LOCUS       NM_008402               7000 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus integrin alpha V (Itgav), transcript variant 1, mRNA.
ACCESSION   NM_008402
VERSION     NM_008402.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7000)
  AUTHORS   Khan,I.S., Molina,C., Ren,X., Auyeung,V.C., Cohen,M., Tsukui,T.,
            Atakilit,A. and Sheppard,D.
  TITLE     Impaired myofibroblast proliferation is a central feature of
            pathologic post-natal alveolar simplification
  JOURNAL   Elife 13, 94425 (2024)
   PUBMED   39660606
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7000)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   3  (bases 1 to 7000)
  AUTHORS   Zhu,C., Zheng,R., Han,X., Tang,Z., Li,F., Hu,X., Lin,R., Shen,J.,
            Pei,Q., Wang,R., Wei,G., Peng,Z., Chen,W., Liang,Z. and Zhou,Y.
  TITLE     Knockout of integrin alphavbeta6 protects against renal
            inflammation in chronic kidney disease by reduction of
            pro-inflammatory macrophages
  JOURNAL   Cell Death Dis 15 (6), 397 (2024)
   PUBMED   38844455
  REMARK    GeneRIF: Knockout of integrin alphavbeta6 protects against renal
            inflammation in chronic kidney disease by reduction of
            pro-inflammatory macrophages.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7000)
  AUTHORS   Bader,B.L., Rayburn,H., Crowley,D. and Hynes,R.O.
  TITLE     Extensive vasculogenesis, angiogenesis, and organogenesis precede
            lethality in mice lacking all alpha v integrins
  JOURNAL   Cell 95 (4), 507-519 (1998)
   PUBMED   9827803
REFERENCE   5  (bases 1 to 7000)
  AUTHORS   Kambe,M., Miyamoto,Y. and Hayashi,M.
  TITLE     Characterization of the integrin alpha(v) gene promoter in mice
  JOURNAL   Biochim Biophys Acta 1395 (2), 209-219 (1998)
   PUBMED   9473675
REFERENCE   6  (bases 1 to 7000)
  AUTHORS   Wada,J., Kumar,A., Liu,Z., Ruoslahti,E., Reichardt,L., Marvaldi,J.
            and Kanwar,Y.S.
  TITLE     Cloning of mouse integrin alphaV cDNA and role of the
            alphaV-related matrix receptors in metanephric development
  JOURNAL   J Cell Biol 132 (6), 1161-1176 (1996)
   PUBMED   8601592
REFERENCE   7  (bases 1 to 7000)
  AUTHORS   Mitjans,F., Sander,D., Adan,J., Sutter,A., Martinez,J.M.,
            Jaggle,C.S., Moyano,J.M., Kreysch,H.G., Piulats,J. and Goodman,S.L.
  TITLE     An anti-alpha v-integrin antibody that blocks integrin function
            inhibits the development of a human melanoma in nude mice
  JOURNAL   J Cell Sci 108 (Pt 8), 2825-2838 (1995)
   PUBMED   7593323
REFERENCE   8  (bases 1 to 7000)
  AUTHORS   Tang,D.G., Diglio,C.A., Bazaz,R. and Honn,K.V.
  TITLE     Transcriptional activation of endothelial cell integrin alpha v by
            protein kinase C activator 12(S)-HETE
  JOURNAL   J Cell Sci 108 (Pt 7), 2629-2644 (1995)
   PUBMED   7593304
REFERENCE   9  (bases 1 to 7000)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   10 (bases 1 to 7000)
  AUTHORS   Moulder,K., Roberts,K., Shevach,E.M. and Coligan,J.E.
  TITLE     The mouse vitronectin receptor is a T cell activation antigen
  JOURNAL   J Exp Med 173 (2), 343-347 (1991)
   PUBMED   1703206
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL772301.7.
            
            On Dec 21, 2021 this sequence version replaced NM_008402.3.
