LOCUS       NM_016780               5795 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus integrin beta 3 (Itgb3), mRNA.
ACCESSION   NM_016780
VERSION     NM_016780.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5795)
  AUTHORS   Ezzo,M., Spindler,K., Wang,J.B., Lee,D., Pecoraro,G., Cowen,J.,
            Pakshir,P. and Hinz,B.
  TITLE     Acute contact with profibrotic macrophages mechanically activates
            fibroblasts via alphavbeta3 integrin-mediated engagement of Piezo1
  JOURNAL   Sci Adv 10 (43), eadp4726 (2024)
   PUBMED   39441936
  REMARK    GeneRIF: Acute contact with profibrotic macrophages mechanically
            activates fibroblasts via alphavbeta3 integrin-mediated engagement
            of Piezo1.
REFERENCE   2  (bases 1 to 5795)
  AUTHORS   Janus-Bell,E., Receveur,N., Mercier,L., Mouriaux,C., Magnenat,S.,
            Reiser,J., Lanza,F., Hechler,B., Ho-Tin-Noe,B. and Mangin,P.H.
  TITLE     Cooperation Between Platelet beta1 and beta3 Integrins in the
            Arrest of Bleeding Under Inflammatory Conditions in Mice-Brief
            Report
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (10), 2213-2222 (2024)
   PUBMED   39145395
  REMARK    GeneRIF: Cooperation Between Platelet beta1 and beta3 Integrins in
            the Arrest of Bleeding Under Inflammatory Conditions in Mice-Brief
            Report.
REFERENCE   3  (bases 1 to 5795)
  AUTHORS   Gao,X., Shao,W., Wang,J., Gao,H., Zhang,X., Xia,C., Li,M. and
            Liu,S.
  TITLE     Integrin beta3 enhances glycolysis and increases lactate production
            in endometriosis
  JOURNAL   J Reprod Immunol 165, 104312 (2024)
   PUBMED   39094215
  REMARK    GeneRIF: Integrin beta3 enhances glycolysis and increases lactate
            production in endometriosis.
REFERENCE   4  (bases 1 to 5795)
  AUTHORS   Fan,Y., Dong,S., Xia,Y., Yang,X., Lei,Q., Xu,F., Liang,D.,
            Liang,S., Zhang,M., Yang,F., Jing,Y., Li,L., Zhu,X., Bao,H.,
            Chen,Z. and Zeng,C.
  TITLE     Role of TSP-1 and its receptor ITGB3 in the renal
            tubulointerstitial injury of focal segmental glomerulosclerosis
  JOURNAL   J Biol Chem 300 (8), 107516 (2024)
   PUBMED   38960036
  REMARK    GeneRIF: Role of TSP-1 and its receptor ITGB3 in the renal
            tubulointerstitial injury of focal segmental glomerulosclerosis.
REFERENCE   5  (bases 1 to 5795)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   6  (bases 1 to 5795)
  AUTHORS   Djaffar,I., Chen,Y.P., Creminon,C., Maclouf,J., Cieutat,A.M.,
            Gayet,O. and Rosa,J.P.
  TITLE     A new alternative transcript encodes a 60 kDa truncated form of
            integrin beta 3
  JOURNAL   Biochem J 300 (Pt 1) (Pt 1), 69-74 (1994)
   PUBMED   8198553
REFERENCE   7  (bases 1 to 5795)
  AUTHORS   Sutherland,A.E., Calarco,P.G. and Damsky,C.H.
  TITLE     Developmental regulation of integrin expression at the time of
            implantation in the mouse embryo
  JOURNAL   Development 119 (4), 1175-1186 (1993)
   PUBMED   8306881
REFERENCE   8  (bases 1 to 5795)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   9  (bases 1 to 5795)
  AUTHORS   Chen,Y.Q., Gao,X., Timar,J., Tang,D., Grossi,I.M., Chelladurai,M.,
            Kunicki,T.J., Fligiel,S.E., Taylor,J.D. and Honn,K.V.
  TITLE     Identification of the alpha IIb beta 3 integrin in murine tumor
            cells
  JOURNAL   J Biol Chem 267 (24), 17314-17320 (1992)
   PUBMED   1512266
REFERENCE   10 (bases 1 to 5795)
  AUTHORS   Phillips,D.R., Charo,I.F. and Scarborough,R.M.
  TITLE     GPIIb-IIIa: the responsive integrin
  JOURNAL   Cell 65 (3), 359-362 (1991)
   PUBMED   2018971
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC125520.1, BX000996.4 and BQ033439.1.
