LOCUS       NM_008405               2618 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus integrin beta 2-like (Itgb2l), mRNA.
ACCESSION   NM_008405
VERSION     NM_008405.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2618)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2618)
  AUTHORS   Hojgaard,A., Close,R., Dunn,D.M., Weiss,R.B., Weis,J.J. and
            Weis,J.H.
  TITLE     Altered localization of CXCL13 expressing cells in mice deficient
            in Pactolus following an inflammatory stimulus
  JOURNAL   Immunology 119 (2), 212-223 (2006)
   PUBMED   16836649
REFERENCE   3  (bases 1 to 2618)
  AUTHORS   Hale,J.S., Dahlem,T.J., Margraf,R.L., Debnath,I., Weis,J.J. and
            Weis,J.H.
  TITLE     Transcriptional control of Pactolus: evidence of a negative control
            region and comparison with its evolutionary paralogue, CD18 (beta2
            integrin)
  JOURNAL   J Leukoc Biol 80 (2), 383-398 (2006)
   PUBMED   16735694
  REMARK    GeneRIF: These data implicate Smuc as blocking Pactolus
            transcription in cells expressing PU.1 (and CD18) but not Pactolus.
REFERENCE   4  (bases 1 to 2618)
  AUTHORS   Garrison,S., Hojgaard,A., Margraf,R., Weis,J.J. and Weis,J.H.
  TITLE     Surface translocation of pactolus is induced by cell activation and
            death, but is not required for neutrophil migration and function
  JOURNAL   J Immunol 171 (12), 6795-6806 (2003)
   PUBMED   14662885
  REMARK    GeneRIF: Pactolus does not function as a neutrophil phagocytic or
            adhesion receptor, but may instead serve as a sugar-bearing ligand
            for lectin recognition by other cells.
REFERENCE   5  (bases 1 to 2618)
  AUTHORS   Garrison,S., Hojgaard,A., Patillo,D., Weis,J.J. and Weis,J.H.
  TITLE     Functional characterization of Pactolus, a beta-integrin-like
            protein preferentially expressed by neutrophils
  JOURNAL   J Biol Chem 276 (38), 35500-35511 (2001)
   PUBMED   11461913
REFERENCE   6  (bases 1 to 2618)
  AUTHORS   Pletcher,M.T., Wiltshire,T., Cabin,D.E., Villanueva,M. and
            Reeves,R.H.
  TITLE     Use of comparative physical and sequence mapping to annotate mouse
            chromosome 16 and human chromosome 21
  JOURNAL   Genomics 74 (1), 45-54 (2001)
   PUBMED   11374901
REFERENCE   7  (bases 1 to 2618)
  AUTHORS   Margraf,R.L., Chen,Y., Garrison,S., Weis,J.J. and Weis,J.H.
  TITLE     Genomic organization, chromosomal localization, and transcriptional
            variants of the murine Pactolus gene
  JOURNAL   Mamm Genome 10 (11), 1075-1081 (1999)
   PUBMED   10556426
REFERENCE   8  (bases 1 to 2618)
  AUTHORS   Chen,Y., Garrison,S., Weis,J.J. and Weis,J.H.
  TITLE     Identification of pactolus, an integrin beta subunit-like
            cell-surface protein preferentially expressed by cells of the bone
            marrow
  JOURNAL   J Biol Chem 273 (15), 8711-8718 (1998)
   PUBMED   9535848
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK137534.1.