            
            Summary: This gene encodes a protein that is a member of the
            integrin superfamily. Integrins are transmembrane receptors
            involved cell adhesion and signaling, and they are subdivided based
            on the heterodimer formation of alpha and beta chains. This protein
            has been shown to heterodimerize with beta 1, beta 3, beta 6 and
            beta 8. The heterodimer of alpha v and beta 3 forms the Vitronectin
            receptor. This protein interacts with several extracellular matrix
            proteins to mediate cell adhesion and may play a role in cell
            migration. In mouse, deficiency of this gene is associated with
            defects in vascular morphogenesis in the brain and early post-natal
            death. [provided by RefSeq, May 2013].
            
            Sequence Note:.
            
            CCDS Note: The coding region has been updated to represent a CDS
            sequence that is better supported by available transcript data and
            the reference genome sequence. The protein length is unchanged.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U14135.1, BC133682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               AL772301.7         77112-77579
            469-599             AL772301.7         89170-89300
            600-691             AL772301.7         100513-100604
            692-806             AL772301.7         108466-108580
            807-868             AL772301.7         114528-114589
            869-914             AL772301.7         116312-116357
            915-1040            AL772301.7         118428-118553
            1041-1085           AL772301.7         119287-119331
            1086-1129           AL772301.7         120955-120998
            1130-1186           AL772301.7         121352-121408
            1187-1239           AL772301.7         122713-122765
            1240-1442           AL772301.7         123795-123997
            1443-1634           AL772301.7         129028-129219
            1635-1680           AL772301.7         131674-131719
            1681-1788           AL772301.7         134599-134706
            1789-1847           AL772301.7         136465-136523
            1848-2002           AL772301.7         137993-138147
            2003-2140           AL772301.7         141577-141714
            2141-2208           AL772301.7         143855-143922
            2209-2356           AL772301.7         144553-144700
            2357-2449           AL772301.7         145211-145303
            2450-2529           AL772301.7         146894-146973
            2530-2610           AL772301.7         147579-147659
            2611-2716           AL772301.7         148099-148204
            2717-2875           AL772301.7         148746-148904
            2876-2977           AL772301.7         150011-150112
            2978-3091           AL772301.7         154430-154543
            3092-3199           AL772301.7         154638-154745
            3200-3322           AL772301.7         155540-155662
            3323-7000           AL772301.7         155900-159577
FEATURES             Location/Qualifiers
     source          1..7000
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.33 cM"
     gene            1..7000
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /note="integrin alpha V"
                     /db_xref="GeneID:16410"
                     /db_xref="MGI:MGI:96608"
     exon            1..468
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            469..599