            
            On Nov 16, 2007 this sequence version replaced NM_016780.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC125518.1, AF026509.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2323              BC125520.1         1-2323
            2324-2324           BX000996.4         56977-56977
            2325-2496           BC125520.1         2325-2496
            2497-5759           BX000996.4         58597-61859
            5760-5795           BQ033439.1         1-36                c
FEATURES             Location/Qualifiers
     source          1..5795
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 67.84 cM"
     gene            1..5795
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /note="integrin beta 3"
                     /db_xref="GeneID:16416"
                     /db_xref="MGI:MGI:96612"
     exon            1..165
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..2453
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /note="platelet gpIIIa; GPIIIa; platelet membrane
                     glycoprotein IIIa; platelet glycoprotein IIIa (GP3A)"
                     /codon_start=1
                     /product="integrin beta-3 precursor"
                     /protein_id="NP_058060.2"
                     /db_xref="CCDS:CCDS25536.1"
                     /db_xref="GeneID:16416"
                     /db_xref="MGI:MGI:96612"
                     /translation="MRAQWPGQLWAALLALGALAGVVVGESNICTTRGVNSCQQCLAV
                     SPVCAWCSDETLSQGSPRCNLKENLLKDNCAPESIEFPVSEAQILEARPLSSKGSGSS
                     AQITQVSPQRIALRLRPDDSKIFSLQVRQVEDYPVDIYYLMDLSFSMKDDLSSIQTLG
                     TKLASQMRKLTSNLRIGFGAFVDKPVSPYMYISPPQAIKNPCYNMKNACLPMFGYKHV
                     LTLTDQVSRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTD
                     AKTHIALDGRLAGIVLPNDGHCHIGTDNHYSASTTMDYPSLGLMTEKLSQKNINLIFA
                     VTENVVSLYQNYSELIPGTTVGVLSDDSSNVLQLIVDAYGKIRSKVELEVRDLPEELS
                     LSFNATCLNNEVIPGLKSCVGLKIGDTVSFSIEAKVRGCPQEKEQSFTIKPVGFKDSL
                     TVQVTFDCDCACQAFAQPSSPRCNNGNGTFECGVCRCDQGWLGSMCECSEEDYRPSQQ
                     EECSPKEGQPICSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQ
                     CNCGDCVCDSDWTGYYCNCTTRTDTCMSTNGLLCSGRGNCECGSCVCVQPGSYGDTCE
                     KCPTCPDACSFKKECVECKKFNRGTLHEENTCSRYCRDDIEQVKELTDTGKNAVNCTY
                     KNEDDCVVRFQYYEDTSGRAVLYVVEEPECPKGPDILVVLLSVMGAILLIGLATLLIW
                     KLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT"
     exon            166..251
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /inference="alignment:Splign:2.1.0"
     exon            252..447
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /inference="alignment:Splign:2.1.0"
     exon            448..700
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /inference="alignment:Splign:2.1.0"
     exon            701..863
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1025
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1121
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1211
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1346
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1776
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1999
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2100
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2220
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2387
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..5781
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5762..5767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /note="hexamer: ATTAAA"
     polyA_site      5781
                     /gene="Itgb3"
