LOCUS       NM_008399               3858 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus integrin alpha E, epithelial-associated (Itgae),
            transcript variant 1, mRNA.
ACCESSION   NM_008399
VERSION     NM_008399.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3858)
  AUTHORS   Burton,O.T., Bricard,O., Tareen,S., Gergelits,V., Andrews,S.,
            Biggins,L., Roca,C.P., Whyte,C., Junius,S., Brajic,A., Pasciuto,E.,
            Ali,M., Lemaitre,P., Schlenner,S.M., Ishigame,H., Brown,B.D.,
            Dooley,J. and Liston,A.
  TITLE     The tissue-resident regulatory T cell pool is shaped by transient
            multi-tissue migration and a conserved residency program
  JOURNAL   Immunity 57 (7), 1586-1602 (2024)
   PUBMED   38897202
REFERENCE   2  (bases 1 to 3858)
  AUTHORS   Nakai,S., Kume,M., Matsumura,Y., Koguchi-Yoshioka,H., Matsuda,S.,
            Fujimoto,M. and Watanabe,R.
  TITLE     CD69 Is Indispensable for Development of Functional Local Immune
            Memory in Murine Contact Hypersensitivity
  JOURNAL   J Invest Dermatol 144 (6), 1344-1352 (2024)
   PUBMED   38135026
REFERENCE   3  (bases 1 to 3858)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3858)
  AUTHORS   Zhang,W., An,E.K., Kim,S.J., Park,H.B., Lee,P.C.W. and Jin,J.O.
  TITLE     Escherichia coli adhesion protein FimH exacerbates colitis via
            CD11b+CD103- dendritic cell activation
  JOURNAL   Front Immunol 14, 1284770 (2023)
   PUBMED   38077339
  REMARK    GeneRIF: Escherichia coli adhesion protein FimH exacerbates colitis
            via CD11b[+]CD103[-] dendritic cell activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3858)
  AUTHORS   Shi,F., Tang,S., Chen,D., Mo,F., Li,J., Fang,C., Wei,H., Xing,J.,
            Liu,L., Gong,Y., Tan,Z., Zhang,Z., Pan,X., Zhao,S. and Huang,J.
  TITLE     Immunological characteristics of CD103+CD8+ Tc cells in the liver
            of C57BL/6 mouse infected with plasmodium NSM
  JOURNAL   Parasitol Res 122 (11), 2513-2524 (2023)
   PUBMED   37707607
  REMARK    GeneRIF: Immunological characteristics of CD103[+]CD8[+] Tc cells
            in the liver of C57BL/6 mouse infected with plasmodium NSM.
REFERENCE   6  (bases 1 to 3858)
  AUTHORS   Schon,M.P., Schon,M., Warren,H.B., Donohue,J.P. and Parker,C.M.
  TITLE     Cutaneous inflammatory disorder in integrin alphaE
            (CD103)-deficient mice
  JOURNAL   J Immunol 165 (11), 6583-6589 (2000)
   PUBMED   11086102
REFERENCE   7  (bases 1 to 3858)
  AUTHORS   Brenan,M. and Rees,D.J.
  TITLE     Sequence analysis or rat integrin alphaE1 and alphaE2 subunits:
            tissue expression reveals phenotypic similarities between
            intraepithelial lymphocytes and dendritic cells in lymph
  JOURNAL   Eur J Immunol 30 (6), 1527-1537 (2000)
   PUBMED   10898487
REFERENCE   8  (bases 1 to 3858)
  AUTHORS   Schon,M.P., Arya,A., Murphy,E.A., Adams,C.M., Strauch,U.G.,
            Agace,W.W., Marsal,J., Donohue,J.P., Her,H., Beier,D.R., Olson,S.,
            Lefrancois,L., Brenner,M.B., Grusby,M.J. and Parker,C.M.
  TITLE     Mucosal T lymphocyte numbers are selectively reduced in integrin
            alpha E (CD103)-deficient mice
  JOURNAL   J Immunol 162 (11), 6641-6649 (1999)
   PUBMED   10352281
REFERENCE   9  (bases 1 to 3858)
  AUTHORS   Ibrahim,M.M., Razmara,M., Nguyen,D., Donahue,R.J., Wubah,J.A. and
            Knudsen,T.B.