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            600..691
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            692..806
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            807..868
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            869..914
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1040
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1085
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1129
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1186
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1239
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1442
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1634
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1680
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1788
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1847
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2002
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2140
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2208
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2356
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2449
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2529
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2610
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2716
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2875
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..2977
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3091
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3199
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3322
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..7000
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6974..6979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6997
                     /gene="Itgav"
                     /gene_synonym="1110004F14Rik; 2610028E01Rik; CD51;
                     D430040G12Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtccgggct gctcacggtt ccgaggtact gtgctcgccc cgccacttct cagcgccagg
       61 caccgcgcga gccagcgaca gagccggagt cccgggtcgg acaccgctcc tcctgggtgc
      121 cgcccggctc agcttcgcgc cgcccggccg ccccgccgcc cttgaccgca agcgcacagc
      181 acagctcggc agttcggggg cgcgcaggcg gcgggccgcg gccaccgagc accgggacag
      241 ggactgaagt ctttcggctc tgcgccccgc gcgcgccccg gcgatggctg ctcccgggcg
      301 cctgctgcta cgccctcgcc ccggcggcct cctgctgctg ctgccgggtc tcctgctgcc
      361 cctcgccgac gccttcaacc tggacgtcga aagtcccgcc gagtatgcgg gtcccgaggg
      421 aagttacttc ggattcgccg tggacttctt cgagcccagc acgtcctcca ggatgtttct
      481 cctggtggga gcccccaaag cgaacacgac ccagcctggg attgtagaag gagggcaagt
      541 tctcaaatgt gaatgctcat ccagccgccg gtgccagccc attgagtttg attcaacagg
      601 caatcgagat tatgccaaag atgacccact ggagtttaag tcccaccagt ggtttggagc
      661 ctctgtgagg tcaaagcagg ataaaatctt ggcctgtgct ccattgtacc actggaggac
      721 tgagatgaag caggagagag agccagttgg aacctgcttt cttcaggacg gcacaaagac
      781 cgttgagtat gctccatgca ggtcaaaaaa tattgatgct gatggccagg gattttgtca
      841 aggaggattc agcattgatt ttactaaagc tgacagagta cttctcggtg gtcctggtag
      901 cttttattgg caaggtcagc tcatttcgga ccaagtggca gaaatcatat ctaaatatga
      961 cccaaatgtc tacagcatca aatataataa ccaattagca acacggactg cacaagcaat
     1021 ttttgatgac agttatttgg gttactctgt ggccgtggga gacttcaatg gtgacggcat
     1081 tgaagatttt gtctcaggag ttccaagagc agcaaggact ttgggaatgg tttatattta
     1141 tgatgggaaa aatatgtcct ctttacacaa ttttactggt gaacagatgg ctgcgtattt
     1201 tggattttct gtagctgcta ctgacattaa tggggatgat tacgcagatg tgtttattgg
     1261 agcccccctg ttcatggacc gaggttccga tgggaaactc caggaggttg gccaggtctc
