTHORS   Chen,G., Yao,Y., Xu,G. and Zhang,X.
  TITLE     Regional difference in microRNA regulation in the skull vault
  JOURNAL   Dev Dyn 248 (10), 1009-1019 (2019)
   PUBMED   31397024
REFERENCE   5  (residues 1 to 263)
  AUTHORS   Davies,S.J., Ryan,J., O'Connor,P.B.F., Kenny,E., Morris,D.,
            Baranov,P.V., O'Connor,R. and McCarthy,T.V.
  TITLE     Itm2a silencing rescues lamin A mediated inhibition of 3T3-L1
            adipocyte differentiation
  JOURNAL   Adipocyte 6 (4), 259-276 (2017)
   PUBMED   28872940
  REMARK    GeneRIF: Itm2a knockdown is sufficient to rescue the inhibitory
            effects of lamin A WT and R482W mutant overexpression on 3T3-L1
            differentiation.
REFERENCE   6  (residues 1 to 263)
  AUTHORS   Barber,T.D., Barber,M.C., Tomescu,O., Barr,F.G., Ruben,S. and
            Friedman,T.B.
  TITLE     Identification of target genes regulated by PAX3 and PAX3-FKHR in
            embryogenesis and alveolar rhabdomyosarcoma
  JOURNAL   Genomics 79 (3), 278-284 (2002)
   PUBMED   11863357
REFERENCE   7  (residues 1 to 263)
  AUTHORS   Yamaza,H., Matsuo,K., Kiyoshima,T., Shigemura,N., Kobayashi,I.,
            Wada,H., Akamime,A. and Sakai,H.
  TITLE     Detection of differentially expressed genes in the early
            developmental stage of the mouse mandible
  JOURNAL   Int J Dev Biol 45 (4), 675-680 (2001)
   PUBMED   11461004
REFERENCE   8  (residues 1 to 263)
  AUTHORS   Mahler,M., Bristol,I.J., Sundberg,J.P., Churchill,G.A.,
            Birkenmeier,E.H., Elson,C.O. and Leiter,E.H.
  TITLE     Genetic analysis of susceptibility to dextran sulfate
            sodium-induced colitis in mice
  JOURNAL   Genomics 55 (2), 147-156 (1999)
   PUBMED   9933561
REFERENCE   9  (residues 1 to 263)
  AUTHORS   Pittois,K., Wauters,J., Bossuyt,P., Deleersnijder,W. and
            Merregaert,J.
  TITLE     Genomic organization and chromosomal localization of the Itm2a gene
  JOURNAL   Mamm Genome 10 (1), 54-56 (1999)
   PUBMED   9892734
REFERENCE   10 (residues 1 to 263)
  AUTHORS   Deleersnijder,W., Hong,G., Cortvrindt,R., Poirier,C.,
            Tylzanowski,P., Pittois,K., Van Marck,E. and Merregaert,J.
  TITLE     Isolation of markers for chondro-osteogenic differentiation using
            cDNA library subtraction. Molecular cloning and characterization of
            a gene belonging to a novel multigene family of integral membrane
            proteins
  JOURNAL   J Biol Chem 271 (32), 19475-19482 (1996)
   PUBMED   8702637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L38971.1 and BQ568915.1.
            
            On Aug 26, 2004 this sequence version replaced NP_032435.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167351.1, AK051956.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..263
                     /organism="Mus musculus"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 47.52 cM"
     Protein         1..263
                     /product="integral membrane protein 2A"
                     /calculated_mol_wt=29560
     Site            54..74
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61500.2)"
     Region          133..225
                     /region_name="BRICHOS"
                     /note="The BRICHOS domain is found in a variety of
                     proteins implicated in dementia, respiratory distress and
                     cancer; smart01039"
                     /db_xref="CDD:198107"
     Site            166
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61500.2)"
     CDS             1..263
                     /gene="Itm2a"
                     /gene_synonym="Bricd2a; E25; Itm2"
                     /coded_by="NM_008409.2:145..936"
                     /db_xref="CCDS:CCDS30349.1"
                     /db_xref="GeneID:16431"
                     /db_xref="MGI:MGI:107706"
ORIGIN      
        1 mvkiafntpt avqkeearqd vealvsrtvr aqiltgkelr vvpqekdgss grcmltllgl
       61 sfilaglivg gaciykyfmp kstiyhgemc ffdsedpvns ipggepyflp vteeadired
      121 dniaiidvpv psfsdsdpaa iihdfekgmt ayldlllgnc ylmplntsiv mtpknlvelf
      181 gklasgkylp htyvvredlv aveeirdvsn lgifiyqlcn nrksfrlrrr dlllgfnkra
      241 idkcwkirhf pnefivetki cqe
//
