LOCUS       NM_172471               7942 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus inter-alpha-trypsin inhibitor, heavy chain 5 (Itih5),
            mRNA.
ACCESSION   NM_172471
VERSION     NM_172471.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7942)
  AUTHORS   Sessler,T.M., Beier,J.P., Villwock,S., Jonigk,D., Dahl,E. and
            Ruhl,T.
  TITLE     Genetic deletion of ITIH5 leads to increased development of adipose
            tissue in mice
  JOURNAL   Biol Res 57 (1), 58 (2024)
   PUBMED   39198923
  REMARK    GeneRIF: Genetic deletion of ITIH5 leads to increased development
            of adipose tissue in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7942)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7942)
  AUTHORS   Whiley,P.A.F., O'Donnell,L., Moody,S.C., Handelsman,D.J.,
            Young,J.C., Richards,E.A., Almstrup,K., Western,P.S. and
            Loveland,K.L.
  TITLE     Activin A Determines Steroid Levels and Composition in the Fetal
            Testis
  JOURNAL   Endocrinology 161 (7) (2020)
   PUBMED   32274496
REFERENCE   4  (bases 1 to 7942)
  AUTHORS   Huth,S., Huth,L., Marquardt,Y., Fietkau,K., Dahl,E., Esser,P.R.,
            Martin,S.F., Heise,R., Merk,H.F. and Baron,J.M.
  TITLE     Inter-alpha-Trypsin Inhibitor Heavy Chain 5 (ITIH5) Is a Natural
            Stabilizer of Hyaluronan That Modulates Biological Processes in the
            Skin
  JOURNAL   Skin Pharmacol Physiol 33 (4), 198-206 (2020)
   PUBMED   32799206
  REMARK    GeneRIF: Inter-alpha-Trypsin Inhibitor Heavy Chain 5 (ITIH5) Is a
            Natural Stabilizer of Hyaluronan That Modulates Biological
            Processes in the Skin.
REFERENCE   5  (bases 1 to 7942)
  AUTHORS   Chen,X., Rivard,L., Naqvi,S., Nakada,S., Padbury,J.F.,
            Sanchez-Esteban,J., Stopa,E.G., Lim,Y.P. and Stonestreet,B.S.
  TITLE     Expression and localization of Inter-alpha Inhibitors in rodent
            brain
  JOURNAL   Neuroscience 324, 69-81 (2016)
   PUBMED   26964679
REFERENCE   6  (bases 1 to 7942)
  AUTHORS   Wang,Q., Chow,J., Hong,J., Smith,A.F., Moreno,C., Seaby,P.,
            Vrana,P., Miri,K., Tak,J., Chung,E.D., Mastromonaco,G., Caniggia,I.
            and Varmuza,S.
  TITLE     Recent acquisition of imprinting at the rodent Sfmbt2 locus
            correlates with insertion of a large block of miRNAs
  JOURNAL   BMC Genomics 12, 204 (2011)
   PUBMED   21510876
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7942)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 7942)
  AUTHORS   Sewell,W., Sparrow,D.B., Smith,A.J., Gonzalez,D.M., Rappaport,E.F.,
            Dunwoodie,S.L. and Kusumi,K.
  TITLE     Cyclical expression of the Notch/Wnt regulator Nrarp requires
            modulation by Dll3 in somitogenesis
  JOURNAL   Dev Biol 329 (2), 400-409 (2009)
   PUBMED   19268448
REFERENCE   9  (bases 1 to 7942)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   10 (bases 1 to 7942)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB595829.2, AK087428.1, AL953853.8 and AW046694.1.
