LOCUS       NM_021334               4043 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus integrin alpha X (Itgax), transcript variant 1, mRNA.
ACCESSION   NM_021334
VERSION     NM_021334.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4043)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   2  (bases 1 to 4043)
  AUTHORS   Hou,L., Sin,Y.C., Chen,Y. and Yuki,K.
  TITLE     Integrin CD11c regulates B cell homeostasis
  JOURNAL   Front Immunol 15, 1359608 (2024)
   PUBMED   38380335
  REMARK    GeneRIF: Integrin CD11c regulates B cell homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4043)
  AUTHORS   Hu,Y., Wang,X., Zhao,Z., Liu,M., Ren,X., Xian,X., Liu,C. and
            Wang,Q.
  TITLE     The Downregulation of ITGAX Exacerbates Amyloid-beta Plaque
            Deposition in Alzheimer's Disease by Increasing Polarization of M1
            Microglia
  JOURNAL   J Alzheimers Dis 100 (2), 657-673 (2024)
   PUBMED   38905043
  REMARK    GeneRIF: The Downregulation of ITGAX Exacerbates Amyloid-beta
            Plaque Deposition in Alzheimer's Disease by Increasing Polarization
            of M1 Microglia.
REFERENCE   4  (bases 1 to 4043)
  AUTHORS   Gruper,Y., Wolff,A.S.B., Glanz,L., Spoutil,F., Marthinussen,M.C.,
            Osickova,A., Herzig,Y., Goldfarb,Y., Aranaz-Novaliches,G.,
            Dobes,J., Kadouri,N., Ben-Nun,O., Binyamin,A., Lavi,B., Givony,T.,
            Khalaila,R., Gome,T., Wald,T., Mrazkova,B., Sochen,C., Besnard,M.,
            Ben-Dor,S., Feldmesser,E., Orlova,E.M., Hegedus,C., Lampe,I.,
            Papp,T., Felszeghy,S., Sedlacek,R., Davidovich,E., Tal,N.,
            Shouval,D.S., Shamir,R., Guillonneau,C., Szondy,Z., Lundin,K.E.A.,
            Osicka,R., Prochazka,J., Husebye,E.S. and Abramson,J.
  TITLE     Autoimmune amelogenesis imperfecta in patients with APS-1 and
            coeliac disease
  JOURNAL   Nature 624 (7992), 653-662 (2023)
   PUBMED   37993717
REFERENCE   5  (bases 1 to 4043)
  AUTHORS   Carroll,J.A., Striebel,J.F., Baune,C., Chesebro,B. and Race,B.
  TITLE     CD11c is not required by microglia to convey neuroprotection after
            prion infection
  JOURNAL   PLoS One 18 (11), e0293301 (2023)
   PUBMED   37910561
  REMARK    GeneRIF: CD11c is not required by microglia to convey
            neuroprotection after prion infection.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4043)
  AUTHORS   Brocker,T., Riedinger,M. and Karjalainen,K.
  TITLE     Targeted expression of major histocompatibility complex (MHC) class
            II molecules demonstrates that dendritic cells can induce negative
            but not positive selection of thymocytes in vivo
  JOURNAL   J Exp Med 185 (3), 541-550 (1997)
   PUBMED   9053454
REFERENCE   7  (bases 1 to 4043)
  AUTHORS   Huleatt,J.W. and Lefrancois,L.
  TITLE     Antigen-driven induction of CD11c on intestinal intraepithelial
            lymphocytes and CD8+ T cells in vivo
  JOURNAL   J Immunol 154 (11), 5684-5693 (1995)
   PUBMED   7751620
REFERENCE   8  (bases 1 to 4043)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   9  (bases 1 to 4043)
  AUTHORS   Liu,Y., Jones,B., Brady,W., Janeway,C.A. Jr. and Linsley,P.S.
  TITLE     Co-stimulation of murine CD4 T cell growth: cooperation between B7
            and heat-stable antigen
  JOURNAL   Eur J Immunol 22 (11), 2855-2859 (1992)
   PUBMED   1385153
  REMARK    Erratum:[Eur J Immunol 1993 Mar;23(3):780. Linley PS [corrected to
            Linsley PS]]
REFERENCE   10 (bases 1 to 4043)
  AUTHORS   Metlay,J.P., Witmer-Pack,M.D., Agger,R., Crowley,M.T., Lawless,D.
            and Steinman,R.M.
  TITLE     The distinct leukocyte integrins of mouse spleen dendritic cells as
            identified with new hamster monoclonal antibodies
  JOURNAL   J Exp Med 171 (5), 1753-1771 (1990)
   PUBMED   2185332
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124566.5.
