LOCUS       NM_026348                774 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus integrin beta 3 binding protein (beta3-endonexin)
            (Itgb3bp), transcript variant 1, mRNA.
ACCESSION   NM_026348
VERSION     NM_026348.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 774)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 774)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 774)
  AUTHORS   Gresakova,V., Novosadova,V., Prochazkova,M., Prochazka,J. and
            Sedlacek,R.
  TITLE     Dual role of Fam208a during zygotic cleavage and early embryonic
            development
  JOURNAL   Exp Cell Res 406 (2), 112723 (2021)
   PUBMED   34216590
REFERENCE   4  (bases 1 to 774)
  AUTHORS   Okumura,K., Kagawa,N., Saito,M., Yoshizawa,Y., Munakata,H.,
            Isogai,E., Fukagawa,T. and Wakabayashi,Y.
  TITLE     CENP-R acts bilaterally as a tumor suppressor and as an oncogene in
            the two-stage skin carcinogenesis model
  JOURNAL   Cancer Sci 108 (11), 2142-2148 (2017)
   PUBMED   28795467
  REMARK    GeneRIF: These results indicate Cenp-r functions bilaterally in
            cancer development: during early developmental stages, Cenp-r
            functions as a tumor suppressor, but during the expansion and
            progression of papillomas it functions as a tumor-promoting factor
REFERENCE   5  (bases 1 to 774)
  AUTHORS   Besta,F., Muller,I., Lorenz,M., Massberg,S., Bultmann,A.,
            Cabeza,N., Richter,T., Kremmer,E., Nothdurfter,C., Brand,K. and
            Gawaz,M.
  TITLE     Reduced beta3-endonexin levels are associated with enhanced
            urokinase-type plasminogen activator receptor expression in ApoE-/-
            mice
  JOURNAL   Thromb Res 114 (4), 283-292 (2004)
   PUBMED   15381392
  REMARK    GeneRIF: in contrast to uPAR or NF-kappaB, the expression of
            beta(3)-endonexin was reduced in extracts of advanced
            atherosclerotic aortic tissue
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK165072.1 and AK045037.1.
            
            On May 4, 2018 this sequence version replaced NM_026348.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049557.1, BU937552.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AK165072.1         20-59
            41-774              AK045037.1         2-735
FEATURES             Location/Qualifiers
     source          1..774
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 45.71 cM"
     gene            1..774
                     /gene="Itgb3bp"
                     /gene_synonym="4930471O16Rik; CENP-R"
                     /note="integrin beta 3 binding protein (beta3-endonexin)"
                     /db_xref="GeneID:67733"
                     /db_xref="MGI:MGI:1914983"
     exon            1..76
                     /gene="Itgb3bp"
                     /gene_synonym="4930471O16Rik; CENP-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..602
                     /gene="Itgb3bp"
                     /gene_synonym="4930471O16Rik; CENP-R"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centromere protein R; nuclear receptor-interacting factor
                     3"
                     /codon_start=1
                     /product="centromere protein R isoform 1"
                     /protein_id="NP_080624.1"
                     /db_xref="CCDS:CCDS18387.1"
                     /db_xref="GeneID:67733"
                     /db_xref="MGI:MGI:1914983"
                     /translation="MPVKRSLKLDDQFEKNSFSPSKIVRKKSITAYSPTTGTYQLSPF
                     SSPATPKEQEHRNGPSNETRKRSNLSSPVRQESTVKDRDGFMVLLSKIEISSEKTMEI
                     MKNLSSIQALEGNRQLEDLIGVSLVPCSLKSEARKTKELMTKVIKQKLFEKKKSRITP
                     KDHHLDSFEFLKAILN"
     exon            77..119
                     /gene="Itgb3bp"
                     /gene_synonym="4930471O16Rik; CENP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            120..255
                     /gene="Itgb3bp"
                     /gene_synonym="4930471O16Rik; CENP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            256..322
                     /gene="Itgb3bp"
                     /gene_synonym="4930471O16Rik; CENP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            323..401
                     /gene="Itgb3bp"
                     /gene_synonym="4930471O16Rik; CENP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            402..495
                     /gene="Itgb3bp"
                     /gene_synonym="4930471O16Rik; CENP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            496..555
                     /gene="Itgb3bp"
                     /gene_synonym="4930471O16Rik; CENP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            556..603
                     /gene="Itgb3bp"
                     /gene_synonym="4930471O16Rik; CENP-R"
                     /inference="alignment:Splign:2.1.0"
     exon            604..774
                     /gene="Itgb3bp"
                     /gene_synonym="4930471O16Rik; CENP-R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actacgcggg ctttttatgc ttccgcgttt gcggtttctc agttggttct gtccagcaac
       61 ggagtcccga aatgccagtt aaaagatcac tgaaactgga tgatcagttt gaaaaaaatt
      121 catttagtcc ttcaaaaatc gtgaggaaga aaagtattac agcttattct cctactactg
      181 gaacttatca gttgagccca ttttcttctc ccgcaacccc caaagaacag gagcacagaa
      241 acggaccatc aaatgaaaca aggaaacgga gtaacttgag ctcacctgta agacaggagt
      301 ccacagtgaa agacagggat ggattcatgg tgttgctatc taaaattgag atatcatcag
      361 agaaaaccat ggagataatg aaaaatctaa gtagtataca ggctttggag ggcaacagac
      421 aacttgaaga tctcattggt gtttccctag taccatgctc cttaaaaagt gaagcaagga
      481 aaaccaaaga actaatgact aaagtaataa aacaaaagtt gtttgaaaag aaaaaatcaa
      541 gaattactcc caaagatcat catcttgaca gctttgaatt ccttaaagcc attttgaact
      601 gagtgttacc ttcaagtctg acaactgtca acctacctgg atactagtca agccgtaaga
      661 atgcagacca gcctgaagta aagagtcagt gaaagactgt cacatttgca acctttctta
      721 aaagacgata tgctgagtat tctaaatagg aaaaaaataa aggcatccac cgtg
//
