LOCUS       NM_010578               4194 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus integrin beta 1 (fibronectin receptor beta) (Itgb1),
            mRNA.
ACCESSION   NM_010578 XM_134403
VERSION     NM_010578.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4194)
  AUTHORS   Zhang,J., Gao,J., Zeng,X., Wang,Z., Chen,C., Rong,C., Li,S.,
            Cai,L., Wang,L., Zhang,L. and Tian,Z.
  TITLE     A novel Cdc42-YAP-fibronectin signaling axis regulates ameloblast
            differentiation during early enamel formation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (2), 167570 (2025)
   PUBMED   39547518
REFERENCE   2  (bases 1 to 4194)
  AUTHORS   Arriagada,C., Lin,E., Schonning,M. and Astrof,S.
  TITLE     Mesodermal fibronectin controls cell shape, polarity, and
            mechanotransduction in the second heart field during cardiac
            outflow tract development
  JOURNAL   Dev Cell 60 (1), 62-84 (2025)
   PUBMED   39413783
REFERENCE   3  (bases 1 to 4194)
  AUTHORS   Weberling,A., Siriwardena,D., Penfold,C., Christodoulou,N.,
            Boroviak,T.E. and Zernicka-Goetz,M.
  TITLE     Primitive to visceral endoderm maturation is essential for mouse
            epiblast survival beyond implantation
  JOURNAL   iScience 28 (1), 111671 (2024)
   PUBMED   39868030
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4194)
  AUTHORS   Makhlouf,A., Wang,A., Sato,N., Rosa,V.S. and Shahbazi,M.N.
  TITLE     Integrin signaling in pluripotent cells acts as a gatekeeper of
            mouse germline entry
  JOURNAL   Sci Adv 10 (36), eadk2252 (2024)
   PUBMED   39231227
REFERENCE   5  (bases 1 to 4194)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4194)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 4194)
  AUTHORS   Gurish,M.F., Bell,A.F., Smith,T.J., Ducharme,L.A., Wang,R.K. and
            Weis,J.H.
  TITLE     Expression of murine beta 7, alpha 4, and beta 1 integrin genes by
            rodent mast cells
  JOURNAL   J Immunol 149 (6), 1964-1972 (1992)
   PUBMED   1381390
REFERENCE   8  (bases 1 to 4194)
  AUTHORS   von der Mark,H., Durr,J., Sonnenberg,A., von der Mark,K.,
            Deutzmann,R. and Goodman,S.L.
  TITLE     Skeletal myoblasts utilize a novel beta 1-series integrin and not
            alpha 6 beta 1 for binding to the E8 and T8 fragments of laminin
  JOURNAL   J Biol Chem 266 (35), 23593-23601 (1991)
   PUBMED   1748636
REFERENCE   9  (bases 1 to 4194)
  AUTHORS   Cooper,H.M., Tamura,R.N. and Quaranta,V.
  TITLE     The major laminin receptor of mouse embryonic stem cells is a novel
            isoform of the alpha 6 beta 1 integrin
  JOURNAL   J Cell Biol 115 (3), 843-850 (1991)
   PUBMED   1833411
REFERENCE   10 (bases 1 to 4194)
  AUTHORS   Sonnenberg,A., Linders,C.J., Daams,J.H. and Kennel,S.J.
  TITLE     The alpha 6 beta 1 (VLA-6) and alpha 6 beta 4 protein complexes:
            tissue distribution and biochemical properties
  JOURNAL   J Cell Sci 96 (Pt 2), 207-217 (1990)
   PUBMED   1698797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156608.10 and BC050906.1.
