LOCUS       NM_010582               3114 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus inter-alpha trypsin inhibitor, heavy chain 2 (Itih2),
            mRNA.
ACCESSION   NM_010582
VERSION     NM_010582.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3114)
  AUTHORS   Chen,X., Rivard,L., Naqvi,S., Nakada,S., Padbury,J.F.,
            Sanchez-Esteban,J., Stopa,E.G., Lim,Y.P. and Stonestreet,B.S.
  TITLE     Expression and localization of Inter-alpha Inhibitors in rodent
            brain
  JOURNAL   Neuroscience 324, 69-81 (2016)
   PUBMED   26964679
REFERENCE   2  (bases 1 to 3114)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 3114)
  AUTHORS   Naba,A., Clauser,K.R., Hoersch,S., Liu,H., Carr,S.A. and Hynes,R.O.
  TITLE     The matrisome: in silico definition and in vivo characterization by
            proteomics of normal and tumor extracellular matrices
  JOURNAL   Mol Cell Proteomics 11 (4), M111.014647 (2012)
   PUBMED   22159717
REFERENCE   4  (bases 1 to 3114)
  AUTHORS   Wang,Q., Chow,J., Hong,J., Smith,A.F., Moreno,C., Seaby,P.,
            Vrana,P., Miri,K., Tak,J., Chung,E.D., Mastromonaco,G., Caniggia,I.
            and Varmuza,S.
  TITLE     Recent acquisition of imprinting at the rodent Sfmbt2 locus
            correlates with insertion of a large block of miRNAs
  JOURNAL   BMC Genomics 12, 204 (2011)
   PUBMED   21510876
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3114)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   6  (bases 1 to 3114)
  AUTHORS   Tanaka,K., Tamura,H., Tanaka,H., Katoh,M., Futamata,Y., Seki,N.,
            Nishimune,Y. and Hara,T.
  TITLE     Spermatogonia-dependent expression of testicular genes in mice
  JOURNAL   Dev Biol 246 (2), 466-479 (2002)
   PUBMED   12051830
REFERENCE   7  (bases 1 to 3114)
  AUTHORS   Chan,P., Risler,J.L., Raguenez,G. and Salier,J.P.
  TITLE     The three heavy-chain precursors for the inter-alpha-inhibitor
            family in mouse: new members of the multicopper oxidase protein
            group with differential transcription in liver and brain
  JOURNAL   Biochem J 306 (Pt 2) (Pt 2), 505-512 (1995)
   PUBMED   7534067
REFERENCE   8  (bases 1 to 3114)
  AUTHORS   Salier,J.P., Chan,P., Raguenez,G., Zwingman,T. and Erickson,R.P.
  TITLE     Developmentally regulated transcription of the four liver-specific
            genes for inter-alpha-inhibitor family in mouse
  JOURNAL   Biochem J 296 (Pt 1) (Pt 1), 85-91 (1993)
   PUBMED   7504460
REFERENCE   9  (bases 1 to 3114)
  AUTHORS   Salier,J.P., Simon,D., Rouet,P., Raguenez,G., Muscatelli,F.,
            Gebhard,W., Guenet,J.L. and Mattei,M.G.
  TITLE     Homologous chromosomal locations of the four genes for
            inter-alpha-inhibitor and pre-alpha-inhibitor family in human and
            mouse: assignment of the ancestral gene for the lipocalin
            superfamily
  JOURNAL   Genomics 14 (1), 83-88 (1992)
   PUBMED   1385302
REFERENCE   10 (bases 1 to 3114)
  AUTHORS   Salier,J.P., Verga,V., Doly,J., Diarra-Mehrpour,M. and
            Erickson,R.P.
  TITLE     The genes for the inter-alpha-inhibitor family share a homologous
            organization in human and mouse
  JOURNAL   Mamm Genome 2 (4), 233-239 (1992)
   PUBMED   1371941
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772367.7.