            
            On Jan 30, 2007 this sequence version replaced NM_172471.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062196.1, AK140756.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                BB595829.2         2-74
            74-3194             AK087428.1         2-3122
            3195-7777           AL953853.8         21801-26383
            7778-7942           AW046694.1         1-165               c
FEATURES             Location/Qualifiers
     source          1..7942
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 6.94 cM"
     gene            1..7942
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /note="inter-alpha-trypsin inhibitor, heavy chain 5"
                     /db_xref="GeneID:209378"
                     /db_xref="MGI:MGI:1925751"
     exon            1..213
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..2982
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /note="inter-alpha trypsin inhibitor heavy chain precursor
                     5; inter-alpha-trypsin inhibitor heavy chain H5; ITI-HC5;
                     ITI heavy chain H5; inter-alpha-inhibitor heavy chain 5;
                     inter-alpha (globulin) inhibitor H5"
                     /codon_start=1
                     /product="inter-alpha-trypsin inhibitor heavy chain H5
                     precursor"
                     /protein_id="NP_766059.1"
                     /db_xref="CCDS:CCDS15678.1"
                     /db_xref="GeneID:209378"
                     /db_xref="MGI:MGI:1925751"
                     /translation="MLLLLGLCLGLPLFSESQEEARSWDDTSEQVVLRVPRQLRLLQR
                     LKTKPLMAEFSVKSTIISRYAFTTVSCRMLNRASEDQEAEFQMQIPESAFITNFTMLI
                     GDSVYRGEITQKDKKSSESVKDKRNRTSDDNEENGSDMFKASLVIPSKDKAAFFLSYE
                     ELLQRRLGKYEHSISVRPQQLVGRLTVEVDILERSGITSLEVLPLHNSRKKGSGKAEG
                     DVGPPPSTLINQNETFAKVIFKPTVVQQAKIAQNGILGDFIVRYDVEREQNIGDIQVL
                     NGYFVHYFAPKNLPPLPKNVVFVLDISASMVGAKLQQTREALVTILNDLRPQDRFNII
                     GFSNRIKMWKDHLLPVTPDNIRNGKIYMYHLSPTGGTDINGALQAAIKLLNNYVAQND
                     IEDRSVSLIIFLTDGKPTFGETNTLKILSNTKEATRGQICIFTVGIGDDVDFKLLEKL
                     SLENCGLTRRVHEEDKAGAQLIGFYDEIRTPLLSDIRIDYPPDVVEHATKTLFPNYFN
                     GSEIVIAGKMVDKKFDQLHVEVTASNSKKFVILKRDIPVEFRKMGNDVSVTPGSARDG
                     GKDLNHIERLWSYLTVKELLSSWRQSNSEQEKEQLRQKAQDLALNYHFLTPFTSMKLR
                     KPGLRTNQLEDTYGMSAATGPATVVQNLREAGKQPEPDLKKTYDPRIKISKTSVDGDP
                     HFVVDFPLSKLTVCFNIDGEPGDILRLVSDHLNSGVTVNGELIGAPAPPNGHKKQRTY
                     FRTITILINRPERSYLEITPSRVILDGGDRLVLPCNQSVVVGSRGLEVSVSANANITV
                     VIQGNIAFVILIHLYKNPAPFQRDHLGFYIANSRGLSDNCHGLLGQFLNQDAKLVGAP
                     EEYGKNLSNQPFPRAEGMPEAILKVKGRRVPVVWKQRKIYNGQAQVDCWFDRNNAAKL
                     IDGVYKDYLASHPFDTESALGLSTPRKPETDRPHEESV"
     exon            214..258
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /inference="alignment:Splign:2.1.0"
     exon            259..422
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /inference="alignment:Splign:2.1.0"
     exon            423..524
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /inference="alignment:Splign:2.1.0"
     exon            525..775
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /inference="alignment:Splign:2.1.0"
     exon            776..945
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1062
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1231
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1541
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..2101