            
            On Jul 30, 2009 this sequence version replaced NM_010578.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050906.1, AK167682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AC156608.10        81674-81800         c
            128-3478            BC050906.1         1-3351
            3479-4194           AC156608.10        33875-34590         c
FEATURES             Location/Qualifiers
     source          1..4194
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 76.09 cM"
     gene            1..4194
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /note="integrin beta 1 (fibronectin receptor beta)"
                     /db_xref="GeneID:16412"
                     /db_xref="MGI:MGI:96610"
     exon            1..306
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..2703
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /note="integrin beta-1; VLA-4 subunit beta; fibronectin
                     receptor subunit beta"
                     /codon_start=1
                     /product="integrin beta-1 precursor"
                     /protein_id="NP_034708.1"
                     /db_xref="CCDS:CCDS22791.1"
                     /db_xref="GeneID:16412"
                     /db_xref="MGI:MGI:96610"
                     /translation="MNLQLVSWIGLISLICSVFGQTDKNRCLKANAKSCGECIQAGPN
                     CGWCTNTTFLQEGMPTSARCDDLEALKKKGCQPSDIENPRGSQTIKKNKNVTNRSKGM
                     AEKLRPEDITQIQPQQLLLKLRSGEPQKFTLKFKRAEDYPIDLYYLMDLSYSMKDDLE
                     NVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFS
                     YKNVLSLTDRGEFFNELVGQQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVF
                     STDAGFHFAGDGKLGGIVLPNDGQCHLENNVYTMSHYYDYPSIAHLVQKLSENNIQTI
                     FAVTEEFQPVYKELKNLIPKSAVGTLSGNSSNVIQLIIDAYNSLSSEVILENSKLPDG
                     VTINYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITANKCPNKESETIKIKPLGF
                     TEEVEVVLQFICKCNCQSHGIPASPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVN
                     SEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGL
                     ICGGNGVCRCRVCECYPNYTGSACDCSLDTGPCLASNGQICNGRGICECGACKCTDPK
                     FQGPTCETCQTCLGVCAEHKECVQCRAFNKGEKKDTCAQECSHFNLTKVESREKLPQP
                     VQVDPVTHCKEKDIDDCWFYFTYSVNGNNEAIVHVVETPDCPTGPDIIPIVAGVVAGI
                     VLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK
                     "
     exon            307..373
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            374..459
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            460..682
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            683..853
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1092
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1248
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1344
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1434
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1575
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1775
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..2014
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2237
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2470
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2637
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..4194
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3789..3794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /note="hexamer: AATAAA"
     polyA_site      3812
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /note="major polyA site"
     regulatory      4125..4130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
                     /note="hexamer: CATAAA"
     polyA_site      4155
                     /gene="Itgb1"
                     /gene_synonym="4633401G24Rik; CD29; Fnrb; Gm9863; gpIIa"
ORIGIN      
        1 gtttccggag ggagagaaaa gccgggcagc ccgggagaaa gagcttcgcg gcgggggcgg
       61 ggcggggcgg cttcctgagg gacaggcggg ccgagtctcc gcccactcgc tgaagagccg
      121 ccagacccgc ggagcggccg aggcccgccg acgccacccg agaccaaccg agaagccgag
      181 gcccgccgac gccggcccga gaccctccga aaggccgagg tccgccgaca ccgacccgag
      241 accctccgag aggcggaacg cggcggagcc cgggccgccc gcgtgtcggg cggacgctgc
      301 gaaaagatga atttgcaact ggtttcctgg attggattga tcagtttgat ttgttctgta
      361 tttggccaaa cagataaaaa tagatgttta aaagcaaatg ccaaatcttg cggagaatgt
      421 atacaagcag ggccaaattg tgggtggtgt acaaatacga catttttgca agaaggaatg
      481 cctacttctg cacgatgtga tgatttagaa gctttgaaaa agaagggttg ccagccaagt
