LOCUS       NM_008400               5219 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus integrin alpha L (Itgal), transcript variant 2, mRNA.
ACCESSION   NM_008400
VERSION     NM_008400.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5219)
  AUTHORS   Thierry,G.R., Baudon,E.M., Bijnen,M., Bellomo,A., Lagueyrie,M.,
            Mondor,I., Simonnet,L., Carrette,F., Fenouil,R., Keshvari,S.,
            Hume,D.A., Dombrowicz,D. and Bajenoff,M.
  TITLE     Non-classical monocytes scavenge the growth factor CSF1 from
            endothelial cells in the peripheral vascular tree to ensure
            survival and homeostasis
  JOURNAL   Immunity 57 (9), 2108-2121 (2024)
   PUBMED   39089257
REFERENCE   2  (bases 1 to 5219)
  AUTHORS   Burton,O.T., Bricard,O., Tareen,S., Gergelits,V., Andrews,S.,
            Biggins,L., Roca,C.P., Whyte,C., Junius,S., Brajic,A., Pasciuto,E.,
            Ali,M., Lemaitre,P., Schlenner,S.M., Ishigame,H., Brown,B.D.,
            Dooley,J. and Liston,A.
  TITLE     The tissue-resident regulatory T cell pool is shaped by transient
            multi-tissue migration and a conserved residency program
  JOURNAL   Immunity 57 (7), 1586-1602 (2024)
   PUBMED   38897202
REFERENCE   3  (bases 1 to 5219)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5219)
  AUTHORS   Niu,T., Li,Z., Huang,Y., Ye,Y., Liu,Y., Ye,Z., Jiang,L., He,X.,
            Wang,L. and Li,J.
  TITLE     LFA-1 knockout inhibited the tumor growth and is correlated with
            treg cells
  JOURNAL   Cell Commun Signal 21 (1), 233 (2023)
   PUBMED   37723552
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5219)
  AUTHORS   Hou,L. and Yuki,K.
  TITLE     CD11a regulates hematopoietic stem and progenitor cells
  JOURNAL   Front Immunol 14, 1219953 (2023)
   PUBMED   37781399
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5219)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 5219)
  AUTHORS   Liu,Y., Jones,B., Aruffo,A., Sullivan,K.M., Linsley,P.S. and
            Janeway,C.A. Jr.
  TITLE     Heat-stable antigen is a costimulatory molecule for CD4 T cell
            growth
  JOURNAL   J Exp Med 175 (2), 437-445 (1992)
   PUBMED   1346270
REFERENCE   8  (bases 1 to 5219)
  AUTHORS   Kyuwa,S., Yamaguchi,K., Toyoda,Y., Fujiwara,K. and Hilgers,J.
  TITLE     Acute and late disease induced by murine coronavirus, strain JHM,
            in a series of recombinant inbred strains between BALB/cHeA and
            STS/A mice
  JOURNAL   Microb Pathog 12 (2), 95-104 (1992)
   PUBMED   1316530
REFERENCE   9  (bases 1 to 5219)
  AUTHORS   Hogarth,P.M. and McKenzie,I.F.
  TITLE     Ly-15.2 and Ly-21.2 are distinct polymorphisms of the LFA-1 heavy
            chain
  JOURNAL   Immunogenetics 36 (6), 396-399 (1992)
   PUBMED   1526659
REFERENCE   10 (bases 1 to 5219)
  AUTHORS   Suzuki,H., Chung,F.Z., Palmer,E., Sasaki,T., Ohara,N., Taylor,B.A.
            and Ohara,J.
  TITLE     Gene mapping of mouse IL-4 receptor: the loci of interleukin 4
            (IL-4) receptor gene and lymphocyte function associated antigen 1
            (LFA-1) gene are closely linked on chromosome 7
  JOURNAL   Immunogenetics 34 (4), 252-256 (1991)
   PUBMED   1680807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133494.4 and BC145096.1.
            
            On Dec 9, 2011 this sequence version replaced NM_008400.2.
