LOCUS       NM_013566               2696 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus integrin beta 7 (Itgb7), mRNA.
ACCESSION   NM_013566
VERSION     NM_013566.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2696)
  AUTHORS   Li,Y., Gunderson,R.C., Xu,Z., Ai,W., Shen,F., Ye,J., Xu,B. and
            Michie,S.A.
  TITLE     Mucosal Addressin Cell Adhesion Molecule-1 Mediates T Cell
            Migration into Pancreas-Draining Lymph Nodes for Initiation of the
            Autoimmune Response in Type 1 Diabetes
  JOURNAL   Int J Mol Sci 25 (21), 11350 (2024)
   PUBMED   39518902
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2696)
  AUTHORS   Assayag,M., Obedeyah,T., Abutbul,A. and Berkman,N.
  TITLE     The integrin receptor beta7 subunit mediates airway remodeling and
            hyperresponsiveness in allergen exposed mice
  JOURNAL   Respir Res 25 (1), 273 (2024)
   PUBMED   38997751
  REMARK    GeneRIF: The integrin receptor beta7 subunit mediates airway
            remodeling and hyperresponsiveness in allergen exposed mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2696)
  AUTHORS   Ryu,S., Kim,K.A., Kim,J., Lee,D.H., Bae,Y.S., Lee,H., Kim,B.C. and
            Kim,H.Y.
  TITLE     The protective roles of integrin alpha4beta7 and
            Amphiregulin-expressing innate lymphoid cells in lupus nephritis
  JOURNAL   Cell Mol Immunol 21 (7), 723-737 (2024)
   PUBMED   38806623
  REMARK    GeneRIF: The protective roles of integrin alpha4beta7 and
            Amphiregulin-expressing innate lymphoid cells in lupus nephritis.
REFERENCE   4  (bases 1 to 2696)
  AUTHORS   Kamioka,Y., Ueda,Y., Kondo,N., Tokuhiro,K., Ikeda,Y., Bergmeier,W.
            and Kinashi,T.
  TITLE     Distinct bidirectional regulation of LFA1 and alpha4beta7 by Rap1
            and integrin adaptors in T cells under shear flow
  JOURNAL   Cell Rep 42 (6), 112580 (2023)
   PUBMED   37267105
  REMARK    GeneRIF: Distinct bidirectional regulation of LFA1 and alpha4beta7
            by Rap1 and integrin adaptors in T cells under shear flow.
REFERENCE   5  (bases 1 to 2696)
  AUTHORS   Fidelle,M., Rauber,C., Alves Costa Silva,C., Tian,A.L., Lahmar,I.,
            de La Varende,A.M., Zhao,L., Thelemaque,C., Lebhar,I.,
            Messaoudene,M., Pizzato,E., Birebent,R., Mbogning Fonkou,M.D.,
            Zoppi,S., Reni,A., Dalban,C., Leduc,M., Ferrere,G., Durand,S.,
            Ly,P., Silvin,A., Mulder,K., Dutertre,C.A., Ginhoux,F.,
            Yonekura,S., Roberti,M.P., Tidjani-Alou,M., Terrisse,S., Chen,J.,
            Kepp,O., Schippers,A., Wagner,N., Suarez-Gosalvez,J., Kobold,S.,
            Fahrner,J.E., Richard,C., Bosq,J., Lordello,L., Vitali,G.,
            Galleron,N., Quinquis,B., Le Chatelier,E., Blanchard,L.,
            Girard,J.P., Jarry,A., Gervois,N., Godefroy,E., Labarriere,N.,
            Koschny,R., Daillere,R., Besse,B., Truntzer,C., Ghiringhelli,F.,
            Coatnoan,N., Mhanna,V., Klatzmann,D., Drubay,D., Albiges,L.,
            Thomas,A.M., Segata,N., Danlos,F.X., Marabelle,A., Routy,B.,
            Derosa,L., Kroemer,G. and Zitvogel,L.
  TITLE     A microbiota-modulated checkpoint directs immunosuppressive
            intestinal T cells into cancers
  JOURNAL   Science 380 (6649), eabo2296 (2023)
   PUBMED   37289890
REFERENCE   6  (bases 1 to 2696)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 2696)
  AUTHORS   Gurish,M.F., Bell,A.F., Smith,T.J., Ducharme,L.A., Wang,R.K. and
            Weis,J.H.
  TITLE     Expression of murine beta 7, alpha 4, and beta 1 integrin genes by
            rodent mast cells
  JOURNAL   J Immunol 149 (6), 1964-1972 (1992)
   PUBMED   1381390
REFERENCE   8  (bases 1 to 2696)
  AUTHORS   Hu,M.C., Crowe,D.T., Weissman,I.L. and Holzmann,B.