      541 gacatagaga atcccagagg ctctcaaact ataaagaaaa ataaaaatgt caccaatcgc
      601 agcaaaggga tggcagagaa gctccggcca gaagacatta ctcagatcca accacaacag
      661 ctgcttctaa aattgagatc aggagaacca cagaagttta cattaaaatt caagagggct
      721 gaagattacc ctattgatct ctactacctt atggatctct cctactctat gaaagatgat
      781 ctggagaatg tgaaaagtct tggaacggat ttgatgaatg aaatgaggag gattacttca
      841 gacttccgca ttggctttgg ctcatttgtg gagaaaactg tgatgccgta tattagcaca
      901 accccagcaa agctaagaaa tccttgtaca agtgaacaaa actgcaccag cccatttagc
      961 tacaaaaatg tgcttagtct tactgacaga ggagagtttt tcaatgaact tgttggtcag
     1021 caacgcatat ctggaaactt ggattctcca gaaggtggct ttgatgcaat catgcaggtt
     1081 gcggtttgtg gatcgctgat tggctggagg aatgtaacac gactgctggt gttttccacg
     1141 gatgctgggt ttcactttgc tggagatggg aaacttggtg gtattgtttt acccaatgat
     1201 ggacaatgtc acctggaaaa taatgtatat acaatgagcc attactatga ttatccttca
     1261 attgctcacc ttgttcagaa actaagtgaa aataatattc agacgatttt tgcagttact
     1321 gaagagttcc aacctgttta caaggaattg aagaatttga ttcctaagtc agcagtgggc
     1381 acactgtctg gaaactctag taatgtgatc cagctaatca tcgatgccta caactctctt
     1441 tcttcagaag tcattctgga aaatagcaaa ttgccagacg gagtaacaat aaattacaaa
     1501 tcctattgca agaatggggt gaatgggaca ggagaaaatg gacgaaagtg ttccaacatt
     1561 tctattggag atgaggttca atttgaaatt agcataactg ctaataaatg tccaaataag
     1621 gagtctgaaa ccattaaaat taaacctctg ggcttcactg aagaagtaga ggtcgttctt
     1681 cagttcatct gtaagtgcaa ttgtcaaagc catggcatcc cagccagtcc caagtgccat
     1741 gagggaaatg ggacatttga gtgtggagcc tgcaggtgca atgaggggcg tgttgggagg
     1801 cactgtgaat gtagcacaga tgaagtgaac agtgaagaca tggacgctta ctgcaggaaa
     1861 gagaacagtt cggaaatctg cagtaacaat ggagaatgtg tctgtggaca gtgtgtgtgt
     1921 aggaagagag ataatacaaa tgaaatttac tctggaaaat tctgcgagtg tgataacttc
     1981 aactgtgata ggtctaatgg cttaatttgt ggaggcaatg gcgtgtgcag gtgtcgtgtt
     2041 tgtgaatgct atcccaatta cactggcagt gcatgtgact gttctttgga cactggtcca
     2101 tgtctagcgt caaatggtca gatctgcaat ggccggggta tttgtgaatg tggtgcttgt
     2161 aagtgcacag atcccaagtt tcaagggcca acttgtgaga catgtcagac ctgccttggc
     2221 gtctgtgcag agcataaaga atgtgttcag tgcagagcct tcaataaagg agaaaagaaa
     2281 gacacgtgtg cacaggagtg ctcccacttc aatctcacca aagtagaaag cagggagaag
     2341 ttgccccagc cggtgcaggt cgatcctgtg acccattgca aggagaagga cattgatgac
     2401 tgctggttct atttcaccta ttcagtgaat ggcaacaatg aagctatcgt gcatgttgtg
     2461 gagactccag actgtcctac tggtcccgac atcatcccaa ttgtagcagg cgtggttgct
     2521 ggaattgttc ttattggcct tgccttgctg ctgatttgga aacttttaat gataattcat
     2581 gacagaaggg aatttgctaa atttgaaaag gagaaaatga atgccaagtg ggacacgggt
     2641 gaaaatccta tttacaagag tgccgtgaca actgtggtca atccgaagta tgagggaaaa
     2701 tgaatcctac tcaggcggat tttgcaacac caagctcaca gcagcagcat cttagtcaca
     2761 gtagggtagt tttggggctc tgtggccagg gttttattca catgcaggtt tggaaaatgt
     2821 acaatatgta taatttttaa ttttttatta ttttgaaaat aatgttataa tccatgccag
     2881 ggactgacag aagacttgag aaaggatctt tatccttgtc agctgaggtc acagtgtgcc
     2941 tttttaaccc ttccttctgg accattggaa tcaagctctc actagattga atgacactgc
     3001 tagtgccaat gcagggcaga gctgagcagc gtcgcagcat ctgaaccatg actgattttc
     3061 agcttcacag ggtggccagg gctggttata cagaatcaaa gaacagtcct tgctggtggc
     3121 tttgttcttt gtttagcctg ctggctgccc tctgggaatt cccagtgatg tatgtggaag
     3181 acaagagtgt tgacagtttc caattaaaat aaaattgaca cagttgatgt tcaagtccat
     3241 tggaaaaatt ctgagaggtg ggaaggaaat cttagcttta aaacctgtgt gccattgtga
     3301 gttacttgat cctgtaactc cgacgccttt tctttataaa tccaaccttg gataaaagta
     3361 ctgggaactt ctctgctaaa aagtccctga cttagcacta ttcacataaa ggccataatt
     3421 ttagtagcat tgctgagtgg ggaccttttg ggttgagctt attttacctt tttttttttc
     3481 tttaattcct ggtgctcctt tatcaccttc tctaatcttt taatgtgtct gtttgcaata
     3541 tgggggttag actttttatc attacctttt cttttccttg gctgtacatt tacctttttc
     3601 acaaatactg taagctgtcc tgctgcttgc aggactacag ggcctgggca gggcccccca
     3661 gcaacaattc acccacagtg cacctgcaca tgcctttcct acatgcttgc tctgtctcga
     3721 actagtcaca atcttgtttt aagtgccttt tcattttgac agtgctatta actgaagtta
     3781 tttattaaaa taaaaaggcc taaatacatt aagtgatttg ttttggctct gtatttttat
     3841 tagttttgtg catttttatg tgttaaagat atggtagaga aacgtggctc aaaccactta
     3901 agccaaaatg actcatttta gacatgtggg gagtgggtag tagaacagat tttagttagg
     3961 tgttttattc ttacgttagc agaacatttt atgaatatca ttttaggcta ctagatgctg
     4021 gagaactaat agttaagaga ggggttgtat tttcattctt aggaagaact agggaaatct
     4081 taactttctt ttggttttag tttatttttc tgtaaaacta tttccataaa aacacttgtg
     4141 taaggtttaa aagaacttgg gttggcaaag tgtcttaatg ggtaaaatct cttg
//