  TITLE     Altered expression of mitochondrial 16S ribosomal RNA in
            p53-deficient mouse embryos revealed by differential display
  JOURNAL   Biochim Biophys Acta 1403 (3), 254-264 (1998)
   PUBMED   9685670
REFERENCE   10 (bases 1 to 3858)
  AUTHORS   Smith,T.J., Ducharme,L.A., Shaw,S.K., Parker,C.M., Brenner,M.B.,
            Kilshaw,P.J. and Weis,J.H.
  TITLE     Murine M290 integrin expression modulated by mast cell activation
  JOURNAL   Immunity 1 (5), 393-403 (1994)
   PUBMED   7882170
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670399.4.
            
            On Jan 14, 2022 this sequence version replaced NM_008399.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ386608.1, U12236.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AL670399.4         114431-114515
            86-209              AL670399.4         127722-127845
            210-307             AL670399.4         134367-134464
            308-375             AL670399.4         135192-135259
            376-493             AL670399.4         135607-135724
            494-625             AL670399.4         135918-136049
            626-741             AL670399.4         136815-136930
            742-893             AL670399.4         137443-137594
            894-1047            AL670399.4         138718-138871
            1048-1198           AL670399.4         139368-139518
            1199-1266           AL670399.4         139941-140008
            1267-1405           AL670399.4         140975-141113
            1406-1551           AL670399.4         141913-142058
            1552-1692           AL670399.4         142356-142496
            1693-1917           AL670399.4         143191-143415
            1918-2048           AL670399.4         144136-144266
            2049-2179           AL670399.4         145705-145835
            2180-2340           AL670399.4         146969-147129
            2341-2469           AL670399.4         149120-149248
            2470-2543           AL670399.4         150740-150813
            2544-2676           AL670399.4         153030-153162
            2677-2775           AL670399.4         154784-154882
            2776-2855           AL670399.4         155549-155628
            2856-2930           AL670399.4         156555-156629
            2931-2994           AL670399.4         157704-157767
            2995-3102           AL670399.4         157852-157959
            3103-3159           AL670399.4         162316-162372
            3160-3255           AL670399.4         162628-162723
            3256-3351           AL670399.4         164528-164623
            3352-3462           AL670399.4         169402-169512
            3463-3858           AL670399.4         170912-171307
FEATURES             Location/Qualifiers
     source          1..3858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.22 cM"
     gene            1..3858
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /note="integrin alpha E, epithelial-associated"
                     /db_xref="GeneID:16407"
                     /db_xref="MGI:MGI:1298377"
     exon            1..85
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..3552
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; integrin alpha-E; integrin alpha M290"
                     /codon_start=1
                     /product="integrin alpha-E isoform 1 precursor"
                     /protein_id="NP_032425.2"
                     /db_xref="CCDS:CCDS24995.1"
                     /db_xref="GeneID:16407"
                     /db_xref="MGI:MGI:1298377"
                     /translation="MKWLFHTLLCMASLKPQGAFNLDVDWAWVTALQPGAPAVLSSLL
                     HQDPSNNQTCLLVARRSSNRNTAALYRCAISISPDEIACQPVEHICMPKGRYQGVTLV
                     GNHNGVLVCIQVQARKFRSLNSELTGACSLLTPNLDLQAQAYFSDLEGFLDPGAHVDS
                     GDYCRSKGGSTGEEKKSARRRRTVEEEDEEEDGTEIAIVLDGSGSIEPSDFQKAKNFI
                     STMMRNFYEKCFECNFALVQYGAVIQTEFDLQESRDINASLAKVQSIVQVKEVTKTAS
                     AMQHVLDNIFIPSRGSRKKALKVMVVLTDGDIFGDPLNLTTVINSPKMQGVVRFAIGV
                     GDAFKNNNTYRELKLIASDPKEAHTFKVTNYSALDGLLSKLQQHIVHMEGTVGDALQY
