LOCUS       NM_008403               1938 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus integrin beta 1 binding protein 1 (Itgb1bp1),
            transcript variant 2, mRNA.
ACCESSION   NM_008403
VERSION     NM_008403.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1938)
  AUTHORS   Sevilla-Movilla,S., Fuentes,P., Rodriguez-Garcia,Y.,
            Arellano-Sanchez,N., Krenn,P.W., de Val,S.I., Montero-Herradon,S.,
            Garcia-Ceca,J., Burdiel-Herencia,V., Gardeta,S.R.,
            Aguilera-Montilla,N., Barrio-Alonso,C., Crainiciuc,G., Bouvard,D.,
            Garcia-Pardo,A., Zapata,A.G., Hidalgo,A., Fassler,R.,
            Carrasco,Y.R., Toribio,M.L. and Teixido,J.
  TITLE     ICAP-1 loss impairs CD8+ thymocyte development and leads to reduced
            marginal zone B cells in mice
  JOURNAL   Eur J Immunol 52 (8), 1228-1242 (2022)
   PUBMED   35491946
  REMARK    GeneRIF: ICAP-1 loss impairs CD8(+) thymocyte development and leads
            to reduced marginal zone B cells in mice.
REFERENCE   2  (bases 1 to 1938)
  AUTHORS   Bouin,A.P., Kyumurkov,A., Regent-Kloeckner,M., Ribba,A.S.,
            Faurobert,E., Fournier,H.N., Bourrin-Reynard,I., Manet-Dupe,S.,
            Oddou,C., Balland,M., Planus,E. and Albiges-Rizo,C.
  TITLE     ICAP-1 monoubiquitylation coordinates matrix density and rigidity
            sensing for cell migration through ROCK2-MRCKalpha balance
  JOURNAL   J Cell Sci 130 (3), 626-636 (2017)
   PUBMED   28049720
  REMARK    GeneRIF: ICAP-1 monoubiquitylation helps in switching from
            ROCK2-mediated to MRCKalpha-mediated cell contractility.
            Erratum:[J Cell Sci. 2017 Mar 15;130(6):1195. doi:
            10.1242/jcs.202218.. PMID: 28298614]
REFERENCE   3  (bases 1 to 1938)
  AUTHORS   Faurobert,E., Rome,C., Lisowska,J., Manet-Dupe,S., Boulday,G.,
            Malbouyres,M., Balland,M., Bouin,A.P., Keramidas,M., Bouvard,D.,
            Coll,J.L., Ruggiero,F., Tournier-Lasserve,E. and Albiges-Rizo,C.
  TITLE     CCM1-ICAP-1 complex controls beta1 integrin-dependent endothelial
            contractility and fibronectin remodeling
  JOURNAL   J Cell Biol 202 (3), 545-561 (2013)
   PUBMED   23918940
  REMARK    GeneRIF: The CCM1 loss resulted in ICAP-1 destabilization, which
            increased beta1 integrin activation and led to increased
            RhoA-dependent contractility.
REFERENCE   4  (bases 1 to 1938)
  AUTHORS   Millon-Fremillon,A., Brunner,M., Abed,N., Collomb,E., Ribba,A.S.,
            Block,M.R., Albiges-Rizo,C. and Bouvard,D.
  TITLE     Calcium and calmodulin-dependent serine/threonine protein kinase
            type II (CaMKII)-mediated intramolecular opening of integrin
            cytoplasmic domain-associated protein-1 (ICAP-1alpha) negatively
            regulates beta1 integrins
  JOURNAL   J Biol Chem 288 (28), 20248-20260 (2013)
   PUBMED   23720740
  REMARK    GeneRIF: Data show that phosphorylation of ICAP-1alpha by CaMKII
            controls beta1 integrin activation and cell adhesion.
REFERENCE   5  (bases 1 to 1938)
  AUTHORS   Brunner,M., Millon-Fremillon,A., Chevalier,G., Nakchbandi,I.A.,
            Mosher,D., Block,M.R., Albiges-Rizo,C. and Bouvard,D.
  TITLE     Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent
            fibronectin deposition
  JOURNAL   J Cell Biol 194 (2), 307-322 (2011)
   PUBMED   21768292
  REMARK    GeneRIF: The ICAP-1 works in concert with kindlin-2 to control the
            dynamics of beta1 integrin-containing fibrillar adhesions and,
            thereby, regulates fibronectin deposition and osteoblast
            mineralization.
