LOCUS       NM_145467               2357 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus integrin, beta-like 1 (Itgbl1), mRNA.
ACCESSION   NM_145467
VERSION     NM_145467.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2357)
  AUTHORS   Chen,X., Li,X., Wu,X., Ding,Y., Li,Y., Zhou,G., Wei,Y., Chen,S.,
            Lu,X., Xu,J., Liu,S., Li,J. and Cai,L.
  TITLE     Integrin beta-like 1 mediates fibroblast-cardiomyocyte crosstalk to
            promote cardiac fibrosis and hypertrophy
  JOURNAL   Cardiovasc Res 119 (10), 1928-1941 (2023)
   PUBMED   37395147
  REMARK    GeneRIF: Integrin beta-like 1 mediates fibroblast-cardiomyocyte
            crosstalk to promote cardiac fibrosis and hypertrophy.
REFERENCE   2  (bases 1 to 2357)
  AUTHORS   Cheli,Y., Tulic,M.K., El Hachem,N., Nottet,N., Jacquel,A.,
            Gesson,M., Strub,T., Bille,K., Picard-Gauci,A., Montaudie,H.,
            Beranger,G.E., Passeron,T., Close,P., Bertolotto,C. and Ballotti,R.
  TITLE     ITGBL1 is a new immunomodulator that favors development of melanoma
            tumors by inhibiting natural killer cells cytotoxicity
  JOURNAL   Mol Cancer 20 (1), 12 (2021)
   PUBMED   33413419
  REMARK    GeneRIF: ITGBL1 is a new immunomodulator that favors development of
            melanoma tumors by inhibiting natural killer cells cytotoxicity.
            Erratum:[Mol Cancer. 2021 Jan 27;20(1):21. doi:
            10.1186/s12943-021-01319-5.. PMID: 33504341]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2357)
  AUTHORS   Young,R.E., Jones,M.K., Hines,E.A., Li,R., Luo,Y., Shi,W.,
            Verheyden,J.M. and Sun,X.
  TITLE     Smooth Muscle Differentiation Is Essential for Airway Size,
            Tracheal Cartilage Segmentation, but Dispensable for Epithelial
            Branching
  JOURNAL   Dev Cell 53 (1), 73-85 (2020)
   PUBMED   32142630
REFERENCE   4  (bases 1 to 2357)
  AUTHORS   Song,E.K., Jeon,J., Jang,D.G., Kim,H.E., Sim,H.J., Kwon,K.Y.,
            Medina-Ruiz,S., Jang,H.J., Lee,A.R., Rho,J.G., Lee,H.S., Kim,S.J.,
            Park,C.Y., Myung,K., Kim,W., Kwon,T., Yang,S. and Park,T.J.
  TITLE     ITGBL1 modulates integrin activity to promote cartilage formation
            and protect against arthritis
  JOURNAL   Sci Transl Med 10 (462) (2018)
   PUBMED   30305454
  REMARK    GeneRIF: These results reveal ITGBL1 signaling as an underlying
            mechanism of protection against destructive cartilage disorders
REFERENCE   5  (bases 1 to 2357)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 2357)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ154777.1, AK029068.1 and BB676110.1.
            
            On May 13, 2008 this sequence version replaced NM_145467.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020152.1, AK029068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                CJ154777.1         2-36
            36-1977             AK029068.1         3-1944
            1978-2357           BB676110.1         39-418
FEATURES             Location/Qualifiers
     source          1..2357
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 66.1 cM"
     gene            1..2357
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
                     /note="integrin, beta-like 1"
                     /db_xref="GeneID:223272"
                     /db_xref="MGI:MGI:2443439"
     exon            1..267
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1654
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
                     /note="integrin beta-like protein 1; with EGF-like repeat
                     domains"
                     /codon_start=1
                     /product="integrin beta-like protein 1 precursor"
                     /protein_id="NP_663442.2"
                     /db_xref="CCDS:CCDS27354.1"
                     /db_xref="GeneID:223272"
                     /db_xref="MGI:MGI:2443439"
                     /translation="MHPPGFRNFLLLVSSLLFIGLSAAPQSFLPSLRSLSGAPCRLSR
                     AESERRCRAPGQPPGSALCHDRGRCECGVCICHVTEPGTYFGPLCECHEWICETYDGK
                     TCAGHGNCDCGKCKCDVGWSGEACQYPTKCDLTKKISNQMCKNSQDVICSNAGTCHCG
                     RCKCDNSDGHGLIYGKFCECDDRECIDDETEEVCGGHGKCYCGNCYCEAGWHGDKCEF