            
            Transcript Variant: This variant (2) uses an two alternate in-frame
            splice sites in the coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145096.1, AF065901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               AC133494.4         83326-83511
            187-3773            BC145096.1         1-3587
            3774-5219           AC133494.4         120758-122203
FEATURES             Location/Qualifiers
     source          1..5219
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.44 cM"
     gene            1..5219
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /note="integrin alpha L"
                     /db_xref="GeneID:16408"
                     /db_xref="MGI:MGI:96606"
     exon            1..264
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..3692
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; lymphocyte antigen 15; CD11 antigen-like family
                     member A; leukocyte adhesion glycoprotein LFA-1 alpha
                     chain; leukocyte function-associated molecule 1 alpha
                     chain; lymphocyte function associated antigen 1, alpha
                     polypeptide; alpha L integrin"
                     /codon_start=1
                     /product="integrin alpha-L isoform 2 precursor"
                     /protein_id="NP_032426.2"
                     /db_xref="GeneID:16408"
                     /db_xref="MGI:MGI:96606"
                     /translation="MSFRIAGPRLLLLGLQLFAKAWSYNLDTRPTQSFLAQAGRHFGY
                     QVLQIEDGVVVGAPGEGDNTGGLYHCRTSSEFCQPVSLHGSNHTSKYLGMTLATDAAK
                     GSLLACDPGLSRTCDQNTYLSGLCYLFPQSLEGPMLQNRPAYQECMKGKVDLVFLFDG
                     SQSLDRKDFEKILEFMKDVMRKLSNTSYQFAAVQFSTDCRTEFTFLDYVKQNKNPDVL
                     LGSVQPMFLLTNTFRAINYVVAHVFKEESGARPDATKVLVIITDGEASDKGNISAAHD
                     ITRYIIGIGKHFVSVQKQKTLHIFASEPVEEFVKILDTFEKLKDLFTDLQRRIYAIEG
                     TNRQDLTSFNMELSSSGISADLSKGHAVVGAVGAKDWAGGFLDLREDLQGATFVGQEP
                     LTSDVRGGYLGYTVAWMTSRSSRPLLAAGAPRYQHVGQVLLFQAPEAGGRWNQTQKIE
                     GTQIGSYFGGELCSVDLDQDGEAELLLIGAPLFFGEQRGGRVFTYQRRQSLFEMVSEL
                     QGDPGYPLGRFGAAITALTDINGDRLTDVAVGAPLEEQGAVYIFNGKPGGLSPQPSQR
                     IQGAQVFPGIRWFGRSIHGVKDLGGDRLADVVVGAEGRVVVLSSRPVVDVVTELSFSP
                     EEIPVHEVECSYSAREEQKHGVKLKACFRIKPLTPQFQGRLLANLSYTLQLDGHRMRS
                     RGLFPDGSHELSGNTSITPDKSCLDFHFHFPICIQDLISPINVSLNFSLLEEEGTPRD
                     QKGRAMQPILRPSIHTVTKEIPFEKNCGEDKKCEANLTLSSPARSGPLRLMSSASLAV
                     EWTLSNSGEDAYWVRLDLDFPRGLSFRKVEMLQPHSRMPVSCEELTEGSSLLTKTLKC
                     NVSSPIFKAGQEVSLQVMFNTLLNSSWEDFVELNGTVHCENENSSLQEDNSAATHIPV
                     LYPVNILTKEQENSTLYISFTPKGPKTQQVQHVYQVRIQPSAYDHNMPTLEALVGVPW
                     PHSEDPITYTWSVQTDPLVTCHSEDLKRPSSEAEPCLPGVQFRCPIVFRREILIQVTG
                     TVELSKEIKASSTLSLCSSLSVSFNSSKHFHLYGSKASEAQVLVKVDLIHEKEMLHVY
                     VLSGIGGLVLLFLIFLALYKVGFFKRNLKEKMEADGGVPNGSPPEDTDPLAVPGEETK
                     DMGCLEPLRESDKD"
     exon            265..364
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            365..459
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            460..527
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            528..645
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            646..776
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            777..925
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1058
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1209
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1283
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1416
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1568
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1706
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1904
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2035
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2196
