LOCUS       NM_010580               3267 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus integrin beta 5 (Itgb5), transcript variant 2, mRNA.
ACCESSION   NM_010580 XM_358805
VERSION     NM_010580.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3267)
  AUTHORS   Parinot,C., Chatagnon,J., Rieu,Q., Roux,S., Neel,D., Hamieh,F. and
            Nandrot,E.F.
  TITLE     Gas6 and Protein S Ligands Cooperate to Regulate MerTK Rhythmic
            Activity Required for Circadian Retinal Phagocytosis
  JOURNAL   Int J Mol Sci 25 (12), 6630 (2024)
   PUBMED   38928335
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3267)
  AUTHORS   Lin,X., Huang,S., Gao,S., Liu,J., Tang,J. and Yu,M.
  TITLE     Integrin beta5 subunit regulates hyperglycemia-induced vascular
            endothelial cell apoptosis through FoxO1-mediated macroautophagy
  JOURNAL   Chin Med J (Engl) 137 (5), 565-576 (2024)
   PUBMED   37500497
  REMARK    GeneRIF: Integrin beta5 subunit regulates hyperglycemia-induced
            vascular endothelial cell apoptosis through FoxO1-mediated
            macroautophagy.
REFERENCE   3  (bases 1 to 3267)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3267)
  AUTHORS   Datta,R., Mukherjee,D., Podolsky,M.J., Yang,C.D., Alba,D.L.,
            Singh,S., Arnold,T.D., Koliwad,S., Lizama,C.O. and Atabai,K.
  TITLE     PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling
            through the beta5 integrin
  JOURNAL   J Biol Chem 300 (2), 105631 (2024)
   PUBMED   38199575
  REMARK    GeneRIF: PTP1B mediates the inhibitory effect of MFGE8 on insulin
            signaling through the beta5 integrin.
REFERENCE   5  (bases 1 to 3267)
  AUTHORS   Tang,C., Liu,M., Zhou,Z., Li,H., Yang,C., Yang,L. and Xiang,J.
  TITLE     Treadmill Exercise Alleviates Cognition Disorder by Activating the
            FNDC5: Dual Role of Integrin alphaV/beta5 in Parkinson's Disease
  JOURNAL   Int J Mol Sci 24 (9), 7830 (2023)
   PUBMED   37175535
  REMARK    GeneRIF: Treadmill Exercise Alleviates Cognition Disorder by
            Activating the FNDC5: Dual Role of Integrin alphaV/beta5 in
            Parkinson's Disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3267)
  AUTHORS   Wada,J., Kumar,A., Liu,Z., Ruoslahti,E., Reichardt,L., Marvaldi,J.
            and Kanwar,Y.S.
  TITLE     Cloning of mouse integrin alphaV cDNA and role of the
            alphaV-related matrix receptors in metanephric development
  JOURNAL   J Cell Biol 132 (6), 1161-1176 (1996)
   PUBMED   8601592
REFERENCE   7  (bases 1 to 3267)
  AUTHORS   Yamada,S., Brown,K.E. and Yamada,K.M.
  TITLE     Differential mRNA regulation of integrin subunits alpha V, beta 1,
            beta 3, and beta 5 during mouse embryonic organogenesis
  JOURNAL   Cell Adhes Commun 3 (4), 311-325 (1995)
   PUBMED   8821033
REFERENCE   8  (bases 1 to 3267)
  AUTHORS   Collo,G., Domanico,S.Z., Klier,G. and Quaranta,V.
  TITLE     Gradient of integrin alpha 6A distribution in the myocardium during
            early heart development
  JOURNAL   Cell Adhes Commun 3 (2), 101-113 (1995)
   PUBMED   7583004
REFERENCE   9  (bases 1 to 3267)
  AUTHORS   Yamada,S., Yamada,K.M. and Brown,K.E.
  TITLE     Integrin regulatory switching in development: oscillation of beta 5
            integrin mRNA expression during epithelial-mesenchymal interactions
            in tooth development
  JOURNAL   Int J Dev Biol 38 (3), 553-556 (1994)
   PUBMED   7848840
REFERENCE   10 (bases 1 to 3267)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155268.1 and AC165079.2.
            
            On Apr 19, 2022 this sequence version replaced NM_010580.2.