                     /gene_synonym="CD61; GP3A; INGRB3"
                     /note="major polyA site"
ORIGIN      
        1 ctcccttctt ccctcccctc cgcaggaaaa gcagctgcgg gtgccaggct cgccgtggcg
       61 cgcgcgcggc gtgaagggcg gcggacagga tgcgagcgca gtggccggga caactctggg
      121 ccgctctgct ggcgctgggg gcgctggcgg gcgttgttgt tggagagtcc aacatctgta
      181 ccacacgagg cgtgaactcc tgccagcagt gtctggctgt gagtcctgtg tgtgcctggt
      241 gctcagatga gactttgtct cagggctcac cccgatgtaa cctgaaggag aacctgctga
      301 aggacaattg tgctccagag tctattgagt tcccagtcag tgaggcccag atcctggagg
      361 ctaggccact cagcagcaag ggctctggaa gcagcgccca gatcactcaa gtcagccctc
      421 agaggattgc ccttcgacta cggccagatg attcgaagat cttctcactt caagtgcggc
      481 aggtggagga ttaccccgtg gacatctact acttgatgga cctgtctttc tccatgaagg
      541 atgatctgtc cagcatccag accctgggta ccaagttggc ctctcagatg cgcaagctta
      601 ctagcaacct tcggattggc tttggggcct tcgtggacaa gcctgtatcg ccgtacatgt
      661 acatctcccc accacaggca atcaaaaacc cctgttacaa tatgaagaat gcctgcttgc
      721 ccatgtttgg ctacaaacac gtgctgacgc taaccgacca ggtgtcccgc ttcaatgaag
      781 aagtgaagaa acagagcgtg tcccgtaatc gagatgcccc agagggcggc tttgacgcca
      841 tcatgcaggc tacagtatgt gatgaaaaaa ttggctggag gaatgacgca tcccatttgc
      901 tagtgtttac cacggatgcc aagacccata ttgccctgga tggaaggctg gcaggcattg
      961 tcctgcccaa tgatgggcac tgtcacattg gcaccgacaa ccactactct gcctccacta
     1021 ccatggacta cccatctctg gggctgatga ctgagaaact atcccagaaa aacattaact
     1081 tgatctttgc agtgactgaa aatgtcgtca gcctttacca gaattatagt gagctcattc
     1141 ctgggaccac agtgggagtc ctgtctgatg actcaagcaa cgtcctccag ctcattgttg
     1201 atgcttacgg gaaaatccgc tctaaagtgg agctggaagt acgtgacctg ccggaagaac
     1261 tgtcactgtc cttcaatgcc acctgcctca acaacgaggt tatcccgggc ctcaagtctt
     1321 gtgtgggcct caagattgga gacacggtga gctttagtat cgaggccaag gtgcgtggct
     1381 gcccccagga gaaggagcag tctttcacta tcaagcctgt gggctttaag gacagcctca
     1441 ccgtccaggt gaccttcgac tgtgactgtg cctgccaggc ctttgcccag ccttccagcc
     1501 cacgctgcaa caatgggaac gggacttttg agtgtggggt gtgccgctgt gaccagggct
     1561 ggctggggtc catgtgtgag tgctctgagg aggattaccg accctctcag caggaagagt
     1621 gcagccccaa ggagggccag cccatctgca gccagcgggg agagtgcctc tgtggccagt
     1681 gtgtctgcca tagcagcgac ttcggcaaga tcactggcaa gtactgtgag tgcgatgact
     1741 tctcctgcgt ccgctacaaa ggggagatgt gttccggcca tgggcaatgt aactgtgggg
     1801 actgcgtgtg tgactcggac tggactggct actactgcaa ctgtactaca cgcactgaca
     1861 cctgcatgtc caccaatggg ctgctgtgca gcggccgggg caactgcgag tgcggcagct
     1921 gtgtgtgcgt ccagccaggc tcctatggag acacctgtga gaagtgcccc acctgcccag
     1981 atgcctgctc ctttaagaag gagtgtgtgg agtgtaagaa gttcaaccgg ggaacgctcc
     2041 atgaagaaaa cacctgcagc cgctactgcc gggatgacat cgagcaggtg aaagagctga
     2101 cggatactgg caaaaacgcc gtgaattgta cctacaagaa cgaggatgac tgtgtcgtca
     2161 gattccagta ctacgaagac accagtggga gggcagtcct ctatgtggtg gaagagcctg
     2221 agtgtcccaa gggtcctgat atcctggtgg tcctgctgtc agtgatgggg gccatcctgc
     2281 tcattggcct tgctactctg ctcatctgga agctactcat cactatccat gaccggaagg
     2341 aatttgctaa atttgaggaa gaacgagcca gagccaagtg ggacacagca aacaacccgc
     2401 tgtataaaga ggccacctcc accttcacca atatcaccta ccgggggact taatgagacc
     2461 atcttcagat gacgccagga ccgtgggact ctctgccatt atgtttacag aggacatttg
     2521 tgtgtgtgtg ggtgtgtggg tgtatgggtg ggatttgggg cgtgggttgg gctgggctgg
     2581 aagaatgtca gtatgtggga atgtatctct ctgtgtgtac ttatgtgtgt gacgagtgtg
     2641 gggaaatgtg taatttaaaa cttgtgatgt gtctcacagg cagagctcca cagcctttgt
     2701 cctcaggggc cctccccaaa ggattcttcc tgcttagctt gagggggact catgatgccc
     2761 ggcaggtgct cattacctct gagaagctag cttgctttgt caggccattc tcccagaaga
     2821 gaagggcagg gctgaggttc cccaaccccc attccagagg aagtggtgtc aagtcttggt