            Erratum:[J Cell Biol. 2013 May 13;201(4):643]
REFERENCE   6  (bases 1 to 1938)
  AUTHORS   Alvarez,B., Stroeken,P.J., Edel,M.J. and Roos,E.
  TITLE     Integrin Cytoplasmic domain-Associated Protein-1 (ICAP-1) promotes
            migration of myoblasts and affects focal adhesions
  JOURNAL   J Cell Physiol 214 (2), 474-482 (2008)
   PUBMED   17654484
  REMARK    GeneRIF: ICAP-1 regulates beta1 integrin-dependent cell migration
            by affecting the pattern of focal adhesion formation.
REFERENCE   7  (bases 1 to 1938)
  AUTHORS   Bouvard,D., Aszodi,A., Kostka,G., Block,M.R., Albiges-Rizo,C. and
            Fassler,R.
  TITLE     Defective osteoblast function in ICAP-1-deficient mice
  JOURNAL   Development 134 (14), 2615-2625 (2007)
   PUBMED   17567669
  REMARK    GeneRIF: ICAP-1 promotes differentiation of osteoprogenitors by
            supporting their condensation through modulating the integrin high
            affinity state.
REFERENCE   8  (bases 1 to 1938)
  AUTHORS   Stroeken,P.J., Alvarez,B., Van Rheenen,J., Wijnands,Y.M.,
            Geerts,D., Jalink,K. and Roos,E.
  TITLE     Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts
            with the ROCK-I kinase at the plasma membrane
  JOURNAL   J Cell Physiol 208 (3), 620-628 (2006)
   PUBMED   16741948
  REMARK    GeneRIF: Integrin cytoplasmic domain-associated protein-1 (ICAP-1)
            binds ROCK to beta1 integrin at the cell membrane (ICAP-1)
REFERENCE   9  (bases 1 to 1938)
  AUTHORS   Fournier,H.N., Dupe-Manet,S., Bouvard,D., Luton,F., Degani,S.,
            Block,M.R., Retta,S.F. and Albiges-Rizo,C.
  TITLE     Nuclear translocation of integrin cytoplasmic domain-associated
            protein 1 stimulates cellular proliferation
  JOURNAL   Mol Biol Cell 16 (4), 1859-1871 (2005)
   PUBMED   15703214
REFERENCE   10 (bases 1 to 1938)
  AUTHORS   Faisst,A.M. and Gruss,P.
  TITLE     Bodenin: a novel murine gene expressed in restricted areas of the
            brain
  JOURNAL   Dev Dyn 212 (2), 293-303 (1998)
   PUBMED   9626504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY085309.1, AK075577.1, AC156032.4 and BE947737.1.
            
            On Sep 21, 2017 this sequence version replaced NM_008403.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075577.1, AK002786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BY085309.1         3-49
            48-1876             AK075577.1         2-1830
            1877-1879           AC156032.4         88443-88445         c
            1880-1921           AK075577.1         1834-1875
            1922-1938           BE947737.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1938
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.3 cM"
     gene            1..1938
                     /gene="Itgb1bp1"
                     /gene_synonym="Icap1"
                     /note="integrin beta 1 binding protein 1"
                     /db_xref="GeneID:16413"
                     /db_xref="MGI:MGI:1306802"
     exon            1..179
                     /gene="Itgb1bp1"
                     /gene_synonym="Icap1"
                     /inference="alignment:Splign:2.1.0"
     exon            180..310
                     /gene="Itgb1bp1"
                     /gene_synonym="Icap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..841
                     /gene="Itgb1bp1"
                     /gene_synonym="Icap1"
                     /note="integrin cytoplasmic domain-associated protein 1;
                     bodenin"
                     /codon_start=1
                     /product="integrin beta-1-binding protein 1"
                     /protein_id="NP_032429.1"
                     /db_xref="CCDS:CCDS25833.1"
                     /db_xref="GeneID:16413"
                     /db_xref="MGI:MGI:1306802"
                     /translation="MFRKGKKRHSSSSSQSSEISTKSKSVDSSLGGLSRSSTVASLDT
                     DSTKSSGQSNSNLDTCAEFRIKYVGAIEKLAVSEGKSLEGPLDLINYIDVAQQDGKLP
