LOCUS       NM_010584               1149 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus intelectin 1 (galactofuranose binding) (Itln1), mRNA.
ACCESSION   NM_010584 XM_914964
VERSION     NM_010584.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1149)
  AUTHORS   Wang,Y.Y., Zhu,G.Q., Xia,K., Zeng,H.B., He,Y.H., Xie,H., Wang,Z.X.
            and Xu,R.
  TITLE     Omentin-1 inhibits the development of benign prostatic hyperplasia
            by attenuating local inflammation
  JOURNAL   Mol Med 30 (1), 41 (2024)
   PUBMED   38519941
  REMARK    GeneRIF: Omentin-1 inhibits the development of benign prostatic
            hyperplasia by attenuating local inflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1149)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1149)
  AUTHORS   Niu,X., Di,W., Zhang,Z., Li,N., Qiu,Z., Shi,W., Lei,W., Tang,J.,
            Yang,Y., Xu,B. and Tian,Y.
  TITLE     Activation of ITLN-1 attenuates oxidative stress injury via
            activating SIRT1/PGC1-alpha signaling in neuroblastoma cells
  JOURNAL   J Cell Physiol 239 (1), 67-78 (2024)
   PUBMED   37882238
  REMARK    GeneRIF: Activation of ITLN-1 attenuates oxidative stress injury
            via activating SIRT1/PGC1-alpha signaling in neuroblastoma cells.
REFERENCE   4  (bases 1 to 1149)
  AUTHORS   Salvoza,N., Giraudi,P., Gazzin,S., Bonazza,D., Palmisano,S., de
            Manzini,N., Zanconati,F., Raseni,A., Sirianni,F., Tiribelli,C. and
            Rosso,N.
  TITLE     The potential role of omentin-1 in obesity-related metabolic
            dysfunction-associated steatotic liver disease: evidence from
            translational studies
  JOURNAL   J Transl Med 21 (1), 906 (2023)
   PUBMED   38082368
  REMARK    GeneRIF: The potential role of omentin-1 in obesity-related
            metabolic dysfunction-associated steatotic liver disease: evidence
            from translational studies.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1149)
  AUTHORS   Yang,H., Song,S., Li,J., Li,Y., Feng,J., Sun,Q., Qiu,X., Chen,Z.,
            Bai,X., Liu,X., Lian,H., Liu,L., Bai,Y., Zhang,G. and Nie,Y.
  TITLE     Omentin-1 drives cardiomyocyte cell cycle arrest and metabolic
            maturation by interacting with BMP7
  JOURNAL   Cell Mol Life Sci 80 (7), 186 (2023)
   PUBMED   37344704
  REMARK    GeneRIF: Omentin-1 drives cardiomyocyte cell cycle arrest and
            metabolic maturation by interacting with BMP7.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1149)
  AUTHORS   Wrackmeyer,U., Hansen,G.H., Seya,T. and Danielsen,E.M.
  TITLE     Intelectin: a novel lipid raft-associated protein in the enterocyte
            brush border
  JOURNAL   Biochemistry 45 (30), 9188-9197 (2006)
   PUBMED   16866365
  REMARK    GeneRIF: Strategic localization of intelectin at the enterocyte
            brush border suggests that trimeric intelectin serves as an
            organizer and stabilizer of the brush border membrane.
REFERENCE   7  (bases 1 to 1149)
  AUTHORS   Lopez,V., Suzuki,Y.A. and Lonnerdal,B.
  TITLE     Ontogenic changes in lactoferrin receptor and DMT1 in mouse small
            intestine: implications for iron absorption during early life
  JOURNAL   Biochem Cell Biol 84 (3), 337-344 (2006)
   PUBMED   16936804
  REMARK    GeneRIF: These findings support the notion that until the
            development-dependent expression of DMT1 in the intestine is
            induced, mouse LfR may serve as an alternative iron uptake pathway.
