LOCUS       NM_021359               4788 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Mus musculus integrin beta 6 (Itgb6), transcript variant 2, mRNA.
ACCESSION   NM_021359
VERSION     NM_021359.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4788)
  AUTHORS   Zhu,C., Zheng,R., Han,X., Tang,Z., Li,F., Hu,X., Lin,R., Shen,J.,
            Pei,Q., Wang,R., Wei,G., Peng,Z., Chen,W., Liang,Z. and Zhou,Y.
  TITLE     Knockout of integrin alphavbeta6 protects against renal
            inflammation in chronic kidney disease by reduction of
            pro-inflammatory macrophages
  JOURNAL   Cell Death Dis 15 (6), 397 (2024)
   PUBMED   38844455
  REMARK    GeneRIF: Knockout of integrin alphavbeta6 protects against renal
            inflammation in chronic kidney disease by reduction of
            pro-inflammatory macrophages.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4788)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4788)
  AUTHORS   Li,X., Miao,Y., Li,T., Liu,X., Xu,L., Guo,J., Yu,X., Sun,B.,
            Zhu,Y., Ai,D. and Chen,L.
  TITLE     Integrin beta6 mediates epithelial-mesenchymal transition in
            diabetic kidney disease
  JOURNAL   Mol Cell Endocrinol 572, 111955 (2023)
   PUBMED   37187284
  REMARK    GeneRIF: Integrin beta6 mediates epithelial-mesenchymal transition
            in diabetic kidney disease.
REFERENCE   4  (bases 1 to 4788)
  AUTHORS   Xie,H., Jiao,Y., Zhou,X., Liao,X., Chen,J., Chen,H., Chen,L.,
            Yu,S., Deng,Q., Sun,L., Xu,X. and Wang,J.
  TITLE     Integrin alphavbeta6 contributes to the development of intestinal
            fibrosis via the FAK/AKT signaling pathway
  JOURNAL   Exp Cell Res 411 (2), 113003 (2022)
   PUBMED   34979108
REFERENCE   5  (bases 1 to 4788)
  AUTHORS   Bhattacharjee,O., Ayyangar,U., Kurbet,A.S., Lakshmanan,V.,
            Palakodeti,D., Ginhoux,F. and Raghavan,S.
  TITLE     Epithelial-Macrophage Crosstalk Initiates Sterile Inflammation in
            Embryonic Skin
  JOURNAL   Front Immunol 12, 718005 (2021)
   PUBMED   34721382
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4788)
  AUTHORS   Baudoin,C., Goumans,M.J., Mummery,C. and Sonnenberg,A.
  TITLE     Knockout and knockin of the beta1 exon D define distinct roles for
            integrin splice variants in heart function and embryonic
            development
  JOURNAL   Genes Dev 12 (8), 1202-1216 (1998)
   PUBMED   9553049
REFERENCE   7  (bases 1 to 4788)
  AUTHORS   Huang,X.Z., Wu,J.F., Cass,D., Erle,D.J., Corry,D., Young,S.G.,
            Farese,R.V. Jr. and Sheppard,D.
  TITLE     Inactivation of the integrin beta 6 subunit gene reveals a role of
            epithelial integrins in regulating inflammation in the lung and
            skin
  JOURNAL   J Cell Biol 133 (4), 921-928 (1996)
   PUBMED   8666675
REFERENCE   8  (bases 1 to 4788)
  AUTHORS   Wada,J., Kumar,A., Liu,Z., Ruoslahti,E., Reichardt,L., Marvaldi,J.
            and Kanwar,Y.S.
  TITLE     Cloning of mouse integrin alphaV cDNA and role of the
            alphaV-related matrix receptors in metanephric development
  JOURNAL   J Cell Biol 132 (6), 1161-1176 (1996)
   PUBMED   8601592
REFERENCE   9  (bases 1 to 4788)
  AUTHORS   Spur,N.K., Bashir,R., Bushby,K., Cox,A., Cox,S., Hilde Brandt,F.,
            Hill,N., Kao,F.T., Krols,L., Marzella,R., Miller,N., Nothwang,H.G.,
            Rocchi,M., Sarfarazi,M., Stratakis,C.A., Wallgren-Petterson,C. and
            Naylor,S.
