LOCUS       NM_001082960            4682 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus integrin alpha M (Itgam), transcript variant 1, mRNA.
ACCESSION   NM_001082960
VERSION     NM_001082960.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4682)
  AUTHORS   Phadke,R.A., Brack,A., Fournier,L.A., Kruzich,E., Sha,M.,
            Picard,I., Johnson,C., Stroumbakis,D., Salgado,M., Yeung,C., Escude
            Velasco,B., Liu,Y.Y. and Cruz-Martin,A.
  TITLE     The schizophrenia risk gene C4 induces pathological synaptic loss
            by impairing AMPAR trafficking
  JOURNAL   Mol Psychiatry 30 (2), 796-809 (2025)
   PUBMED   39227431
REFERENCE   2  (bases 1 to 4682)
  AUTHORS   Stark,K., Kilani,B., Stockhausen,S., Busse,J., Schubert,I.,
            Tran,T.D., Gaertner,F., Leunig,A., Pekayvaz,K., Nicolai,L.,
            Fumagalli,V., Stermann,J., Stephan,F., David,C., Muller,M.B.,
            Heyman,B., Lux,A., da Palma Guerreiro,A., Frenzel,L.P.,
            Schmidt,C.Q., Dopler,A., Moser,M., Chandraratne,S., von Bruhl,M.L.,
            Lorenz,M., Korff,T., Rudelius,M., Popp,O., Kirchner,M., Mertins,P.,
            Nimmerjahn,F., Iannacone,M., Sperandio,M., Engelmann,B.,
            Verschoor,A. and Massberg,S.
  TITLE     Antibodies and complement are key drivers of thrombosis
  JOURNAL   Immunity 57 (9), 2140-2156 (2024)
   PUBMED   39226900
REFERENCE   3  (bases 1 to 4682)
  AUTHORS   Wang,L., He,L., Yi,W., Wang,M., Xu,F., Liu,H., Nie,J., Pan,Y.H.,
            Dang,S. and Zhang,W.
  TITLE     ADAMTS18-fibronectin interaction regulates the morphology of liver
            sinusoidal endothelial cells
  JOURNAL   iScience 27 (7), 110273 (2024)
   PUBMED   39040056
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4682)
  AUTHORS   Ehirchiou,D., Bernabei,I., Pandian,V.D., Nasi,S., Chobaz,V.,
            Castelblanco,M., So,A., Martinon,F., Li,X., Acha-Orbea,H.,
            Hugle,T., Zhang,L. and Busso,N.
  TITLE     The integrin CD11b inhibits MSU-induced NLRP3 inflammasome
            activation in macrophages and protects mice against MSU-induced
            joint inflammation
  JOURNAL   Arthritis Res Ther 26 (1), 119 (2024)
   PUBMED   38863059
  REMARK    GeneRIF: The integrin CD11b inhibits MSU-induced NLRP3 inflammasome
            activation in macrophages and protects mice against MSU-induced
            joint inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4682)
  AUTHORS   Duan,M., Zhang,X., Lou,Y., Feng,J., Guo,P., Ye,S., Lv,P. and
            Chen,Y.
  TITLE     Deletion of Tmem268 in mice suppresses anti-infectious immune
            responses by downregulating CD11b signaling
  JOURNAL   EMBO Rep 25 (6), 2550-2570 (2024)
   PUBMED   38730209
  REMARK    GeneRIF: Deletion of Tmem268 in mice suppresses anti-infectious
            immune responses by downregulating CD11b signaling.
REFERENCE   6  (bases 1 to 4682)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 4682)
  AUTHORS   Hearne,C.M., McAleer,M.A., Love,J.M., Aitman,T.J., Cornall,R.J.,
            Ghosh,S., Knight,A.M., Prins,J.B. and Todd,J.A.
  TITLE     Additional microsatellite markers for mouse genome mapping
  JOURNAL   Mamm Genome 1 (4), 273-282 (1991)
   PUBMED   1794058
REFERENCE   8  (bases 1 to 4682)
  AUTHORS   Metlay,J.P., Witmer-Pack,M.D., Agger,R., Crowley,M.T., Lawless,D.
            and Steinman,R.M.