                     QCDITPWESKRRCTSPDGKVCSNRGTCVCGECSCHDVDPTGDWGDIHGDTCECDERDC
                     RAVYDRYSDDFCSGHGQCNCGRCDCRAGWYGKKCEHPRNCPLSAEESTKKCQGSSDLP
                     CSGRGRCECGRCTCYPPGDSRVYGKTCECDDRRCEDLDGVVCGGHGMCSCGRCVCEKG
                     WFGKLCQHLRKCNMTEEQSRSLCESADGTLCSGKGSCHCGKCICSGEEWYISGEFCDC
                     DDRDCDKHDGLICTGNGICSCGNCECWDGWNGNACEIWLGTEYP"
     exon            268..485
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            486..632
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            633..755
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            756..896
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1037
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1184
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1301
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1448
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1562
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..2357
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1798..1803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      1825
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
     regulatory      2332..2337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2356
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtcttcgcag gcaactgagc ttccaggagg agcccagaac ctgtgagctc cgctatccca
       61 agtccttctg cctggacatc tgctggtgac acttcctcct gctgcctcgg gtggaagccc
      121 cacctagcag cagtgcagct ggtctgccct ccctcctgca gagctcagca tgcatcctcc
      181 aggcttcagg aacttcttgt tgctggtgtc ctcccttctc ttcattgggc tgtcagctgc
      241 tcctcaaagc ttcttaccat ctctgagaag cctgtcgggc gccccctgca ggctgtcccg
      301 ggcagagtcc gaacgcagat gtcgtgcacc tgggcagccc ccagggagcg ctctgtgcca
      361 tgaccgtggc cggtgcgagt gtggggtctg catctgtcac gtgaccgaac ctggcaccta
      421 cttcggtcca ctgtgtgagt gccatgagtg gatatgcgag acctacgacg ggaaaacctg
      481 tgcaggccac ggtaattgtg actgcggcaa gtgcaagtgt gatgtgggat ggtctgggga
      541 agcttgtcag tacccaacca agtgtgacct gaccaaaaaa atcagcaacc agatgtgcaa
      601 gaactcccaa gatgtcatct gctccaatgc aggtacatgt cactgtggca ggtgtaagtg
      661 tgataattca gatggacatg gactcattta tggtaaattt tgtgaatgtg atgatagaga
      721 atgcatagat gatgaaacag aagaagtatg tggaggccat gggaagtgtt actgtggaaa
      781 ctgttactgt gaggctggtt ggcatggcga taaatgcgag ttccagtgtg acatcacccc
      841 atgggaaagc aagcgaagat gcacatctcc agatggcaaa gtctgtagca acagaggaac
      901 atgtgtatgt ggtgaatgtt cttgccatga tgttgatcca actggggact ggggagacat
      961 tcatggggac acgtgtgagt gtgatgaaag ggactgcaga gctgtttatg atcgatactc
     1021 tgatgatttc tgttcaggtc atgggcagtg taactgtgga agatgtgact gcagagcagg
     1081 ctggtatggg aagaaatgtg agcacccaag gaattgccca ttgtcagctg aggagagcac
     1141 caagaagtgc cagggtagtt ctgatcttcc ttgctctgga aggggcagat gcgaatgtgg
     1201 cagatgcact tgttaccctc ctggggacag cagagtctat ggcaagacct gtgagtgtga
     1261 tgaccggcgc tgcgaggacc tggatggtgt ggtctgcgga ggccatggca tgtgctcctg
     1321 tggtcgctgt gtttgtgaga aaggatggtt tggtaagctc tgccaacacc tgcggaagtg
     1381 taatatgaca gaagaacaaa gcaggagtct gtgtgagtca gcagatggca cattgtgctc
     1441 agggaagggt tcttgtcatt gtggaaagtg catttgttct ggagaagagt ggtatatttc
     1501 aggggagttt tgtgactgtg atgacagaga ctgtgacaaa cacgatggtc tcatttgcac
     1561 agggaatgga atctgtagct gtggaaactg tgaatgctgg gatggatgga atggaaatgc
     1621 atgtgaaatc tggcttggta ccgaatatcc ttaatgatcc catgggagac aactggattc
     1681 ttatttctag gccattttag aaattcagag gaaagcatat tacacagcac taggacagac
     1741 ttttgtgtgt ttctctattt ctgactgccc aactgggtct tcaattcaaa caactttagt
     1801 aaactgatat aagttacacc ataaagaatt gttctcccat aattaacata ggtgtttcac
     1861 aaatgaagag ggcaattttg caacccctaa gacatttgac aatgtctaca gagaatttgg
     1921 ttgtcagact tggtaggtag gagtatttgt gttatgggga tatgtctgta gtggccacag
     1981 acaatggtga ccaccctaaa gaaaatagaa aggcccttac aacaaagtaa tttctgacat
     2041 ccaatgttta caaagatgta gtagaaaaat gctaaatcac atggtattta gtactccaca
     2101 tcccaacacc agaaacactg tatcagaata taaggataat atttattctc acataaacca
     2161 accagtcaga tttttccagg attccatatg actctgaatt tgtatatgat atgattatga
     2221 cagacacata cgaggtgtga tgatggattg ggcgcttccc agatcacaag ggctctaaac
     2281 tcacaagaat ctcttacagg aagaaatgat aaatgcacaa tttgacattt taataaataa
     2341 taacataagt tgtttat
//
