LOCUS       NP_032425               1167 aa            linear   ROD 08-APR-2025
DEFINITION  integrin alpha-E isoform 1 precursor [Mus musculus].
ACCESSION   NP_032425
VERSION     NP_032425.2
DBSOURCE    REFSEQ: accession NM_008399.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1167)
  AUTHORS   Burton,O.T., Bricard,O., Tareen,S., Gergelits,V., Andrews,S.,
            Biggins,L., Roca,C.P., Whyte,C., Junius,S., Brajic,A., Pasciuto,E.,
            Ali,M., Lemaitre,P., Schlenner,S.M., Ishigame,H., Brown,B.D.,
            Dooley,J. and Liston,A.
  TITLE     The tissue-resident regulatory T cell pool is shaped by transient
            multi-tissue migration and a conserved residency program
  JOURNAL   Immunity 57 (7), 1586-1602 (2024)
   PUBMED   38897202
REFERENCE   2  (residues 1 to 1167)
  AUTHORS   Nakai,S., Kume,M., Matsumura,Y., Koguchi-Yoshioka,H., Matsuda,S.,
            Fujimoto,M. and Watanabe,R.
  TITLE     CD69 Is Indispensable for Development of Functional Local Immune
            Memory in Murine Contact Hypersensitivity
  JOURNAL   J Invest Dermatol 144 (6), 1344-1352 (2024)
   PUBMED   38135026
REFERENCE   3  (residues 1 to 1167)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 1167)
  AUTHORS   Zhang,W., An,E.K., Kim,S.J., Park,H.B., Lee,P.C.W. and Jin,J.O.
  TITLE     Escherichia coli adhesion protein FimH exacerbates colitis via
            CD11b+CD103- dendritic cell activation
  JOURNAL   Front Immunol 14, 1284770 (2023)
   PUBMED   38077339
  REMARK    GeneRIF: Escherichia coli adhesion protein FimH exacerbates colitis
            via CD11b[+]CD103[-] dendritic cell activation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1167)
  AUTHORS   Shi,F., Tang,S., Chen,D., Mo,F., Li,J., Fang,C., Wei,H., Xing,J.,
            Liu,L., Gong,Y., Tan,Z., Zhang,Z., Pan,X., Zhao,S. and Huang,J.
  TITLE     Immunological characteristics of CD103+CD8+ Tc cells in the liver
            of C57BL/6 mouse infected with plasmodium NSM
  JOURNAL   Parasitol Res 122 (11), 2513-2524 (2023)
   PUBMED   37707607
  REMARK    GeneRIF: Immunological characteristics of CD103[+]CD8[+] Tc cells
            in the liver of C57BL/6 mouse infected with plasmodium NSM.
REFERENCE   6  (residues 1 to 1167)
  AUTHORS   Schon,M.P., Schon,M., Warren,H.B., Donohue,J.P. and Parker,C.M.
  TITLE     Cutaneous inflammatory disorder in integrin alphaE
            (CD103)-deficient mice
  JOURNAL   J Immunol 165 (11), 6583-6589 (2000)
   PUBMED   11086102
REFERENCE   7  (residues 1 to 1167)
  AUTHORS   Brenan,M. and Rees,D.J.
  TITLE     Sequence analysis or rat integrin alphaE1 and alphaE2 subunits:
            tissue expression reveals phenotypic similarities between
            intraepithelial lymphocytes and dendritic cells in lymph
  JOURNAL   Eur J Immunol 30 (6), 1527-1537 (2000)
   PUBMED   10898487
REFERENCE   8  (residues 1 to 1167)
  AUTHORS   Schon,M.P., Arya,A., Murphy,E.A., Adams,C.M., Strauch,U.G.,
            Agace,W.W., Marsal,J., Donohue,J.P., Her,H., Beier,D.R., Olson,S.,
            Lefrancois,L., Brenner,M.B., Grusby,M.J. and Parker,C.M.
  TITLE     Mucosal T lymphocyte numbers are selectively reduced in integrin
            alpha E (CD103)-deficient mice
  JOURNAL   J Immunol 162 (11), 6641-6649 (1999)
   PUBMED   10352281
REFERENCE   9  (residues 1 to 1167)
  AUTHORS   Ibrahim,M.M., Razmara,M., Nguyen,D., Donahue,R.J., Wubah,J.A. and
            Knudsen,T.B.
  TITLE     Altered expression of mitochondrial 16S ribosomal RNA in
            p53-deficient mouse embryos revealed by differential display
  JOURNAL   Biochim Biophys Acta 1403 (3), 254-264 (1998)
   PUBMED   9685670
REFERENCE   10 (residues 1 to 1167)
  AUTHORS   Smith,T.J., Ducharme,L.A., Shaw,S.K., Parker,C.M., Brenner,M.B.,
            Kilshaw,P.J. and Weis,J.H.
  TITLE     Murine M290 integrin expression modulated by mast cell activation
  JOURNAL   Immunity 1 (5), 393-403 (1994)
   PUBMED   7882170
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670399.4.
            
            On Apr 15, 2009 this sequence version replaced NP_032425.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ386608.1, U12236.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1167
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.22 cM"
     Protein         1..1167
                     /product="integrin alpha-E isoform 1 precursor"
                     /note="integrin alpha-E; integrin alpha M290"
                     /calculated_mol_wt=126749
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2176
     mat_peptide     20..1167
                     /product="Integrin alpha-E. /id=PRO_0000016286"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60677.2)"
                     /calculated_mol_wt=126749
     mat_peptide     20..181
                     /product="Integrin alpha-E light chain.
