LOCUS       NP_663442                494 aa            linear   ROD 27-APR-2025
DEFINITION  integrin beta-like protein 1 precursor [Mus musculus].
ACCESSION   NP_663442
VERSION     NP_663442.2
DBSOURCE    REFSEQ: accession NM_145467.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 494)
  AUTHORS   Chen,X., Li,X., Wu,X., Ding,Y., Li,Y., Zhou,G., Wei,Y., Chen,S.,
            Lu,X., Xu,J., Liu,S., Li,J. and Cai,L.
  TITLE     Integrin beta-like 1 mediates fibroblast-cardiomyocyte crosstalk to
            promote cardiac fibrosis and hypertrophy
  JOURNAL   Cardiovasc Res 119 (10), 1928-1941 (2023)
   PUBMED   37395147
  REMARK    GeneRIF: Integrin beta-like 1 mediates fibroblast-cardiomyocyte
            crosstalk to promote cardiac fibrosis and hypertrophy.
REFERENCE   2  (residues 1 to 494)
  AUTHORS   Cheli,Y., Tulic,M.K., El Hachem,N., Nottet,N., Jacquel,A.,
            Gesson,M., Strub,T., Bille,K., Picard-Gauci,A., Montaudie,H.,
            Beranger,G.E., Passeron,T., Close,P., Bertolotto,C. and Ballotti,R.
  TITLE     ITGBL1 is a new immunomodulator that favors development of melanoma
            tumors by inhibiting natural killer cells cytotoxicity
  JOURNAL   Mol Cancer 20 (1), 12 (2021)
   PUBMED   33413419
  REMARK    GeneRIF: ITGBL1 is a new immunomodulator that favors development of
            melanoma tumors by inhibiting natural killer cells cytotoxicity.
            Erratum:[Mol Cancer. 2021 Jan 27;20(1):21. doi:
            10.1186/s12943-021-01319-5. PMID: 33504341]
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 494)
  AUTHORS   Young,R.E., Jones,M.K., Hines,E.A., Li,R., Luo,Y., Shi,W.,
            Verheyden,J.M. and Sun,X.
  TITLE     Smooth Muscle Differentiation Is Essential for Airway Size,
            Tracheal Cartilage Segmentation, but Dispensable for Epithelial
            Branching
  JOURNAL   Dev Cell 53 (1), 73-85 (2020)
   PUBMED   32142630
REFERENCE   4  (residues 1 to 494)
  AUTHORS   Song,E.K., Jeon,J., Jang,D.G., Kim,H.E., Sim,H.J., Kwon,K.Y.,
            Medina-Ruiz,S., Jang,H.J., Lee,A.R., Rho,J.G., Lee,H.S., Kim,S.J.,
            Park,C.Y., Myung,K., Kim,W., Kwon,T., Yang,S. and Park,T.J.
  TITLE     ITGBL1 modulates integrin activity to promote cartilage formation
            and protect against arthritis
  JOURNAL   Sci Transl Med 10 (462) (2018)
   PUBMED   30305454
  REMARK    GeneRIF: These results reveal ITGBL1 signaling as an underlying
            mechanism of protection against destructive cartilage disorders
REFERENCE   5  (residues 1 to 494)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (residues 1 to 494)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ154777.1, AK029068.1 and BB676110.1.
            
            On May 13, 2008 this sequence version replaced NP_663442.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020152.1, AK029068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 66.1 cM"
     Protein         1..494
                     /product="integrin beta-like protein 1 precursor"
                     /note="integrin beta-like protein 1; with EGF-like repeat
                     domains"
                     /calculated_mol_wt=51467
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2530
     mat_peptide     24..494
                     /product="Integrin beta-like protein 1.
                     /id=PRO_0000323023"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VDV0.2)"
                     /calculated_mol_wt=51467
     Region          51..494
                     /region_name="Cysteine-rich tandem repeats"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VDV0.2)"
     Site            405
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VDV0.2)"
     CDS             1..494
                     /gene="Itgbl1"
                     /gene_synonym="B930011D01Rik"
                     /coded_by="NM_145467.2:170..1654"
                     /db_xref="CCDS:CCDS27354.1"
                     /db_xref="GeneID:223272"
                     /db_xref="MGI:MGI:2443439"
ORIGIN      
        1 mhppgfrnfl llvssllfig lsaapqsflp slrslsgapc rlsraeserr crapgqppgs
       61 alchdrgrce cgvcichvte pgtyfgplce chewicetyd gktcaghgnc dcgkckcdvg
      121 wsgeacqypt kcdltkkisn qmcknsqdvi csnagtchcg rckcdnsdgh gliygkfcec
      181 ddreciddet eevcgghgkc ycgncyceag whgdkcefqc ditpweskrr ctspdgkvcs
      241 nrgtcvcgec schdvdptgd wgdihgdtce cderdcravy drysddfcsg hgqcncgrcd
      301 cragwygkkc ehprncplsa eestkkcqgs sdlpcsgrgr cecgrctcyp pgdsrvygkt
      361 cecddrrced ldgvvcgghg mcscgrcvce kgwfgklcqh lrkcnmteeq srslcesadg
      421 tlcsgkgsch cgkcicsgee wyisgefcdc ddrdcdkhdg lictgngics cgncecwdgw
      481 ngnaceiwlg teyp
//