     1321 agtgtctctg cagagagcag tgggagactt ccagactaca aagctgaacg gctttgaggt
     1381 ttttgccagg tttggaagtg ccatagctcc attgggagac ctggaccagg atggcttcaa
     1441 tgatattgca attgctgctc cctatggtgg tgaagataag aagggacttg tttatatctt
     1501 caatggaagg tccacaggct tgaattcggt gccatctcaa atcctcgagg ggcagtgggc
     1561 tgctcagagc atgcccccaa gctttggcta ttcaatgaag ggagctacag atgtagacag
     1621 gaatggatat ccagacttag ttgtaggagc ttttggtgtg gatcgagctg tcttatacag
     1681 agccagaccc gttgtcactg taaatgctgg ccttgaagtg taccctagca ttttaaatca
     1741 agacaataag atctgcccgt tgcctgggac agctctcaag gtttcctgtt ttaatgtcag
     1801 attctgctta aaggcagatg gcaagggaac ccttcctcgg aagctccact tccaggtgga
     1861 gcttctactg gataaactca agcagaaggg agccatccga cgagcactgt ttctccataa
     1921 caggtccccg gtccactcca agaccatgac tgttttcagg gggggacaga tgcagtgtga
     1981 ggaactggtc gcctatcttc gggatgaatc tgaatttaga gacaagctca ctcccatcac
     2041 cattttcatg gagtatcggt tggaccagag aacggctgct gatgccacag gcttgcagcc
     2101 catcctgaac cagttcactc cggccaacgt cagtcggcag gctcatattc tacttgactg
     2161 tggtgaagac aatgtctgta aacctaaatt ggaagtttct gtaaatagtg atcaaaagaa
     2221 gatctatatt ggggacgaca accctctgac actgactgtg aaggcgcaga atcaagggga
     2281 aggcgcctat gaagctgagc tcatcgtttc tatcccaccg caggctgact tcatcggggt
     2341 tgtccggaac aacgaagcct tagcaagact gtcctgtgca tttaagacag aaaaccaaac
     2401 tcggcaggtg gtgtgcgacc ttggaaaccc gatgaaggct ggaactcaac tgctcgctgg
     2461 tcttcgtttc agcgtgcacc agcagtcaga gatggatact tctgtgaagt ttgacttgaa
     2521 aatccagagc tctaattctt ttgacaatgt aagtccagtt gtgtcttaca aggttgacct
     2581 cgccgttttg gctgctgtgg agataagagg agtttcaagt ccagatcata tctttcttcc
     2641 aattccaaat tgggagtaca aggaaaaccc tgagactgaa gaagacgttg ggcctattgt
     2701 tcagcacata tatgagctga gaaacaatgg tccaagttca ttcagcaagg caattctaaa
     2761 tctccagtgg ccttacaaat acaacaacaa cactctgttg tacattcttc attacgacat
     2821 tgacgggcca atgaactgca cggcagatac agagatcaac cctttgagaa tcaagacacc
     2881 cgaaaagaat gacacagcgg cggcgggaca gggagaaagg aatcatctca tcaccaagcg
     2941 ggatctcacc ctcagagagg gagatgttca cactttgggc tgtggaatcg ccaagtgctt
     3001 gcagatcacc tgccaggttg gtcgactgga tagaggcaag agcgcaatcc tgtacgtgaa
     3061 atccctgctg tggaccgaga cgttcatgaa caaggagaac cagaaccatt cctattcgct
     3121 gaagtcatct gcttccttta atatcataga attcccttac aagaacctgc cgatcgagga
     3181 tctcttcaac tctacactag tcaccactaa catcacctgg ggcattcagc cggcgcccat
     3241 gcctgtgcct gtgtgggtga tcatcttggc agttctcgca gggctgctgc tactggctgt
     3301 gttggtattt gtaatgtaca ggatgggctt tttcaaacgt gtccgaccac ctcaagaaga
     3361 gcaagaaaga gaacagcttc agcctcatga gaatggcgaa ggaaactctg aaacctaagg
     3421 tgcttcttaa gtggcgccac ttctgtccgc tccaagttca ccaccgtggt ggtggatttc
     3481 aacatctctc gtgaacagtg aaatcccagg actgtattgc tgagagcacc cagcagtctc
     3541 agtttatcca caaaattgaa atggatattt gtcgacttct ctttatgaat aagttcagat
     3601 tacatttact tcgcctacac taacgtgtgt tcttagggac ttaagtgatg gaatttcaag
     3661 tgattatctt tgttcagtgt acataagaca gacagcactg agtcagcacg ttacatagca
     3721 tagtacctct tcagttactg ttcctaattg actgtgtggg gtttctctct tcgacgttac
     3781 gttagggcaa ttaggattgt aaagcagttc aaatttagac catcagtaag tttgcacagg
     3841 cacttagaac aggtacacat tacactacag ttgacttcat aagctactga agactttgca
     3901 attgcatgga cttagatttt aatatcattt acacagtaga acttttaaat aacacgatac
     3961 catcaaaatt ctttcctggg actatagctc acttcgaagc gtgtgcaact ccctgggttc
     4021 aatcctgcac actgggagga aaaccagcag tttcctgtat taacaatggt acagtatttt
     4081 tatatgaaag ttaggttttt atttatgtgt agtctgcatt gtgtcttatt gtattttaac