  TITLE     The distinct leukocyte integrins of mouse spleen dendritic cells as
            identified with new hamster monoclonal antibodies
  JOURNAL   J Exp Med 171 (5), 1753-1771 (1990)
   PUBMED   2185332
REFERENCE   9  (bases 1 to 4682)
  AUTHORS   Sastre,L., Roman,J.M., Teplow,D.B., Dreyer,W.J., Gee,C.E.,
            Larson,R.S., Roberts,T.M. and Springer,T.A.
  TITLE     A partial genomic DNA clone for the alpha subunit of the mouse
            complement receptor type 3 and cellular adhesion molecule Mac-1
  JOURNAL   Proc Natl Acad Sci U S A 83 (15), 5644-5648 (1986)
   PUBMED   2942940
REFERENCE   10 (bases 1 to 4682)
  AUTHORS   Springer,T., Galfre,G., Secher,D.S. and Milstein,C.
  TITLE     Mac-1: a macrophage differentiation antigen identified by
            monoclonal antibody
  JOURNAL   Eur J Immunol 9 (4), 301-306 (1979)
   PUBMED   89034
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093175.9 and AC124566.5.
            
            Transcript Variant: This variant (1) is the longer transcript and
            encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AC093175.9         53471-53601         c
            132-237             AC093175.9         51505-51610         c
            238-341             AC093175.9         47545-47648         c
            342-412             AC093175.9         45542-45612         c
            413-530             AC093175.9         45277-45394         c
            531-661             AC093175.9         40079-40209         c
            662-807             AC093175.9         35850-35995         c
            808-961             AC093175.9         34483-34636         c
            962-1112            AC093175.9         32415-32565         c
            1113-1186           AC093175.9         31234-31307         c
            1187-1316           AC093175.9         30569-30698         c
            1317-1459           AC093175.9         30169-30311         c
            1460-1600           AC093175.9         14685-14825         c
            1601-1813           AC093175.9         14395-14607         c
            1814-1944           AC093175.9         8483-8613           c
            1945-2108           AC093175.9         8238-8401           c
            2109-2263           AC093175.9         3959-4113           c
            2264-2395           AC093175.9         3735-3866           c
            2396-2469           AC093175.9         3507-3580           c
            2470-2611           AC093175.9         3143-3284           c
            2612-2737           AC093175.9         2925-3050           c
            2738-2817           AC093175.9         2344-2423           c
            2818-2901           AC093175.9         1422-1505           c
            2902-2977           AC093175.9         1047-1122           c
            2978-3085           AC093175.9         366-473             c
            3086-3169           AC093175.9         140-223             c
            3170-3200           AC093175.9         9-39                c
            3201-3283           AC124566.5         172790-172872       c
            3284-3385           AC124566.5         172602-172703       c
            3386-3496           AC124566.5         172259-172369       c
            3497-4682           AC124566.5         170614-171799       c
FEATURES             Location/Qualifiers
     source          1..4682
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.93 cM"
     gene            1..4682
