LOCUS       NM_008406               3077 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus inter-alpha trypsin inhibitor, heavy chain 1 (Itih1),
            transcript variant 1, mRNA.
ACCESSION   NM_008406
VERSION     NM_008406.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3077)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3077)
  AUTHORS   Chen,X., Rivard,L., Naqvi,S., Nakada,S., Padbury,J.F.,
            Sanchez-Esteban,J., Stopa,E.G., Lim,Y.P. and Stonestreet,B.S.
  TITLE     Expression and localization of Inter-alpha Inhibitors in rodent
            brain
  JOURNAL   Neuroscience 324, 69-81 (2016)
   PUBMED   26964679
REFERENCE   3  (bases 1 to 3077)
  AUTHORS   Hull,R.L., Johnson,P.Y., Braun,K.R., Day,A.J. and Wight,T.N.
  TITLE     Hyaluronan and hyaluronan binding proteins are normal components of
            mouse pancreatic islets and are differentially expressed by islet
            endocrine cell types
  JOURNAL   J Histochem Cytochem 60 (10), 749-760 (2012)
   PUBMED   22821669
REFERENCE   4  (bases 1 to 3077)
  AUTHORS   Morcel,K., Watrin,T., Jaffre,F., Deschamps,S., Omilli,F.,
            Pellerin,I., Leveque,J. and Guerrier,D.
  TITLE     Involvement of ITIH5, a candidate gene for congenital uterovaginal
            aplasia (Mayer-Rokitansky-Kuster-Hauser syndrome), in female
            genital tract development
  JOURNAL   Gene Expr 15 (5-6), 207-214 (2012)
   PUBMED   23539898
REFERENCE   5  (bases 1 to 3077)
  AUTHORS   Zhuo,L., Hascall,V.C. and Kimata,K.
  TITLE     Inter-alpha-trypsin inhibitor, a covalent
            protein-glycosaminoglycan-protein complex
  JOURNAL   J Biol Chem 279 (37), 38079-38082 (2004)
   PUBMED   15151994
  REMARK    Review article
REFERENCE   6  (bases 1 to 3077)
  AUTHORS   Chan,P., Risler,J.L., Raguenez,G. and Salier,J.P.
  TITLE     The three heavy-chain precursors for the inter-alpha-inhibitor
            family in mouse: new members of the multicopper oxidase protein
            group with differential transcription in liver and brain
  JOURNAL   Biochem J 306 (Pt 2) (Pt 2), 505-512 (1995)
   PUBMED   7534067
REFERENCE   7  (bases 1 to 3077)
  AUTHORS   Diarra-Mehrpour,M., Bourguignon,J., Sarafan,N., Bost,F.,
            Sesboue,R., Muschio-Bonnet,F. and Martin,J.P.
  TITLE     Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain
            H1 and H3 genes
  JOURNAL   Biochim Biophys Acta 1219 (2), 551-554 (1994)
   PUBMED   7522574
REFERENCE   8  (bases 1 to 3077)
  AUTHORS   Salier,J.P., Chan,P., Raguenez,G., Zwingman,T. and Erickson,R.P.
  TITLE     Developmentally regulated transcription of the four liver-specific
            genes for inter-alpha-inhibitor family in mouse
  JOURNAL   Biochem J 296 (Pt 1) (Pt 1), 85-91 (1993)
   PUBMED   7504460
REFERENCE   9  (bases 1 to 3077)
  AUTHORS   Salier,J.P., Simon,D., Rouet,P., Raguenez,G., Muscatelli,F.,
            Gebhard,W., Guenet,J.L. and Mattei,M.G.
  TITLE     Homologous chromosomal locations of the four genes for
            inter-alpha-inhibitor and pre-alpha-inhibitor family in human and
            mouse: assignment of the ancestral gene for the lipocalin
            superfamily
  JOURNAL   Genomics 14 (1), 83-88 (1992)
   PUBMED   1385302
REFERENCE   10 (bases 1 to 3077)
  AUTHORS   Salier,J.P., Verga,V., Doly,J., Diarra-Mehrpour,M. and
            Erickson,R.P.
  TITLE     The genes for the inter-alpha-inhibitor family share a homologous
            organization in human and mouse
  JOURNAL   Mamm Genome 2 (4), 233-239 (1992)
   PUBMED   1371941
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK149500.1.
            
            On Apr 6, 2007 this sequence version replaced NM_008406.2.
            
            Summary: This gene encodes a heavy chain of inter-alpha trypsin
            inhibitor (IaI) family of plasma serine protease inhibitors. IaI
            proteins are protein-glycosaminoglycan-protein complexes comprised
            of two heavy chains and a light chain. The encoded protein
            covalently associates with the light chain via a chondroitin
            sulfate moiety. Intravenous administration of the encoded protein
            improved survival of mice after infection with Escherichia coli.
