LOCUS       NM_001253872            5225 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus integrin alpha L (Itgal), transcript variant 1, mRNA.
ACCESSION   NM_001253872
VERSION     NM_001253872.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5225)
  AUTHORS   Thierry,G.R., Baudon,E.M., Bijnen,M., Bellomo,A., Lagueyrie,M.,
            Mondor,I., Simonnet,L., Carrette,F., Fenouil,R., Keshvari,S.,
            Hume,D.A., Dombrowicz,D. and Bajenoff,M.
  TITLE     Non-classical monocytes scavenge the growth factor CSF1 from
            endothelial cells in the peripheral vascular tree to ensure
            survival and homeostasis
  JOURNAL   Immunity 57 (9), 2108-2121 (2024)
   PUBMED   39089257
REFERENCE   2  (bases 1 to 5225)
  AUTHORS   Burton,O.T., Bricard,O., Tareen,S., Gergelits,V., Andrews,S.,
            Biggins,L., Roca,C.P., Whyte,C., Junius,S., Brajic,A., Pasciuto,E.,
            Ali,M., Lemaitre,P., Schlenner,S.M., Ishigame,H., Brown,B.D.,
            Dooley,J. and Liston,A.
  TITLE     The tissue-resident regulatory T cell pool is shaped by transient
            multi-tissue migration and a conserved residency program
  JOURNAL   Immunity 57 (7), 1586-1602 (2024)
   PUBMED   38897202
REFERENCE   3  (bases 1 to 5225)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5225)
  AUTHORS   Niu,T., Li,Z., Huang,Y., Ye,Y., Liu,Y., Ye,Z., Jiang,L., He,X.,
            Wang,L. and Li,J.
  TITLE     LFA-1 knockout inhibited the tumor growth and is correlated with
            treg cells
  JOURNAL   Cell Commun Signal 21 (1), 233 (2023)
   PUBMED   37723552
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5225)
  AUTHORS   Hou,L. and Yuki,K.
  TITLE     CD11a regulates hematopoietic stem and progenitor cells
  JOURNAL   Front Immunol 14, 1219953 (2023)
   PUBMED   37781399
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5225)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 5225)
  AUTHORS   Liu,Y., Jones,B., Aruffo,A., Sullivan,K.M., Linsley,P.S. and
            Janeway,C.A. Jr.
  TITLE     Heat-stable antigen is a costimulatory molecule for CD4 T cell
            growth
  JOURNAL   J Exp Med 175 (2), 437-445 (1992)
   PUBMED   1346270
REFERENCE   8  (bases 1 to 5225)
  AUTHORS   Kyuwa,S., Yamaguchi,K., Toyoda,Y., Fujiwara,K. and Hilgers,J.
  TITLE     Acute and late disease induced by murine coronavirus, strain JHM,
            in a series of recombinant inbred strains between BALB/cHeA and
            STS/A mice
  JOURNAL   Microb Pathog 12 (2), 95-104 (1992)
   PUBMED   1316530
REFERENCE   9  (bases 1 to 5225)
  AUTHORS   Hogarth,P.M. and McKenzie,I.F.
  TITLE     Ly-15.2 and Ly-21.2 are distinct polymorphisms of the LFA-1 heavy
            chain
  JOURNAL   Immunogenetics 36 (6), 396-399 (1992)
   PUBMED   1526659
REFERENCE   10 (bases 1 to 5225)
  AUTHORS   Suzuki,H., Chung,F.Z., Palmer,E., Sasaki,T., Ohara,N., Taylor,B.A.
            and Ohara,J.