            
            On Apr 5, 2007 this sequence version replaced NM_008405.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137534.1, AF051367.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2618              AK137534.1         2-2619
FEATURES             Location/Qualifiers
     source          1..2618
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 56.95 cM"
     gene            1..2618
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /note="integrin beta 2-like"
                     /db_xref="GeneID:16415"
                     /db_xref="MGI:MGI:1277979"
     exon            1..75
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /inference="alignment:Splign:2.1.0"
     exon            76..136
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /inference="alignment:Splign:2.1.0"
     exon            137..225
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /inference="alignment:Splign:2.1.0"
     exon            226..406
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /inference="alignment:Splign:2.1.0"
     exon            407..577
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /inference="alignment:Splign:2.1.0"
     exon            578..735
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /inference="alignment:Splign:2.1.0"
     exon            736..891
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /inference="alignment:Splign:2.1.0"
     exon            892..987
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1077
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1218
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1406
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1651
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1871
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2065
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2227
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2618
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2618
                     /gene="Itgb2l"
                     /gene_synonym="5033406G21Rik; pactolus"
                     /note="putative"
ORIGIN      
        1 acaagcgtcc agagagctat aaggagctga agaatctcca gcctctctga gccaaggcct
       61 ccagggagca aagtggacat gctgggccag tgcactctgc tacctgtcct agctgggctg
      121 ctgtctctgg aatctgcact gtctcagttg tgtaccaagg acaatgtgag cacctgtcag
      181 gactgtatcc ggtcagggcc cagctgtgcc tggtgccaga agctgaactt cacagggcga
      241 ggggagcccg actcagttcg ctgtgataca ccagagcaac tgttgctaaa aggctgcaca
      301 tctgagtacc tcgtggaccc caagagtctt gctgaatccc aggaagacaa ggagagggac
      361 cagaggcagc tgtctccacg aaatgtgaca gttttcttaa gaccgggtca agcggcaaca
      421 ttcaaagtgg acttccagcg gacccaggac aactctgttg acctgtactt cctgatgggc
      481 ctctctggct ctgcgcaagg ccacctctcc aatgtccaga cactgggcag tgacctgctc
      541 aaagccctca atgagatctc caggtcaggc cgaatcggct ttggatccat tgtgaacatg
      601 accttccagc acatcctgaa gctgactgcg gactccagcc aatttcagag ggagctgagg
      661 aagcaactgg tttctggaaa gctggctacc cccaagggac agctggatgc tgtggttcaa
      721 gttgccatat gcctgggaga aatcggctgg cgcaatggga cccgatttct ggtgcttgtt
      781 actgacaacg atttccactt ggctaaagac aagactctgg gtaccagaca gaacaccagc
      841 gatggtcgct gtcacctgga cgacggcatg tacaggagca ggggagaacc tgactaccag
      901 tcagtggtcc agctggcaag caaactggct gaaaacaaca tccagcccat cttcgtggtg
      961 ccctcaagga tggtgaaaac ctatgagaaa cttaccacat tcatccccaa gctgaccatt
     1021 ggggagctgt cagatgactc cagcaacgtg gcacagctca tcaggaacgc ctacagtaaa
     1081 ctctcctcca ttgttgtgct gaaccacagc accatcccca gcatcctgaa agttacctac
     1141 gactcctact gcagcaatgg aacatcaaat ccaggcaaac ccagcgggga ctgcagtggt
     1201 gtacagatca atgaccaggt caccttccag gttaacatca cagcttcaga gtgcttccgg
     1261 gagcagttct ttttcatcca ggcactgggc ttcatggatt cagtgaccgt gcgggtcctt
     1321 cccctgtgtg agtgccagtg ccaggagcag agtcaacacc acagcctctg tggaggcaag
     1381 ggagccatgg agtgtggcat ctgcaggtgc aactctggct acgctgggaa aaactgtgag
     1441 tgccagacac agggcccgag cagccaggat ctggagggaa gctgccggaa ggacaatagt
     1501 tccatcatgt gctcggggct gggagactgt atctgtgggc agtgtgagtg ccacaccagt
     1561 gacatcccca acaaagagat ctatgggcaa tactgcgagt gcaacaatgt caactgtgag
     1621 agatatgatg gccaagtctg cggtggccca gaaagaggcc actgctcctg tggccgatgc
     1681 ttttgtcgtt acggcttcgt gggctcagcc tgccagtgcc ggatgtccac ttcaggctgt
     1741 ctgaacaaca ggatggtgga gtgcagtggc catggtcgat gctactgtaa cagatgcctc
     1801 tgtgacccgg gctaccagcc accactgtgt gagaagcgtc ctggctattt ccatcgctgc
     1861 tccgagtact actcctgtgc caggtgcttg aaagacaaca gtgcaataaa atgcagagag
     1921 tgttggaatc tgctgttttc caacaccccc ttcagtaaca agacctgcat gactgaacgg
     1981 gactcagagg gctgttggac aacctacact ctatatcagc cagaccagag tgacatcaat
     2041 tccatctaca taaaggagag cctagtgtgt gcagaaatct ccaataccac catcctactg
     2101 ggcgttatag tgggcgtctt gctggctgtt atcttcctgc tggtttactg tatggtttac
     2161 ctgaagggaa cccagaaggc tgccaagctc cccagaaagg gtggggctca aagcacactg
     2221 gcacagcagc ctcatttcca agaaccccac catgtggagc cagtgtggaa tcaagagaga
     2281 cagggtaccc aatgaaggtg aggcaccaag accaactgga tgggaccagc aaaccatgct
     2341 tcctccaccc tatgaccaat caggacatga cttacactca ccacagaagc agcagcacaa
     2401 caaaaggtgt tatagtattt ctttccacaa tggccaacct gccaggtctt ctgtggactt
     2461 ctttctaggg acagcatctc tagggacagc atccctttct ggcccatgca gtcattcata
     2521 aagcttgaga aagaaacttc ctaagtctta gaagttcaga cacatgtttt tctgtgtaaa
     2581 aattaagaaa caagttcaat taaatgtagc gataattt
//