            
            On Jun 3, 2018 this sequence version replaced NM_021334.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF211864.1, BC042840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AC124566.5         159449-159555       c
            108-213             AC124566.5         158721-158826       c
            214-317             AC124566.5         158185-158288       c
            318-388             AC124566.5         157826-157896       c
            389-503             AC124566.5         157561-157675       c
            504-634             AC124566.5         155968-156098       c
            635-780             AC124566.5         155692-155837       c
            781-934             AC124566.5         155291-155444       c
            935-1085            AC124566.5         154033-154183       c
            1086-1159           AC124566.5         153745-153818       c
            1160-1289           AC124566.5         153475-153604       c
            1290-1432           AC124566.5         153245-153387       c
            1433-1573           AC124566.5         152928-153068       c
            1574-1783           AC124566.5         152631-152840       c
            1784-1914           AC124566.5         149080-149210       c
            1915-2072           AC124566.5         148798-148955       c
            2073-2227           AC124566.5         148531-148685       c
            2228-2359           AC124566.5         147774-147905       c
            2360-2433           AC124566.5         147115-147188       c
            2434-2596           AC124566.5         146761-146923       c
            2597-2725           AC124566.5         144382-144510       c
            2726-2805           AC124566.5         144224-144303       c
            2806-2889           AC124566.5         144061-144144       c
            2890-2968           AC124566.5         141179-141257       c
            2969-3073           AC124566.5         140986-141090       c
            3074-3157           AC124566.5         140792-140875       c
            3158-3271           AC124566.5         140491-140604       c
            3272-3373           AC124566.5         140263-140364       c
            3374-3484           AC124566.5         139891-140001       c
            3485-4043           AC124566.5         138448-139006       c
FEATURES             Location/Qualifiers
     source          1..4043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.98 cM"
     gene            1..4043
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /note="integrin alpha X"
                     /db_xref="GeneID:16411"
                     /db_xref="MGI:MGI:96609"
     exon            1..107
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..3580
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD11C (p150) alpha polypeptide; complement
                     receptor 4; CD11 antigen-like family member C; leukocyte
                     adhesion receptor p150,95; leukocyte adhesion glycoprotein
                     p150,95 alpha chain; integrin aX"
                     /codon_start=1
                     /product="integrin alpha-X isoform 1 precursor"
                     /protein_id="NP_067309.1"
                     /db_xref="CCDS:CCDS40150.1"
                     /db_xref="GeneID:16411"
                     /db_xref="MGI:MGI:96609"
                     /translation="MSCTWIAFLLLLGFVSCLGFNLDAEKLTHFHMDGAEFGHSVLQY
                     DSSWVVVGAPKEIKATNQIGGLYKCGYHTGNCEPISLQVPPEAVNISLGLSLAAATNP
                     SWLLACGPTVHHTCRENIYLTGLCFLLSSSFKQSQNFPTAQQECPKQDQDIVFLIDGS
                     GSISSTDFEKMLDFVKAVMSQLQRPSTRFSLMQFSDYFRVHFTFNNFISTSSPLSLLG
                     SVRQLRGYTYTASAIKHVITELFTTQSGARQDATKVLIVITDGRKQGDNLSYDSVIPM
                     AEAASIIRYAIGVGKAFYNEHSKQELKAIASMPSHEYVFSVENFDALKDIENQLKEKI
                     FAIEGTETPSSSTFELEMSQEGFSAVFTPDGPVLGAVGSFSWSGGAFLYPSNMRPTFI
                     NMSQENEDMRDAYLGYSTALAFWKGVHSLILGAPRHQHTGKVVIFTQESRHWRPKSEV
                     RGTQIGSYFGASLCSVDMDRDGSTDLVLIGVPHYYEHTRGGQVSVCPMPGVGSRWHCG
