LOCUS       NM_013712               1316 bp    mRNA    linear   ROD 17-SEP-2023
DEFINITION  Mus musculus integrin beta 1 binding protein 2 (Itgb1bp2), mRNA.
ACCESSION   NM_013712
VERSION     NM_013712.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1316)
  AUTHORS   Arina P, Sorge M, Gallo A, Di Mauro V, Vitale N, Cappello P, Brazzi
            L, Barandalla-Sobrados M, Cimino J, Ranieri VM, Altruda F, Singer
            M, Catalucci D, Brancaccio M and Fanelli V.
  TITLE     Modulation of LTCC Pathways by a Melusin Mimetic Increases
            Ventricular Contractility During LPS-Induced Cardiomyopathy
  JOURNAL   Shock 57 (6), 318-325 (2022)
   PUBMED   35271535
  REMARK    GeneRIF: Modulation of LTCC Pathways by a Melusin Mimetic Increases
            Ventricular Contractility During LPS-Induced Cardiomyopathy.
REFERENCE   2  (bases 1 to 1316)
  AUTHORS   Tannous C, Deloux R, Karoui A, Mougenot N, Burkin D, Blanc J,
            Coletti D, Lavery G, Li Z and Mericskay M.
  TITLE     NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required
            for Cardiac Function and NAD Levels during Aging
  JOURNAL   Int J Mol Sci 22 (7), 3534 (2021)
   PUBMED   33805532
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1316)
  AUTHORS   Penna C, Brancaccio M, Tullio F, Rubinetto C, Perrelli MG, Angotti
            C, Pagliaro P and Tarone G.
  TITLE     Overexpression of the muscle-specific protein, melusin, protects
            from cardiac ischemia/reperfusion injury
  JOURNAL   Basic Res Cardiol 109 (4), 418 (2014)
   PUBMED   24859929
  REMARK    GeneRIF: Findings implicate melusin as an enhancer of AKT and ERK
            pathways and as a novel player in cardioprotection from
            ischemia-reperfusion injury.
REFERENCE   4  (bases 1 to 1316)
  AUTHORS   Unsold B, Kaul A, Sbroggio M, Schubert C, Regitz-Zagrosek V,
            Brancaccio M, Damilano F, Hirsch E, Van Bilsen M, Munts C, Sipido
            K, Bito V, Detre E, Wagner NM, Schafer K, Seidler T, Vogt J, Neef
            S, Bleckmann A, Maier LS, Balligand JL, Bouzin C, Ventura-Clapier
            R, Garnier A, Eschenhagen T, El-Armouche A, Knoll R, Tarone G and
            Hasenfuss G.
  TITLE     Melusin protects from cardiac rupture and improves functional
            remodelling after myocardial infarction
  JOURNAL   Cardiovasc Res 101 (1), 97-107 (2014)
   PUBMED   24130190
  REMARK    GeneRIF: reduces maladaptive remodelling after myocardial
            infarction
            Erratum:[Cardiovasc Res. 2020 Apr 1;116(5):1005. PMID: 32087012]
REFERENCE   5  (bases 1 to 1316)
  AUTHORS   Aro J, Tokola H, Ronkainen VP, Koivisto E, Tenhunen O, Ilves M,
            Szokodi I, Ruskoaho H and Rysa J.
  TITLE     Regulation of cardiac melusin gene expression by hypertrophic
            stimuli in the rat
  JOURNAL   Acta Physiol (Oxf) 207 (3), 470-484 (2013)
   PUBMED   23198998
  REMARK    GeneRIF: Multiple hypertrophic stimuli regulate melusin expression
            predominately in the atria, which may represent a necessary initial
            step in early adaptive remodelling processes in left ventricular
            hypertrophy.
REFERENCE   6  (bases 1 to 1316)
  AUTHORS   Davie JK, Cho JH, Meadows E, Flynn JM, Knapp JR and Klein WH.