            
            Transcript Variant: This variant (2) uses an alternate donor splice
            site at the penultimate coding exon compared to transcript variant
            1. This results in a frame-shift, translation termination at a
            downstream stop codon, and a longer isoform (2) with a distinct
            C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF043257.1, SRR7974084.16769.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               AC155268.1         93363-93742         c
            381-466             AC155268.1         78322-78407         c
            467-671             AC155268.1         57741-57945         c
            672-921             AC155268.1         47342-47591         c
            922-1090            AC155268.1         38272-38440         c
            1091-1252           AC155268.1         23991-24152         c
            1253-1348           AC155268.1         22788-22883         c
            1349-1438           AC155268.1         20510-20599         c
            1439-1573           AC155268.1         12794-12928         c
            1574-2003           AC155268.1         3179-3608           c
            2004-2226           AC165079.2         54611-54833
            2227-2327           AC165079.2         58225-58325
            2328-2447           AC165079.2         60612-60731
            2448-2585           AC165079.2         61836-61973
            2586-3267           AC165079.2         62778-63459
FEATURES             Location/Qualifiers
     source          1..3267
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 24.22 cM"
     gene            1..3267
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /note="integrin beta 5"
                     /db_xref="GeneID:16419"
                     /db_xref="MGI:MGI:96614"
     exon            1..380
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..2761
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="integrin beta-5 isoform 2 precursor"
                     /protein_id="NP_034710.2"
                     /db_xref="CCDS:CCDS28135.1"
                     /db_xref="GeneID:16419"
                     /db_xref="MGI:MGI:96614"
                     /translation="MPRVPATLYACLLGLCALVPRLAGLNICTSGSATSCEECLLIHP
                     KCAWCSKEYFGNPRSITSRCDLKANLIRNGCEGEIESPASSTHVLRNLPLSSKGSSAT
                     GSDVIQMTPQEIAVSLRPGEQTTFQLQVRQVEDYPVDLYYLMDLSLSMKDDLENIRSL
                     GTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFR
                     HLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFT
                     TDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLI
                     FAVTKNHYMLYKNFTALIPGTTVEILHGDSKNIIQLIINAYSSIRAKVELSVWDQPED
                     LNLFFTATCQDGISYPGQRKCEGLKIGDTASFEVSVEARSCPGRQAAQSFTLRPVGFR
                     DSLQVEVAYNCTCGCSTGLEPNSARCSGNGTYTCGLCECDPGYLGTRCECQEGENQSG
                     YQNLCREAEGKPLCSGRGECSCNQCSCFESEFGRIYGPFCECDSFSCARNKGVLCSGH
                     GECHCGECKCHAGYIGDNCNCSTDVSTCRAKDGQICSDRGRCVCGQCQCTEPGAFGET
                     CEKCPTCPDACSSKRDCVECLLLHQGKPDNQTCHHQCKDEVITWVDTIVKDDQEAVLC
                     FYKTAKDCVMMFSYTELPNGRSNLTVLREPECGSAPNAMTILLAVVGSILLIGMALLA
                     IWKLLVTIHDRREFAKFQSLKPPVQKAHLHTHCRFRLQQVQQILQWLSGLRLLDGWRG
                     TKDEDSGVPWTSWTICSR"
     exon            381..466
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /inference="alignment:Splign:2.1.0"
     exon            467..671
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /inference="alignment:Splign:2.1.0"
     exon            672..921
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1090
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1252
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1348
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1438
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1573
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..2003
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2226
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2327
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2447
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2585
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..3267
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3055..3060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /note="hexamer: AATAAA"
     polyA_site      3082
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /note="major polyA site"
