LOCUS       NM_001405127            5821 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus integrin beta 4 (Itgb4), transcript variant 3, mRNA.
ACCESSION   NM_001405127 XM_036156445
VERSION     NM_001405127.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5821)
  AUTHORS   Liu,H., Su,P., Li,Y., Hoover,A., Hu,S., King,S.A., Zhao,J.,
            Guan,J.L., Chen,S.Y., Zhao,Y., Tan,M. and Wu,X.
  TITLE     VAMP2 controls murine epidermal differentiation and carcinogenesis
            by regulation of nucleophagy
  JOURNAL   Dev Cell 59 (15), 2005-2016 (2024)
   PUBMED   38810653
REFERENCE   2  (bases 1 to 5821)
  AUTHORS   Ayyangar,U., Karkhanis,A., Tay,H., Afandi,A.F.B., Bhattacharjee,O.,
            Ks,L., Lee,S.H., Chan,J. and Raghavan,S.
  TITLE     Metabolic rewiring of macrophages by epidermal-derived lactate
            promotes sterile inflammation in the murine skin
  JOURNAL   EMBO J 43 (7), 1113-1134 (2024)
   PUBMED   38418556
REFERENCE   3  (bases 1 to 5821)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   4  (bases 1 to 5821)
  AUTHORS   Zhou,R., Wang,Q., Zeng,S., Liang,Y. and Wang,D.
  TITLE     METTL14-mediated N6-methyladenosine modification of
            Col17a1/Itgalpha6/Itgbeta4 governs epidermal homeostasis
  JOURNAL   J Dermatol Sci 112 (3), 138-147 (2023)
   PUBMED   37951776
REFERENCE   5  (bases 1 to 5821)
  AUTHORS   Chen,Y., Jiang,W., Wang,J.M., Ma,X.D., Wu,D., Liu,L.X., Ji,M.,
            Qu,X.P., Liu,C., Liu,H.J., Qin,X.Q. and Xiang,Y.
  TITLE     Conditional knockout of ITGB4 in bronchial epithelial cells directs
            bronchopulmonary dysplasia
  JOURNAL   J Cell Mol Med 27 (23), 3760-3772 (2023)
   PUBMED   37698050
  REMARK    GeneRIF: Conditional knockout of ITGB4 in bronchial epithelial
            cells directs bronchopulmonary dysplasia.
REFERENCE   6  (bases 1 to 5821)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 5821)
  AUTHORS   Gomez,M., Navarro,P., Quintanilla,M. and Cano,A.
  TITLE     Expression of alpha 6 beta 4 integrin increases during malignant
            conversion of mouse epidermal keratinocytes: association of beta 4
            subunit to the cytokeratin fraction
  JOURNAL   Exp Cell Res 201 (2), 250-261 (1992)
   PUBMED   1379191
REFERENCE   8  (bases 1 to 5821)
  AUTHORS   Wadsworth,S., Halvorson,M.J. and Coligan,J.E.
  TITLE     Developmentally regulated expression of the beta 4 integrin on
            immature mouse thymocytes
  JOURNAL   J Immunol 149 (2), 421-428 (1992)
   PUBMED   1385605
REFERENCE   9  (bases 1 to 5821)
  AUTHORS   Kennel,S.J., Godfrey,V., Ch'ang,L.Y., Lankford,T.K., Foote,L.J. and
            Makkinje,A.
  TITLE     The beta 4 subunit of the integrin family is displayed on a
            restricted subset of endothelium in mice
  JOURNAL   J Cell Sci 101 (Pt 1), 145-150 (1992)
   PUBMED   1569120
REFERENCE   10 (bases 1 to 5821)
  AUTHORS   Sonnenberg,A., Linders,C.J., Daams,J.H. and Kennel,S.J.
  TITLE     The alpha 6 beta 1 (VLA-6) and alpha 6 beta 4 protein complexes:
            tissue distribution and biochemical properties
  JOURNAL   J Cell Sci 96 (Pt 2), 207-217 (1990)
   PUBMED   1698797
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645647.8 and AL607108.17.
            
            On Apr 20, 2022 this sequence version replaced XM_036156445.1.