  TITLE     Gene mapping of mouse IL-4 receptor: the loci of interleukin 4
            (IL-4) receptor gene and lymphocyte function associated antigen 1
            (LFA-1) gene are closely linked on chromosome 7
  JOURNAL   Immunogenetics 34 (4), 252-256 (1991)
   PUBMED   1680807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133494.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156251.1, BC145802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               AC133494.4         83326-83589
            265-364             AC133494.4         84684-84783
            365-459             AC133494.4         86600-86694
            460-527             AC133494.4         86804-86871
            528-645             AC133494.4         87956-88073
            646-776             AC133494.4         88190-88320
            777-925             AC133494.4         89077-89225
            926-1058            AC133494.4         91999-92131
            1059-1209           AC133494.4         92272-92422
            1210-1283           AC133494.4         93714-93787
            1284-1416           AC133494.4         93880-94012
            1417-1568           AC133494.4         97251-97402
            1569-1706           AC133494.4         97692-97829
            1707-1904           AC133494.4         98284-98481
            1905-2035           AC133494.4         98609-98739
            2036-2196           AC133494.4         101125-101285
            2197-2348           AC133494.4         101378-101529
            2349-2438           AC133494.4         104343-104432
            2439-2492           AC133494.4         108961-109014
            2493-2563           AC133494.4         109118-109188
            2564-2705           AC133494.4         109547-109688
            2706-2816           AC133494.4         111611-111721
            2817-2896           AC133494.4         112088-112167
            2897-2983           AC133494.4         112263-112349
            2984-3059           AC133494.4         114775-114850
            3060-3173           AC133494.4         115253-115366
            3174-3230           AC133494.4         115565-115621
            3231-3332           AC133494.4         115719-115820
            3333-3428           AC133494.4         116491-116586
            3429-3539           AC133494.4         117195-117305
            3540-5225           AC133494.4         120518-122203
FEATURES             Location/Qualifiers
     source          1..5225
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.44 cM"
     gene            1..5225
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /note="integrin alpha L"
                     /db_xref="GeneID:16408"
                     /db_xref="MGI:MGI:96606"
     exon            1..264
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..3698
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; lymphocyte antigen 15; CD11 antigen-like family
                     member A; leukocyte adhesion glycoprotein LFA-1 alpha
                     chain; leukocyte function-associated molecule 1 alpha
                     chain; lymphocyte function associated antigen 1, alpha
                     polypeptide; alpha L integrin"
                     /codon_start=1
                     /product="integrin alpha-L isoform 1 precursor"
                     /protein_id="NP_001240801.1"
                     /db_xref="CCDS:CCDS57589.1"
                     /db_xref="GeneID:16408"
                     /db_xref="MGI:MGI:96606"