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2155
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2272
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2650
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..7928
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7610..7615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /note="hexamer: AATAAA"
     polyA_site      7636
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /note="major polyA site"
     regulatory      7909..7914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /note="hexamer: AATAAA"
     polyA_site      7928
                     /gene="Itih5"
                     /gene_synonym="4631408O11Rik; 5430408M01Rik; E130106B02"
                     /note="major polyA site"
ORIGIN      
        1 attgatgggc ggggctttgg tggaggaagg gctggatgca gcgtgtttct ctgcagccgc
       61 ggctcctcca actccctgaa aaaccttcgc tgtcccagag aggtcgcgcg ctctggcttc
      121 gccatgctcc tgctgctagg gctgtgcttg gggttgcccc tcttctcaga gtcccaggaa
      181 gaggcaagga gttgggacga cacctcggag caagtcgtgc tcagggtccc caggcagctc
      241 aggctgttgc aaagactgaa aaccaagccc ttgatggcag agttttcggt gaagtctacc
      301 atcatttccc gctatgcctt caccacggtg tcctgcagga tgctcaacag agcttctgaa
      361 gaccaggagg ctgagttcca gatgcagatt ccagaatcag ctttcatcac caacttcacc
      421 atgcttatag gagacagcgt gtatcggggt gaaattacac agaaagataa gaaaagcagt
      481 gagagcgtaa aagataaaag gaacagaacc tcagacgata atgaagaaaa cgggagtgac
      541 atgttcaaag cgtctttagt gattcccagc aaggacaaag ctgctttctt cctcagttat
      601 gaagagcttc tgcagaggag gctggggaaa tacgagcata gcatcagcgt gcgcccccag
      661 cagctggtgg ggaggctgac tgtggaggtg gacatcctgg agcgatcggg catcacatcc
      721 ttggaagtgc tgcctctcca caacagcagg aagaagggta gtgggaaggc agaaggtgat
      781 gtgggtcctc ccccttctac tctcatcaac caaaatgaga catttgccaa agtcatcttt
      841 aagcctactg tggtccaaca agctaagatt gcccagaatg ggatcttggg agatttcatc
      901 gttcggtatg atgtcgagag agagcagaac attggtgaca tccaggttct gaatggttat
      961 ttcgtgcact actttgctcc taaaaacctc cctcctctac ccaagaacgt ggtcttcgtg
     1021 cttgacatca gcgcttccat ggtgggagcg aaactccagc agaccaggga ggctctcgtc
     1081 acaattctca atgacctccg accccaggat cgcttcaata tcattgggtt ctccaatcgg
     1141 attaaaatgt ggaaggacca cttactacca gtgactcctg acaacattag gaatggcaag
     1201 atctacatgt accatctgtc acccactgga ggcacagaca tcaatggggc ccttcaggct
     1261 gccatcaaac tgctcaacaa ctacgtggcc cagaatgaca ttgaagaccg aagtgtgtcc
     1321 ctcatcatct tcctcaccga tgggaaaccc acctttgggg agaccaatac cctcaagatt
     1381 ctcagcaaca ccaaggaagc caccagaggt cagatctgca tcttcaccgt tggcattggc
     1441 gatgacgtgg acttcaaact gttagagaaa ctctcgctgg agaactgcgg tctcacgagg
     1501 cgtgttcatg aggaggacaa ggcgggcgca cagctcatcg ggttctatga tgagatccgg
     1561 accccgcttc tttctgacat ccgcatagat tatcctcctg acgtagtaga gcatgccacc
     1621 aagaccctgt tccctaacta cttcaatggc tctgagatag tgattgcagg gaagatggtg
     1681 gacaagaagt ttgatcaact gcatgtggag gtcactgcca gcaacagtaa gaaatttgtc
     1741 atcctaaaaa gagacatccc cgtggagttc cggaagatgg ggaatgatgt ctcagtcaca
     1801 cctggctcag ccagagatgg cgggaaggac ctaaaccaca ttgagcgact ttggagctac
     1861 ctcactgtga aggagctgct aagctcctgg aggcagagca acagtgagca agagaaagag
     1921 cagctgaggc agaaggccca ggacttagcc ttgaactatc atttcctcac ccccttcacc
     1981 tccatgaagc tgaggaagcc agggctccgc acaaaccagc tggaggacac ctatggcatg
     2041 tctgcagcta caggacctgc gaccgtggtg cagaaccttc gagaggccgg caagcagcca
     2101 gaacctgatc tcaaaaaaac atatgaccca agaattaaaa tctctaaaac atcagtggat
     2161 ggtgatcctc attttgtagt ggatttcccc ctaagcaaac tcactgtctg ctttaacatc