            This gene is located adjacent to two other IaI heavy chain genes.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms that may undergo similar proteolytic
            processing to generate mature protein. [provided by RefSeq, Oct
            2015].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149500.1, X70391.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3077              AK149500.1         2-3078
FEATURES             Location/Qualifiers
     source          1..3077
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.09 cM"
     gene            1..3077
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /note="inter-alpha trypsin inhibitor, heavy chain 1"
                     /db_xref="GeneID:16424"
                     /db_xref="MGI:MGI:96618"
     exon            1..131
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..2747
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; inter-alpha-trypsin inhibitor heavy chain H1;
                     inter-alpha (globulin) inhibitor, H1 polypeptide"
                     /codon_start=1
                     /product="inter-alpha-trypsin inhibitor heavy chain H1
                     isoform 1 preproprotein"
                     /protein_id="NP_032432.2"
                     /db_xref="CCDS:CCDS49435.1"
                     /db_xref="GeneID:16424"
                     /db_xref="MGI:MGI:96618"
                     /translation="MEGATGLRVLLCLLPLLTLQARPALGLATGRPRGSEKRHAVDTS
                     VNGVSIKSLKVNCKVTSRFAHYVITSQVVNNADKAREVAFDVEIPKTAFISDFAITSD
                     GKAFIGDIKDKVTAWKQYRKAAVLGESAGLVRASGRNMEQFTIHITVGAQSKATFRLT
                     YEEVLKRRLMQYDITIKVRPKQLVQHFEIDVDIFEPQGISKLDAQASFLSEELAAQTI
                     KKSFSGKKGHVLFRPTVSQQQSCPTCSTSLLNGEFKVTYDVNRDKLCDLLVANNYFTH
                     FFAPKNLTNMSKNLVFVIDISGSMEGQKVRQTKEALLKILEDMRPVDNFDLVLFGSKV
                     QSWKGSLVPASNANLQAAQDFVRRFSLAGATNLNGGLLRGIEILNKAQGSHPELSSPA
                     SILIMLTDGEPTEGETDRSQILKNVRNAIRGRFPLYNLGFGHDLDFSFLEVMSTENNG
                     WAQRIYEDHDATQQLQGFYNQVANPLLTDVELQYPQDAVLALTQHRHKQYYDGSEIVV
                     AGRIANHKLNTFKADVRARGEKQEFRATCLVDEEEMKKLLRERGHVLENHVERLWAYL
                     TIQELLAKRMKTEGEERANLSSQVLKMSLDYHFVTPLTSLTIRGLTDEDGLEPTIDKP
                     LEDSQPLEMVGPRRTFVLSAIQPSPTAHPIDSKLPLRVTGVDTDPHFIIYVPSKEDSL
                     CFNINEEPGVILNLVQDPDTGFTVNGQLIGNKASSPGQHESTYFGRLGISSPTSDFQL
                     EVTPQNITLNPSSSGSMFSWRDQAVLQKDGVVVTINKKRNLVVSVDDGATFEIVLHRT
                     WKGSAVHQDFLGFYVLDSFRMSARTKGLLGQFFSPLDFEVFDLHPGSDPTKTDATMVV
                     KNRQLTVTRGLQKDYSKDPRHGAEVPCWFVHDNGAGLIDGVHTDYVVSDIF"
     exon            132..152
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            153..319
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..424
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            425..587
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..701
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..827
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..944
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1113
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1239
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1421
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1607
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1747
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1902
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..1917
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..1938
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2016
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2130
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2332
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2505
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2617
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..3077
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2874..2879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /note="hexamer: ATTAAA"
     polyA_site      2894