            
            On Dec 22, 2021 this sequence version replaced NM_010582.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X70392.1, BC034341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               AL772367.7         101315-101514
            201-275             AL772367.7         102693-102767
            276-308             AL772367.7         104189-104221
            309-478             AL772367.7         105676-105845
            479-583             AL772367.7         108482-108586
            584-746             AL772367.7         112367-112529
            747-854             AL772367.7         114550-114657
            855-983             AL772367.7         115264-115392
            984-1100            AL772367.7         116651-116767
            1101-1269           AL772367.7         121433-121601
            1270-1395           AL772367.7         122390-122515
            1396-1577           AL772367.7         125162-125343
            1578-1763           AL772367.7         126191-126376
            1764-1903           AL772367.7         126715-126854
            1904-2073           AL772367.7         129042-129211
            2074-2211           AL772367.7         129784-129921
            2212-2325           AL772367.7         133429-133542
            2326-2524           AL772367.7         133896-134094
            2525-2697           AL772367.7         134747-134919
            2698-2809           AL772367.7         135434-135545
            2810-3114           AL772367.7         137095-137399
FEATURES             Location/Qualifiers
     source          1..3114
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 6.89 cM"
     gene            1..3114
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /note="inter-alpha trypsin inhibitor, heavy chain 2"
                     /db_xref="GeneID:16425"
                     /db_xref="MGI:MGI:96619"
     exon            1..200
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..2957
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /note="inter-alpha-trypsin inhibitor heavy chain H2; ITI
                     heavy chain H2; inter-alpha-inhibitor heavy chain 2"
                     /codon_start=1
                     /product="inter-alpha-trypsin inhibitor heavy chain H2
                     precursor"
                     /protein_id="NP_034712.3"
                     /db_xref="CCDS:CCDS15677.2"
                     /db_xref="GeneID:16425"
                     /db_xref="MGI:MGI:96619"
                     /translation="MQRPVCLLIWLFLLEAQAFEIPINGNSEFAEYSDLVELAPDKLP
                     FVQENGRHQRSLPEESGEETDTVDPVTLYSYKVQSTITSRVATTTIQSKLVNNSPLPQ
                     SVVFDVQIPKGAFISNFTMTVNGMTFTSSIKEKTVGRALYSQARAKGKTAGWVRSRTL
                     DMENFNTEVNIPPGAKVQFELHYQEVKWRKLGSYEHKIHLQPGKLAKHLEVNVWIIEP
                     QGMRFLHVPDTFEGHFQGVPVISKGQQKAHVSFKPTVAQQRKCPNCTETAVNGELVVM
                     YDVNREEKAGELEVFNGYFVHFFAPENLDPIPKNILFVIDVSGSMWGIKMKQTVEAMK
                     TILDDLRTDDQFSVVDFNHNVRTWRNDLVSATKTQIADAKRYIEKIQPSGGTNINEAL
                     LRAIFILNEASNMGLLNPDSVSLIILVSDGDPTVGELKLSKIQKNVKQSIQDNISLFS
                     LGIGFDVDYDFLKRLSNENRGIAQRIYGNQDTSSQLKKFYNQVSTPLLRNVQFNYPQA
                     SVTDVTQNNFHNYFGGSEIVVAGKFDPSKLTEVQSIITATSANTELVLETLSQMDDLE
                     EFLSKDKHADPDFTKKLWAYLTINQLLAERSLAPTAAIKRKITKTILQMSLDHHIVTP
                     LTAMVIENDAGDERMLADSPPQDHSCCSGALYYGTKVASGPIPSWANPSPTPMSAMLA
                     VGAKPLESTPPTHLNQVENDPHFIIYLPKSKRNICFNIDSEPGKILSLVSDPESGIVV
                     NGQLIGAKRAENGKLSTYFGKLGFYFQKEGMKIEISTETITLSSGSSTSRLSWSDTAH
                     LGNSRVLISVKKEKSVTLTLNKELFFSVLLHRVWRKHPVNVDFLGIYAPPIDKFSPRV
                     HGLLGQFMQEPAIHIFNERPGKEPGKPEASMEVKGHKLTVTRGLQKDYRTDIVFGTDV
                     PCWFVHNSGKGFIDGHYKDYFVPQLYSFLKRP"
     exon            201..275
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            276..308
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            309..478
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..583
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..746
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            747..854
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            855..983
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1100
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1269
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1395
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1577
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1763
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1903
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2073
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2211