                     /translation="MSFRIAGPRLLLLGLQLFAKAWSYNLDTRPTQSFLAQAGRHFGY
                     QVLQIEDGVVVGAPGEGDNTGGLYHCRTSSEFCQPVSLHGSNHTSKYLGMTLATDAAK
                     GSLLACDPGLSRTCDQNTYLSGLCYLFPQSLEGPMLQNRPAYQECMKGKVDLVFLFDG
                     SQSLDRKDFEKILEFMKDVMRKLSNTSYQFAAVQFSTDCRTEFTFLDYVKQNKNPDVL
                     LGSVQPMFLLTNTFRAINYVVAHVFKEESGARPDATKVLVIITDGEASDKGNISAAHD
                     ITRYIIGIGKHFVSVQKQKTLHIFASEPVEEFVKILDTFEKLKDLFTDLQRRIYAIEG
                     TNRQDLTSFNMELSSSGISADLSKGHAVVGAVGAKDWAGGFLDLREDLQGATFVGQEP
                     LTSDVRGGYLGYTVAWMTSRSSRPLLAAGAPRYQHVGQVLLFQAPEAGGRWNQTQKIE
                     GTQIGSYFGGELCSVDLDQDGEAELLLIGAPLFFGEQRGGRVFTYQRRQSLFEMVSEL
                     QGDPGYPLGRFGAAITALTDINGDRLTDVAVGAPLEEQGAVYIFNGKPGGLSPQPSQR
                     IQGAQVFPGIRWFGRSIHGVKDLGGDRLADVVVGAEGRVVVLSSRPVVDVVTELSFSP
                     EEIPVHEVECSYSAREEQKHGVKLKACFRIKPLTPQFQGRLLANLSYTLQLDGHRMRS
                     RGLFPDGSHELSGNTSITPDKSCLDFHFHFPICIQDLISPINVSLNFSLLEEEGTPRD
                     QKVGRAMQPILRPSIHTVTKEIPFEKNCGEDKKCEANLTLSSPARSGPLRLMSSASLA
                     VEWTLSNSGEDAYWVRLDLDFPRGLSFRKVEMLQPHSRMPVSCEELTEGSSLLTKTLK
                     CNVSSPIFKAGQEVSLQVMFNTLLNSSWEDFVELNGTVHCENENSSLQEDNSAATHIP
                     VLYPVNILTKEQENSTLYISFTPKGPKTQQVQHVYQVRIQPSAYDHNMPTLEALVGVP
                     WPHSEDPITYTWSVQTDPLVTCHSEDLKRPSSEAEQPCLPGVQFRCPIVFRREILIQV
                     TGTVELSKEIKASSTLSLCSSLSVSFNSSKHFHLYGSKASEAQVLVKVDLIHEKEMLH
                     VYVLSGIGGLVLLFLIFLALYKVGFFKRNLKEKMEADGGVPNGSPPEDTDPLAVPGEE
                     TKDMGCLEPLRESDKD"
     exon            265..364
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            365..459
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            460..527
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            528..645
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            646..776
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            777..925
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1058
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1209
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1283
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1416
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1568
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1706
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1904
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2035
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2196
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2348
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2438
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2492
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2563
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2705
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2816
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2896
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..2983
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3059
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3173
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..3230
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3332
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            3333..3428
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            3429..3539
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..5225
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3957..3962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /note="hexamer: AATAAA"