     4141 ttttgtaatt taaattctac atcaaatcct ttaagtcgtt tcctgcagaa aattttataa
     4201 ttaaaaatac ccgttaagta atagtgtggt ctcagctgct gctgctgctg ctgctgctgc
     4261 tgactgaagc ccgtggagtt ggaaggggtt tttgaagtac atctattccc tttgtttggc
     4321 tgcctgcaat gtggaaaagc cctggagact ctccatgggt ctctactcta actgctcatc
     4381 aaaaagacat tctttaattg gaccagagcg tttaattatt agtaatttat tttcctcctg
     4441 tcctcatatt ttccttccac ttccaaaact gagaatggct caagaccttc ttcataacct
     4501 ataggaacct ggatctcgcg cccttacccc acgagagatg cctgggaccc acattccaaa
     4561 ggtggctcat gggatggttt ctagcaatag catggtagaa cctcaggtta agcaaggtga
     4621 tctataaaac ctgcctccac tgtcagaaag aatgctacaa aggtgttttt gtaagcagtt
     4681 cttgttcctt aaaccttcta actctgtctt acatttttta atttaaatta cctttctggg
     4741 actttaatag aggcagcaga ggaagcacgg gaccgtctta agtggtggtg atttattcac
     4801 agttcctcaa ggccccggga taactatcaa ttatagctct atttttgtgc aattacatca
     4861 tgttatgcat tggaagttga gaattttaat agctttttaa aatgctgtcc tcattaagca
     4921 atgaaaaata tttctcttaa ataattgaat atttttctac attttaaaag taattgaagt
     4981 ttgtctcacc gtatcttagg ctaattccat gtgcatatgg atgagctaat ttggagaata
     5041 tattttcata acatgaagca catttatgtg agttgtacga attagaatat agacaggacc
     5101 ctatatttag ctttaataaa attttaaatt aatgagttct ggcttgaaag atcataatca
     5161 tatatgcaat aattattttt ttaaaccaat acatttaaat tcttttaaga aacattttgg
     5221 tcttagggac aagtgtctct aagctactta ggactaccac acaggtcact aagttggcct
     5281 atacaaactt ttaccttctt tgtctgtcaa cataatagtt gtcattcctg aaaatcaatg
     5341 aaattcattc tttgtaaaaa tcaatattga tttttacagt tattcctatt atggcttcta
     5401 tgccaaggaa taactttctg ttagagattg aaagatattt gtaattggaa attaacatga
     5461 tgtagttttc aacaatagca tggattttct tttaaaaaat ataaatttgt atctctgtaa
     5521 acttaggaac tgtaatttga gagttaacac tctgaaaaaa atgttgagat actctttatc
     5581 ccataacagc ataggcatgt agtcaacaaa atagcaagag attattttag attcatattt
     5641 gtaatttacc aataattaac atttatttct aagcataaaa ttttcataat ataggttaat
     5701 taaagaaatt gattgatcca gaggacattt gacacatgtg aggaatatta acgtggatac
     5761 tgatttctta tagagatatt tattttagag ttggtacttt aaaacatctg tgtgagggtt
     5821 actttcctcc cttatgttta attatcatca taattctgat tgtgttctga atgactacgg
     5881 aaggtgaaac agtcaaaata ttgtcttaaa tctacctgta ttacaatatt acttattaat
     5941 agtaaatcct catgaataca ttatttatat aatgaggaaa atcactaaga gcagacaaga
     6001 gtttgttgcc gccttacgag aacagtgtga gtttctgtag tgagtctaac cccgaggagg
     6061 gaatttagtg gcaaagtata tattggtaga gcaactggtt cttgtagggc aacagaaggc
     6121 caaggtggca tccatcccca tttgagagaa ttctggggag agcctcaagg agaaggaaag
     6181 gaagttgttc tagagtctct gtgtgtggcc attgcctatc tctgtgtcac cttgttctta
     6241 ctcgtggcta gcttgtacat ttaatttgat gagtaagggg agatgaccaa aatgtattat
     6301 gggatctaaa aagacaaata caattgcttg atgtctagta atttgtaaag gtttctttgg
     6361 acttggtcct tttatttgaa ccatgaacct gtggctatgc catctgcagt atacactggc
     6421 attcattata atttctgata tgtcatggac ttcctgtgag gtactgaatc tttgaatttt
     6481 gttgtcattg ttcttaagtg caatataaca atgtaacgaa acttaaatat aagtcactat
     6541 ttagtaatct taatccgaaa tttattagta tttttttgtt agcagaaaag aacaactctg
     6601 ctgtagttgt agatatatag gtgaaatttt ttgttttttg ctttttcttt gctttttttt
     6661 ttttgtttgt ttgttttttt tacctctaaa ccatccaatc tgcattttat tttaggtgga
     6721 agatgaacta ttccttacca gttttaaaac actttcagta tattaaggta acttggaagc
     6781 tgtgtgtatc aaattctttt gctcgctaag taacctggaa gataattttt tttggcttct
     6841 ctcgtgatca cccacattgg gtgagacata agatgagtct ctcctgaaat ctgtcatttg
     6901 ctaacttgtt ttgagttagt aaaagcaggt accatgttct gctttgtttc cagtgtgtaa
     6961 cttgtgactg tacaataaac ttgaacgtgt ggtgccagct
//