  TITLE     Cloning and expression of mouse integrin beta p(beta 7): a
            functional role in Peyer's patch-specific lymphocyte homing
  JOURNAL   Proc Natl Acad Sci U S A 89 (17), 8254-8258 (1992)
   PUBMED   1518854
REFERENCE   9  (bases 1 to 2696)
  AUTHORS   Yuan,Q., Jiang,W.M., Leung,E., Hollander,D., Watson,J.D. and
            Krissansen,G.W.
  TITLE     Molecular cloning of the mouse integrin beta 7 subunit
  JOURNAL   J Biol Chem 267 (11), 7352-7358 (1992)
   PUBMED   1559978
REFERENCE   10 (bases 1 to 2696)
  AUTHORS   Yuan,Q., Kozak,C.A., Jiang,W.M., Hollander,D., Watson,J.D. and
            Krissansen,G.W.
  TITLE     Genetic mapping of the gene coding for the integrin beta 7 subunit
            to the distal part of mouse chromosome 15
  JOURNAL   Immunogenetics 35 (6), 403-407 (1992)
   PUBMED   1349587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK078871.1, AK155594.1 and AI322899.1.
            
            On Nov 20, 2007 this sequence version replaced NM_013566.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011184.1, M95633.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               AK078871.1         2-469
            469-735             AK155594.1         441-707
            736-2610            AK078871.1         737-2611
            2611-2671           AK155594.1         2584-2644
            2672-2696           AI322899.1         345-369
FEATURES             Location/Qualifiers
     source          1..2696
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.39 cM"
     gene            1..2696
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /note="integrin beta 7"
                     /db_xref="GeneID:16421"
                     /db_xref="MGI:MGI:96616"
     exon            1..85
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /inference="alignment:Splign:2.1.0"
     exon            86..289
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..2509
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /note="integrin beta-P; M290 IEL antigen"
                     /codon_start=1
                     /product="integrin beta-7 precursor"
                     /protein_id="NP_038594.2"
                     /db_xref="CCDS:CCDS49740.1"
                     /db_xref="GeneID:16421"
                     /db_xref="MGI:MGI:96616"
                     /translation="MVDSSTVLIFLLVLGGGQSELDTKITSSGEAAEWEDPDLSLQGS
                     CQPVPSCQKCILSHPSCAWCKQLNFTASGEAEARRCARREELLARGCPAQELEEPRGR
                     QEVLQDKPLSQGDRGEGATQLAPQRIRVTLRPGEPQKFRVRFLRAAGYPVDLYYLMDL
                     SYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLHHPCPS
                     RLERCQPPFSFHHVLSLTGDAQAFEREVGRQNVSGNLDSPEGGFDAILQAALCQEQIG
                     WRNVSRLLVFTSDDTFHTAGDGKLGGIFMPSDGRCHLDSNGVYTNSAEFDYPSVGQVA
                     QALTAANIQPIFAVTGATLPVYQELRQLIPKSAVGELSEDSSNVVQLIMDAYDSLSST
                     VTLEHSPLPPGVSISFESHCKGPEKTEGEAGDRGQCNDVRVNQTVDFWVTLQATHCLP
                     EAHVLRLWALGFSEELTVELHTVCDCNCGDAQPHAPYCSDGQGDLQCGICSCAPGRLG
                     QLCECSEADLSSPDLESGCRAPNGTGPLCSGKGRCQCGRCSCSGQSSGRLCECDDASC
                     ERHEGILCGGFGHCQCGVCHCHANHTGRACECSKSVDSCVSPEGGLCSGHGYCKCNRC
                     QCLDGYYGALCDQCLGCKSPCEQYRDCAECGAFGTGPLAANCSVVCADVNVTLTLAPN
                     LDDGWCKERTIDNQLFFFLVEHAASGIVLRVRPQEKGVDHTRAIILGCTGGIVAVGLG
                     LVLAYRLSVEIYDRREYRRFEKEQQQLNWKQDNNPLYKSAITTTVNPRFQGTNGRSPS
                     LSLTREAD"
     exon            290..491
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /inference="alignment:Splign:2.1.0"
     exon            492..662
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /inference="alignment:Splign:2.1.0"
     exon            663..904
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1063
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1159
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1249
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1396
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1590
