LOCUS       NM_008407               2832 bp    mRNA    linear   ROD 12-SEP-2023
DEFINITION  Mus musculus inter-alpha trypsin inhibitor, heavy chain 3 (Itih3),
            mRNA.
ACCESSION   NM_008407
VERSION     NM_008407.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2832)
  AUTHORS   Chen X, Rivard L, Naqvi S, Nakada S, Padbury JF, Sanchez-Esteban J,
            Stopa EG, Lim YP and Stonestreet BS.
  TITLE     Expression and localization of Inter-alpha Inhibitors in rodent
            brain
  JOURNAL   Neuroscience 324, 69-81 (2016)
   PUBMED   26964679
REFERENCE   2  (bases 1 to 2832)
  AUTHORS   Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K,
            Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre
            A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt
            AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,
            Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S,
            Wohnoutka P, Hawrylycz MJ, Puelles L and Jones AR.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   3  (bases 1 to 2832)
  AUTHORS   Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S,
            Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ,
            Jones AR, Amaral DG, Sestan N, Gage FH and Lein ES.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   4  (bases 1 to 2832)
  AUTHORS   Naba A, Clauser KR, Hoersch S, Liu H, Carr SA and Hynes RO.
  TITLE     The matrisome: in silico definition and in vivo characterization by
            proteomics of normal and tumor extracellular matrices
  JOURNAL   Mol Cell Proteomics 11 (4), M111.014647 (2012)
   PUBMED   22159717
REFERENCE   5  (bases 1 to 2832)
  AUTHORS   Ghesquiere B, Van Damme J, Martens L, Vandekerckhove J and Gevaert
            K.
  TITLE     Proteome-wide characterization of N-glycosylation events by
            diagonal chromatography
  JOURNAL   J Proteome Res 5 (9), 2438-2447 (2006)
   PUBMED   16944957
REFERENCE   6  (bases 1 to 2832)
  AUTHORS   Chan P, Risler JL, Raguenez G and Salier JP.
  TITLE     The three heavy-chain precursors for the inter-alpha-inhibitor
            family in mouse: new members of the multicopper oxidase protein
            group with differential transcription in liver and brain
  JOURNAL   Biochem J 306 (Pt 2) (Pt 2), 505-512 (1995)
   PUBMED   7534067
REFERENCE   7  (bases 1 to 2832)
  AUTHORS   Diarra-Mehrpour M, Bourguignon J, Sarafan N, Bost F, Sesboue R,
            Muschio-Bonnet F and Martin JP.
  TITLE     Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain
            H1 and H3 genes
  JOURNAL   Biochim Biophys Acta 1219 (2), 551-554 (1994)
   PUBMED   7522574
REFERENCE   8  (bases 1 to 2832)
  AUTHORS   Salier JP, Chan P, Raguenez G, Zwingman T and Erickson RP.
  TITLE     Developmentally regulated transcription of the four liver-specific
            genes for inter-alpha-inhibitor family in mouse
  JOURNAL   Biochem J 296 (Pt 1) (Pt 1), 85-91 (1993)
   PUBMED   7504460
REFERENCE   9  (bases 1 to 2832)
  AUTHORS   Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W,
            Guenet JL and Mattei MG.
  TITLE     Homologous chromosomal locations of the four genes for
            inter-alpha-inhibitor and pre-alpha-inhibitor family in human and
            mouse: assignment of the ancestral gene for the lipocalin
            superfamily
  JOURNAL   Genomics 14 (1), 83-88 (1992)
   PUBMED   1385302
REFERENCE   10 (bases 1 to 2832)
  AUTHORS   Salier JP, Verga V, Doly J, Diarra-Mehrpour M and Erickson RP.
  TITLE     The genes for the inter-alpha-inhibitor family share a homologous
            organization in human and mouse
  JOURNAL   Mamm Genome 2 (4), 233-239 (1992)
   PUBMED   1371941
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK146700.1 and AW047821.1.
            
            [WARNING] On Sep 25, 2023 this sequence was replaced by
            NM_008407.3.
            
            On Nov 2, 2007 this sequence version replaced NM_008407.1.
            
            Summary: This gene encodes one of the heavy subunits of inter alpha
            trypsin inhibitor that functions as a protease inhibitor
            circulating in the plasma. The encoded protein undergoes
            proteolytic processing to generate a mature glycoprotein that is
            linked to the other subunits via an ester bond between the
            C-terminal aspartic acid residue and the N-acetyl galactosamine
            residue of chondroitin sulfate. This gene is located in a cluster
            of related inter alpha trypsin inhibitor genes on chromosome 14.