                     /gene="Itih1"
                     /gene_synonym="Intin1; ITI-HC1; Itih-1"
                     /note="major polyA site"
ORIGIN      
        1 ggggaattga gagcctggag atcatggagg gtgccacagg gctccgggtg ctgctgtgct
       61 tgctgccgct cctcactctg caggccaggc ctgctttggg cttggcaaca ggcagaccca
      121 ggggcagtga gaagcgacac gctgtggaca cttcagtcaa tggtgtgtcc atcaagagct
      181 tgaaagtcaa ttgcaaagtc acctctcgct ttgcccacta cgtcatcacc agccaagtgg
      241 tcaacaatgc tgataaagcc agggaagtgg cttttgatgt ggaaatcccc aagacagcct
      301 tcatcagtga ctttgccata acatcagatg ggaaggcgtt cattggggac ataaaggaca
      361 aagtgactgc atggaagcag taccggaagg cagccgtttt aggggagagc gctggccttg
      421 tcagagcctc gggcagaaat atggagcagt tcaccatcca tatcactgtt ggagcccaga
      481 gcaaggccac gttccggctc acctatgagg aggtactaaa gaggagactg atgcagtatg
      541 acatcaccat caaagtcaga cccaagcagc tggtacagca ttttgagatc gatgtggaca
      601 tctttgaacc ccaggggatc agcaagctgg acgctcaggc ctccttcctc agtgaggaac
      661 tggctgctca aaccatcaag aagtctttct cagggaaaaa gggtcatgtg ctcttccgcc
      721 ccactgtgag ccagcagcag tcctgcccca catgttctac atccttgcta aatggagaat
      781 tcaaggtgac ctacgatgtc aatcgagaca agctctgtga cctcctggtg gccaacaact
      841 actttacaca tttctttgcc cccaaaaacc tgaccaacat gagcaagaac ctggtttttg
      901 tgattgacat cagtggctcc atggaaggcc agaaagtgag gcagacaaag gaggcactcc
      961 ttaagatcct ggaggacatg aggccagtag acaactttga cctggtcctc tttggctcta
     1021 aagtgcaatc atggaagggc tccctggtac ctgcgtctaa tgccaatctg caagcagctc
     1081 aagactttgt gaggcgcttt tctttggctg gagccacaaa cctgaatgga ggcttgctcc
     1141 gaggaatcga gatcttaaac aaagctcaag gaagccaccc agaactcagc agcccggcct
     1201 caattcttat catgttgaca gacggagagc ccactgaagg ggagacggac cgttcccaga
     1261 tcctcaagaa tgtacgcaac gctatccggg gcaggttccc gctctacaac ctcggctttg
     1321 gccacgacct ggacttcagc ttcctggagg tcatgtccac tgagaacaac ggatgggccc
     1381 agagaattta tgaggaccat gatgccaccc aacagctaca gggtttctac aatcaagtag
     1441 ccaatcccct gctgacagat gtggaactgc agtaccccca ggatgctgtc ttggctctaa
     1501 cccagcaccg acataaacag tactatgacg gctcggagat tgtggtggct gggcgcattg
     1561 ctaaccacaa actgaacacc tttaaggctg acgttcgggc tcgtggggaa aagcaagaat
     1621 tcagggcaac ctgcctagtg gacgaggaag agatgaagaa actgctccga gagcgtggcc
     1681 acgtgctaga gaatcatgtg gagaggctct gggcctacct cacgatccag gagctcctgg
     1741 ctaagcggat gaagacggaa ggggaggaga gggccaacct gtcatcccag gtcctgaaga
     1801 tgtcactgga ctatcatttc gtaacgccac tgacctctct gactatcaga ggcctgacag
     1861 acgaggatgg gctggagccc accattgaca agcccctgga ggattctcag cccttagaga
     1921 tggtgggacc cagaagaacg tttgtgctgt cagccataca gccatctcct acagcccacc
     1981 ccatagactc aaagttgcca ctccgtgtga caggtgtgga caccgatccc cacttcatca
     2041 tctatgtgcc ctcaaaagag gatagcttgt gcttcaacat caatgaggaa cctggtgtga
     2101 tcctgaacct agtacaggac cctgacacag gcttcaccgt gaatgggcag ctcattggga
     2161 acaaggccag cagccctggg caacacgaga gcacatactt cgggagattg ggaatctcaa
     2221 gtcccacatc agactttcag ctggaagtga ctcctcagaa cattacactg aaccccagct
     2281 ccagcgggtc catgttctcc tggagggacc aggctgtgct gcagaaggat ggggtagtgg
     2341 tgacaatcaa caagaagagg aacctggtgg tgtctgtgga tgatggggct acctttgaga
     2401 ttgtcctgca cagaacatgg aaggggagtg cagtccacca ggacttcctg ggtttctatg
     2461 tgctggacag cttccggatg tcagcccgga caaaggggct actgggacaa ttcttctccc
     2521 cactggattt tgaagtattt gacctccacc caggctctga ccctacaaag acagatgcca
     2581 caatggtggt gaagaatcgg cagctgacag tcacccgagg gttgcaaaaa gactacagca
     2641 aggaccccag acatggagca gaagtgcctt gctggtttgt ccacgacaat ggagctggac
     2701 tgattgatgg tgttcacact gactatgtcg tctctgacat cttctgagcc ctccagctaa
     2761 cacagcagcc tttgcctgga acggcctatg aaggaggaga ggagagcaga gcatcagatt
     2821 aactccacct tcctgagcat actggtccct gtgtcaagac atcctgtgat ctcattaaag
     2881 agaggctgtg tccagtgcag agttggctgc ctttggggag agaggtagca gggggtagct
     2941 caggacctca tcagactcaa agatgggcaa agaagacaga aatgggagga atctaccgat
     3001 tctgcagcat tgactgcatc ctgttctctt cttggcacat ggcctctgaa tcccttgaat
     3061 aaacccttca cacagtc
//