  TITLE     Report and abstracts of the Fourth International Workshop on Human
            Chromosome 2 Mapping 1996
  JOURNAL   Cytogenet Cell Genet 73 (4), 255-273 (1996)
   PUBMED   8751373
REFERENCE   10 (bases 1 to 4788)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008867.1, AK036439.1 and AL928546.5.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_021359.4.
            
            On Apr 21, 2009 this sequence version replaced NM_021359.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049185.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               AK008867.1         2-305
            305-2849            AK036439.1         412-2956
            2850-4788           AL928546.5         153542-155480       c
FEATURES             Location/Qualifiers
     source          1..4788
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 34.81 cM"
     gene            1..4788
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /note="integrin beta 6"
                     /db_xref="GeneID:16420"
                     /db_xref="MGI:MGI:96615"
     exon            1..292
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..2595
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /codon_start=1
                     /product="integrin beta-6 precursor"
                     /protein_id="NP_067334.1"
                     /db_xref="CCDS:CCDS16060.1"
                     /db_xref="GeneID:16420"
                     /db_xref="MGI:MGI:96615"
                     /translation="MGIELVCLFLLLLGRNDHVQGGCAWGGAESCSDCLLTGPHCAWC
                     SQENFTHLSGAGERCDTPANLLAKGCQLPFIENPVSRIEVLQNKPLSVGRQKNSSDIV
                     QIAPQSLVLKLRPGREQTLQVQVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLA
                     KEMSKLTSNFRLGFGSFVEKPVSPFMKTTPEEITNPCSSIPYFCLPTFGFKHILPLTD
                     DAERFNEIVRKQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHF
                     GMDSKLAGIVIPNDGLCHLDHRNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQ
                     VHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTA
                     LCNNGVLFPHQKKCSHMKVGDTASFNVTVSVSNCEKRSRNLIIKPVGLGDTLEILVSA
                     ECDCDCQREIETNSSKCHNGNGSFQCGVCTCNPGHMGPHCECGEDMVSTDSCKESPGH
                     PSCSGRGDCYCGQCICHLSPYGSIYGPYCQCDNFSCLRHKGLLCGDNGDCDCGECVCR
                     DGWTGEYCNCTTNRDSCTSEDGVLCSGRGDCVCGKCVCRNPGASGPTCERCPTCGDPC
                     NSKRSCIECYLSADGQAQEECADKCKAIGATISEEDFSKDTSVSCSLQGENECLITFL
                     ITTDNEGKTIIHNINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKE
                     VAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKHKAGLSSDG"
     exon            293..372
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            373..577
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            578..824
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            825..990
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1152
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1248
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1338
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1473
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1891
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2114