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2348
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2435
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2489
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2560
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2702
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2813
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..2893
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..2980
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..3056
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3170
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..3227
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3326
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3422
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3533
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            3534..5219
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3951..3956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /note="hexamer: AATAAA"
     polyA_site      3972
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /note="major polyA site"
     regulatory      5114..5119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /note="hexamer: AATAGA"
     polyA_site      5133
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
ORIGIN      
        1 gagaggtttc acaacccgga caggagcgca ccccctcctt ccacccccac ccagtgtcat
       61 cagcctggca gccctgagaa agttccactg gaaggggccc catgcaagag aagccaccat
      121 ttccctcttc ctcccgggtc taggttgcca gcaaatctca agagctctct gagatcgagt
      181 ccggacccac aggtccctcc taagcgcaga tgagtttccg gattgcgggc cccagacttt
      241 tgctactggg actccagctg tttgccaagg cctggagcta caacctggac acacggccta
      301 cgcagagctt cttggcacaa gctggaagac attttgggta ccaggtcttg cagattgaag
      361 atggggttgt cgtgggagcc ccaggtgagg gggacaacac gggaggcctc tatcactgcc
      421 gaacaagcag cgagttctgc cagccagtca gcctacatgg ttctaaccat acctccaagt
      481 acttgggaat gacgctggca acagatgccg ccaagggaag ccttttggcc tgtgaccctg
      541 gactgtctcg gacatgcgat cagaacactt acctcagtgg cctctgctac ctcttccccc
      601 agagtctgga gggacctatg ttacaaaatc gtcccgccta tcaggaatgt atgaagggca
      661 aagtcgacct ggtgtttctg ttcgatggct cacagagctt ggatagaaag gactttgaaa
      721 aaatcctgga attcatgaag gatgtgatga ggaagctcag caatacttcc taccagtttg
      781 ctgccgtcca gttctccaca gactgcagaa cagaatttac tttcttggac tacgttaagc
      841 agaacaagaa ccccgatgtt ctgctaggca gcgtgcagcc catgttcttg ctgaccaata
      901 cctttcgtgc catcaactat gtggtggcac acgtgttcaa agaagagtct ggtgccaggc
      961 cggatgctac caaggtgctt gtcatcatta cagacgggga ggcaagtgat aaaggcaaca
     1021 tcagtgcggc ccacgacata acccgctaca tcatcgggat tggcaagcat tttgtgagcg
     1081 tacaaaagca aaagacgctc cacatatttg cctcagaacc tgtagaggaa tttgtgaaga
     1141 ttctggacac ctttgagaag ctgaaggatc tttttactga cctgcagagg aggatttatg
     1201 ctattgaggg cacaaacaga caggacctga catcctttaa catggaactc tcctccagcg
     1261 ggatcagcgc agacctcagc aagggccatg cagttgtggg agctgttggg gctaaggatt
     1321 gggccggggg ctttctggac ctgcgtgaag acctgcaggg tgccacattt gttgggcagg
     1381 aaccgctgac ctcagatgtg agagggggct acctgggtta cactgtggcc tggatgacct
     1441 cccggagctc cagacccctg ctggcagcag gagccccacg gtaccagcat gtgggacaag
     1501 tactgctttt ccaagcccca gaggctggag gacgttggaa ccaaacccag aagatagaag
     1561 ggactcagat cggatcttac tttggtgggg aactatgtag tgttgacctg gaccaagatg
     1621 gcgaggcaga gctgctgctg attggagcac ccctgttctt tggggagcag agaggaggcc
     1681 gagtgttcac ttaccagaga agacagtcgc tgtttgaaat ggtctcagag ctacagggtg
     1741 accctggcta cccgcttggt cggtttggag ccgccataac tgccctgacg gacatcaatg
     1801 gggataggct gactgatgtg gctgtgggag cccctttgga ggagcagggg gctgtgtaca
     1861 tcttcaatgg gaagcctggt gggctcagtc cccagccaag ccagcgtata caaggagccc
     1921 aggtgttccc aggaatccgg tggtttggcc gctccatcca tggggtgaag gaccttggag
     1981 gggacaggct ggcagatgtg gttgtaggag ctgagggtcg ggtggttgtg ctgagctcca
     2041 ggccggtggt ggatgtggtc actgagctgt cgttctcccc agaggaaatc ccagtgcacg