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /note="integrin alpha M"
                     /db_xref="GeneID:16409"
                     /db_xref="MGI:MGI:96607"
     exon            1..131
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..3568
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD11B (p170); cell surface glycoprotein MAC-1
                     alpha subunit; leukocyte adhesion receptor MO1; CR-3 alpha
                     chain; CD11 antigen-like family member B; cell surface
                     glycoprotein MAC-1 subunit alpha; macrophage antigen
                     alpha; complement receptor type 3; Mac-1 alpha"
                     /codon_start=1
                     /product="integrin alpha-M isoform 1 precursor"
                     /protein_id="NP_001076429.1"
                     /db_xref="CCDS:CCDS40149.1"
                     /db_xref="GeneID:16409"
                     /db_xref="MGI:MGI:96607"
                     /translation="MTLKALLVTALALCHGFNLDTEHPMTFQENAKGFGQSVVQLGGT
                     SVVVAAPQEAKAVNQTGALYQCDYSTSRCHPIPLQVPPEAVNMSLGLSLAVSTVPQQL
                     LACGPTVHQNCKENTYVNGLCYLFGSNLLRPPQQFPEALRECPQQESDIVFLIDGSGS
                     INNIDFQKMKEFVSTVMEQFKKSKTLFSLMQYSDEFRIHFTFNDFKRNPSPRSHVSPI
                     KQLNGRTKTASGIRKVVRELFHKTNGARENAAKILVVITDGEKFGDPLDYKDVIPEAD
                     RAGVIRYVIGVGNAFNKPQSRRELDTIASKPAGEHVFQVDNFEALNTIQNQLQEKIFA
                     IEGTQTGSTSSFEHEMSQEGFSASITSNGPLLGSVGSFDWAGGAFLYTSKDKVTFINT
                     TRVDSDMNDAYLGYASAVILRNRVQSLVLGAPRYQHIGLVVMFRENFGTWEPHTSIKG
                     SQIGSYFGASLCSVDMDADGNTNLILIGAPHYYEKTRGGQVSVCPLPRGQRARWQCEA
                     LLHGDQGHPWGRFGAALTVLGDVNGDKLTDVAIGAPGEQENQGAVYIFYGASIASLSA
                     SHSQRIIGAHFSPGLQYFGQSLSGGKDLTMDGLMDLAVGAQGHLLLLRAQPVLRLEAT
                     MEFSPKKVARSVFACQEQVLKNKDAGEVRVCLRVRKNTKDRLREGDIQSTVTYDLALD
                     PGRSRIRAFFDETKNNTRRRTQVFGLMQKCETLKLILPDCVDDSVSPIILRLNYTLVG
                     EPLRSFGNLRPVLAMDAQRFFTAMFPFEKNCGNDSICQDDLSITMSAMGLDTLVVGGP
                     QDFNMSVTLRNDGEDSYGTQVTVYYPSGLSYRKDSASQNPLTKKPWFVKPAESSSSSE
                     GHGALKSTTWNINHPIFPANSEVTFNVTFDVDSHASFGNKLLLKAIVASENNMSRTHK
                     TKFQLELPVKYAIYMIVTSDESSIRYLNFTASEMTSKVIQHQYQFNNLGQRSLPVSVV
                     FWIPVQINNVTVWDHPQVIFSQNLSSACHTEQKSPPHSNFRDQLERTPVLNCSVAVCK
                     RIQCDLPSFNTQEIFNVTLKGNLSFDWYIKTSHGHLLLVSSTEILFNDSAFALLPGQE
                     SYVRSKTETKVEPYEVHNPVPLIVGSSIGGLVLLALITAGLYKLGFFKRQYKDMMNEA
                     APQDAPPQ"
     exon            132..237
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            238..341
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..412
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..530
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..661
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..807
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..961
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1112
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1186
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1316
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1459
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1600
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1813
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1944
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2108
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2263
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2395