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2209
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2329
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2496
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..4788
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4766..4771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4788
                     /gene="Itgb6"
                     /gene_synonym="2210409C20Rik; 4831415H04Rik"
                     /note="major polyA site"
ORIGIN      
        1 agcttttctg ctttgcctgt ccaggtagct tctgttttca ttttagtctt agtgaaaggt
       61 tttgaattta cagctcaagt tacttttcaa agcagtgtga gtagttttac ttaaaaaaca
      121 aaacaaaacc aaaaaccccg gcaagaaaga ctttcacggc ttccagcttt ggtcttgtaa
      181 ccctgaaggt aattcatttt taatctgtct gcacagtgaa aactgaaccg aatggggatt
      241 gagctggtct gcctgtttct gctacttcta ggaaggaatg atcacgtcca aggtggctgt
      301 gcctggggtg gtgcagaaag ctgctcagac tgcctgctca caggacccca ctgcgcctgg
      361 tgctcccagg agaatttcac ccacctgtct ggagctggcg agaggtgcga caccccagcg
      421 aatcttttag ccaaaggatg tcaactaccc ttcattgaaa accctgtctc ccgcatagaa
      481 gtccttcaaa ataagcctct cagcgtgggc cgacagaaga acagttctga cattgttcag
      541 attgctcctc aaagcttggt tcttaaattg agaccagggc gtgagcagac tctgcaagtg
      601 caggtccgcc aaactgaaga ttacccagta gatctgtatt acctcatgga cctctccgcc
      661 tctatggatg acgacctcaa caccatcaaa gagcttggct cccggctggc caaagagatg
      721 tccaaactaa ccagcaactt tagactgggc tttggctctt ttgtggaaaa gcccgtttct
      781 ccttttatga aaacaacccc agaggaaatc accaaccctt gcagtagtat cccctatttc
      841 tgcttaccta catttggatt caagcacatt ttgccattaa ctgatgatgc cgagagattc
      901 aatgaaattg tgaggaaaca gaagatttct gctaatattg acacacctga aggtggattt
      961 gatgcaatca tgcaggctgc tgtgtgtaag gaaaagattg gctggcgcaa tgactcgctc
     1021 cacctcctgg tttttgtgag tgatgccgat tctcattttg gaatggacag caagctggca
     1081 ggcattgtca ttcccaatga tggactctgt cacttggacc acaggaatga atattccatg
     1141 tcaactgtct tggaatatcc aactatcggc caactcattg ataaactggt acaaaacaac
     1201 gtgctactga tctttgcagt cacccaagaa caagtccatc tgtatgagaa ctatgcaaaa
     1261 ctcattcctg gagcaaccgt gggactgctt cagaaggatt ctgggaacat ccttcagctg
     1321 atcatctccg cttatgaaga actgcggtct gaggtggaac tggaagtgtt aggggacaca
     1381 gaaggactca acctgtcttt cacagctctc tgtaacaatg gtgtcctctt cccacaccaa
     1441 aagaaatgct cccacatgaa agttggagac acagcatcct tcaatgtgac tgtgagcgta
     1501 tccaactgtg agaaaagaag caggaacctc atcataaagc cagtggggct gggggacacc
     1561 ctagaaatac tcgtcagtgc agaatgtgac tgcgactgcc agagagaaat agaaactaac
     1621 agctctaagt gtcacaatgg gaatggctcc ttccagtgtg gggtgtgtac ctgcaacccc
     1681 ggccacatgg gtcctcactg cgagtgtggt gaggatatgg tgagcacgga ttcctgcaag
     1741 gagtccccgg gtcacccttc atgcagtgga aggggtgact gctattgtgg gcagtgcatc
     1801 tgccacttat cgccgtacgg aagcatctac ggaccttact gccagtgtga caacttctcc
     1861 tgtctgagac acaaaggcct tctctgtgga gataacggtg actgtgactg tggcgagtgt
     1921 gtgtgccggg atggctggac aggtgaatac tgtaactgta caaccaacag ggactcgtgt
     1981 acatctgagg atggagtgct gtgcagtgga cgtggggact gtgtctgtgg caagtgtgtc
     2041 tgcagaaacc ctggagcctc aggacccacc tgtgaacgct gtcctacctg tggcgacccc
     2101 tgtaactcta aacggagttg catcgagtgc tacctgtctg cagatggcca ggcccaagaa
     2161 gagtgtgctg acaagtgtaa agccattggt gccaccatca gtgaggaaga tttttcaaag