     2881 tctataccaa ctttgtaatt ttccggttct tggggctgac tgtcaacagc tgtggtagaa
     2941 agtgcttgac gttgaagctc agctgtatcg tctgtgcctc tgcccacctc cctcccttcc
     3001 tcaggctgat ggtggagtta ggggagaatc gagtcctcaa gagttgcctg tggcttttgc
     3061 cagcacctca gtcctgctat ggctctctct ctcataagga aagtccttgt cacctggctc
     3121 tttggcctgt taagggtgag gatggcaagg ccactcaggg gtcatgcatg gcctgggggg
     3181 tgtgccagca cctccaagat cataatcaca gccattcaga attgcctcat tggtagctct
     3241 tcccaggaga tttgtgaaca tgtgtcattg tgtcaacacc atctcttacc tcctgcttct
     3301 acaccctgat ggccacagac ttgtgctatg tgctgagact ctctctcatg gtcagatgct
     3361 atgggctgag gctctctctc atggtcagat gctatgggct gaggctctct ctcatggtca
     3421 gatgctatgt gctgaggctc tctgtcatgg tcagatgcta tgggctgagg ctctctgtca
     3481 tggtcagatg ctatgggctg aggctctctg acattgtcag atgctatggg ctgaggctct
     3541 ctctcatggt cagatgctat gggctgaggc tctctctcat ggtcagatgc tttctcctca
     3601 ggggagagtg cagtggtcag agctggaggt ccatccccac tctccaggct ttctgctcct
     3661 ctttccgggc acctccacac acctcatcct atgcctctgt gtgcttgcta cacccatcca
     3721 tgggggtgct tgtgtgtatc tacctcttcg gtgtcttgtg aaggagtccc ccgagtctcc
     3781 catgagtctg ttgaacaacg tgccagggag gagttgaaag gccagtcaga actgcatgtg
     3841 tggcctgttc tcctgtgggc tggacaacct cattttatct cagcctttaa tctgggaggc
     3901 cacaagtgca attttatttt attccctatg gggacaccca aaactatgat gaggcccgat
     3961 cactctagag gagcacgtat ataaacatac ttgcattatt atatttataa ttttgtatga
     4021 tgacaaagga gagcataaaa aaccccacac agagtgtgtg gcaaacattc ttagtaactt
     4081 gccagtcagt ggctgggtct gcaaggggct tccctcttcc tggaagcatg tgaagatggg
     4141 tatgtggaca cactgaccct ttcttgaaga ggtttctcga ctgggttctg ggttctgttg
     4201 gcccagcaag catggtttgc tctgctggca ttgacttaga tctaatgtta aaaatcagtg
     4261 cttaccaccc agagacaaga ggcctataaa cagcatcttg atgatctgag acctgagtcc
     4321 tggcctcggg atcgctgtca aaacacctga aagttaattc agaaaagcca tttcccccac
     4381 ccctctggag ttcaatattc ttttggattt ggtaacttgg aaagtctatt tcaagtgtca
     4441 ctattctttt tttctgaaag acagggtctc atgtatccca ggatggcttt gaacttgcta
     4501 tgtagccaag gttgacttga acttctgatc ctttttctac acttctcagg tgctacaatt
     4561 acaggcatga gttatcctgc ctggcttatg cagtgctggg aatagaaccc aggacatcac
     4621 acatgctagg caagaacatt accaactgat ctgtattccc agctttagta tcaacatcct
     4681 aagatgccga gagtaaatac ggtatcaagc ctgcggtcca gattctgtgt gtgtataagg
     4741 aggctggaat gttgaccagt agtagaacaa gcagttaagg aatgtcctgg gtttgattcc
     4801 cagcactgaa aacgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt
     4861 ttgtgggggg agaggtggtg ttgctcctgt ttgtctttca gtttccagac tgaatgcctt
     4921 ggctttcacg agagcagatg ctattcttag aacttgtctc agcgagtctc attccttctc
     4981 agactccctt catcttttgt tagtgggtgc atctgatgta gcacttagtt tttatccaac
     5041 ttgttctttc ttgttcactc tgcatacagt tgcatctgca taccagggag gaccttcagt
     5101 aaggagtggc tgatccagat gttggtgtgg tgagcaggcc tcgagtacag gagaaagcca
     5161 gcgactgtcc ggttgtgccc ttgggttact cttggcttag gtggtgggag tacagtagag
     5221 ggacagggaa gatggtcaga gatccatcct ttagctactg aggcagagtc cgtgagagta
     5281 gagtggggtt ttctttagag aagactgttt agatgaggaa actagcaggg aaggaagaaa
     5341 atgtattaga agagtgaaag gtgagtagga atcttgacgg tttctggaat gaggcttgtg
     5401 gtgcttgggc ggcaacgccg gtcaggactc gggcatatct gtagctgttc tctccggagg
     5461 ctgaggaaca gtctgagtgg tttccagggg atgaacatct aaaattgtgc tgggaatgaa
     5521 tgcgcagcac agagcggctg ggcccgttct cttacaggtg gtttcggtcc agtctctgtc
     5581 tgaggacaac aggaagagac agagaatgcc tggcaggtag ctctgttccc gttctttccc
     5641 tcagagacag tcattctgaa gctgcccaca gcaacatcag agtctttgtc catttttggt
     5701 tgaaattgct tacgcgcctt cctgacaccc tccccacctc ctctgagttg tgtaacagag
     5761 aattaaatgt gctttccaaa aaaaaaaaaa aaaaa
//