            
            Summary: Integrins are heterodimers comprised of alpha and beta
            subunits, that are noncovalently associated transmembrane
            glycoprotein receptors. Different combinations of alpha and beta
            polypeptides form complexes that vary in their ligand-binding
            specificities. Integrins mediate cell-matrix or cell-cell adhesion,
            and transduced signals that regulate gene expression and cell
            growth. This gene encodes the integrin beta 4 subunit, a receptor
            for the laminins. This subunit tends to associate with alpha 6
            subunit and is likely to play a pivotal role in the biology of
            invasive carcinoma. Multiple alternatively spliced transcript
            variants encoding distinct isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.12411.1,
                                           SRR10223970.14943.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AL645647.8         137235-137315
            82-173              AL645647.8         139947-140038
            174-256             AL645647.8         141237-141319
            257-358             AL645647.8         141522-141623
            359-563             AL645647.8         141775-141979
            564-660             AL645647.8         142836-142932
            661-832             AL645647.8         143102-143273
            833-1096            AL645647.8         144862-145125
            1097-1186           AL645647.8         145420-145509
            1187-1309           AL645647.8         145804-145926
            1310-1474           AL645647.8         146198-146362
            1475-1551           AL645647.8         147183-147259
            1552-1754           AL607108.17        2974-3176
            1755-1858           AL607108.17        4817-4920
            1859-1957           AL607108.17        5014-5112
            1958-2087           AL607108.17        5247-5376
            2088-2207           AL607108.17        6079-6198
            2208-2314           AL607108.17        6295-6401
            2315-2348           AL607108.17        7032-7065
            2349-2540           AL607108.17        7241-7432
            2541-2644           AL607108.17        7666-7769
            2645-2703           AL607108.17        8015-8073
            2704-2727           AL607108.17        8243-8266
            2728-2876           AL607108.17        9412-9560
            2877-3056           AL607108.17        9634-9813
            3057-3205           AL607108.17        10619-10767
            3206-3410           AL607108.17        14307-14511
            3411-3568           AL607108.17        16155-16312
            3569-3749           AL607108.17        16596-16776
            3750-3887           AL607108.17        16900-17037
            3888-4070           AL607108.17        19699-19881
            4071-4202           AL607108.17        19960-20091
            4203-4439           AL607108.17        21888-22124
            4440-4598           AL607108.17        22254-22412
            4599-4748           AL607108.17        22818-22967
            4749-4937           AL607108.17        23343-23531
            4938-5093           AL607108.17        23616-23771
            5094-5258           AL607108.17        23858-24022
            5259-5369           AL607108.17        24112-24222
            5370-5821           AL607108.17        24318-24769
FEATURES             Location/Qualifiers
     source          1..5821
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.91 cM"
     gene            1..5821
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /note="integrin beta 4"
                     /db_xref="GeneID:192897"
                     /db_xref="MGI:MGI:96613"
     exon            1..81
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            82..173
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..5509
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; Integrin beta-4"
                     /codon_start=1
                     /product="integrin beta-4 isoform 3 precursor"
                     /protein_id="NP_001392056.1"
                     /db_xref="GeneID:192897"
                     /db_xref="MGI:MGI:96613"