     polyA_site      3978
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /note="major polyA site"
     regulatory      5120..5125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
                     /note="hexamer: AATAGA"
     polyA_site      5139
                     /gene="Itgal"
                     /gene_synonym="(p180); Cd11a; LFA-1; LFA-1A; Ly-15; Ly-21"
ORIGIN      
        1 gagaggtttc acaacccgga caggagcgca ccccctcctt ccacccccac ccagtgtcat
       61 cagcctggca gccctgagaa agttccactg gaaggggccc catgcaagag aagccaccat
      121 ttccctcttc ctcccgggtc taggttgcca gcaaatctca agagctctct gagatcgagt
      181 ccggacccac aggtccctcc taagcgcaga tgagtttccg gattgcgggc cccagacttt
      241 tgctactggg actccagctg tttgccaagg cctggagcta caacctggac acacggccta
      301 cgcagagctt cttggcacaa gctggaagac attttgggta ccaggtcttg cagattgaag
      361 atggggttgt cgtgggagcc ccaggtgagg gggacaacac gggaggcctc tatcactgcc
      421 gaacaagcag cgagttctgc cagccagtca gcctacatgg ttctaaccat acctccaagt
      481 acttgggaat gacgctggca acagatgccg ccaagggaag ccttttggcc tgtgaccctg
      541 gactgtctcg gacatgcgat cagaacactt acctcagtgg cctctgctac ctcttccccc
      601 agagtctgga gggacctatg ttacaaaatc gtcccgccta tcaggaatgt atgaagggca
      661 aagtcgacct ggtgtttctg ttcgatggct cacagagctt ggatagaaag gactttgaaa
      721 aaatcctgga attcatgaag gatgtgatga ggaagctcag caatacttcc taccagtttg
      781 ctgccgtcca gttctccaca gactgcagaa cagaatttac tttcttggac tacgttaagc
      841 agaacaagaa ccccgatgtt ctgctaggca gcgtgcagcc catgttcttg ctgaccaata
      901 cctttcgtgc catcaactat gtggtggcac acgtgttcaa agaagagtct ggtgccaggc
      961 cggatgctac caaggtgctt gtcatcatta cagacgggga ggcaagtgat aaaggcaaca
     1021 tcagtgcggc ccacgacata acccgctaca tcatcgggat tggcaagcat tttgtgagcg
     1081 tacaaaagca aaagacgctc cacatatttg cctcagaacc tgtagaggaa tttgtgaaga
     1141 ttctggacac ctttgagaag ctgaaggatc tttttactga cctgcagagg aggatttatg
     1201 ctattgaggg cacaaacaga caggacctga catcctttaa catggaactc tcctccagcg
     1261 ggatcagcgc agacctcagc aagggccatg cagttgtggg agctgttggg gctaaggatt
     1321 gggccggggg ctttctggac ctgcgtgaag acctgcaggg tgccacattt gttgggcagg
     1381 aaccgctgac ctcagatgtg agagggggct acctgggtta cactgtggcc tggatgacct
     1441 cccggagctc cagacccctg ctggcagcag gagccccacg gtaccagcat gtgggacaag
     1501 tactgctttt ccaagcccca gaggctggag gacgttggaa ccaaacccag aagatagaag
     1561 ggactcagat cggatcttac tttggtgggg aactatgtag tgttgacctg gaccaagatg
     1621 gcgaggcaga gctgctgctg attggagcac ccctgttctt tggggagcag agaggaggcc
     1681 gagtgttcac ttaccagaga agacagtcgc tgtttgaaat ggtctcagag ctacagggtg
     1741 accctggcta cccgcttggt cggtttggag ccgccataac tgccctgacg gacatcaatg
     1801 gggataggct gactgatgtg gctgtgggag cccctttgga ggagcagggg gctgtgtaca
     1861 tcttcaatgg gaagcctggt gggctcagtc cccagccaag ccagcgtata caaggagccc
     1921 aggtgttccc aggaatccgg tggtttggcc gctccatcca tggggtgaag gaccttggag
     1981 gggacaggct ggcagatgtg gttgtaggag ctgagggtcg ggtggttgtg ctgagctcca
     2041 ggccggtggt ggatgtggtc actgagctgt cgttctcccc agaggaaatc ccagtgcacg
     2101 aggtggagtg ctcctactca gccagggagg agcagaaaca cggagtcaag ctcaaggcat
     2161 gcttccggat caagcccctc acgccacagt ttcaaggtcg cctgcttgcc aacctcagct
     2221 acaccctgca gctggatggc catcggatga ggagccgagg gttgttccca gatggaagcc
     2281 acgagctcag tggaaacacc tccatcaccc cagataaatc ctgcttggac ttccacttcc
     2341 acttcccgat ctgcattcaa gacctcatct cccctatcaa tgtctccctg aatttctctc
     2401 ttttggagga agaaggaaca ccaagggacc aaaaggtggg cagggccatg cagcctatcc