            [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015276.1, X70393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1113              AK146700.1         2-1114
            1114-2815           AK146700.1         1603-3304
            2816-2832           AW047821.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2832
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.09 cM"
     gene            1..2832
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /note="inter-alpha trypsin inhibitor, heavy chain 3"
                     /db_xref="GeneID:16426"
                     /db_xref="MGI:MGI:96620"
     exon            1..131
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..2708
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /note="inter-alpha-trypsin inhibitor heavy chain H3;
                     inter-alpha-inhibitor H3 chain; ITI heavy chain H3;
                     inter-alpha-inhibitor heavy chain 3"
                     /codon_start=1
                     /product="inter-alpha-trypsin inhibitor heavy chain H3
                     preproprotein"
                     /protein_id="NP_032433.2"
                     /db_xref="CCDS:CCDS49434.1"
                     /db_xref="GeneID:16426"
                     /db_xref="MGI:MGI:96620"
                     /translation="MRTMWWPCLVLALLSGLETSGFPRSPLQLLGKRSLPEGVVDGIE
                     VYSTKISCKVTSRFAHNVVTTRAVNRADTAKEVSFDVELPKTAFITNFTLTIDGVTYP
                     GNVKEKEVAQKQYEKAVSQGKTAGLVKASGRKLEKFTVSVNVAAGSKVTFELTYEELL
                     KRNKGKYEMYLKVQPKQLVRHFEIDAHIFEPQGISMLDAEASFITNDLLGSALTKSFS
                     GKKGHVSFKPSLDQQRSCPTCTDSLLNGDFTIVYDVNRESPGNVQIVNGYFVHFFAPQ
                     GLPVVPKNIVFVIDVSGSMSGRKIQQTREALLKILDDVKEDDYLNFILFSTDVTTWKD
                     HLVQATPANLKEAKTFVKNIHDQSMTNINDGLLKGIEMLNKAREDHTVPERSTSIIIM
                     LTDGDANTGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLETLALENHGLARRI
                     YEDSDANLQLQGFYEEVANPLLTNVEVEYPENAILDLTRNSYPHFYDGSEIVVAGRLV
                     DRNMDNFKADVKGHGALNDLTFTEEVDMEEMDAALKEQGYIFGDYIERLWAYLTIEQL
                     LEKRKNAKGDEKENITAEALDLSLKYHFVTPLTSMVVTKPEDNEDQTSIADKPGEEAI
                     AETTTMSFLTTQQSSQSPYYYVDGDPHFIIQIPGKNDSICFNIDEKPGTVLRLIQDPV
                     TGITVTGQIIGDKRSNASSRTGKTYFGKLGITNAWMDFRVEVTTEKIILGTGAELSTF
                     SWLDTITVTQTGLSVTINRKKNMVVSFGDGISFVIILHQVWKKHPVHQDFLGFYVVDS
                     HRMSAQTHGLLGQFFQPFDFKVFGIRPGSDPTKPDATMVVKNHRLTVTRGSQKDYRKD
                     ASVGTKVICWFVHNNGEGLIDGVHTDYIVPSLF"
     exon            132..152
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            153..319
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            320..424
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            425..587
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            588..701
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            702..827
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            828..944
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1113
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1239
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1421
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1607
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1747
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1902
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..1905
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..1938
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..1974
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2088
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2293
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2466
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2578
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2819