                     FVPLEEEFILGVSKYGIKVSTTDQHGVLHRHALYLIIRMVCYDDGLGAGKSLLALKTT
                     DASNEEYSLWVYQCNSLEQAQAICKVLSTAFDSVLTSDKS"
     exon            311..389
                     /gene="Itgb1bp1"
                     /gene_synonym="Icap1"
                     /inference="alignment:Splign:2.1.0"
     exon            390..526
                     /gene="Itgb1bp1"
                     /gene_synonym="Icap1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..619
                     /gene="Itgb1bp1"
                     /gene_synonym="Icap1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..769
                     /gene="Itgb1bp1"
                     /gene_synonym="Icap1"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1925
                     /gene="Itgb1bp1"
                     /gene_synonym="Icap1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1005..1010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgb1bp1"
                     /gene_synonym="Icap1"
                     /note="hexamer: AATAAA"
     polyA_site      1031
                     /gene="Itgb1bp1"
                     /gene_synonym="Icap1"
                     /note="major polyA site"
     regulatory      1905..1910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgb1bp1"
                     /gene_synonym="Icap1"
                     /note="hexamer: AATATA"
     polyA_site      1922
                     /gene="Itgb1bp1"
                     /gene_synonym="Icap1"
ORIGIN      
        1 gaggcgcggc ctaaagactg cgcctgcgca tgataggggc gtggcccagc ggaccagggc
       61 aggaaaactg gcaaagccgg agctggaata cgaactggaa taacctaccg gccgccgccg
      121 ctggaccatc ccacaccccg cgagaccggg gcgaccgggg aacgagccga ggaggcgagt
      181 cctggaaaca acacttgttc cactgcggca tcttctctgg atcgagctat ggtgaaagat
      241 gtttcgcaaa ggcaagaaga gacacagcag cagcagttcc cagagcagtg aaatcagtac
      301 aaagagcaag tctgtggatt ccagccttgg aggactttca agatccagca ctgtcgccag
      361 cctcgataca gactccacta aaagctcagg acagagtaac agcaatttag acacatgtgc
      421 tgagttccga ataaagtatg ttggtgccat cgagaaactg gccgtgtctg aggggaagag
      481 ccttgaagga ccactagacc tgataaatta catagatgtc gcccagcaag atggaaagtt
      541 gccttttgtg cctttggaag aggagttcat tctgggcgtt tctaagtacg gcataaaagt
      601 ctcgaccacg gatcagcatg gtgttctgca taggcatgcc ctgtatctaa tcatccggat
      661 ggtgtgttac gatgacggcc tgggagctgg gaaaagcttg ctggcactca agaccacaga
      721 tgcaagcaac gaagagtaca gcctgtgggt ttaccagtgt aacagcctgg agcaagccca
      781 agcaatctgc aaggtcttat ccacagcatt tgactctgtg ttgacctctg acaagtcctg
      841 aactctgcag gcaagtggaa actgacccac ggagcttacc tgttcctaca tctatctgca
      901 gctgtggact attagagggt gtaatgccct gacccggttt tctaaagtgt aatgtatgaa
      961 atattggttt tatactaaaa ggtgttaaca gtaggtcaac ttccaataaa ttacctgctt
     1021 tctggacaaa agagaagcct tggggtctgg acagatggct tggtacttaa gagcatttgc
     1081 agaggatctg ggttcagttc ccagcaccaa tatggtggct caaaactgtc tgtaactcca
     1141 gtgccaagag atccaactcc ctcttctggc ttcctcaggt accaggcata catgtataca
     1201 tacatacata catacatgca gccactcaca catgcacata aaacataaaa tctaagaaag
     1261 ataaagaaac ctctgttgtc atcccaggtt gctctgaatg acctgcaccc tgtagcttcc
     1321 cagggacttg ggatcacttg cttggaactg agacatgcag aggtttggac tggggaacct
     1381 caattgcatg tgaccttaga gtgatgatgt cagcttggga caaaaagcac cctaccagag
     1441 aggtactgtc tagacaatac ccagtacact tagtttatca cagagttaga agaatcttgg
     1501 aggacgcctg ctggttgctg ggcgccagta gctaatactt tacagatgaa ccatgtccat
     1561 ttaaaagtac tttatttttt ttccagtcaa atgactggtt aacaggaagt caatttatta
     1621 aacatgctct aattataaat cactgcatta agacaatgaa aataatccgt ttaggttata
     1681 cagtatatac agttgcgctg caactagacc aaagtaatca agtgaatgaa ttgaatatca
     1741 tacatctcaa aatagcattc ttggctgcag gtcattctcc acctcagcag atcacattag
     1801 tctgcgcact atttctcagt catcgtcccc caagtcagac ctgatggaaa gcagcggaaa
     1861 aaaagtccga ttccgcagct gacgcttgtg aaatgtaaac tttaaatata aatagatatc
     1921 tacaaaaaaa aaaaaaaa
//