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2325
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2524
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2697
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2809
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..3114
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3054..3059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /note="hexamer: ATTATA"
     polyA_site      3084
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /note="major polyA site"
     regulatory      3094..3099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /note="hexamer: AATAAA"
     polyA_site      3114
                     /gene="Itih2"
                     /gene_synonym="Intin2; ITI-HC2; Itih-2"
                     /note="major polyA site"
ORIGIN      
        1 ctttttaaaa cgatctgctc tcatcaacag acaagttcct gctaacctgg ttccgtaggt
       61 ggggagttct ccccagacca tctgctcggg ggagcttggc acagatgtcc agcaaaatgc
      121 agcggcctgt gtgccttctc atctggctgt ttcttctgga agcacaagcc ttcgaaatcc
      181 ccataaacgg aaactcagaa tttgcagaat acagtgatct tgtggaactg gccccagata
      241 aactcccatt tgtgcaagag aatggaagac atcagagaag ccttcctgag gaatccggag
      301 aggagacgga cactgttgat ccagtgactc tttatagcta caaagtccag tccactatta
      361 cttctcgggt ggccacaact accatccaga gcaaactggt gaacaattcc ccattgcctc
      421 agagtgtcgt gttcgatgtt cagattccca aaggagcctt tatctccaac ttcaccatga
      481 ctgtgaacgg catgacattt acaagctcca ttaaagagaa aactgtgggc cgagctcttt
      541 attcacaggc aagagcaaag ggcaagacgg ctggatgggt aaggagcaga actctggata
      601 tggagaactt caacacagag gtgaacatcc cgcctggagc caaggtgcag tttgaacttc
      661 attaccagga ggtgaagtgg aggaagctgg gatcctatga gcacaagatt catttgcagc
      721 ccgggaagct ggccaaacac ttggaggtga atgtgtggat tatcgaaccc caaggaatga
      781 gatttcttca tgttcctgac acatttgaag gccatttcca aggcgtccct gtcatatcta
      841 aaggacaaca gaaggcacat gtatccttca agcccacagt agcacaacaa agaaaatgcc
      901 ccaactgcac agagactgca gtgaacgggg agctggtggt gatgtatgat gtcaacagag
      961 aagagaaggc cggggaactt gaggtgttta atggatattt tgttcacttc tttgctcctg
     1021 agaacctgga cccaatcccc aagaacatcc tttttgttat tgacgtcagt ggctccatgt
     1081 gggggattaa gatgaagcag actgtggagg caatgaagac gatattggat gacctaagaa
     1141 cagacgacca attctctgtg gttgatttca accataatgt tcgaacctgg agaaatgatt
     1201 tagtttcagc tactaaaaca caaattgcag atgccaagag atacattgag aaaattcagc
     1261 ctagtggagg cacgaatatc aacgaggcac tgcttcgagc aattttcatt ttgaatgaag
     1321 ccagtaacat gggattgctg aaccccgact cagtctctct gatcattttg gtttctgatg
     1381 gagatccaac cgtaggggaa ctaaaattgt ccaaaattca gaaaaatgtg aagcagagca
     1441 tccaagataa catctccctg tttagtttgg gaatcggatt tgatgtcgac tatgattttt
     1501 tgaagaggct gtccaatgaa aatcgtggta ttgctcaacg gatctacggg aaccaggaca
     1561 catcctctca gctcaagaaa ttttacaacc aggtctctac tccactgctc agaaatgttc
     1621 agtttaacta cccgcaggca tcagtaacag atgtcaccca aaacaatttc cacaactact
     1681 tcggaggttc tgagatcgtg gtggcaggga aatttgatcc cagcaaactg acagaagtcc
     1741 agagcatcat cacggcaact tcggctaaca cagaattggt cttggaaacc ctgagccaga
     1801 tggatgactt ggaggagttt ctgtcaaagg acaagcatgc agaccctgac ttcaccaaga
     1861 agctgtgggc ctatctcacc atcaaccaac tactagcaga gagaagtctg gctcctactg
     1921 ctgccatcaa aaggaaaatc accaaaacaa tcctgcagat gtctctagac catcacatcg
     1981 tgactccgct tactgccatg gtgatagaga atgatgctgg agatgaacgc atgctggctg
     2041 actccccgcc acaggaccac tcctgctgct caggcgcact gtattatggc accaaggttg
     2101 cctcgggtcc catcccatca tgggccaacc catctccgac accaatgtcg gccatgcttg
     2161 cagtcggagc gaagccactt gagtctactc cacctactca tttgaatcaa gtggaaaatg
     2221 acccccactt catcatttac ctgcccaaaa gcaaaaggaa tatttgtttc aatattgact
     2281 cagaacctgg gaaaatccta agcctggtgt ctgacccaga atcagggatt gtagtcaacg
     2341 gtcagcttat cggcgccaag agggcagaga atggaaagct aagcacctac tttggaaaac
     2401 tggggtttta tttccaaaag gaaggcatga agatagaaat cagcaccgag accatcaccc
     2461 tgagctctgg ctcctctaca tctcgactgt cctggtccga cacagctcat cttggaaact
     2521 cgagggtgct catctctgtg aagaaagaaa aatctgtgac tctcaccctg aataaagagc
     2581 tgttcttttc cgttctgctg catcgtgtgt ggaggaagca cccagttaac gtggacttcc
     2641 tggggatcta cgctcccccc atagacaagt tctcacctag agtgcatgga ctgttaggcc
     2701 agttcatgca ggagccagcc atccacatct tcaatgagag acccggaaag gagccgggaa
     2761 aacccgaggc aagcatggag gtgaaaggac ataagctgac tgtcaccaga ggcctgcaga
     2821 aggactacag gacggatatc gtgtttggaa cagacgttcc ctgctggttt gtacacaaca
     2881 gtgggaaagg tttcatcgat ggacattata aggattattt tgtgcctcag ctctacagct
     2941 ttctcaagcg gccttaatgg cttatagttt tggaaactgt atgtgtatcc ttttctccct
     3001 tgatactttt tgcagttact cccccgtttc agcaactcaa aataaacgca gatattatag
     3061 tggcctaaaa ggcctgctaa cccaccggag aaaaataaat atttgcaaaa aagg
//