  TITLE     Target gene selectivity of the myogenic basic helix-loop-helix
            transcription factor myogenin in embryonic muscle
  JOURNAL   Dev Biol 311 (2), 650-664 (2007)
   PUBMED   17904117
REFERENCE   7  (bases 1 to 1316)
  AUTHORS   Kuninger D, Kuzmickas R, Peng B, Pintar JE and Rotwein P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   8  (bases 1 to 1316)
  AUTHORS   Brancaccio M, Menini N, Bongioanni D, Ferretti R, De Acetis M,
            Silengo L and Tarone G.
  TITLE     Chp-1 and melusin, two CHORD containing proteins in vertebrates
  JOURNAL   FEBS Lett 551 (1-3), 47-52 (2003)
   PUBMED   12965203
REFERENCE   9  (bases 1 to 1316)
  AUTHORS   Brancaccio M, Fratta L, Notte A, Hirsch E, Poulet R, Guazzone S, De
            Acetis M, Vecchione C, Marino G, Altruda F, Silengo L, Tarone G and
            Lembo G.
  TITLE     Melusin, a muscle-specific integrin beta1-interacting protein, is
            required to prevent cardiac failure in response to chronic pressure
            overload
  JOURNAL   Nat Med 9 (1), 68-75 (2003)
   PUBMED   12496958
  REMARK    GeneRIF: Data show that melusin prevents cardiac dilation during
            chronic pressure overload by specifically sensing mechanical
            stress.
REFERENCE   10 (bases 1 to 1316)
  AUTHORS   Brancaccio M, Guazzone S, Menini N, Sibona E, Hirsch E, De Andrea
            M, Rocchi M, Altruda F, Tarone G and Silengo L.
  TITLE     Melusin is a new muscle-specific interactor for beta(1) integrin
            cytoplasmic domain
  JOURNAL   J Biol Chem 274 (41), 29282-29288 (1999)
   PUBMED   10506186
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK003906.1 and BC030035.1.
            
            [WARNING] On Dec 6, 2023 this sequence was replaced by NM_013712.3.
            
            On Sep 20, 2006 this sequence version replaced NM_013712.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030035.1, SRR5189673.44399.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               AK003906.1         2-507
            507-1147            BC030035.1         482-1122
            1148-1290           AK003906.1         1149-1291
            1291-1316           BC030035.1         1266-1291
FEATURES             Location/Qualifiers
     source          1..1316
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 44.17 cM"
     gene            1..1316
                     /gene="Itgb1bp2"
                     /gene_synonym="Chordc3"
                     /note="integrin beta 1 binding protein 2"
                     /db_xref="GeneID:26549"
                     /db_xref="MGI:MGI:1353420"
     exon            1..128
                     /gene="Itgb1bp2"
                     /gene_synonym="Chordc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1117
                     /gene="Itgb1bp2"
                     /gene_synonym="Chordc3"
                     /note="melusin"
                     /codon_start=1
                     /product="integrin beta-1-binding protein 2"
                     /protein_id="NP_038740.1"
                     /db_xref="CCDS:CCDS41079.1"
                     /db_xref="GeneID:26549"
                     /db_xref="MGI:MGI:1353420"
                     /translation="MSLLCYNKGCGQHFDPNTNLPDSCRYHPGVPIFHDALKGWSCCR
                     KRTVDFSEFLNIKGCTVGLHCAEKLPEVPPQPEGPATSSLQEQKPLNTIPKSAETLFR
                     ERPKSEMPPKLLPLLISQALGVALEQKELDQEPGAGLDNSLIWTGSSCQNPGCDAVYQ
                     GPESDATPCTYHPGAPRFHEGMKSWSCCGIQTLDFGAFLAQPGCRVGRHDWAKQLPAS
                     CRHDWHQTDSVVVLTVYGQIPLPAFNWVKASQTELHVHIVFDGNRVFQAQMKLWGVIN