REFERENCE   8  (bases 1 to 1149)
  AUTHORS   Pemberton,A.D., Knight,P.A., Gamble,J., Colledge,W.H., Lee,J.K.,
            Pierce,M. and Miller,H.R.
  TITLE     Innate BALB/c enteric epithelial responses to Trichinella spiralis:
            inducible expression of a novel goblet cell lectin, intelectin-2,
            and its natural deletion in C57BL/10 mice
  JOURNAL   J Immunol 173 (3), 1894-1901 (2004)
   PUBMED   15265922
REFERENCE   9  (bases 1 to 1149)
  AUTHORS   Suzuki,Y.A. and Lonnerdal,B.
  TITLE     Baculovirus expression of mouse lactoferrin receptor and tissue
            distribution in the mouse
  JOURNAL   Biometals 17 (3), 301-309 (2004)
   PUBMED   15222482
  REMARK    GeneRIF: Data show that the mouse lactoferrin receptor (MLfR)
            functions as a receptor for MLf, is expressed and localized in
            various tissues, and may be involved in the indispensable function
            of MLf during early embryonic development.
REFERENCE   10 (bases 1 to 1149)
  AUTHORS   Komiya,T., Tanigawa,Y. and Hirohashi,S.
  TITLE     Cloning of the novel gene intelectin, which is expressed in
            intestinal paneth cells in mice
  JOURNAL   Biochem Biophys Res Commun 251 (3), 759-762 (1998)
   PUBMED   9790983
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK007447.1 and AY157364.1.
            
            On Feb 26, 2011 this sequence version replaced NM_010584.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB016496.1, BC150795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AK007447.1         1-25
            26-1149             AY157364.1         10-1133
FEATURES             Location/Qualifiers
     source          1..1149
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.49 cM"
     gene            1..1149
                     /gene="Itln1"
                     /gene_synonym="IntL; Itln; Itln2; Itln3; Itln5; Itlna;
                     Lfr"
                     /note="intelectin 1 (galactofuranose binding)"
                     /db_xref="GeneID:16429"
                     /db_xref="MGI:MGI:1333831"
     exon            1..74
                     /gene="Itln1"
                     /gene_synonym="IntL; Itln; Itln2; Itln3; Itln5; Itlna;
                     Lfr"
                     /inference="alignment:Splign:2.1.0"
     exon            75..138
                     /gene="Itln1"
                     /gene_synonym="IntL; Itln; Itln2; Itln3; Itln5; Itlna;
                     Lfr"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1022
                     /gene="Itln1"
                     /gene_synonym="IntL; Itln; Itln2; Itln3; Itln5; Itlna;
                     Lfr"
                     /note="intelectin 2; intelectin a; intelectin-1a;
                     intelectin 5; calcium-dependent galactosyl-specific
                     lectin; galactofuranose-binding lectin; intestinal
                     lactoferrin receptor"
                     /codon_start=1
                     /product="intelectin-1a precursor"
                     /protein_id="NP_034714.1"
                     /db_xref="CCDS:CCDS35777.1"
                     /db_xref="GeneID:16429"
                     /db_xref="MGI:MGI:1333831"
                     /translation="MTQLGFLLFIMVATRGCSAAEENLDTNRWGNSFFSSLPRSCKEI
                     KQEHTKAQDGLYFLRTKNGVIYQTFCDMTTAGGGWTLVASVHENNMRGKCTVGDRWSS
                     QQGNRADYPEGDGNWANYNTFGSAEAATSDDYKNPGYFDIQAENLGIWHVPNKSPLHN