                     QLAQTGFSAQILDKGQVLLGTVGAFNWSGGALLYSTQNGRGCFLNQTAKEDSRTVQYS
                     YLGYSLAVLHKAHGVSYVAGAPRHKLRGAVFELRKEDREEDAFVRRIEGEQMGSYFGS
                     VLCPVDIDMDGTTDFLLVAAPFYHIRGEEGRVYVYQVPEQDASFSLAHTLSGHPGLTN
                     SRFGFAMAAVGDINQDKFTDVAIGAPLEGFGAGDGASYGSVYIYNGHSGGLYDSPSQQ
                     IRASSVASGLHYFGMSVSGGLDFNGDGLADITVGSRDSAVVLRSRPVVDLTVSMTFTP
                     DALPMVFIGKMDVKLCFEVDSSGVASEPGLREMFLNFTVDVDVTKQRQRLQCEDSSGC
                     QSCLRKWNGGSFLCEHFWLISTEELCEEDCFSNITIKVTYEFQTSGGRRDYPNPTLDH
                     YKEPSAIFQLPYEKDCKNKVFCIAEIQLTTNISQQELVVGVTKEVTMNISLTNSGEDS
                     YMTNMALNYPRNLQFKKIQKPVSPDVQCDDPKPVASVLVMNCKIGHPILKRSSVNVSV
                     TWQLEESVFPNRTADITVTISNSNEKSLARETRSLQFRHAFIAVLSRPSVMYMNTSQS
                     PSDHKEFFFNVHGENLFGAVFQLQICVPIKLQDFQIVRVKNLTKTQDHTECTQSQEPA
                     CGSDPVQHVKEWHSVVCAITSNKENVTVAAEISVGHTKQLLRDVSELPILGEISFNKS
                     LYEGLNAENHRTKITVIFLKEEETRSLPLIIGSSIGGLLVLVVIIAILFKCGFFKRKY
                     QQLNLESTRRAQLKADSLLQD"
     exon            86..209
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            210..307
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            308..375
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            376..493
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            494..625
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            626..741
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            742..893
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1047
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1198
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1266
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1405
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1551
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1692
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1917
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2048
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2179
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2340
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2469
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2543
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2676
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2775
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2855
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..2930
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..2994
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3102
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            3103..3159
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            3160..3255
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3351
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            3352..3462
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3858
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3741..3746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /note="hexamer: ATTAAA"
     polyA_site      3760
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
     regulatory      3836..3841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /note="hexamer: ATTAAA"
     polyA_site      3858
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /note="major polyA site"
ORIGIN      
        1 ccttctgtgt cgccccactc agctcacaca gctgcatctg ctccagctat gaagtggctc
       61 ttccataccc ttctctgcat ggccagcctg aagccccagg gagccttcaa tttggatgtg
      121 gactgggcct gggtcacagc actccagcca ggtgcaccgg ctgtgctcag ctcccttctg
      181 catcaagacc ccagcaacaa ccagacctgc ctcctggtag ccagacgcag ctccaacagg
      241 aatacagccg ccctgtatcg atgcgctata tccatcagtc cagatgaaat tgcttgccag
      301 ccagtggagc acatctgtat gccaaagggc aggtaccagg gagtgacatt ggtcgggaac
      361 cacaatggtg ttttggtgtg cattcaggta caggcccgga agttccgcag cctcaactca
      421 gagctcacgg gtgcctgcag cctactcacc cccaatttgg acctccaggc ccaagcctac
      481 ttctctgacc tcgaagggtt cctggatcca ggagcacatg tggactctgg tgactactgt
      541 agaagcaaag gaggcagcac aggggaggag aagaagtcag ccaggagacg ccggacagtg