                     /id=PRO_0000016287"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60677.2)"
                     /calculated_mol_wt=17618
     Region          27..81
                     /region_name="FG-GAP 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60677.2)"
     Site            51
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60677.2)"
     Region          84..142
                     /region_name="FG-GAP 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60677.2)"
     Region          149..192
                     /region_name="X-domain (extra domain)"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60677.2)"
     Region          163..191
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60677.2)"
     mat_peptide     183..1167
                     /product="Integrin alpha-E heavy chain.
                     /id=PRO_0000016288"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60677.2)"
                     /calculated_mol_wt=108993
     Region          196..371
                     /region_name="vWA_integrins_alpha_subunit"
                     /note="Integrins are a class of adhesion receptors that
                     link the extracellular matrix to the cytoskeleton and
                     cooperate with growth factor receptors to promote celll
                     survival, cell cycle progression and cell migration.
                     Integrins consist of an alpha and a beta...; cd01469"
                     /db_xref="CDD:238746"
     Site            order(196,217,299,301,330,360)
                     /site_type="active"
                     /note="integrin inhibitor binding pocket [active]"
                     /db_xref="CDD:238746"
     Site            order(201,203,205,272,305)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238746"
     Site            order(203..205,207,272)
                     /site_type="active"
                     /note="integrin-collagen binding site [active]"
                     /db_xref="CDD:238746"
     Site            256
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60677.2)"
     Site            314
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60677.2)"
     Site            341
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60677.2)"
     Site            364
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60677.2)"
     Region          383..435
                     /region_name="FG-GAP 3.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60677.2)"
     Site            418
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60677.2)"
     Site            437
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60677.2)"
     Region          438..491
                     /region_name="FG-GAP 4.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60677.2)"
     Region          492..552
                     /region_name="FG-GAP 5.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60677.2)"
     Region          502..558
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          555..619
                     /region_name="FG-GAP 6.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60677.2)"
     Region          566..625
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          623..683
                     /region_name="FG-GAP 7.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60677.2)"
     Region          636..>659
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          669..>939
                     /region_name="Integrin_alpha2"
                     /note="Integrin alpha; pfam08441"
                     /db_xref="CDD:462478"
     Site            718
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60677.2)"
     Site            773
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60677.2)"
     Site            829
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60677.2)"
     Site            846
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60677.2)"
     Site            911
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60677.2)"
     Site            925
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60677.2)"
     Site            968
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60677.2)"
     Site            1013
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60677.2)"
     Site            1055
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60677.2)"
     Site            1086
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60677.2)"
     Site            1115..1137
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60677.2)"
     Region          1140..1144
                     /region_name="GFFKR motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60677.2)"
     CDS             1..1167
                     /gene="Itgae"
                     /gene_synonym="A530055J10; alpha-E1; alpha-M290; aM290;
                     CD103"
                     /coded_by="NM_008399.4:49..3552"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS24995.1"
                     /db_xref="GeneID:16407"
                     /db_xref="MGI:MGI:1298377"
ORIGIN      
        1 mkwlfhtllc maslkpqgaf nldvdwawvt alqpgapavl ssllhqdpsn nqtcllvarr
       61 ssnrntaaly rcaisispde iacqpvehic mpkgryqgvt lvgnhngvlv ciqvqarkfr
      121 slnseltgac slltpnldlq aqayfsdleg fldpgahvds gdycrskggs tgeekksarr
      181 rrtveeedee edgteiaivl dgsgsiepsd fqkaknfist mmrnfyekcf ecnfalvqyg
      241 aviqtefdlq esrdinasla kvqsivqvke vtktasamqh vldnifipsr gsrkkalkvm
      301 vvltdgdifg dplnlttvin spkmqgvvrf aigvgdafkn nntyrelkli asdpkeahtf
      361 kvtnysaldg llsklqqhiv hmegtvgdal qyqlaqtgfs aqildkgqvl lgtvgafnws
      421 ggallystqn grgcflnqta kedsrtvqys ylgyslavlh kahgvsyvag aprhklrgav
      481 felrkedree dafvrriege qmgsyfgsvl cpvdidmdgt tdfllvaapf yhirgeegrv
      541 yvyqvpeqda sfslahtlsg hpgltnsrfg famaavgdin qdkftdvaig aplegfgagd
      601 gasygsvyiy nghsgglyds psqqirassv asglhyfgms vsggldfngd gladitvgsr
      661 dsavvlrsrp vvdltvsmtf tpdalpmvfi gkmdvklcfe vdssgvasep glremflnft
      721 vdvdvtkqrq rlqcedssgc qsclrkwngg sflcehfwli steelceedc fsnitikvty
      781 efqtsggrrd ypnptldhyk epsaifqlpy ekdcknkvfc iaeiqlttni sqqelvvgvt
      841 kevtmnislt nsgedsymtn malnyprnlq fkkiqkpvsp dvqcddpkpv asvlvmncki
      901 ghpilkrssv nvsvtwqlee svfpnrtadi tvtisnsnek slaretrslq frhafiavls
      961 rpsvmymnts qspsdhkeff fnvhgenlfg avfqlqicvp iklqdfqivr vknltktqdh
     1021 tectqsqepa cgsdpvqhvk ewhsvvcait snkenvtvaa eisvghtkql lrdvselpil
     1081 geisfnksly eglnaenhrt kitviflkee etrslpliig ssiggllvlv viiailfkcg
     1141 ffkrkyqqln lestrraqlk adsllqd
//