                     TTLHGEQGHPWGRFGAALTVLGDVNGDSLADVAIGAPGEEENRGAVYIFHGASRQDIA
                     PSPSQRISASQIPSRIQYFGQSLSGGQDLTRDGLVDLAVGSKGRVLLLRTRPILRVSP
                     TVHFTPAEISRSVFECQEQVAPEQTLSDATVCLHIHESPKTQLGDLRSTVTFDLALDH
                     GRLSTRAIFKETKTRALTRVKTLGLNKHCESVKLLLPACVEDSVTPITLRLNFSLVGV
                     PISSLQNLQPMLAVDDQTYFTASLPFEKNCGADHICQDDLSVVFGFPDLKTLVVGSDL
                     ELNVDVTVSNDGEDSYGTTVTLFYPVGLSFRRVAEGQVFLRKKEDQQWQRRGQHSLHL
                     MCDSTPDRSQGLWSTSCSSRHVIFRGGSQMTFLVTFDVSPKAELGDRLLLRARVGSEN
                     NVPGTPKTTFQLELPVKYAVYTMISSHDQFTKYLNFSTSEKEKTSVVEHRFQVNNLGQ
                     RDVPVSINFWVPIELKGEAVWTVMVSHPQNPLTQCYRNRLKPTQFDLLTHMQKSPVLD
                     CSIADCLHLRCDIPSLGILDELYFILKGNLSFGWISQTLQKKVLLLSEAEITFNTSVY
                     SQLPGQEAFLRAQTKTVLEMYKVHNPVPLIVGSSVGGLLLLAIITAILYKAGFFKRQY
                     KEMLEEANGQFVSDGTPTPQVAQ"
     exon            108..213
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            214..317
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            318..388
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            389..503
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            504..634
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            635..780
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            781..934
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1085
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1159
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1289
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1432
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1573
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1783
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1914
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2072
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2227
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2359
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2433
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2596
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2725
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2805
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2889
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..2968
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3073
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3157
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3271
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3373
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3484
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     exon            3485..4043
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4023..4028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /note="hexamer: AATAAA"
     polyA_site      4043
                     /gene="Itgax"
                     /gene_synonym="Cd11c; Cr4; N418"
                     /note="major polyA site"
ORIGIN      
        1 catttgcttc ttctgtggtg acttggcagc tgtctccaag ttgctcagag cctgcttctg
       61 ttctccagtc atgagctgta cctggatagc ctttcttctg ctgttggggt ttgtttcttg
      121 tcttggcttc aacttggatg cagagaagct gacacatttt cacatggacg gtgctgagtt
      181 cggacacagt gtgctccagt atgatagttc ctgggtggtg gttggagcac caaaggaaat
      241 aaaagccact aaccaaatag gtggcctcta caaatgtggc tatcacacag gcaactgtga
      301 gcccatctcc ctccaggtgc ccccagaggc tgtgaacata tccctgggcc tgtcccttgc
      361 tgctgccacc aacccttcct ggctgttggc ttgtggtcct actgtgcacc acacatgcag
      421 agagaatata tacttgacag ggctctgctt tctactgagt tcatcattca agcagagcca
      481 gaacttccca actgcacagc aggagtgtcc aaagcaagac caagacatcg tgttcctgat
      541 tgatggctcg ggtagcatca gttccacaga ttttgaaaaa atgctggact ttgttaaagc
      601 tgtgatgagc cagcttcaga gacctagcac acggttctcc ctgatgcagt tctctgatta
      661 cttccgagta cattttactt tcaacaactt catctccacg tcaagccctt taagtctgtt
      721 gggttctgta aggcagctaa gagggtacac atacacagcc tcggctatca agcatgtcat
      781 aacagaactg ttcaccaccc aaagtggagc tcggcaagat gccaccaagg tcctcattgt