     regulatory      3242..3247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
                     /note="hexamer: AATGAA"
     polyA_site      3267
                     /gene="Itgb5"
                     /gene_synonym="beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A;
                     [b]5B"
ORIGIN      
        1 gtaaactgac cgagtggcgg cccgcaggag aggggggagg agaaagcaga gaagagtggg
       61 ggctggcggc cgaggaaaaa gggaagggtc tccgagagta gacgcgcggg ggactcggcg
      121 agggtgcgtc cggagcagcg acaactccga gcgtcccagc gggccagcga ggaggatggt
      181 ggcggccggg cgcggaccag cccggccgcg ggcgccgtga gccggagcgc agcgcccggc
      241 atgcggctgc ggtccccggc ctcggccccg ctccgccccc gccgagcgcc ccagccgagc
      301 ggcgcgcatc atgccgcggg tgcccgcgac cctctacgcc tgtctgctcg ggctctgcgc
      361 gctcgttccg cgcctcgcag ggctcaacat atgcactagt ggaagtgcca cctcgtgtga
      421 agaatgcctg ttgatccacc caaaatgtgc ctggtgctcc aaagagtact ttggcaatcc
      481 acggtccatc acctctcggt gtgacctgaa ggcaaacctc atccggaatg gctgtgaagg
      541 tgagattgag agtccagcca gcagcaccca cgtcctccgg aacctacctc tcagcagcaa
      601 gggttccagt gccacgggct ctgacgtcat ccagatgacg ccgcaggaga ttgcagtgag
      661 cctccggcca ggcgagcaga ctacgttcca gctgcaggtg cgccaggtgg aggactaccc
      721 tgtagacctg tactacctga tggacctctc cctctccatg aaggatgact tggagaacat
      781 ccggagcctg ggcaccaagc ttgcggagga aatgaggaag ctcactagta acttccgctt
      841 aggtttcggg tcttttgttg acaaggacat ctctcctttc tcctacacgg caccgagata
      901 ccagaccaat ccgtgtattg gttacaagtt attccccaac tgcgtcccct ccttcgggtt
      961 ccggcatctg ctgcctctca cagacagagt cgacagcttc aacgaggaag tgaggaagca
     1021 gagggtgtcc cggaaccgag atgcccccga gggggggttt gatgcggtcc tccaggctgc
     1081 tgtctgcaag gagaagatcg gatggcgaaa agatgctctg cacttgctgg tgttcacaac
     1141 agacgatgtg ccccacatcg cactggatgg aaaactgggt ggcctggtcc agccccacga
     1201 tggccagtgt cacctgaatg aagccaatga gtacacagcc tctaaccaga tggactatcc
     1261 atcgcttgcc ttgcttgggg agaagctggc agagaacaat atcaacctca tttttgctgt
     1321 gacgaagaac cactatatgc tctacaagaa ttttacagcc ctgatacctg gaaccactgt
     1381 ggagattttg catggagatt ccaaaaatat tattcaactg attatcaatg cgtacagtag
     1441 catccgggct aaagtggagc tgtcagtgtg ggatcagcca gaagacctta atctcttctt
     1501 cactgccacc tgccaagatg gcatatctta ccctggtcag aggaagtgtg agggtctgaa
     1561 gattggggac acggcatcct ttgaagtgtc cgtggaggct cggagctgcc ccggcagaca
     1621 agcagcacag tctttcacct tgaggcccgt gggcttccgg gacagtctgc aggtggaagt
     1681 cgcctacaat tgcacatgcg gctgtagcac ggggctggag cccaacagtg ccagatgcag
     1741 tgggaatgga acatacacct gtgggctgtg cgagtgtgac cccggctacc tgggcactag
     1801 gtgcgagtgc caggaggggg agaaccagag cgggtaccag aacctgtgcc gggaggcaga
     1861 gggcaagcct ctgtgcagcg ggcgtggaga gtgtagctgc aaccagtgct cctgcttcga
     1921 gagtgagttc gggaggatct acggaccttt ctgcgagtgt gacagctttt cctgtgccag
     1981 aaacaagggc gtcctatgct caggccatgg agagtgtcac tgtggagaat gcaaatgcca
     2041 cgcaggttac attggggaca attgtaactg ctcaacagac gtcagcacat gcagggccaa
     2101 ggatgggcag atctgcagtg accgaggccg ttgtgtctgt gggcagtgcc agtgcacaga
     2161 gcctggagcc tttggggaga cgtgtgagaa gtgcccaacc tgcccggatg cttgcagctc
     2221 taagagagac tgtgtcgaat gcttgctact tcaccagggg aaacctgaca accagacctg
     2281 ccaccaccag tgcaaagatg aggtgatcac gtgggtagac accatcgtca aagatgacca
     2341 ggaggctgtg ctttgcttct acaaaactgc taaggactgc gttatgatgt tcagctacac
     2401 agaactgccc aatgggaggt ccaacttgac ggtcctccgg gagccagaat gtggaagtgc
     2461 ccccaatgcc atgaccatcc tgctggctgt ggttggcagc atcctcctga ttgggatggc
     2521 actcctggcc atctggaagc tgctcgtcac catccacgac cgccgagagt ttgccaagtt
     2581 ccaaagcctc aaaccccctg tacagaaagc ccatctccac acacactgtc gatttcgcct
     2641 tcaacaagtt caacaaatcc tacaatggct cagtggactg aggctcctgg atggctggag
     2701 ggggactaag gatgaagact ctggcgtgcc ttggacttcc tggaccattt gctcacgcta
     2761 gctaggcacg cacggataat ggagatgccc tccattgagc cctaagggac ctggtagcca
     2821 cacagcgggc cacaggcact tggggccact tccctccaag ccagggaaag caaggagact
     2881 ctggtgttct cagcttcccc tctgccgcct ccagcttgct gtctccatga acctctgaag
     2941 gcctggctgc cctcttccct gctgggccag acaagaaggt atccggaaga gtctgtgtgt
     3001 acaaagctag cgcgcagcct ggctttttcc agttgatcgt ttttttttct atgaaataaa
     3061 aaggtcacgc atttatggtg tagatctgat tactggttcc ctgagggctg tctgcctggc
     3121 atctgtgggt gttggtagaa ttggggagtt gcctgttgaa agtacatgcc ttgcaaatgt
     3181 taggttttgc cctccggtct gtgtttgttt agtgcttttg taatgaaaag gaaagactgg
     3241 gaatgaaaaa gtaaggatgg aaaccaa
//