      601 gaggaggaag acgaggagga agatggcact gagatcgcta ttgtcctgga tggctcagga
      661 agcattgaac cctcagactt ccagaaggcc aaaaatttca tctctaccat gatgaggaac
      721 ttctatgaga agtgttttga gtgcaacttt gccctggtgc agtatggggc cgtgatccag
      781 actgagtttg atcttcaaga gagccgggac attaacgcct cccttgccaa agttcagagc
      841 atcgttcaag tgaaggaagt cactaagacc gcctcagcca tgcagcatgt cctagacaat
      901 atcttcattc caagccgtgg ctccagaaaa aaagcattga aggtcatggt ggtacttact
      961 gatggtgaca tatttgggga ccctctcaat cttacgactg tcatcaactc cccaaagatg
     1021 cagggtgttg tgcgctttgc cattggggtg ggtgatgcat tcaagaataa caacacttac
     1081 agagaactga agctgattgc ctcagacccc aaagaggccc acactttcaa ggtgaccaac
     1141 tactcagctc tggatgggct gctgagcaag ctgcaacaac acatcgttca tatggaaggt
     1201 acagttggag atgcccttca atatcaactc gcacagactg gtttcagtgc ccagatcctg
     1261 gacaaggggc aggtgttgct tggcactgtg ggggccttta actggtctgg gggtgcgctg
     1321 ctctacagca cacagaatgg ccggggctgc ttcctaaacc agacagccaa ggaggactcc
     1381 aggactgtac agtacagcta cctaggttac tcccttgcgg tgctacacaa ggcccacggc
     1441 gtctcttacg tggcaggggc tccaaggcac aagctccgtg gggctgtgtt tgagctccgg
     1501 aaggaggaca gagaggagga tgcctttgtg cgacggatag aaggagagca gatggggtcc
     1561 tactttggct ctgtgctgtg ccctgtggat atcgacatgg atgggaccac agattttcta
     1621 ctggtggctg ctccatttta ccacatccgt ggagaagaag gcagagtcta tgtgtaccag
     1681 gtgcctgagc aggatgcttc cttctccttg gcacacacac tgagtgggca ccctgggctc
     1741 accaatagcc gctttggctt tgccatggca gctgtggggg atatcaacca agacaaattc
     1801 acagatgtgg ccattggggc ccctctggag ggttttgggg caggtgacgg ggccagctat
     1861 ggcagcgtgt acatctacaa cggacactca ggtggcttgt atgacagtcc ttcccagcag
     1921 atccgagcct cctctgtggc ctcgggactc cactacttcg gcatgtctgt gtccggtggg
     1981 ttagatttca atggcgatgg ccttgccgat atcacagttg gctctcggga ctcggcggtt
     2041 gtgctccgct cacgccctgt ggttgacctg accgtatcta tgacctttac ccccgatgca
     2101 ctgcccatgg tcttcatagg caagatggat gtaaaactgt gttttgaagt tgactcttca
     2161 ggcgtagctt ctgagccagg ccttagagag atgttcctca actttacggt ggatgtggat
     2221 gtgaccaagc aaaggcagag gctgcagtgt gaggactcga gcggttgtca gagctgcctc
     2281 aggaagtgga acggagggtc ctttctgtgt gaacacttct ggctcatctc cacagaggag
     2341 ctttgtgagg aggactgctt ctccaacatc accatcaagg tcacctacga gttccagacg
     2401 tctgggggaa ggagggacta ccccaacccc accctggacc actacaagga accctctgcc
     2461 atcttccagc tgccctacga gaaggactgc aagaacaaag tgttctgcat cgctgagatc
     2521 cagctgacca ccaacatctc ccagcaggaa ctggtggtgg gcgtcacaaa ggaggtgacc
     2581 atgaacatca gcctgactaa ctctggagag gattcctaca tgacaaacat ggctctcaat
     2641 tatcccagaa acttacagtt taagaagata caaaagccag tatctccaga tgttcagtgt
     2701 gatgacccca agccagttgc ttctgtcctg gtcatgaact gcaagattgg tcaccccata
     2761 ctcaagagat catctgtgaa tgtctcagta acttggcagc tagaggagag tgtctttcca
     2821 aataggacag cagatatcac tgtgaccatc tccaattcca atgagaagtc tttggccaga
     2881 gagacacgca gccttcaatt cagacatgcc ttcattgcag ttctttccag accctcagtg
     2941 atgtacatga acacaagcca aagcccttct gaccacaaag aattcttctt caatgtgcat
     3001 ggggagaatc tttttggagc tgtattccag ttgcaaattt gtgtccccat caaattacaa
     3061 gatttccaga ttgtaagagt gaagaatctg acaaagactc aggaccacac tgagtgcacc
     3121 cagagtcaag agcctgcgtg tggaagcgat cctgtgcagc atgtaaaaga atggcattca
     3181 gtggtctgtg ctatcacatc taataaagaa aatgtaaccg tggccgcaga gatctccgtg
     3241 ggccacacta agcagttact aagagatgta tctgaactgc cgatccttgg tgaaatatct
     3301 ttcaacaaat ctctctatga ggggctgaat gcagagaacc acaggacgaa gatcactgtc
     3361 atcttcctga aagaggagga gacacgctct ttgcctctca tcattggcag cagcatcgga
     3421 ggcctcctgg tcttggttgt gattatagcc attttgttca agtgtggctt tttcaaaaga
     3481 aaatatcaac aactgaactt ggagagcaca aggagggccc agctgaaggc tgacagtctg
     3541 ctccaagatt agccccctgc ttcctcaccg gaaggaggga gtttgagcca gtcggaagcc
     3601 gggatgcccc ctatcggggc cccttactct ccttaggacg atcaagcaac atcaaagaac
     3661 tgtagagtgt tgttcatagc cacacactat gcccacagtg tcttgtgaat tgagcaaaag
     3721 ggaaacttag gatgtgtgct attaaataca tttactttta cagcagtgcc tttaatgagc
     3781 acggttccca gtttgccatg cgttttgatg actgatagac caaagtctta ttcctattaa
     3841 aatattaatt atatcatt
//