      841 catcactgat gggagaaaac aaggggacaa cttgagttat gatagtgtca tccccatggc
      901 agaggctgca agcatcattc gttatgcaat tggggtagga aaggcctttt acaatgaaca
      961 ttccaagcaa gaattaaagg ccattgcatc gatgccttcc catgaatacg tattcagcgt
     1021 ggagaacttt gatgctttga aggatattga gaatcagctg aaggagaaga tctttgccat
     1081 tgagggcaca gagacaccaa gcagcagtac ttttgaattg gagatgtccc aggagggctt
     1141 cagtgctgtg tttacacctg atggaccagt tctgggggct gtgggaagct tcagctggtc
     1201 tggaggtgcc ttcttgtacc cctcaaatat gagacccacc ttcatcaaca tgtctcagga
     1261 gaacgaggac atgagggacg cttacctggg ttactccacc gcactggcct tttggaaggg
     1321 ggtccacagc ctgatcctgg gggcccctcg ccaccagcac acggggaagg ttgtcatctt
     1381 tacccaggaa tccaggcact ggaggcccaa gtctgaagtc agagggacac agatcggctc
     1441 ctactttggg gcatctcttt gttctgtgga catggataga gatggcagca ctgacctggt
     1501 cctgattgga gtcccccatt actatgagca cacccgaggg gggcaggtgt cagtgtgccc
     1561 catgcccggt gtggggagca ggtggcattg tgggaccacc ctccatgggg agcagggcca
     1621 tccttggggc cgctttgggg cggctctgac agtgctaggg gacgtgaatg gggacagtct
     1681 ggcagatgtg gctattggtg cacccggaga ggaggagaac agaggtgctg tctacatatt
     1741 tcatggagcc tcaagacagg acatcgctcc ctcacccagc cagaggattt cagcatccca
     1801 gatcccctcc aggattcaat attttgggca gtcactgagt gggggccagg acctcacccg
     1861 ggatggactg gtggatctgg ccgtgggctc caagggacgc gtgctgctgc tcaggaccag
     1921 accaattctt agagtgtcac caactgttca cttcacacct gcagagattt ccaggtctgt
     1981 gtttgagtgt caggagcagg tggcccctga gcagacactg agtgatgcca ctgtctgcct
     2041 tcatattcat gaaagcccca agacccaact aggtgacctc cgaagtactg tcacctttga
     2101 cctggctcta gaccatggcc gtctgagtac ccgggccatc ttcaaggaga caaagacccg
     2161 ggctctgact cgagttaaaa ctcttggtct gaacaagcac tgtgaaagtg tgaagttgct
     2221 tctcccggcc tgtgtggagg actcagtgac cccgatcact cttcgcctca acttttctct
     2281 tgttggtgtg cccatcagtt ccttacaaaa tctccaaccc atgctggctg tagatgacca
     2341 aacgtacttc acggcctctc ttccctttga gaagaactgt ggagctgacc acatctgcca
     2401 ggatgacctt agtgtcgtat ttggcttccc agacttgaag accctggtgg tgggaagtga
     2461 cctggagctg aatgtagatg tgacggtgtc taatgatgga gaagattcct acggaaccac
     2521 agtcactctg ttctaccccg tgggtctgtc ctttagacga gttgcagaag gccaagtatt
     2581 ccttcggaag aaagaggacc agcagtggca gcggcgtggg cagcactccc tgcacctcat
     2641 gtgtgacagc accccagaca ggagtcaggg cctctggagt accagctgta gcagcagaca
     2701 tgtcattttc cgtggaggct cacagatgac ttttttggta acttttgacg tctcccccaa
     2761 agctgagctg ggggaccggc tgcttctaag agccagagtg ggaagtgaga ataatgtacc
     2821 cggaacccca aaaaccacct tccagttgga gcttccagta aaatatgcgg tgtacaccat
     2881 gatcagcagc catgaccagt ttaccaagta tcttaacttc tcaacctcag aaaaggagaa
     2941 gaccagtgtg gtcgaacata gattccaggt gaataacctg ggccagagag acgtgccagt
     3001 cagcatcaac ttttgggtgc ccatagagct gaagggagaa gctgtgtgga cagtgatggt
     3061 ctcccaccct cagaacccac tcacccaatg ctatcggaat agactcaagc caacacaatt
     3121 tgacctcctg actcacatgc aaaagagtcc cgtgctggac tgctccatcg ctgactgcct
     3181 gcacctccgc tgtgacatcc cctccttggg catcctggat gagctttact tcattctgaa
     3241 gggcaacctc agcttcggct ggatcagtca gacattgcag aaaaaggtgt tgctcctgag
     3301 tgaggctgaa atcacattca acacatctgt gtattcccag ctgccgggac aggaggcatt
     3361 tctgagagcc cagacgaaga cagtgctgga gatgtataaa gttcacaacc ccgtccctct
     3421 tatcgtgggc agctcagtgg gaggtctgct gctgctggct atcatcacag ctatacttta
     3481 caaggctggt ttcttcaaac gtcagtacaa ggagatgttg gaggaagcaa atggacagtt
     3541 tgtctcagac gggaccccaa ctccccaggt tgcccagtga gaacttccct ccccatcgtc
     3601 tttgaacccg cccatctgag aggtgtccca gatcttgtac tctcctctaa gtcagcccca
     3661 atggtaaaga agcattctgc aataggattc ccaggaccag accaactttg ctctttgtgt
     3721 cttaatttgg aagggccatt gtctggtcaa aactttacct agaaacttgg aacacagggt
     3781 ctctgctatg gcccagagaa cttccatagg aatttctacc cagggacaca tagtcagctt
     3841 gtggcccctt gtttcgttgg cctctaacga gctttctgtg atgaagaatg aagcagccat
     3901 tcatccttgt ctaccccagt gcctcccatc tacttttgca acgttggaat tgagttctat
     3961 ctcaaggagg ggagcttcag ctagccctgg atggtccgtg cttccatgtt atcctcattt
     4021 ctaataaagt attgttaaca cca
//