                     VEQSSVSLMPSRVEISLVKADPGSWAQLEHPDSLAEKARAGVLLEMDEEESEDSDDDL
                     SWTEEEDEEEEEAMGE"
     exon            129..178
                     /gene="Itgb1bp2"
                     /gene_synonym="Chordc3"
                     /inference="alignment:Splign:2.1.0"
     exon            179..235
                     /gene="Itgb1bp2"
                     /gene_synonym="Chordc3"
                     /inference="alignment:Splign:2.1.0"
     exon            236..381
                     /gene="Itgb1bp2"
                     /gene_synonym="Chordc3"
                     /inference="alignment:Splign:2.1.0"
     exon            382..476
                     /gene="Itgb1bp2"
                     /gene_synonym="Chordc3"
                     /inference="alignment:Splign:2.1.0"
     exon            477..535
                     /gene="Itgb1bp2"
                     /gene_synonym="Chordc3"
                     /inference="alignment:Splign:2.1.0"
     exon            536..606
                     /gene="Itgb1bp2"
                     /gene_synonym="Chordc3"
                     /inference="alignment:Splign:2.1.0"
     exon            607..706
                     /gene="Itgb1bp2"
                     /gene_synonym="Chordc3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..820
                     /gene="Itgb1bp2"
                     /gene_synonym="Chordc3"
                     /inference="alignment:Splign:2.1.0"
     exon            821..883
                     /gene="Itgb1bp2"
                     /gene_synonym="Chordc3"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1293
                     /gene="Itgb1bp2"
                     /gene_synonym="Chordc3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1268..1273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgb1bp2"
                     /gene_synonym="Chordc3"
                     /note="putative"
ORIGIN      
        1 gaggtgttcc ccactctgca gccagactcc ttgaaatacc ctttgagtga gcttcagtgt
       61 ctccatgtct ctgctctgct ataacaaagg ctgtgggcaa cactttgacc ccaataccaa
      121 tctccctgat tcctgtcgct atcaccctgg ggtgccaatc tttcatgatg cacttaaggg
      181 ttggtcctgc tgccgaaagc gaactgtaga tttctctgag ttcttaaaca tcaagggctg
      241 tactgtggga ctacactgtg cagagaagct gcctgaggtc cctcctcagc ctgagggccc
      301 tgccacaagt tcacttcagg agcaaaaacc tctaaataca attccaaagt cagcagagac
      361 cttgttccga gaaaggccta agtctgagat gcctcccaaa ctgctaccac ttcttatatc
      421 tcaagccctg ggagtggctt tggaacagaa ggaactagac caggaaccgg gagcaggact
      481 tgacaatagt ctgatctgga ctggttccag ctgccagaac ccaggatgtg atgctgttta
      541 ccaaggtcct gagagtgatg ctactccgtg tacctatcac ccaggggcac ctcggtttca
      601 tgaggggatg aagtcttgga gctgttgtgg tatccagact ctggattttg gggcattcct
      661 ggcacagcca ggatgtagag ttggtagaca tgattgggca aagcagctgc cagcatcttg
      721 ccgccatgat tggcaccaga cagactctgt agtagtgctg acggtctatg gccagattcc
      781 gcttcctgca ttcaactggg tgaaggccag tcaaactgag cttcatgtcc acattgtctt
      841 tgatggtaac cgtgtgttcc aagcacagat gaagctctgg ggggtcataa acgtggagca
      901 gagctctgtc tctttgatgc catcacgggt tgaaatctcc ctggtcaagg ctgacccagg
      961 atcctgggcc cagctggagc accctgattc actagctgag aaggctaggg caggggtttt
     1021 actagagatg gatgaggaag aatctgagga ttcagatgat gacctgagct ggacagagga
     1081 ggaagatgaa gaggaggaag aagctatggg ggaatagtaa cagcagacag ttgagtttct
     1141 aggtaggccc tcagtgaccg ccttagaatc tcagagacca ggatatggtt gaccgtgtgg
     1201 tgtcactggg cagcaggaag ctaaaggagg agagaacaaa atgtgcaaat gtgcctctgc
     1261 tcccctgaat aaaccttcta ttctacagtc tcaaaaaaaa aaaaaaaaaa aaaaaa
//