     2461 tgagaccttc aatccacaca gtgactaagg agatcccttt tgagaagaac tgtggtgaag
     2521 ataagaagtg tgaggcaaac ctgaccctgt catcccctgc cagatctgga cccctgcgtc
     2581 tgatgtcctc tgccagcctt gctgtggagt ggacactgag caactcaggg gaagatgcct
     2641 actgggtgcg attagacctg gacttccctc ggggactctc cttccggaaa gtggagatgc
     2701 ttcagccaca cagccgaatg cctgtgagct gcgaggagct caccgagggg tcaagtctcc
     2761 tgactaagac actgaaatgc aatgtaagct ctcccatctt caaagcaggc caggaggtga
     2821 gcctccaggt gatgtttaac acgctactca acagctcctg ggaagacttc gttgagctga
     2881 atggcactgt gcactgtgag aatgagaact caagcctcca ggaggacaac tcagccgcca
     2941 cccacattcc tgtcctgtac cctgtcaaca tccttactaa ggagcaggag aactccactc
     3001 tctatatcag tttcacccct aaaggtccca agacccaaca agtccagcat gtctaccagg
     3061 tgaggattca gccatctgcc tatgaccaca acatgcccac actagaggcc ttggttgggg
     3121 tgccctggcc tcacagtgag gaccccatca catacacatg gagtgtacag acggatcccc
     3181 ttgtcacttg ccacagcgag gacctgaaga ggccgtccag cgaagctgag cagccttgtc
     3241 tgcctggagt ccagttccgc tgtccaattg tcttcaggcg ggagatcctc atccaagtga
     3301 cggggaccgt ggaactctcc aaggaaatca aggcctcctc cacactcagc ctctgcagct
     3361 cactctccgt ctccttcaac agcagcaagc atttccattt gtatggcagc aaagcctccg
     3421 aggcccaggt cctcgtgaag gttgacctga tccacgagaa ggagatgctt cacgtgtacg
     3481 tactcagcgg cattgggggc ctcgtgcttc tgttcctgat tttcctggcg ctctacaagg
     3541 ttggcttctt caaacggaac ctgaaggaga agatggaggc tgatggaggt gttccaaatg
     3601 gaagccctcc agaagacact gaccctctgg cagtacctgg ggaagagacc aaagatatgg
     3661 gctgtctaga gcccctccgg gagagtgaca aggactaagg cctaggtctg atacactgac
     3721 agcccaggaa tagacttgag agccctggct ctgaccagct tcagtcacat gccaccgtgt
     3781 atcctgtcct tcactagtca ttgctgttcc tagtcctcag ttttcccatc tcgagcatag
     3841 aactcattcc tatgttatct acaggtgcct ggcaagtagg ctgatgaagg ccaagagggc
     3901 catcggtgaa gcctgtcttc tgctagcctg ccttgtccct ctgagagaat ctttgaaata
     3961 aactcggaga aactgccatc tcaggaccca gtaatacccc agccttccca acttccctca
     4021 gctgtcccta cctcctggat ctgccccaca ctctctcctg cctagagtct agcctggact
     4081 ctgctgccag acagcagatc acatctgtgt cactgcatgg ctactgcaga tgccttcttg
     4141 agtcagtgac agcattcctt aatgagcctt aggtcttata aagccaggcc ccagtggcct
     4201 ccccagcctc tgctggagat gacccacctc tctttcccag gctgcagcta ctatgccagc
     4261 ctttcccaga gtctttctcc ttcctgcatt gctgtatttg agctcatgtc ctcttcccct
     4321 ggactgtttc tgcctcctcc tgtcctgact aaggagggtt ccacgctgtg caccttgcac
     4381 cagcctgtcc ttgcctctgt ccaccaagtt atatttcttc tctctttgat gacttagttc
     4441 atttctacct atcactgagc tccttcaggt tagggtattc tttctgttca ccttgggacg
     4501 ctctggtgac atcataggct agggagcgat atactaggtg tagtttcact gaattgatgg
     4561 aggctctggt agagaaatag cttgggtggg ccccagcatt gcatccttca gggctctgcc
     4621 tttccaggct ccatcacacc ccgtaaagcg taaaagtggt tcaaggagct ccatacaaag
     4681 cacgtgtgtg gccgtttgac tgacaaatgt cccacacaag ctcaggcatc taaacgcttg
     4741 gtccccgttg gtggctcaga gaggccacgg ggaggcacag ccttgcttga agaagcacgg
     4801 aagggtggtg agggtttaca gagtgcaagt tcactcccag cttcatacag ttgattgctt
     4861 actctctccg cttcccgctg tcttgcctgc ttctggctgc tgtgtgtctt tgtcataaaa
     4921 agactcttaa actctctgga atcatacgcc caaataaact tacttgagtg tgctagttta
     4981 ccatagcaac agaaaaagta gctaatacag catgcttgta tctgcttatg cagtaggtgt
     5041 ggaattctgt ccgcctctga tggtttcgtg ctagtgcagt gcttatttaa atgaatatat
     5101 ttcctcaaat gctgtaccaa atagaaccaa aattatcaac tctgcttctc ttcttctgta
     5161 ttagggttgg gttttttgtt ttgttttatg ttttgttttc tgcaataaag caccctaaag
     5221 aaagc
//