                     /translation="MAGPCCSPWVKLLLLAAMLSASLPGDLANRCKKAQVKSCTECIR
                     VDKSCAYCTDELFKERRCNTQAELLAAGCRGESILVMESSLEITENTQIDTSLHRSQV
                     SPQGLQVRLRPGEERSFVFQVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKI
                     LRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTENVEEFW
                     NKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGAN
                     VLAGIMNRNDEKCHLDASGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYY
                     EKLHKYFPVSSLGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSDTLQ
                     KTETGSFHIKRGEVGTYNVHLRAVEDIDGTHVCQLAKEDQGGNIHLKPSFSDGLRMDA
                     SVICDVCPCELQKEVRSARCHFRGDFMCGHCVCNEGWSGKTCNCSTGSLSDTQPCLRE
                     GEDKPCSGHGECQCGRCVCYGEGRYEGHFCEYDNFQCPRTSGFLCNDRGRCSMGECVC
                     EPGWTGRSCDCPLSNATCIDSNGGICNGRGYCECGRCHCNQQSLYTDTTCEINYSAIR
                     LGLCEDLRSCVQCQAWGTGEKKGRACDDCPFKVKMVDELKKEEVVEYCSFRDEDDDCT
                     YSYNVEGDGSPGPNSTVLVHKKKDCPPGSFWWLIPLLIFLLLLLALLLLLCWKYCACC
                     KACLGLLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDTVRWKITNN
                     VQRPGFATHAASTSPTELVPYGLSLRLGRLCTENLMKPGTRECDQLRQEVEENLNEVY
                     RQVSGAHKLQQTKFRQQPNTGKKQDHTIVDTVLLAPRSAKQMLLKLTEKQVEQGSFHE
                     LKVAPGYYTVTAEQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPVGT
                     ATLGRRLVNITIIKEQASGVVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQ
                     DNTAHGHRDYVPVEGELLFHPGETWKELQVKLLELQEVDSLLRGRQVRRFQVQLSNPK
                     FGARLGQPSTTTVILGEHDETDRSLINQTLSSPPPPHGDLGAPQNPNAKAAGSRKIHF
                     NWLPPPGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG
                     EGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVN
                     EDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQ
                     PKRPMSIPIIPDIPIVDAQGGEDYENFLMYSDDVLRSPASSQRPSVSDDTEHLVNGRM
                     DFAYPGSANSLHRMTAANVAYGTHLSPHLSHRVLSTSSTLTRDYHSLTRTEHSHSGTL
                     PRDYSTLTSLSSQGLPPIWEDGRSRLPLSWTLGSLSRAHMKGVPASRGSPDSIILAGQ
                     SAAPSWGTDSRGAVGVPDTPTRLVFSALGPTSLKVSWQEPQCDRMLLGYSVEYQLLNG
                     GEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSP
                     LCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGA
                     PARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQVGGPFP
                     QLGSHSGLFQNPVQSEFSSVTSTHSTTTEPFLMDGLTLGTQRLEAGGSLTRHVTQEFV
                     TRTLTASGSLSTHMDQQFFQT"
     exon            174..256
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            257..358
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            359..563
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            564..660
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            661..832
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1096
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1186
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1309
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1474
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1551
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1754
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1858
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1957
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2087
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2207
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2314
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2348
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2540
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2644
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2703
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2727
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2876
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3056
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3205
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3410
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            3411..3568
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            3569..3749