     2221 gacggagagc cgggggacat cctacgtctg gtctctgatc atctgaactc tggtgtgact
     2281 gtgaatggcg agcttattgg ggcccccgca cctccgaatg gtcacaagaa acagcgcacc
     2341 tacttccgca ccatcaccat cctcatcaac cggccagaga gatcttacct ggagatcaca
     2401 ccaagcaggg tcatcctgga cggtggggac aggctggtac tcccctgcaa ccagagcgtg
     2461 gtagtaggga gtcgaggatt ggaggtgtca gtgtctgcca atgccaacat caccgtggtc
     2521 atccagggca acattgcctt tgtcatcctc atccacctgt acaaaaaccc agcacccttc
     2581 cagagagacc acctgggctt ctacatcgcc aacagcagag gtctctccga caactgccac
     2641 ggactgctag gtcagttcct gaaccaggat gccaaacttg taggagctcc tgaggaatac
     2701 ggcaagaatc ttagtaacca gccatttcct cgggcagaag ggatgcctga ggctatcctg
     2761 aaggtgaaag ggcgccgagt tccagtggtc tggaaacaaa ggaagattta caacgggcaa
     2821 gcacaggtag actgctggtt tgacagaaac aatgctgcca agctgattga cggtgtctat
     2881 aaggactacc tggcatctca tccgtttgac acagagagtg cactgggcct gagcacgccc
     2941 aggaaacctg agaccgacag gccccatgag gagagtgtct aaaagggaag ggatattggg
     3001 tctactctgg acgcaactct ttttatgtgt ggctaccttg gctcttgcta tgcgctgtac
     3061 tgtgtagccc gccccctggt gagctggagg tccaatgtct cttagagcaa tgagtcaggg
     3121 caggaagctg aaatgcaaat acttcccttc ctgccttcct catctatact agataaaaaa
     3181 aaaaacaaac aaacaaacaa aaaaaaaacg gtagcaccaa gaagagtaat taagtaaaat
     3241 cgtgtagcac ctggcttatc cctcttattc taccgtcacg taatgcctta tgaggaagag
     3301 gggttgccat gacatttgtt ttctgtgtaa ctgtgtccga gtttggccgc tctgcttttt
     3361 gccctatctc aatgcttagg aaggaagatc tcttttcagc tgccttctcc agatggtgct
     3421 cccaaccact ccttccaagg tcatttacat tgaggccaga ctaccaatta tccacacaaa
     3481 tagtttgtac attggatctc taaacaactg ggtattttct tagcagaaga tatttttttc
     3541 ctactgtgga aacttgccca gtcaatatcc cagatactga tcttgtcctg attgcctttg
     3601 caggtcactt ggccttgctg gtgggtgttt tccaatttat tccaataaac caagtgattt
     3661 taataaatag gaaaactccc cacggatgtc ttttactggc ttgccttagt gccggagagc
     3721 cagctagttg aaaaataatc cttctactca gagcagttta gtttttctgt aattccagaa
     3781 aattttgttt ttgcctttgg gggcccagga actaataaat cagatgagaa cagtgcatga
     3841 cagacagatg cagcctagag tgagcggctc agcctatggg tgggaagaat caactgtaca
     3901 ttctcagagg gaagtggacc catgcctgca cacagggctg ctgcaccatg ggctagcagc
     3961 ggttagctga agaagacagg acccatccag gatggggaga gggatcatga gtccctgctc
     4021 ctagaagggg ctggtcatat ccctcagttg caaagccact gctaagttgc ccttgctcaa
     4081 agaaataacc cccaatttat agcaagcaat tctaattgaa tgcagagtca catacttata
     4141 aagaaacacg aagatagggc atgtggagtg gggacttttg gggacaaagg aaaccataag
     4201 agaatatcat ggaaaatgga gggggtgcga tccagtacat tagagatatg catgagtttg
     4261 tgaatgaata aaccaaggga aagaaactct gaggagagat tcccacatct ccaatgagca
     4321 cgagctagga gactggcgtg agttttagtt ctggtactta gaggtgaatc tactaaggag
     4381 agggttgcaa tccaaggggg cttctaagat gtaacaagtg taatattatt gtgactctcc
     4441 tccatctagc ctagccatcc tattcaagag caagggtgat agatgcagca gaacacggat
     4501 ctcccttctt acaccctgtg ttcttctccg ccatgttggg gctggtgtgg gagtggcctg
     4561 ctgggaaaca ggtgaacagg gactgatagg attgaacaga gaaagggaaa accatgcatg
     4621 ggggaagcaa gagtgttttg atgtggacca ccagagtgaa ggcctctacg tgtccccaca
     4681 taagatttct cccatcaggc accacgccat gatattctct acagtgagac aggaaggcca
     4741 cttagcactt ggagagaaag cagcatcaag aaaattgttt tccttcctgt gggaagtgtt
     4801 tgagcagcac aatgacatcc acatgttcct gtctgaccca gcagcctcaa gagccagttg
     4861 gggcttgagt gggtctcttt ctgttctatg aacccaccag gccacagccg ggcagctgtg
     4921 ctatttatct gactccccat gttcccagac tcatctgtcc gttctcaggc caggagtgca
     4981 aagatgagca acccttatgg ctgccagatg tttccatctt ttcaggctta gaaaaaggag
     5041 gacctcagcc aggcctaacc agggccggcc ccagggcatg tccctgggac cttgctatta