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2794..2799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
     polyA_site      2819
                     /gene="Itih3"
                     /gene_synonym="Intin3; ITI-HC3; Itih-3"
ORIGIN      
        1 atatataaag aaagcaggcc aggcccctgt gctcagcaat gaggactatg tggtggccct
       61 gccttgtctt ggctctgctc tctggcttgg agacctctgg ctttccgaga agtcccctcc
      121 agctgcttgg gaaacggagc ctcccagagg gggtggtgga tggcattgag gtttacagca
      181 ccaagatcag ctgcaaggtg acctcccgct ttgctcacaa tgttgtcacc acaagggctg
      241 tcaaccgtgc agacacagcc aaggaggtgt cctttgatgt ggaactgccc aagacagcct
      301 tcatcaccaa cttcaccttg accattgatg gtgtcaccta ccccgggaac gtcaaggaga
      361 aggaagttgc ccagaaacaa tatgaaaagg ctgtgtccca gggcaagaca gccggtttgg
      421 tcaaggcctc tgggaggaaa ctggagaaat tcacagtgtc tgtcaacgtg gctgcaggca
      481 gcaaagtcac ctttgagcta acctatgaag aactgctcaa gagaaacaag ggcaagtacg
      541 agatgtacct taaggtccag cccaaacaac tggtcagaca ctttgagatt gatgcacaca
      601 tcttcgagcc acagggcatt agcatgctag atgctgaagc ctcattcatc actaatgacc
      661 tcctgggaag cgccctcacc aagtccttct caggcaagaa ggggcacgtg tctttcaagc
      721 ccagcttaga ccagcagcgt tcatgcccga cctgtacaga ctccctcctc aacggggact
      781 tcaccattgt ctacgatgtg aacagagagt ctccagggaa tgtgcagata gtcaatggct
      841 actttgtgca cttctttgca ccccaaggcc ttccagtggt gcctaagaac atagtctttg
      901 tgattgatgt cagcggctcc atgtctggtc ggaaaatcca gcagaccagg gaagcccttc
      961 ttaaaatcct ggatgacgtg aaagaagatg actacctgaa tttcattctc ttcagcaccg
     1021 atgtgaccac ctggaaagat cacctagttc aagccacccc tgcaaacctc aaggaggcca
     1081 agacatttgt gaagaacatc catgatcaaa gcatgaccaa catcaatgat gggctgctga
     1141 agggtattga aatgctgaac aaggcccgag aggaccacac tgtcccagag aggagcacct
     1201 ccatcatcat catgttgaca gacggggatg ccaatactgg cgagagcaga ccagaaaaga
     1261 tccaggaaaa cgtccggaat gccatcgggg gcaagttccc tttgtataac ctgggttttg
     1321 gcaacaatct gaattataat ttcctggaga ctctggccct ggagaaccat gggcttgccc
     1381 ggcgcattta tgaagattct gatgccaact tgcagctgca gggcttctat gaagaggtag
     1441 ctaatccact gctgactaat gtggaggtgg aataccccga gaacgccatc ctagacctca
     1501 ccaggaacag ttacccccac ttctacgatg gctctgagat tgttgtagca gggcgcctgg
     1561 tggacaggaa catggacaac ttcaaagcag atgtgaaggg ccatggggcc ttgaatgacc
     1621 tgaccttcac agaggaggta gacatggagg aaatggatgc agccctgaag gagcaaggct
     1681 acatttttgg ggactacatt gagcgactct gggcctacct cactattgag cagctactgg
     1741 agaaacgcaa gaatgccaaa ggggatgaga aggagaacat cacagcggag gccctggatc
     1801 tgtccctcaa gtaccacttt gtaaccccac tgacctccat ggtggtgacc aagcctgagg
     1861 acaatgaaga ccagacatcc attgctgaca agcctgggga agaagccatc gctgagacca
     1921 cgaccatgtc cttcttgacc actcagcagt ccagtcagag cccctactat tatgtggatg
     1981 gggaccccca ctttatcatc caaatcccgg gaaaaaacga cagcatctgc ttcaacatcg
     2041 acgagaagcc tggaaccgtg ctgcgcctga ttcaggaccc agtcacaggt atcactgtga
     2101 ccggacagat catcggagat aagcgaagta acgcttcttc caggacaggg aaaacttatt
     2161 ttggcaaact gggcattacc aatgcttgga tggacttccg ggttgaggtg accacggaga
     2221 aaatcatcct agggactggg gccgagctga gcacgttcag ttggctagac acaatcacgg
     2281 tcacacagac tgggctgtct gtaacaatca acaggaaaaa gaatatggtg gtgtcctttg
     2341 gagatgggat tagctttgtg atcatcctac accaggtttg gaagaaacat ccagttcacc
     2401 aggacttcct agggttctac gtggtggaca gtcaccggat gtcagcacag acacatgggc
     2461 tgctgggcca gttcttccaa ccctttgact ttaaagtgtt tggcatccgc ccaggctctg
     2521 accctacaaa gccagatgcc acaatggtgg tgaagaatca tcggttgact gtcacaaggg
     2581 gctcccagaa agattacagg aaggatgcca gtgttggcac caaggtcatc tgctggtttg
     2641 tccataacaa tggagaagga ctaattgatg gtgtccatac cgactatatt gttcccagct
     2701 tgttctgagt agcatgtcag ctgctgatga agtagaaggc ctgggtggcc tggaaaaagg
     2761 acacagaatg gggcttgtgg gaaagaccgg gacaataaag cccaccatgt aaaccaaaaa
     2821 aaaaaaaaaa aa
//