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            3750..3887
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..4070
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            4071..4202
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            4203..4439
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            4440..4598
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            4599..4748
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            4749..4937
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            4938..5093
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            5094..5258
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            5259..5369
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     exon            5370..5821
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5798..5803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /note="hexamer: AATAAA"
     polyA_site      5821
                     /gene="Itgb4"
                     /gene_synonym="C230078O20; CD104"
                     /note="major polyA site"
ORIGIN      
        1 gcccgccctg ctgtcccgcc gggctcgccc gcgcgctcag ctcgacccaa cgcagcccaa
       61 gtccgaggta gtctcactaa ggaggaggag gatggcaggg ccctgttgca gcccatgggt
      121 gaagctgctg ctgctggcag caatgctgag tgccagcctc cctggagacc tggccaaccg
      181 ctgcaagaag gctcaggtga agagctgtac cgagtgcatc cgggtggaca agagctgtgc
      241 ctactgcaca gacgagctgt tcaaggagag gcgctgcaac acccaggcgg agcttctggc
      301 tgcaggctgc aggggagaga gcatcctggt catggagagc agccttgaaa tcacagagaa
      361 cacccagatc gacaccagcc tgcaccgcag ccaggtatct ccccaaggcc tgcaagtccg
      421 gctgcggccg ggtgaggagc gcagctttgt gttccaggtg tttgagcccc tggagagccc
      481 cgtggatctg tatatcctca tggacttctc caactccatg tctgacgatc tggacaacct
      541 caagcagatg gggcagaacc tggccaagat cctgcgccag ctcaccagcg actacaccat
      601 tggatttgga aagtttgtgg acaaagtcag cgtcccacag acagacatga ggcccgagaa
      661 actgaaggag ccctggccca acagtgatcc cccgttctcc ttcaagaacg ttatcagctt
      721 aacggagaat gtggaagaat tctggaacaa actgcaagga gaacgcatct caggcaacct
      781 ggacgctcct gaagggggct ttgatgccat cctgcagaca gctgtgtgca caagggacat
      841 tggctggagg gctgacagca cccacctgct ggtgttctcc accgagtctg ccttccacta
      901 cgaggctgat ggtgccaacg tgctggccgg catcatgaac cgcaatgatg agaaatgcca
      961 cctggacgcc tcgggcgcct acacccaata caagacacag gactacccat cagtgcccac
     1021 gctggttcgc ctgcttgcca agcataacat catccccatc tttgctgtca ccaactactc
     1081 ttacagctac tatgagaagc tccataagta tttccccgtc tcctctctgg gcgtcctgca
     1141 ggaggattca tccaacatcg tggagctgct ggaggaggcc ttctatcgaa ttcgctccaa
     1201 cctggacatc cgggctctgg acagccccag aggcctgaga acagaggtca cctccgatac
     1261 tctccagaag acggagactg ggtcctttca catcaagcgg ggggaagtgg gcacatacaa
     1321 tgtgcatctc cgggcagtgg aggacataga tgggacacat gtgtgccagc tggctaaaga
     1381 agaccaaggg ggcaacatcc acctgaaacc ctccttctct gatggcctcc ggatggacgc
     1441 gagtgtgatc tgtgacgtgt gcccctgtga gctgcaaaag gaagttcgat cagctcgctg
     1501 tcacttcaga ggagacttca tgtgtggaca ctgtgtgtgc aatgagggct ggagtggcaa
     1561 aacctgcaac tgctccaccg gctctctgag tgacacacag ccctgcctgc gtgagggtga
     1621 ggacaaaccg tgctcgggcc acggcgagtg ccagtgcgga cgctgtgtgt gctatggtga
     1681 aggccgctac gagggtcact tctgcgagta tgacaacttc cagtgtcccc ggacctctgg
     1741 attcctgtgc aatgaccggg gtcgctgttc tatgggagag tgtgtgtgtg agcctggttg
     1801 gacaggccgc agctgtgact gtcccctcag caatgccacc tgcatcgata gcaacggggg
     1861 catctgcaac ggccgaggct actgtgagtg tggccgttgt cactgcaacc agcagtcgct
     1921 ctacacggac accacctgtg agatcaacta ctctgcgata cgcctgggtc tctgtgagga
     1981 tctccgctcc tgcgtacagt gccaggcctg gggcaccggg gagaagaaag ggcgcgcgtg
     2041 tgacgattgc ccctttaaag tcaagatggt agacgagctt aagaaagaag aggtggtgga
     2101 gtactgctcc ttccgggatg aggatgacga ctgcacttac agctacaacg tggagggcga
     2161 tggcagccct gggcccaaca gcacagtcct ggtccacaaa aagaaagact gccctcccgg
     2221 ctccttctgg tggctcatcc ccctgctcat cttcctcctg ttgctcctgg cgttgcttct
     2281 gctgctctgc tggaaatact gtgcctgctg caaagcctgc ctggggcttc ttccttgctg
     2341 caaccgaggt cacatggtgg gctttaagga agatcactat atgcttcggg agaacctgat
     2401 ggcctctgac cacctggaca cgcccatgct acgaagcggg aacctcaagg gacgagacac