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2469
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2611
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2737
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2817
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..2901
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..2977
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3085
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3086..3169
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3283
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3385
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3496
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..4682
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4657..4662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /note="hexamer: AATAAA"
     polyA_site      4682
                     /gene="Itgam"
                     /gene_synonym="Cd11b; CD11b/CD18; CR3; CR3A;
                     F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1"
                     /note="major polyA site"
ORIGIN      
        1 tgtttttacc cctccctcct ggccttggtg gcttcctcaa agtgtctgtg gtgcctgaaa
       61 taccacagtt cacacttctt tcagggcctt gttcctttaa gtcatgactc ttaaagctct
      121 tctggtcaca gccctagcct tgtgtcatgg cttcaatctg gacactgaac atcccatgac
      181 cttccaagag aatgcaaaag gctttggaca gagtgtggtc cagcttggcg gaaccagtgt
      241 ggttgttgca gccccccagg aggcaaaggc tgttaaccag acaggtgccc tctaccagtg
      301 tgactacagc acaagccggt gtcaccccat ccccctgcaa gtacctccag aggctgtgaa
      361 tatgtccttg ggcctgtccc tggctgtttc tactgtcccc cagcagctgc tggcctgtgg
      421 ccccacggtg caccaaaact gcaaggagaa tacttatgtg aatggattgt gctatttgtt
      481 cggctccaac ctgctgaggc cgccccagca gttcccagag gctctcagag aatgtcctca
      541 gcaggagagt gacattgtct tcttgattga tggctccggt agcatcaaca acattgactt
      601 tcagaagatg aaggagtttg tctcaactgt gatggagcag ttcaaaaagt ctaaaacctt
      661 gttctctttg atgcagtact cggacgagtt ccggattcac ttcaccttca atgacttcaa
      721 gagaaaccct agcccaagat cacatgtgag ccccataaag cagctgaatg ggaggacaaa
      781 aactgcctca gggatccgga aagtagtgag agaactgttt cacaaaacca atggggcccg
      841 ggagaatgct gcgaagatcc tagttgtcat cacagatgga gaaaaattcg gtgatccctt
      901 ggattataag gatgtcatcc ccgaggcaga cagagcaggg gtcattcgct acgtaattgg
      961 ggtgggaaat gccttcaaca aaccacagtc ccgcagagag ctcgacacca tcgcatctaa
     1021 gccagctggt gaacacgtgt tccaagtgga caactttgaa gccctgaata ccattcagaa
     1081 ccagcttcag gaaaagatct ttgcaattga gggcacgcag acaggaagta ccagctcctt
     1141 tgagcatgag atgtctcaag aaggcttcag tgcttccatt acctctaatg gtcccttgct
     1201 gggctctgtg gggagctttg actgggcagg tggagccttc ctgtatacat cgaaggataa
     1261 agtcaccttc atcaacacaa ccagagtgga ttcagacatg aatgatgctt acctgggtta
     1321 tgcttctgca gtcatcttga ggaaccgtgt ccaaagcttg gttttaggag cacctcggta
     1381 tcagcatatt ggcttggtgg tgatgttcag ggagaatttc ggtacctggg agccccacac
     1441 tagcatcaag ggcagccaga ttggctctta ttttggggcc tccctttgct ctgtggacat
     1501 ggacgctgat ggcaatacca acttgatcct cattggggcc cctcattact atgagaagac
     1561 ccgaggaggc caggtgtcag tgtgtccctt gcctcgaggg cagagggcac ggtggcagtg
     1621 tgaagctctt ctccacggtg atcagggtca tccctggggt cgctttgggg cagccctgac
     1681 agtgctggga gacgtgaatg gggacaaact gacagatgtg gccattgggg ccccaggaga
     1741 gcaggagaat cagggcgctg tctacatttt ttatggagca tcaatagcca gcctcagtgc
     1801 ctcccacagc cagcggatca taggcgccca cttctcccct gggctccagt acttcgggca
     1861 gtctctgagt gggggtaagg atctcacaat ggatggcttg atggacctgg ctgttggggc