     5101 cataaatccc aactggagag acagctctgg agccaggtgg ctggctctcc tgggttgcac
     5161 tcagagcgat gataggataa tacgagtgtg ttgttctaga tattgtcttc accatcaaca
     5221 caggagtatc attaggcaag aacagattct gcttgctgtt gtctaggagc agaagcacgt
     5281 gggagattcc agcaagatgc ccatccctca ctgttttgtc agcaatcaaa tcaacctaaa
     5341 agtttgagag attttaccta gaaaaccctt tcttttgtct ttaggcaaat attctacaaa
     5401 tgtagctcac tctctctttc tttctctttc tctttctcta tctccttatc tctctctctt
     5461 cctgaaagcc atttactatc tatcgatcta aattatctca tatagctgga aaatcctatt
     5521 tgaggactca caaccaaaca ccaacagaaa agttttcatt tgactgggta caagcgttgt
     5581 agatagaaaa ttccaatacc tgcaaagaag aggactgtca tttcaaatgg ggaaacagag
     5641 gcagctgagc cactttcccc aagtcacaca taggacttag agcaggagta cagttgaacc
     5701 tgaaggattc acatgttaga cctggcattc ttttgttacc tggtgaagca tttcttttcc
     5761 tcgagcattt agtaaaagat ggggtgtgag gtcaccaaat aaacaattgg ctgggctgaa
     5821 gacaaatgtg gaagttaaat gggataaatc aagttgttat tgcagtactt aattatgaag
     5881 agtcggtgaa ctgagttgtt gagcagaatt gtggctttgg cttccagtac caccccctcc
     5941 cccaatgaag aaaggaatag aaatgggtca ttttaaagag acttctcact aaagtttcat
     6001 atacagtgat ctcactacct cctatccatc catccatgtg ttgctgtatc ttctcccatt
     6061 ccacctttcc atgatctacc acttctagct ggaggctggg gatgtttggc aagatgaagt
     6121 atagagatac cacttctggg ccccaaagtc accctgagga tgtggaaatc tggaaaccag
     6181 agactgcagc caatggtttt ttttttaatc aggaatcaca gtcaatattt acctgacctt
     6241 caggaggcag agacaggcag atctctgatt ctgaggccaa cctggtctac atagtgagtt
     6301 ccaggacagc cagggatatg tagggagaac tatgctgaga acctgtttct gaaaatccaa
     6361 agtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tttctgtctg tctgtctgtt
     6421 cttctgtctg tctttgtgtg tgttataacc tgaactgcat gttctcacag acaaattaag
     6481 aacagggttc tttgaataaa taaatgctgt ggactaaaag catcctttca aaacacacat
     6541 ccttaagcct aaatctgctc tgtaacggtc cctccaagtg gagtctttca gaaggggtca
     6601 agtcctgaga acagagctct tacacactgg tttagagtgt tcatgagaag aaatttacat
     6661 gggagaatct gatgggaggg agtatggaaa tgctttagat agagaattca tatgtgaaat
     6721 tttcaaaaaa tgtttagtta ataataatca gggaggctgg ttggtaaagc attctcttgc
     6781 aagcacaaga aactgagttg agccaccaga actcaaaaaa gtcaggtgtg ggtgatgcgc
     6841 tttccattcc cagtactgag gaggctgagg caggctgatc cctggcgctc gctggccagt
     6901 cagtttagtg tccttagtga atctcaggcc agtgaaacaa tctgttcaaa aacaaaaaga
     6961 ggatgtcatc tgaggaatgg aaaccaaggt tatcttctgg cctccacatg tgcatgaaca
     7021 cgtggacata tatgtgtacc tacacgtatg aacacacata cacacaaaca caaaaaagat
     7081 ataagagaca caaagttgct cctctttgtc atataagagc attaaaaaag gtggctgtgt
     7141 agaagccagg agccacacac cagatctgtg ccttgatcca gatcatctca gtctctgaaa
     7201 ctgtaagtaa taagtgcatt ttggttaaac tgcccagttt aaaatattct tcataaagca
     7261 acccagcctt gctgaaataa agagagtctc cacaacatga gtttccacct ttattcgggc
     7321 tacccagaat atacaaaagc aatgctgttg taagatctga aagagtccta caagcctaag
     7381 gacgtggtcc agctaaaata aacagcaaat acaataacac agctaaccaa atacttagag
     7441 atgcaatgtt aaatatttat tttagcctgt ttcaagtaag taggtacaga ttgttcacat
     7501 cccaagagac tctgtttctt aaaagtttgt aagaaaaaaa aatgatgtct aaaaacaaac
     7561 agtacagtgt gtttattttt taggggaaac tgaaatcagg gctactgaaa ataaaacttg
     7621 atcattctaa ccgcaatgct tgtttgtaga aatgtctgca tttccgtcct gatcataagt
     7681 attcttatct cagtgatgtc tatcgctggt ggttacgaca gtagtctgta aggttacaac
     7741 agaattgaag attctcttgc ccagtattgc tactctatag ctaatgtcta gatctattca
     7801 catgcacaaa tatttaccat tgtgttatag ctgcttaaag attcatagtc acactaaata
     7861 tgtttatatt ctagaagcaa tgcaatatgc tatgtagcat tgttgtataa taaagtatac
     7921 catctagaaa aaaaaaaaaa aa
//