                     WRKSSLLRYRTFTGFLQHLGHNLFGLYKKYPVKYGEGKCWTDNGPALPVVYDFGDARK
                     TASYYSPSGQREFTAGYVQFRVFNNERAASALCAGVRVTGCNTEHHCIGGGGFFPEGN
                     PVQCGDFASFDWDGYGTHNGYSSSRKITEAAVLLFYR"
     exon            139..237
                     /gene="Itln1"
                     /gene_synonym="IntL; Itln; Itln2; Itln3; Itln5; Itlna;
                     Lfr"
                     /inference="alignment:Splign:2.1.0"
     exon            238..485
                     /gene="Itln1"
                     /gene_synonym="IntL; Itln; Itln2; Itln3; Itln5; Itlna;
                     Lfr"
                     /inference="alignment:Splign:2.1.0"
     exon            486..644
                     /gene="Itln1"
                     /gene_synonym="IntL; Itln; Itln2; Itln3; Itln5; Itlna;
                     Lfr"
                     /inference="alignment:Splign:2.1.0"
     exon            645..765
                     /gene="Itln1"
                     /gene_synonym="IntL; Itln; Itln2; Itln3; Itln5; Itlna;
                     Lfr"
                     /inference="alignment:Splign:2.1.0"
     exon            766..869
                     /gene="Itln1"
                     /gene_synonym="IntL; Itln; Itln2; Itln3; Itln5; Itlna;
                     Lfr"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1140
                     /gene="Itln1"
                     /gene_synonym="IntL; Itln; Itln2; Itln3; Itln5; Itlna;
                     Lfr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1119..1124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itln1"
                     /gene_synonym="IntL; Itln; Itln2; Itln3; Itln5; Itlna;
                     Lfr"
                     /note="hexamer: GATAAA"
     polyA_site      1140
                     /gene="Itln1"
                     /gene_synonym="IntL; Itln; Itln2; Itln3; Itln5; Itlna;
                     Lfr"
                     /note="major polyA site"
ORIGIN      
        1 ggagcctcag cagagaaagg ttcctgccat tactcagcta gcaactctca gctcctgcct
       61 ggtgcagagg gaagaccacc atgacccaac tgggattcct gctgtttatc atggttgcta
      121 ccagaggttg cagtgcagct gaagagaacc tggacaccaa caggtggggc aattctttct
      181 tttcctctct gcccagaagc tgcaaggaaa tcaagcagga gcacacaaag gcacaagatg
      241 gtctctattt cctgcgcacg aagaatggtg tcatctacca gaccttctgt gacatgacca
      301 ctgcaggtgg tggctggacc ctggtggcta gtgtgcatga gaacaacatg cgtgggaagt
      361 gcactgtggg tgatcgctgg tccagtcagc aaggcaacag agctgactac ccagaggggg
      421 atggcaactg ggccaactac aacacctttg ggtctgcaga ggctgccaca agtgatgact
      481 acaagaaccc tggctacttt gacatccagg ctgagaacct gggcatctgg cacgtgccca
      541 acaaaagccc cctgcacaac tggaggaaga gctccctgct gaggtaccgc accttcactg
      601 gcttcctgca gcacttggga cataatctgt ttggcctcta caagaagtac ccagtgaaat
      661 acggagaagg aaagtgttgg actgacaatg gcccagcatt acctgtggtc tatgactttg
      721 gtgatgctcg gaagacagcc tcttattact ccccctctgg ccagagggaa tttactgcag
      781 gatatgttca gttcagagtg tttaataatg agagagcggc cagtgccttg tgtgctggcg
      841 tgagggtcac tggatgtaat actgaacatc actgcatcgg tggaggagga ttcttcccag
      901 aaggtaaccc cgtgcagtgt ggagactttg cgtcatttga ttgggatgga tatggaactc
      961 acaatgggta cagcagtagc cggaagataa ctgaagcagc tgtgcttctg ttttatcgct
     1021 gagaactctg cgggattggc cctgacttct ccattgtggg ctccaaggca tgagaaacac
     1081 tgacttagta actggaatgc taatgagcaa taaagcagga taaatcatgt tccttgcaaa
     1141 aaaaaaaaa
//