     1921 gcaggggcat cttctgctgc tcagagccca gccggtgctg agactggagg caaccatgga
     1981 attcagcccc aagaaagtag caaggagtgt gtttgcatgt caagaacaag tattaaaaaa
     2041 caaggatgct ggggaggtca gagtctgcct ccgtgtccgc aagaacacca aggaccgtct
     2101 gcgcgaagga gatatccaga gcactgtcac ttatgacctg gctttagacc ctggccgctc
     2161 acgtatccgt gccttctttg atgagacaaa gaacaacaca cgcaggcgca cccaggtctt
     2221 tggattgatg cagaaatgtg aaacactgaa gctaatttta ccggactgcg tggacgactc
     2281 agtgagcccc atcatcctgc gcctcaatta tacactggtt ggggagccct tgaggtcctt
     2341 tgggaacctc cgaccagttc tggctatgga tgctcagagg ttcttcacag ctatgtttcc
     2401 ctttgagaaa aattgcggca atgacagcat ctgccaagac gatctcagca tcaccatgag
     2461 tgccatgggc ttggacactt tggtggtggg aggcccccag gactttaaca tgagtgtgac
     2521 tctgagaaat gacggtgagg attcctacgg gacccaggtt accgtctact acccatctgg
     2581 cttatcttac cggaaggatt cagcaagcca gaacccgctc accaagaagc cttggtttgt
     2641 aaagcctgct gagtccagct cttcttctga agggcatggg gctctgaaga gtaccacctg
     2701 gaacataaac catcccatct ttcctgctaa ttctgaggtc acatttaatg tcacatttga
     2761 tgtggactct catgcctcct ttgggaacaa actgctcctc aaagccattg tggccagtga
     2821 gaacaacatg tccaggaccc acaaaaccaa gtttcagttg gagctgcctg tgaagtacgc
     2881 catctacatg attgtcacca gtgatgagag ttctatcaga tatctcaact tcacggcttc
     2941 agagatgacc agtaaggtca tacagcatca gtaccagttc aacaacctgg gccagaggag
     3001 cctccctgtc agtgtagtct tctggatccc tgttcagatc aacaatgtga ccgtatggga
     3061 tcatccccag gtcatcttct cccagaacct ctcaagtgcc tgtcacactg agcagaaatc
     3121 cccccctcac tccaatttcc gggatcagct tgaaaggacc ccagtgctga actgctctgt
     3181 tgcagtctgt aagagaattc agtgtgacct tccatccttc aacactcagg aaatattcaa
     3241 tgtcaccctc aagggcaacc tatcatttga ctggtacatc aagacttctc atggtcacct
     3301 cctgcttgtg agcagcactg agatcctgtt taatgactct gcgtttgccc tgcttccagg
     3361 gcaggagtcg tatgtgaggt ctaagacaga gaccaaagtg gagccatatg aagttcacaa
     3421 tcctgtacca ctcattgtgg gcagctccat tgggggcctg gtgctcttgg ctctcatcac
     3481 tgctggccta tacaagcttg gctttttcaa gcggcagtac aaggacatga tgaatgaagc
     3541 tgccccccaa gacgccccac ctcagtaacg gccttttctc catgcattga cctccccagc
     3601 aacaagcagg tctagatggt cagaccaaca ccgaagctga tggacacata tgttgttgct
     3661 gtgatgtctt atacaaaaat ggaatgtgtg tgtgtgtgtg tgtgtgagag agagagagag
     3721 agagaaagag agagagagaa agagagaggg agagggagag agagagagag agagagagag
     3781 aagaaaagag gaagcaagct ctgtgtgtgg ctcacacatt tcttgcctgt gaccaatgcc
     3841 ttaaatgcat cctcttggaa ggaaaggcat ctcttgggtt tcctagtgtg ttagggaagc
     3901 tgctaatggg tccttctctg ggcaaggctg tgggaccctt gtgggtaagc atagctaaat
     3961 gctgtgctgt cctctctgaa ggaagtaata tttccttgtt tgtgtgagct gcagacttgc
     4021 aagggtttag gtgctgagaa tacaagagaa gttggaatag agaactggaa agccagcaga
     4081 gatgttcagt gaaaaatgag acgcctccta ccatctagtc atttattatt ttaacattaa
     4141 tttaaataat tgaatcgatt aacccgtcaa agtacaaaaa ccaaaagata ctcaagaatg
     4201 gtaaaaggca gggggtgggg aggatgcagc tcacagcaca gtgctcacct ggaatatgca
     4261 aggccttggg ctcagcatgc gacagtgaaa accaaggcaa agaaaaaaca aaccaaacca
     4321 aaaatgtaag tggaaagact cccttcctag ctgttggggg tctctcctta gggatattaa
     4381 agggtatatg tttagaatct attccacaaa gattgtaggt acctatatac acacacacac
     4441 acacacacac atatacacac actgctttaa acaagtggta acacattttt ttactattat
     4501 gaatgttgtc tttttattaa tatgctcaaa taaatttata taagttataa agtagctcag
     4561 agaattaccc tgtgattgta atgtatttaa catttaatgt agtctccttt ggatatataa
     4621 tttccagcca tttgctatta tgtacaatgc tgaattaata aattgggtat atgtaaattt
     4681 ta
//