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1814
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..2034
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2240
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2401
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2674
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2656..2661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /note="hexamer: AATAAA"
     polyA_site      2674
                     /gene="Itgb7"
                     /gene_synonym="Ly69"
                     /note="major polyA site"
ORIGIN      
        1 acttcctcct ctgctgcctc tccatctgta cacaagggct gccactgcca ccggcggagg
       61 aagggctgct cctcctcaag cacctgccat ggtggattca tcaactgttc tcatttttct
      121 gctggttctg ggcggaggtc agagtgagtt agataccaag attacatcct ctggggaggc
      181 cgcagaatgg gaggatcctg acctgtctct gcagggatcc tgccagccag ttccttcctg
      241 ccagaagtgt attctctcac atcccagctg tgcatggtgc aaacaactga acttcactgc
      301 ctcgggagag gcagaggcga ggcgctgcgc gcggcgagag gagctactgg ctcgcgggtg
      361 ccccgcgcag gagctagagg agccgagagg ccgccaggag gtgctgcagg acaagccgct
      421 cagccaggga gatcgcggcg agggggccac ccagctggcc ccgcagcgga tccgcgtcac
      481 gctgcgacca ggggagcccc agaaattccg ggtccgcttc ctccgagctg cggggtaccc
      541 cgtggaccta tattacctta tggacctgag ctactcaatg aaggacgact tggaacgtgt
      601 gcgccagcta gggcatgccc tgctggtcag gctgcaggag gtcacacatt ctgtgcgcat
      661 aggttttggc tccttcgtgg acaaaacggt gctgcccttt gtaagcaccg tgccctccaa
      721 gcttcaccac ccatgcccca gccgactgga gcgttgtcag ccacccttca gctttcacca
      781 cgtgctgtcc ctcaccgggg acgctcaagc cttcgagaga gaggtgggac gccagaatgt
      841 ctctggcaac ctggactcac ccgaaggcgg ctttgatgcc attttgcagg ctgccctctg
      901 ccaggaacag attggctgga gaaatgtctc ccgtcttcta gtgttcactt cagacgatac
      961 attccacaca gctggggatg ggaaactggg tggcattttc atgcccagcg acgggcggtg
     1021 ccatctggac agcaatggtg tctacacgaa cagcgcagag tttgactatc cctctgtggg
     1081 tcaagtagcc caggccctca ctgcagcgaa tatccaacct atctttgctg tcaccggtgc
     1141 aacactgcct gtgtatcagg agctgagaca gttgattccc aagtctgctg tcggggagct
     1201 gagtgaggac tccagcaatg tggtgcagct catcatggat gcttatgata gcctgtcatc
     1261 cactgtgact cttgagcact ctccactccc accaggagtc agcatctcct ttgaatctca
     1321 ctgtaagggt cctgagaaga cggagggtga ggctggggac cggggacagt gcaatgatgt
     1381 ccgagtcaac cagacggtgg atttctgggt cactcttcaa gctactcact gcctcccaga
     1441 agcccacgtc ctacgactct gggctcttgg cttctcagag gagttaactg tggagctgca
     1501 cacagtgtgc gactgtaact gtggtgatgc ccagcctcac gctccctact gcagtgatgg
     1561 acagggggac cttcagtgcg ggatatgcag ctgtgcccct ggccgtcttg gtcagctgtg
     1621 tgaatgctct gaggctgacc tgtcctcccc agatttggaa tctggttgcc gggccccaaa
     1681 cgggacaggg cccctatgca gcgggaaggg tcgatgccaa tgtggacgct gcagctgcag
     1741 tgggcagagc tctgggcgtc tgtgcgagtg tgatgatgcc agctgtgagc gacatgaggg
     1801 catcctctgt ggaggctttg gccactgcca gtgtggagta tgtcactgtc acgccaacca
     1861 caccggcaga gcttgcgagt gcagcaagag tgtagacagc tgtgtcagtc ctgaaggagg
     1921 gctctgcagt gggcacggat actgcaaatg caaccgttgc cagtgcctgg atggctacta
     1981 cggggctctg tgtgaccagt gcctaggctg caagtcacca tgtgagcagt acagggattg
     2041 tgcagagtgc ggggcatttg gtaccggtcc cctggcagcc aactgtagtg tggtctgtgc
     2101 tgacgtgaat gtgaccttga ccttggcccc taacttggat gatggctggt gcaaagaaag
     2161 gacaatagac aaccagctgt tcttcttcct ggtggagcat gcagccagcg ggatcgtact
     2221 gagagtgaga ccccaagaga agggagtgga tcacacccgt gccatcatac tgggctgcac
     2281 agggggcatc gtggcagtgg gactagggct ggttctggct taccggctct ctgtggaaat
     2341 ctacgaccga cgggagtaca ggcgctttga gaaggagcag cagcaactca actggaagca
     2401 ggacaacaat cctctctaca aaagtgcgat cacaaccact gtcaaccccc gcttccaagg
     2461 gacaaacggt cggtcgccat ccctctctct gaccagggaa gcagactgac ttaggattct
     2521 tgtcttggag gacagtggag atagaagggc agggcagcgt ctgtcaggca aagatgctgc
     2581 caccgctgag atttttcaga gtgaccttca gagggcagca gccattccca ccacacgaag
     2641 ggctggtcct tccataataa agctttgccc cagaaaaaaa aaaaaaaaaa aaaaaa
//