     2101 aggtggagtg ctcctactca gccagggagg agcagaaaca cggagtcaag ctcaaggcat
     2161 gcttccggat caagcccctc acgccacagt ttcaaggtcg cctgcttgcc aacctcagct
     2221 acaccctgca gctggatggc catcggatga ggagccgagg gttgttccca gatggaagcc
     2281 acgagctcag tggaaacacc tccatcaccc cagataaatc ctgcttggac ttccacttcc
     2341 acttcccgat ctgcattcaa gacctcatct cccctatcaa tgtctccctg aatttctctc
     2401 ttttggagga agaaggaaca ccaagggacc aaaagggcag ggccatgcag cctatcctga
     2461 gaccttcaat ccacacagtg actaaggaga tcccttttga gaagaactgt ggtgaagata
     2521 agaagtgtga ggcaaacctg accctgtcat cccctgccag atctggaccc ctgcgtctga
     2581 tgtcctctgc cagccttgct gtggagtgga cactgagcaa ctcaggggaa gatgcctact
     2641 gggtgcgatt agacctggac ttccctcggg gactctcctt ccggaaagtg gagatgcttc
     2701 agccacacag ccgaatgcct gtgagctgcg aggagctcac cgaggggtca agtctcctga
     2761 ctaagacact gaaatgcaat gtaagctctc ccatcttcaa agcaggccag gaggtgagcc
     2821 tccaggtgat gtttaacacg ctactcaaca gctcctggga agacttcgtt gagctgaatg
     2881 gcactgtgca ctgtgagaat gagaactcaa gcctccagga ggacaactca gccgccaccc
     2941 acattcctgt cctgtaccct gtcaacatcc ttactaagga gcaggagaac tccactctct
     3001 atatcagttt cacccctaaa ggtcccaaga cccaacaagt ccagcatgtc taccaggtga
     3061 ggattcagcc atctgcctat gaccacaaca tgcccacact agaggccttg gttggggtgc
     3121 cctggcctca cagtgaggac cccatcacat acacatggag tgtacagacg gatccccttg
     3181 tcacttgcca cagcgaggac ctgaagaggc cgtccagcga agctgagcct tgtctgcctg
     3241 gagtccagtt ccgctgtcca attgtcttca ggcgggagat cctcatccaa gtgacgggga
     3301 ccgtggaact ctccaaggaa atcaaggcct cctccacact cagcctctgc agctcactct
     3361 ccgtctcctt caacagcagc aagcatttcc atttgtatgg cagcaaagcc tccgaggccc
     3421 aggtcctcgt gaaggttgac ctgatccacg agaaggagat gcttcacgtg tacgtactca
     3481 gcggcattgg gggcctcgtg cttctgttcc tgattttcct ggcgctctac aaggttggct
     3541 tcttcaaacg gaacctgaag gagaagatgg aggctgatgg aggtgttcca aatggaagcc
     3601 ctccagaaga cactgaccct ctggcagtac ctggggaaga gaccaaagat atgggctgtc
     3661 tagagcccct ccgggagagt gacaaggact aaggcctagg tctgatacac tgacagccca
     3721 ggaatagact tgagagccct ggctctgacc agcttcagtc acatgccacc gtgtatcctg
     3781 tccttcacta gtcattgctg ttcctagtcc tcagttttcc catctcgagc atagaactca
     3841 ttcctatgtt atctacaggt gcctggcaag taggctgatg aaggccaaga gggccatcgg
     3901 tgaagcctgt cttctgctag cctgccttgt ccctctgaga gaatctttga aataaactcg
     3961 gagaaactgc catctcagga cccagtaata ccccagcctt cccaacttcc ctcagctgtc
     4021 cctacctcct ggatctgccc cacactctct cctgcctaga gtctagcctg gactctgctg
     4081 ccagacagca gatcacatct gtgtcactgc atggctactg cagatgcctt cttgagtcag
     4141 tgacagcatt ccttaatgag ccttaggtct tataaagcca ggccccagtg gcctccccag
     4201 cctctgctgg agatgaccca cctctctttc ccaggctgca gctactatgc cagcctttcc
     4261 cagagtcttt ctccttcctg cattgctgta tttgagctca tgtcctcttc ccctggactg
     4321 tttctgcctc ctcctgtcct gactaaggag ggttccacgc tgtgcacctt gcaccagcct
     4381 gtccttgcct ctgtccacca agttatattt cttctctctt tgatgactta gttcatttct
     4441 acctatcact gagctccttc aggttagggt attctttctg ttcaccttgg gacgctctgg
     4501 tgacatcata ggctagggag cgatatacta ggtgtagttt cactgaattg atggaggctc
     4561 tggtagagaa atagcttggg tgggccccag cattgcatcc ttcagggctc tgcctttcca
     4621 ggctccatca caccccgtaa agcgtaaaag tggttcaagg agctccatac aaagcacgtg
     4681 tgtggccgtt tgactgacaa atgtcccaca caagctcagg catctaaacg cttggtcccc
     4741 gttggtggct cagagaggcc acggggaggc acagccttgc ttgaagaagc acggaagggt
     4801 ggtgagggtt tacagagtgc aagttcactc ccagcttcat acagttgatt gcttactctc
     4861 tccgcttccc gctgtcttgc ctgcttctgg ctgctgtgtg tctttgtcat aaaaagactc
     4921 ttaaactctc tggaatcata cgcccaaata aacttacttg agtgtgctag tttaccatag
     4981 caacagaaaa agtagctaat acagcatgct tgtatctgct tatgcagtag gtgtggaatt
     5041 ctgtccgcct ctgatggttt cgtgctagtg cagtgcttat ttaaatgaat atatttcctc
     5101 aaatgctgta ccaaatagaa ccaaaattat caactctgct tctcttcttc tgtattaggg
     5161 ttgggttttt tgttttgttt tatgttttgt tttctgcaat aaagcaccct aaagaaagc
//