     2221 gatacttctg tctcctgctc tctacaagga gaaaatgaat gccttattac attcctaata
     2281 actacggata atgaagggaa aaccatcatt cacaacatca atgaaaaaga ctgccccaaa
     2341 cctccaaaca ttcccatgat catgttgggg gtgtcactgg cgatcctgct catcggagtt
     2401 gtgctactgt gcatttggaa gctgctggta tcatttcatg accggaagga agttgctaaa
     2461 tttgaagcag aacgctctaa ggccaagtgg caaacgggaa ccaatcctct gtaccgaggt
     2521 tccaccagca cttttaagaa cgtgacctac aagcacaggg agaagcacaa agcaggcctt
     2581 tcctcagatg ggtagacaga cctccttcgg ccagagaaag tcaactccgc ttgcgttaaa
     2641 ggtttactgc actgtatggt ttatcatgct ttgtcgcttc aaaaggaggt cgacttaaga
     2701 taataacagg tcattcaaca accagtcatt cagggcatga aggtgagaca ttgttcgctg
     2761 attggaaaca atcaagaaaa gaatatccca agcaaagaga tgaattcaag atcccttgaa
     2821 gaatataaac tctgttgcat taatgcctca aaaaaaaaaa tcatcaaaac gattcccggg
     2881 aacttgattt gcatttgaaa aatgttcaga attagaatct catttgcttc cggaatccag
     2941 ctacctaaag tctttgtctc caaaaaaatc ccggagtcct tatgcattgt ctacccatac
     3001 ttgcagaaaa atctatttcc tgaaggaatt tgtttctttg gttggtttgg tttggttttg
     3061 tttttttatt tcctttcctt ttcttttttt cttttttctt tctttctttc tttctttctt
     3121 tctttctttc tttctttctt tctttctttt tctttttttt ttttttttag aaagggtgtc
     3181 tctatggcca ttctggaact gaccaggctg cctggccttg aactcacaac catggaactg
     3241 cctgtctctg ccttccattt catgctcaga gatcttaact tttatgtatg agaaatgaga
     3301 gtctgatttc ccatcaactg aaagaatcca gttctcccag agtgacttcc caagtgagag
     3361 attgaaaatt aagtcatggg cttgtactct taaaagacat ggacacaagt attttgtttg
     3421 aaagaggagg aaggggtaat ttataaaatg tgttgctagt aacactaaag atatgggtcc
     3481 tccgtgttca attgccctct gatccccaag tttccctcct attattccac atttctcaat
     3541 tattgcactc aactacagtc ttcaaaactc cacaactgtc atacaaaagt atccactttt
     3601 taaaaaatca ctttaagtta ttcgcttgtc aactagaatt ttgagaatag aaaagaaacc
     3661 tagggtaaca gaatcaaagg ctacacagct ttatatcaaa tgtgtcaaga ctgtggaagt
     3721 cccgcatgaa gtctgcccta catgtaggac attcctatcc cgtatgtacc acccagaaca
     3781 cacatcccag cttcaggagg tgggcatgcc acccacttgc tctaaaaagt aaaaccactt
     3841 acaaaatcta tgcaaggcaa caaacaaaac cggtagaaga ttggagggat agtctctgga
     3901 gggtttcatt tcttatagtt actgctgcat tacaaaccac tttgatctca ctggatctcc
     3961 atagagatgc tgagaggatg ggcagaagag gtgggtacag actctcaatc ttataacccc
     4021 aagccctttg ttctctctac tgcacgagac tcttttgtca gtaaaatgat ggaaggattg
     4081 tattagttat ggtataactg tcttagtttg aaagtatact gacacaaaac aattagcacc
     4141 taggcccccg gaatgtggac cggttgctgt atttttgtgc tgtgtgtgtt gccttcactg
     4201 gatattaagg tgaatccact ccctaggtga acagctctgt gtttgtgagt ggaggctttg
     4261 acagctgtct gttgaattgt cagcttggtc tcaaacctcc ttcactcctg ccatataggt
     4321 ctgtgtacgt gtccacatca tctaggttct ttcttttctg gtttttaaat gactcaggta
     4381 aattagtctg ttagggagta cacagctaaa tttaaaagtc ttaatgaatc tcctttggat
     4441 ccctgaatgg tccaagatct tggagtctgg agcaaccagc agattcactc ccagtgatgt
     4501 ggtgagactg ctgaggatac acggggctgt ttgtgctgtt tttgtgttat tgctgaaatg
     4561 agatgttagg aaatagaagt ttctctcatg tgtgtatcag gaagaatttg ttctttctct
     4621 aattaccgtt ttgacccaag gcaggacctt gaaagagcca aaacattaac agtagtgctt
     4681 ctgttcactg aagaattatg ttacatggag ataaaatggt tgtttttttt tttaaagtgg
     4741 ttttattgta ttttgcgttg acataaataa acataattta aacaatga
//