     2461 agtccgctgg aagatcacca acaatgtgca gcgccctggc tttgccaccc atgccgccag
     2521 caccagcccc acggagctcg taccctacgg gctgtccctg cgccttggcc gcctctgcac
     2581 tgagaacctt atgaagccgg gcacccgaga gtgtgaccag ctacgccagg aggtggagga
     2641 aaatctgaat gaggtgtata gacaggtcag cggcgcacac aagctccagc agacgaagtt
     2701 ccgacagcag cccaacaccg ggaaaaagca agaccacacc attgtggaca cagtgttgct
     2761 ggcgccccgc tccgccaagc agatgctgct gaagctgaca gagaagcagg tggagcaggg
     2821 gtccttccat gaactgaagg tggcccctgg ctactacact gtcacggcag agcaggatgc
     2881 ccggggcatg gtggagttcc aggagggcgt ggagctggtg gatgtgcgag tgcccctctt
     2941 catccggcct gaggatgatg atgagaagca gctgctggtg gaggccattg atgtccctgt
     3001 gggcactgcc acccttggtc gccgtctggt aaacatcacc attatcaagg aacaagctag
     3061 tggggtagtg tccttcgagc agcctgaata ctcggtgagt cgtggagacc aggtggcccg
     3121 catccctgtc atccggcaca tcctggacaa tggcaagtcc caggtctcct atagcacaca
     3181 ggataataca gcacacggac accgggatta tgtccctgtg gagggagagc tgctgttcca
     3241 tcctggggag acctggaagg agttgcaggt gaagctactg gagctgcagg aggtcgactc
     3301 cctcctgcgt ggccgccagg tccgccgctt ccaagtccaa ctcagcaacc ccaagttcgg
     3361 agcccgcctg ggccagccca gcacaaccac cgttattctc ggtgagcacg atgaaacgga
     3421 caggagtctc ataaatcaaa cactttcatc gcctccgcca ccccatggag acctgggcgc
     3481 cccacagaac cccaatgcca aggctgccgg gtccaggaag atccatttca actggctgcc
     3541 ccctcctggc aagccaatgg ggtacagggt gaagtactgg atccagggcg actctgagtc
     3601 tgaagcccac cttctagaca gcaaggtgcc ctcagtggaa ctcaccaacc tgtatcccta
     3661 ttgcgactac gaaatgaagg tgtgtgccta tggggcacag ggtgaggggc cctatagctc
     3721 actggtgtcc tgccgcaccc accaggaagt acccagcgag ccagggaggc tggctttcaa
     3781 tgtagtctct tctacggtga cgcagctgag ctgggcagag ccagctgaga ccaatggcga
     3841 gatcacagcc tacgaggtct gctatggact ggtcaatgag gacaaccgac ccattggacc
     3901 tatgaagaag gtgctcgtgg acaaccccaa gaaccggatg ctgctcattg agaatctgcg
     3961 agaatcccag ccataccgat acacggttaa ggcgcgcaat ggggcaggat ggggacccga
     4021 gagagaggct atcatcaacc tggctacaca gcccaagcgg cccatgtcca tccctatcat
     4081 cccagacatc cccatagtgg acgcccaggg tggagaagac tacgaaaact tccttatgta
     4141 cagtgatgac gtcctgcggt ccccagccag cagccagagg cccagcgttt ctgatgacac
     4201 tgagcacctg gtgaatggcc ggatggactt tgcctatcca ggcagcgcca actccctgca
     4261 cagaatgact gcagccaatg tggcctatgg cacgcatctg agcccacacc tgtcccaccg
     4321 agtgctgagc acgtcctcca cccttacccg ggactaccac tctctgacac gcacagagca
     4381 ctcccactca ggcacacttc ccagggacta ctccaccctc acttcccttt cctcccaagg
     4441 cctccctcct atctgggaag atgggaggag caggcttccg ctgtcctgga ctcttgggtc
     4501 cttgagccgg gctcacatga agggtgtgcc cgcatccagg ggttcaccag actctataat
     4561 cctggccggg cagtcagcag caccctcctg gggtacagat tcccgtgggg ctgtgggtgt
     4621 gcctgacaca cccactcggc tggtgttctc tgccctgggg cccacgtctt tgaaggtgag
     4681 ctggcaggag ccacagtgtg atcggatgct gctgggctac agtgtggaat accagctact
     4741 aaacggcggc gagatgcatc ggctcaacat ccctaaccct ggccaaacct cggtggtggt
     4801 agaggatctc ctgcctaacc actcctatgt gttccgggta cgggcccaga gccaggaggg
     4861 ctggggccga gagcgagagg gtgtcatcac catcgagtcc caggtgcacc cgcagagccc
     4921 tctctgcccc ctgccaggct cagccttcac tctgagcacc cccagcgccc cgggaccgct
     4981 ggtgttcact gccctaagcc cagactccct gcagctcagc tgggagcggc cgaggaggcc
     5041 caatggagat atccttggct acctggtgac ctgtgagatg gcccaaggag gagcaccagc
     5101 caggaccttc cgggtggacg gagacaaccc tgagagccgg ttgactgtac ctggcctcag
     5161 tgagaacgtt ccttacaagt tcaaggttca ggccaggacg accgagggct tcgggccaga
     5221 gcgtgagggt atcatcacca tcgagtctca ggttggaggc cccttcccac agctgggcag
     5281 ccattctggg ctcttccaga acccagtgca aagcgagttc agcagcgtga ccagcacgca
     5341 cagcaccacg actgagccct tcctcatgga tggtctaacc ctggggaccc agcgcctgga
     5401 agcaggaggc tccctcaccc ggcatgtgac ccaggaattc gtgacccgga ccttaacggc
     5461 cagtggctct ctcagcactc atatggacca acagttcttc caaacctgaa cctcccccgc
     5521 gccccagcca cctgggcccc tccttgcctc ctctcctagc gccttcttcc tctgctgctc
     5581 tacccacgag cttgctgacc acagagccag cccctgtagt cagagagcag gggtaggtgc
     5641 tgtccaggaa ccataaagtg ggtagaggtg atacaaggtc tttctgactg catcccaccc
     5701 tgggtccaat cccacatgta accaaaaaaa aaaaaaaaaa aaccaaaaaa caaaaaactg
     5761 gagctggcac aagtccccag ccttttgttc tgcacttaat aaaaggtttt gctactgctt
     5821 a
//
